Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3C8_LEIMU

TriTrypDb:

LmxM.31.3440

Length:

864

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3C8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3C8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.635
CLV_C14_Caspase3-7	723	727	PF00656	0.594
CLV_NRD_NRD_1	100	102	PF00675	0.426
CLV_NRD_NRD_1	116	118	PF00675	0.448
CLV_NRD_NRD_1	163	165	PF00675	0.755
CLV_NRD_NRD_1	177	179	PF00675	0.698
CLV_NRD_NRD_1	376	378	PF00675	0.597
CLV_NRD_NRD_1	579	581	PF00675	0.638
CLV_NRD_NRD_1	608	610	PF00675	0.693
CLV_NRD_NRD_1	771	773	PF00675	0.546
CLV_NRD_NRD_1	96	98	PF00675	0.427
CLV_PCSK_FUR_1	606	610	PF00082	0.509
CLV_PCSK_KEX2_1	116	118	PF00082	0.448
CLV_PCSK_KEX2_1	162	164	PF00082	0.749
CLV_PCSK_KEX2_1	176	178	PF00082	0.717
CLV_PCSK_KEX2_1	376	378	PF00082	0.641
CLV_PCSK_KEX2_1	411	413	PF00082	0.410
CLV_PCSK_KEX2_1	606	608	PF00082	0.680
CLV_PCSK_KEX2_1	771	773	PF00082	0.546
CLV_PCSK_KEX2_1	96	98	PF00082	0.427
CLV_PCSK_PC1ET2_1	411	413	PF00082	0.410
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.423
CLV_PCSK_SKI1_1	15	19	PF00082	0.402
CLV_PCSK_SKI1_1	419	423	PF00082	0.425
CLV_PCSK_SKI1_1	535	539	PF00082	0.547
CLV_PCSK_SKI1_1	771	775	PF00082	0.539
CLV_PCSK_SKI1_1	793	797	PF00082	0.565
CLV_PCSK_SKI1_1	97	101	PF00082	0.434
CLV_Separin_Metazoa	562	566	PF03568	0.519
DEG_APCC_DBOX_1	770	778	PF00400	0.540
DEG_Nend_UBRbox_4	1	3	PF02207	0.451
DOC_CYCLIN_RxL_1	91	103	PF00134	0.420
DOC_CYCLIN_yClb1_LxF_4	803	808	PF00134	0.462
DOC_CYCLIN_yCln2_LP_2	169	175	PF00134	0.610
DOC_CYCLIN_yCln2_LP_2	364	370	PF00134	0.590
DOC_MAPK_gen_1	162	171	PF00069	0.597
DOC_MAPK_gen_1	580	587	PF00069	0.517
DOC_MAPK_gen_1	771	777	PF00069	0.535
DOC_MAPK_HePTP_8	159	171	PF00069	0.587
DOC_MAPK_JIP1_4	693	699	PF00069	0.502
DOC_MAPK_MEF2A_6	162	171	PF00069	0.597
DOC_MAPK_MEF2A_6	315	323	PF00069	0.531
DOC_MAPK_MEF2A_6	580	587	PF00069	0.480
DOC_MAPK_MEF2A_6	8	16	PF00069	0.410
DOC_PP1_RVXF_1	803	809	PF00149	0.456
DOC_PP1_RVXF_1	89	95	PF00149	0.439
DOC_PP2B_LxvP_1	169	172	PF13499	0.608
DOC_PP4_FxxP_1	303	306	PF00568	0.511
DOC_PP4_FxxP_1	322	325	PF00568	0.542
DOC_USP7_MATH_1	128	132	PF00917	0.551
DOC_USP7_MATH_1	133	137	PF00917	0.497
DOC_USP7_MATH_1	332	336	PF00917	0.620
DOC_USP7_MATH_1	383	387	PF00917	0.781
