WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family UPF0564, putative

Species:

Leishmania mexicana

UniProt:

E9B3C7_LEIMU

TriTrypDb:

LmxM.31.3431

Length:

685

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0035869	ciliary transition zone	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3C7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3C7

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.644
CLV_C14_Caspase3-7	473	477	PF00656	0.622
CLV_C14_Caspase3-7	6	10	PF00656	0.451
CLV_NRD_NRD_1	144	146	PF00675	0.686
CLV_NRD_NRD_1	155	157	PF00675	0.570
CLV_NRD_NRD_1	17	19	PF00675	0.544
CLV_NRD_NRD_1	185	187	PF00675	0.645
CLV_NRD_NRD_1	195	197	PF00675	0.481
CLV_NRD_NRD_1	482	484	PF00675	0.422
CLV_NRD_NRD_1	50	52	PF00675	0.464
CLV_NRD_NRD_1	505	507	PF00675	0.342
CLV_NRD_NRD_1	575	577	PF00675	0.325
CLV_NRD_NRD_1	61	63	PF00675	0.582
CLV_NRD_NRD_1	88	90	PF00675	0.488
CLV_PCSK_FUR_1	153	157	PF00082	0.615
CLV_PCSK_FUR_1	183	187	PF00082	0.641
CLV_PCSK_KEX2_1	143	145	PF00082	0.677
CLV_PCSK_KEX2_1	155	157	PF00082	0.625
CLV_PCSK_KEX2_1	17	19	PF00082	0.544
CLV_PCSK_KEX2_1	185	187	PF00082	0.645
CLV_PCSK_KEX2_1	482	484	PF00082	0.422
CLV_PCSK_KEX2_1	50	52	PF00082	0.485
CLV_PCSK_KEX2_1	504	506	PF00082	0.349
CLV_PCSK_KEX2_1	577	579	PF00082	0.333
CLV_PCSK_KEX2_1	61	63	PF00082	0.530
CLV_PCSK_PC1ET2_1	504	506	PF00082	0.419
CLV_PCSK_PC1ET2_1	577	579	PF00082	0.422
CLV_PCSK_PC7_1	139	145	PF00082	0.740
CLV_PCSK_SKI1_1	102	106	PF00082	0.535
CLV_PCSK_SKI1_1	135	139	PF00082	0.681
CLV_PCSK_SKI1_1	20	24	PF00082	0.704
CLV_PCSK_SKI1_1	408	412	PF00082	0.517
CLV_PCSK_SKI1_1	450	454	PF00082	0.343
CLV_PCSK_SKI1_1	483	487	PF00082	0.238
CLV_PCSK_SKI1_1	592	596	PF00082	0.382
CLV_PCSK_SKI1_1	610	614	PF00082	0.379
DEG_APCC_DBOX_1	121	129	PF00400	0.705
DEG_COP1_1	323	331	PF00400	0.599
DEG_Nend_UBRbox_3	1	3	PF02207	0.591
DEG_SCF_FBW7_1	260	265	PF00400	0.565
DOC_CYCLIN_yCln2_LP_2	295	298	PF00134	0.543
DOC_MAPK_gen_1	119	128	PF00069	0.535
DOC_MAPK_gen_1	183	191	PF00069	0.652
DOC_MAPK_MEF2A_6	164	172	PF00069	0.544
DOC_MAPK_MEF2A_6	423	431	PF00069	0.622
DOC_MAPK_RevD_3	468	483	PF00069	0.556
DOC_PP1_RVXF_1	186	192	PF00149	0.656
DOC_PP2B_LxvP_1	295	298	PF13499	0.543
DOC_PP2B_LxvP_1	491	494	PF13499	0.543
DOC_PP4_FxxP_1	630	633	PF00568	0.600
DOC_USP7_MATH_1	275	279	PF00917	0.731
DOC_USP7_MATH_1	285	289	PF00917	0.768
DOC_USP7_MATH_1	357	361	PF00917	0.713
DOC_USP7_MATH_1	379	383	PF00917	0.678
DOC_USP7_MATH_1	395	399	PF00917	0.685
DOC_USP7_MATH_1	404	408	PF00917	0.624
DOC_USP7_MATH_1	410	414	PF00917	0.393
DOC_WW_Pin1_4	210	215	PF00397	0.771
DOC_WW_Pin1_4	221	226	PF00397	0.609
DOC_WW_Pin1_4	258	263	PF00397	0.762
DOC_WW_Pin1_4	273	278	PF00397	0.559