DOC_USP7_MATH_1	49	53	PF00917	0.437
DOC_USP7_MATH_1	638	642	PF00917	0.600
DOC_USP7_MATH_1	662	666	PF00917	0.556
DOC_USP7_MATH_1	702	706	PF00917	0.522
DOC_USP7_MATH_1	714	718	PF00917	0.520
DOC_USP7_MATH_1	849	853	PF00917	0.650
DOC_USP7_MATH_1	858	862	PF00917	0.428
DOC_USP7_UBL2_3	555	559	PF12436	0.480
DOC_USP7_UBL2_3	98	102	PF12436	0.440
DOC_WW_Pin1_4	118	123	PF00397	0.496
DOC_WW_Pin1_4	129	134	PF00397	0.489
DOC_WW_Pin1_4	171	176	PF00397	0.675
DOC_WW_Pin1_4	20	25	PF00397	0.419
DOC_WW_Pin1_4	309	314	PF00397	0.629
DOC_WW_Pin1_4	328	333	PF00397	0.569
DOC_WW_Pin1_4	346	351	PF00397	0.695
DOC_WW_Pin1_4	390	395	PF00397	0.534
DOC_WW_Pin1_4	467	472	PF00397	0.488
DOC_WW_Pin1_4	620	625	PF00397	0.663
DOC_WW_Pin1_4	687	692	PF00397	0.612
DOC_WW_Pin1_4	766	771	PF00397	0.602
DOC_WW_Pin1_4	785	790	PF00397	0.399
LIG_14-3-3_CanoR_1	116	124	PF00244	0.597
LIG_14-3-3_CanoR_1	191	197	PF00244	0.492
LIG_14-3-3_CanoR_1	267	271	PF00244	0.553
LIG_14-3-3_CanoR_1	366	371	PF00244	0.595
LIG_14-3-3_CanoR_1	461	468	PF00244	0.655
LIG_14-3-3_CanoR_1	565	575	PF00244	0.601
LIG_14-3-3_CanoR_1	637	647	PF00244	0.471
LIG_14-3-3_CanoR_1	703	709	PF00244	0.661
LIG_14-3-3_CanoR_1	73	79	PF00244	0.464
LIG_14-3-3_CanoR_1	772	778	PF00244	0.531
LIG_Actin_WH2_2	88	103	PF00022	0.402
LIG_APCC_ABBAyCdc20_2	299	305	PF00400	0.395
LIG_BRCT_BRCA1_1	395	399	PF00533	0.457
LIG_BRCT_BRCA1_1	437	441	PF00533	0.489
LIG_CaM_NSCaTE_8	266	273	PF13499	0.479
LIG_CSL_BTD_1	648	651	PF09270	0.532
LIG_EH1_1	39	47	PF00400	0.418
LIG_EH1_1	500	508	PF00400	0.399
LIG_EVH1_2	760	764	PF00568	0.609
LIG_FHA_1	352	358	PF00498	0.589
LIG_FHA_1	37	43	PF00498	0.398
LIG_FHA_1	448	454	PF00498	0.551
LIG_FHA_1	461	467	PF00498	0.474
LIG_FHA_1	537	543	PF00498	0.498
LIG_FHA_1	567	573	PF00498	0.601
LIG_FHA_1	680	686	PF00498	0.649
LIG_FHA_1	840	846	PF00498	0.448
LIG_FHA_2	266	272	PF00498	0.535
LIG_FHA_2	291	297	PF00498	0.511
LIG_FHA_2	510	516	PF00498	0.578
LIG_FHA_2	721	727	PF00498	0.584
LIG_LIR_Apic_2	3	9	PF02991	0.442
LIG_LIR_Apic_2	47	51	PF02991	0.440
LIG_LIR_Apic_2	652	657	PF02991	0.520
LIG_LIR_Gen_1	209	216	PF02991	0.534
LIG_LIR_Gen_1	37	48	PF02991	0.416
LIG_LIR_Nem_3	209	215	PF02991	0.530
LIG_LIR_Nem_3	37	43	PF02991	0.398
LIG_LIR_Nem_3	852	857	PF02991	0.406
LIG_LYPXL_S_1	529	533	PF13949	0.484
LIG_LYPXL_yS_3	530	533	PF13949	0.483
LIG_NRBOX	12	18	PF00104	0.402