DOC_WW_Pin1_4	303	308	PF00397	0.685
DOC_WW_Pin1_4	382	387	PF00397	0.782
DOC_WW_Pin1_4	468	473	PF00397	0.582
DOC_WW_Pin1_4	508	513	PF00397	0.502
DOC_WW_Pin1_4	521	526	PF00397	0.468
DOC_WW_Pin1_4	65	70	PF00397	0.616
LIG_14-3-3_CanoR_1	112	118	PF00244	0.504
LIG_14-3-3_CanoR_1	196	204	PF00244	0.655
LIG_14-3-3_CanoR_1	483	493	PF00244	0.622
LIG_14-3-3_CanoR_1	576	584	PF00244	0.554
LIG_14-3-3_CanoR_1	592	601	PF00244	0.435
LIG_Actin_WH2_2	106	121	PF00022	0.658
LIG_EVH1_2	352	356	PF00568	0.668
LIG_EVH1_2	71	75	PF00568	0.747
LIG_FHA_1	387	393	PF00498	0.712
LIG_FHA_1	538	544	PF00498	0.507
LIG_FHA_1	593	599	PF00498	0.513
LIG_FHA_2	136	142	PF00498	0.722
LIG_LIR_Gen_1	107	118	PF02991	0.655
LIG_LIR_Nem_3	107	113	PF02991	0.654
LIG_LIR_Nem_3	419	425	PF02991	0.622
LIG_LIR_Nem_3	562	568	PF02991	0.582
LIG_LIR_Nem_3	9	14	PF02991	0.461
LIG_NRP_CendR_1	682	685	PF00754	0.506
LIG_Pex14_2	442	446	PF04695	0.507
LIG_PROFILIN_1	370	376	PF00235	0.598
LIG_PTAP_UEV_1	348	353	PF05743	0.572
LIG_RPA_C_Fungi	234	246	PF08784	0.524
LIG_RPA_C_Plants	40	51	PF08784	0.647
LIG_SH2_NCK_1	220	224	PF00017	0.799
LIG_SH2_STAP1	544	548	PF00017	0.517
LIG_SH2_STAP1	79	83	PF00017	0.501
LIG_SH2_STAT3	425	428	PF00017	0.517
LIG_SH2_STAT3	547	550	PF00017	0.425
LIG_SH2_STAT5	4	7	PF00017	0.556
LIG_SH2_STAT5	547	550	PF00017	0.327
LIG_SH2_STAT5	582	585	PF00017	0.355
LIG_SH3_1	66	72	PF00018	0.609
LIG_SH3_3	126	132	PF00018	0.662
LIG_SH3_3	254	260	PF00018	0.550
LIG_SH3_3	277	283	PF00018	0.821
LIG_SH3_3	293	299	PF00018	0.545
LIG_SH3_3	304	310	PF00018	0.648
LIG_SH3_3	314	320	PF00018	0.608
LIG_SH3_3	325	331	PF00018	0.612
LIG_SH3_3	33	39	PF00018	0.688
LIG_SH3_3	333	339	PF00018	0.621
LIG_SH3_3	346	352	PF00018	0.651
LIG_SH3_3	360	366	PF00018	0.802
LIG_SH3_3	367	373	PF00018	0.617
LIG_SH3_3	389	395	PF00018	0.702
LIG_SH3_3	434	440	PF00018	0.517
LIG_SH3_3	461	467	PF00018	0.517
LIG_SH3_3	509	515	PF00018	0.461
LIG_SH3_3	66	72	PF00018	0.609
LIG_SH3_3	665	671	PF00018	0.533
LIG_TRFH_1	468	472	PF08558	0.461
LIG_UBA3_1	21	26	PF00899	0.470
LIG_WW_2	299	302	PF00397	0.554
LIG_WW_3	37	41	PF00397	0.669
LIG_WW_3	528	532	PF00397	0.328
MOD_CDC14_SPxK_1	215	218	PF00782	0.795
MOD_CDK_SPK_2	521	526	PF00069	0.369
MOD_CDK_SPxK_1	212	218	PF00069	0.784
MOD_CDK_SPxxK_3	468	475	PF00069	0.425
MOD_CK1_1	114	120	PF00069	0.607
MOD_CK1_1	258	264	PF00069	0.766
MOD_CK1_1	276	282	PF00069	0.516
MOD_CK1_1	382	388	PF00069	0.808
MOD_CK1_1	397	403	PF00069	0.610
MOD_CK1_1	524	530	PF00069	0.396
MOD_CK1_1	654	660	PF00069	0.531
MOD_CK2_1	117	123	PF00069	0.673
MOD_CK2_1	135	141	PF00069	0.454
MOD_CK2_1	176	182	PF00069	0.658
MOD_Cter_Amidation	480	483	PF01082	0.517
MOD_GlcNHglycan	113	116	PF01048	0.655
MOD_GlcNHglycan	147	150	PF01048	0.581