LIG_NRBOX	58	64	PF00104	0.439
LIG_PDZ_Class_2	859	864	PF00595	0.445
LIG_Pex14_1	649	653	PF04695	0.522
LIG_Pex14_2	303	307	PF04695	0.592
LIG_SH2_CRK	212	216	PF00017	0.521
LIG_SH2_CRK	6	10	PF00017	0.434
LIG_SH2_CRK	60	64	PF00017	0.440
LIG_SH2_CRK	857	861	PF00017	0.464
LIG_SH2_NCK_1	857	861	PF00017	0.464
LIG_SH2_SRC	144	147	PF00017	0.473
LIG_SH2_STAP1	212	216	PF00017	0.521
LIG_SH2_STAP1	29	33	PF00017	0.393
LIG_SH2_STAT5	144	147	PF00017	0.514
LIG_SH2_STAT5	212	215	PF00017	0.514
LIG_SH2_STAT5	358	361	PF00017	0.451
LIG_SH2_STAT5	6	9	PF00017	0.438
LIG_SH3_1	376	382	PF00018	0.535
LIG_SH3_2	172	177	PF14604	0.661
LIG_SH3_2	691	696	PF14604	0.506
LIG_SH3_3	169	175	PF00018	0.719
LIG_SH3_3	176	182	PF00018	0.589
LIG_SH3_3	376	382	PF00018	0.630
LIG_SH3_3	472	478	PF00018	0.478
LIG_SH3_3	582	588	PF00018	0.610
LIG_SH3_3	594	600	PF00018	0.518
LIG_SH3_3	645	651	PF00018	0.538
LIG_SH3_3	688	694	PF00018	0.688
LIG_SH3_3	696	702	PF00018	0.525
LIG_SH3_3	755	761	PF00018	0.603
LIG_SUMO_SIM_anti_2	502	507	PF11976	0.452
LIG_SUMO_SIM_par_1	388	393	PF11976	0.480
LIG_SUMO_SIM_par_1	454	460	PF11976	0.391
LIG_SUMO_SIM_par_1	488	494	PF11976	0.455
LIG_SUMO_SIM_par_1	773	781	PF11976	0.532
LIG_SUMO_SIM_par_1	841	848	PF11976	0.454
LIG_TRAF2_1	483	486	PF00917	0.414
LIG_TYR_ITIM	855	860	PF00017	0.463
LIG_UBA3_1	404	411	PF00899	0.528
LIG_WRC_WIRS_1	650	655	PF05994	0.521
MOD_CDC14_SPxK_1	174	177	PF00782	0.659
MOD_CDK_SPK_2	171	176	PF00069	0.663
MOD_CDK_SPK_2	766	771	PF00069	0.532
MOD_CDK_SPxK_1	171	177	PF00069	0.662
MOD_CDK_SPxK_1	309	315	PF00069	0.615
MOD_CDK_SPxK_1	687	693	PF00069	0.681
MOD_CDK_SPxK_1	766	772	PF00069	0.528
MOD_CDK_SPxxK_3	171	178	PF00069	0.660
MOD_CK1_1	118	124	PF00069	0.502
MOD_CK1_1	131	137	PF00069	0.468
MOD_CK1_1	280	286	PF00069	0.527
MOD_CK1_1	331	337	PF00069	0.648
MOD_CK1_1	393	399	PF00069	0.458
MOD_CK1_1	447	453	PF00069	0.537
MOD_CK1_1	513	519	PF00069	0.578
MOD_CK1_1	612	618	PF00069	0.634
MOD_CK1_1	641	647	PF00069	0.625
MOD_CK1_1	683	689	PF00069	0.624
MOD_CK1_1	763	769	PF00069	0.559
MOD_CK1_1	839	845	PF00069	0.569
MOD_CK2_1	192	198	PF00069	0.489
MOD_CK2_1	265	271	PF00069	0.630
MOD_CK2_1	480	486	PF00069	0.448
MOD_CK2_1	509	515	PF00069	0.506
MOD_CK2_1	773	779	PF00069	0.566
MOD_Cter_Amidation	160	163	PF01082	0.568
MOD_GlcNHglycan	102	105	PF01048	0.441
MOD_GlcNHglycan	107	110	PF01048	0.476
MOD_GlcNHglycan	117	120	PF01048	0.494
MOD_GlcNHglycan	135	138	PF01048	0.492
MOD_GlcNHglycan	141	144	PF01048	0.538
MOD_GlcNHglycan	151	155	PF01048	0.594
MOD_GlcNHglycan	217	220	PF01048	0.609
MOD_GlcNHglycan	254	257	PF01048	0.609
MOD_GlcNHglycan	279	282	PF01048	0.517
MOD_GlcNHglycan	341	344	PF01048	0.614
MOD_GlcNHglycan	385	388	PF01048	0.650
MOD_GlcNHglycan	640	643	PF01048	0.600
MOD_GlcNHglycan	682	685	PF01048	0.658
MOD_GlcNHglycan	69	72	PF01048	0.486
MOD_GlcNHglycan	704	707	PF01048	0.627
MOD_GlcNHglycan	715	719	PF01048	0.490
MOD_GlcNHglycan	76	79	PF01048	0.463
MOD_GSK3_1	129	136	PF00069	0.511
MOD_GSK3_1	167	174	PF00069	0.636
MOD_GSK3_1	185	192	PF00069	0.519
MOD_GSK3_1	206	213	PF00069	0.534
MOD_GSK3_1	257	264	PF00069	0.695
MOD_GSK3_1	286	293	PF00069	0.635
MOD_GSK3_1	328	335	PF00069	0.600
MOD_GSK3_1	362	369	PF00069	0.634
MOD_GSK3_1	393	400	PF00069	0.457
MOD_GSK3_1	4	11	PF00069	0.432
MOD_GSK3_1	419	426	PF00069	0.399
MOD_GSK3_1	435	442	PF00069	0.458
MOD_GSK3_1	444	451	PF00069	0.581
MOD_GSK3_1	467	474	PF00069	0.532
MOD_GSK3_1	509	516	PF00069	0.391
MOD_GSK3_1	609	616	PF00069	0.687
MOD_GSK3_1	662	669	PF00069	0.485
MOD_GSK3_1	672	679	PF00069	0.550
MOD_GSK3_1	683	690	PF00069	0.579
MOD_GSK3_1	759	766	PF00069	0.584
MOD_GSK3_1	773	780	PF00069	0.489
MOD_N-GLC_1	257	262	PF02516	0.428
MOD_N-GLC_2	242	244	PF02516	0.556
MOD_N-GLC_2	549	551	PF02516	0.552
MOD_NEK2_1	100	105	PF00069	0.433
MOD_NEK2_1	139	144	PF00069	0.507
MOD_NEK2_1	215	220	PF00069	0.586
MOD_NEK2_1	339	344	PF00069	0.640
MOD_NEK2_1	672	677	PF00069	0.555
MOD_NEK2_1	680	685	PF00069	0.609
MOD_NEK2_1	764	769	PF00069	0.553
MOD_NEK2_1	850	855	PF00069	0.515
MOD_NEK2_2	135	140	PF00069	0.472
MOD_NEK2_2	36	41	PF00069	0.400
MOD_NEK2_2	858	863	PF00069	0.423
MOD_PIKK_1	397	403	PF00454	0.513
MOD_PIKK_1	419	425	PF00454	0.397
MOD_PIKK_1	435	441	PF00454	0.478
MOD_PIKK_1	566	572	PF00454	0.601
MOD_PIKK_1	641	647	PF00454	0.625
MOD_PIKK_1	798	804	PF00454	0.513
MOD_PK_1	366	372	PF00069	0.597
MOD_PK_1	581	587	PF00069	0.527
MOD_PK_1	8	14	PF00069	0.411
MOD_PKA_2	100	106	PF00069	0.445
MOD_PKA_2	115	121	PF00069	0.524
MOD_PKA_2	192	198	PF00069	0.620
MOD_PKA_2	266	272	PF00069	0.656
MOD_PKA_2	460	466	PF00069	0.615
MOD_PKA_2	516	522	PF00069	0.755
MOD_PKA_2	612	618	PF00069	0.743