MOD_GlcNHglycan	287	290	PF01048	0.778
MOD_GlcNHglycan	324	327	PF01048	0.631
MOD_GlcNHglycan	359	362	PF01048	0.823
MOD_GlcNHglycan	366	369	PF01048	0.753
MOD_GlcNHglycan	381	384	PF01048	0.819
MOD_GlcNHglycan	397	400	PF01048	0.630
MOD_GlcNHglycan	472	475	PF01048	0.414
MOD_GlcNHglycan	486	489	PF01048	0.277
MOD_GlcNHglycan	500	503	PF01048	0.456
MOD_GlcNHglycan	526	529	PF01048	0.483
MOD_GlcNHglycan	579	582	PF01048	0.517
MOD_GlcNHglycan	656	659	PF01048	0.735
MOD_GSK3_1	114	121	PF00069	0.486
MOD_GSK3_1	145	152	PF00069	0.577
MOD_GSK3_1	191	198	PF00069	0.654
MOD_GSK3_1	258	265	PF00069	0.728
MOD_GSK3_1	343	350	PF00069	0.713
MOD_GSK3_1	382	389	PF00069	0.734
MOD_GSK3_1	400	407	PF00069	0.612
MOD_GSK3_1	517	524	PF00069	0.289
MOD_LATS_1	590	596	PF00433	0.461
MOD_N-GLC_1	517	522	PF02516	0.399
MOD_N-GLC_1	554	559	PF02516	0.259
MOD_NEK2_1	191	196	PF00069	0.652
MOD_NEK2_1	486	491	PF00069	0.428
MOD_NEK2_1	651	656	PF00069	0.521
MOD_NEK2_2	427	432	PF00069	0.517
MOD_PIKK_1	411	417	PF00454	0.386
MOD_PIKK_1	537	543	PF00454	0.355
MOD_PIKK_1	651	657	PF00454	0.522
MOD_PKA_1	156	162	PF00069	0.604
MOD_PKA_1	577	583	PF00069	0.517
MOD_PKA_2	111	117	PF00069	0.534
MOD_PKA_2	118	124	PF00069	0.482
MOD_PKA_2	195	201	PF00069	0.643
MOD_PKA_2	530	536	PF00069	0.517
MOD_PKA_2	577	583	PF00069	0.517
MOD_PKA_2	605	611	PF00069	0.370
MOD_PKB_1	143	151	PF00069	0.754
MOD_Plk_1	517	523	PF00069	0.406
MOD_Plk_4	291	297	PF00069	0.529
MOD_Plk_4	71	77	PF00069	0.578
MOD_ProDKin_1	210	216	PF00069	0.773
MOD_ProDKin_1	221	227	PF00069	0.607
MOD_ProDKin_1	258	264	PF00069	0.766
MOD_ProDKin_1	273	279	PF00069	0.559
MOD_ProDKin_1	303	309	PF00069	0.683
MOD_ProDKin_1	382	388	PF00069	0.775
MOD_ProDKin_1	468	474	PF00069	0.461
MOD_ProDKin_1	508	514	PF00069	0.349
MOD_ProDKin_1	521	527	PF00069	0.301
MOD_ProDKin_1	65	71	PF00069	0.613
MOD_SUMO_rev_2	473	480	PF00179	0.480
TRG_DiLeu_BaEn_1	31	36	PF01217	0.751
TRG_DiLeu_BaEn_2	186	192	PF01217	0.656
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.741
TRG_ENDOCYTIC_2	79	82	PF00928	0.505
TRG_ER_diArg_1	100	103	PF00400	0.583
TRG_ER_diArg_1	142	145	PF00400	0.676
TRG_ER_diArg_1	153	156	PF00400	0.600
TRG_ER_diArg_1	183	186	PF00400	0.646
TRG_ER_diArg_1	39	42	PF00400	0.720
TRG_ER_diArg_1	482	484	PF00400	0.370
TRG_ER_diArg_1	50	53	PF00400	0.524
TRG_ER_diArg_1	575	578	PF00400	0.386
TRG_ER_diArg_1	682	685	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	592	596	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NTK5	Trypanosomatidae	32%	83%
A0A3Q8IJN1	Leishmania donovani	90%	85%
A4HKY6	Leishmania braziliensis	73%	100%
A4I8G7	Leishmania infantum	89%	100%
E9B3C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q4S9	Leishmania major	90%	100%