MOD_PKA_2	702	708	PF00069	0.590
MOD_PKA_2	72	78	PF00069	0.469
MOD_PKA_2	777	783	PF00069	0.429
MOD_PKA_2	84	90	PF00069	0.586
MOD_PKB_1	607	615	PF00069	0.579
MOD_Plk_1	210	216	PF00069	0.600
MOD_Plk_1	581	587	PF00069	0.635
MOD_Plk_1	809	815	PF00069	0.328
MOD_Plk_4	185	191	PF00069	0.564
MOD_Plk_4	192	198	PF00069	0.528
MOD_Plk_4	210	216	PF00069	0.415
MOD_Plk_4	649	655	PF00069	0.523
MOD_Plk_4	662	668	PF00069	0.483
MOD_Plk_4	720	726	PF00069	0.548
MOD_Plk_4	8	14	PF00069	0.411
MOD_Plk_4	810	816	PF00069	0.375
MOD_Plk_4	850	856	PF00069	0.506
MOD_ProDKin_1	118	124	PF00069	0.499
MOD_ProDKin_1	129	135	PF00069	0.490
MOD_ProDKin_1	171	177	PF00069	0.674
MOD_ProDKin_1	20	26	PF00069	0.421
MOD_ProDKin_1	309	315	PF00069	0.628
MOD_ProDKin_1	328	334	PF00069	0.573
MOD_ProDKin_1	346	352	PF00069	0.689
MOD_ProDKin_1	390	396	PF00069	0.530
MOD_ProDKin_1	467	473	PF00069	0.482
MOD_ProDKin_1	620	626	PF00069	0.664
MOD_ProDKin_1	687	693	PF00069	0.614
MOD_ProDKin_1	766	772	PF00069	0.597
MOD_ProDKin_1	785	791	PF00069	0.398
MOD_SUMO_for_1	90	93	PF00179	0.443
MOD_SUMO_rev_2	406	413	PF00179	0.424
TRG_DiLeu_BaEn_1	211	216	PF01217	0.598
TRG_DiLeu_BaEn_1	409	414	PF01217	0.398
TRG_DiLeu_BaEn_1	485	490	PF01217	0.409
TRG_DiLeu_BaEn_1	502	507	PF01217	0.400
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.401
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.415
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.677
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.398
TRG_DiLeu_BaLyEn_6	428	433	PF01217	0.467
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.397
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.426
TRG_ENDOCYTIC_2	212	215	PF00928	0.514
TRG_ENDOCYTIC_2	29	32	PF00928	0.391
TRG_ENDOCYTIC_2	530	533	PF00928	0.483
TRG_ENDOCYTIC_2	60	63	PF00928	0.442
TRG_ENDOCYTIC_2	857	860	PF00928	0.404
TRG_ER_diArg_1	115	117	PF00400	0.478
TRG_ER_diArg_1	162	164	PF00400	0.634
TRG_ER_diArg_1	175	178	PF00400	0.588
TRG_ER_diArg_1	190	193	PF00400	0.495
TRG_ER_diArg_1	606	609	PF00400	0.684
TRG_ER_diArg_1	770	772	PF00400	0.560
TRG_Pf-PMV_PEXEL_1	315	320	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC97	Leptomonas seymouri	37%	100%
A0A3Q8IGI2	Leishmania donovani	89%	100%
A4HKY7	Leishmania braziliensis	74%	100%
A4I8G8	Leishmania infantum	89%	100%
Q4Q4S8	Leishmania major	90%	100%