Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family UPF0564, putative

Species:

Leishmania mexicana

UniProt:

E9B3C6_LEIMU

TriTrypDb:

LmxM.31.3430

Length:

810

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0035869	ciliary transition zone	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B3C6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3C6

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0030030	cell projection organization	4	1
GO:0044782	cilium organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.421
CLV_C14_Caspase3-7	336	340	PF00656	0.551
CLV_C14_Caspase3-7	615	619	PF00656	0.552
CLV_C14_Caspase3-7	76	80	PF00656	0.531
CLV_NRD_NRD_1	128	130	PF00675	0.386
CLV_NRD_NRD_1	13	15	PF00675	0.607
CLV_NRD_NRD_1	155	157	PF00675	0.515
CLV_NRD_NRD_1	188	190	PF00675	0.447
CLV_NRD_NRD_1	199	201	PF00675	0.621
CLV_NRD_NRD_1	226	228	PF00675	0.462
CLV_NRD_NRD_1	282	284	PF00675	0.670
CLV_NRD_NRD_1	293	295	PF00675	0.550
CLV_NRD_NRD_1	323	325	PF00675	0.558
CLV_NRD_NRD_1	333	335	PF00675	0.552
CLV_NRD_NRD_1	624	626	PF00675	0.352
CLV_NRD_NRD_1	647	649	PF00675	0.296
CLV_NRD_NRD_1	717	719	PF00675	0.303
CLV_NRD_NRD_1	89	91	PF00675	0.579
CLV_NRD_NRD_1	97	99	PF00675	0.563
CLV_PCSK_FUR_1	291	295	PF00082	0.573
CLV_PCSK_FUR_1	321	325	PF00082	0.561
CLV_PCSK_KEX2_1	128	130	PF00082	0.383
CLV_PCSK_KEX2_1	13	15	PF00082	0.531
CLV_PCSK_KEX2_1	155	157	PF00082	0.515
CLV_PCSK_KEX2_1	188	190	PF00082	0.468
CLV_PCSK_KEX2_1	199	201	PF00082	0.589
CLV_PCSK_KEX2_1	281	283	PF00082	0.658
CLV_PCSK_KEX2_1	293	295	PF00082	0.599
CLV_PCSK_KEX2_1	323	325	PF00082	0.558
CLV_PCSK_KEX2_1	624	626	PF00082	0.352
CLV_PCSK_KEX2_1	646	648	PF00082	0.301
CLV_PCSK_KEX2_1	719	721	PF00082	0.312
CLV_PCSK_KEX2_1	807	809	PF00082	0.554
CLV_PCSK_KEX2_1	97	99	PF00082	0.550
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.393
CLV_PCSK_PC1ET2_1	646	648	PF00082	0.349
CLV_PCSK_PC1ET2_1	719	721	PF00082	0.352
CLV_PCSK_PC1ET2_1	807	809	PF00082	0.554
CLV_PCSK_PC7_1	277	283	PF00082	0.647
CLV_PCSK_SKI1_1	158	162	PF00082	0.615
CLV_PCSK_SKI1_1	240	244	PF00082	0.507
CLV_PCSK_SKI1_1	273	277	PF00082	0.601
CLV_PCSK_SKI1_1	55	59	PF00082	0.511
CLV_PCSK_SKI1_1	550	554	PF00082	0.511
CLV_PCSK_SKI1_1	592	596	PF00082	0.309
CLV_PCSK_SKI1_1	625	629	PF00082	0.222
CLV_PCSK_SKI1_1	734	738	PF00082	0.324
CLV_PCSK_SKI1_1	752	756	PF00082	0.356
CLV_PCSK_SKI1_1	790	794	PF00082	0.524
DEG_APCC_DBOX_1	259	267	PF00400	0.609
DEG_COP1_1	465	473	PF00400	0.570
DEG_Nend_UBRbox_2	1	3	PF02207	0.476
DEG_SCF_FBW7_1	398	403	PF00400	0.534
DOC_CYCLIN_yCln2_LP_2	433	436	PF00134	0.540
DOC_MAPK_gen_1	257	266	PF00069	0.510
DOC_MAPK_gen_1	321	329	PF00069	0.565
DOC_MAPK_MEF2A_6	302	310	PF00069	0.531
DOC_MAPK_MEF2A_6	565	573	PF00069	0.607
DOC_MAPK_RevD_3	610	625	PF00069	0.505
DOC_PP1_RVXF_1	324	330	PF00149	0.566
DOC_PP2B_LxvP_1	28	31	PF13499	0.507
DOC_PP2B_LxvP_1	433	436	PF13499	0.528
DOC_PP2B_LxvP_1	633	636	PF13499	0.496
DOC_PP4_FxxP_1	772	775	PF00568	0.545
DOC_USP7_MATH_1	111	115	PF00917	0.457
DOC_USP7_MATH_1	413	417	PF00917	0.654
DOC_USP7_MATH_1	423	427	PF00917	0.693
DOC_USP7_MATH_1	499	503	PF00917	0.685
DOC_USP7_MATH_1	521	525	PF00917	0.647
DOC_USP7_MATH_1	537	541	PF00917	0.638
DOC_USP7_MATH_1	546	550	PF00917	0.595
DOC_USP7_MATH_1	552	556	PF00917	0.391
DOC_USP7_MATH_1	72	76	PF00917	0.559
DOC_WW_Pin1_4	203	208	PF00397	0.586
DOC_WW_Pin1_4	348	353	PF00397	0.677
DOC_WW_Pin1_4	359	364	PF00397	0.566
DOC_WW_Pin1_4	396	401	PF00397	0.669
DOC_WW_Pin1_4	411	416	PF00397	0.536
DOC_WW_Pin1_4	441	446	PF00397	0.656
DOC_WW_Pin1_4	524	529	PF00397	0.762
DOC_WW_Pin1_4	610	615	PF00397	0.524
DOC_WW_Pin1_4	650	655	PF00397	0.467
DOC_WW_Pin1_4	663	668	PF00397	0.443
DOC_WW_Pin1_4	97	102	PF00397	0.579
LIG_14-3-3_CanoR_1	112	118	PF00244	0.410
LIG_14-3-3_CanoR_1	120	127	PF00244	0.352
LIG_14-3-3_CanoR_1	250	256	PF00244	0.474
LIG_14-3-3_CanoR_1	334	342	PF00244	0.622
LIG_14-3-3_CanoR_1	625	635	PF00244	0.552
LIG_14-3-3_CanoR_1	718	726	PF00244	0.534
LIG_14-3-3_CanoR_1	734	743	PF00244	0.423
LIG_14-3-3_CanoR_1	97	101	PF00244	0.579
LIG_Actin_WH2_2	244	259	PF00022	0.561
LIG_EVH1_2	209	213	PF00568	0.638
LIG_EVH1_2	494	498	PF00568	0.612
LIG_FHA_1	529	535	PF00498	0.659
LIG_FHA_1	680	686	PF00498	0.485
LIG_FHA_1	735	741	PF00498	0.491
LIG_FHA_2	274	280	PF00498	0.719
LIG_FHA_2	44	50	PF00498	0.527
LIG_FHA_2	56	62	PF00498	0.468
LIG_FHA_2	74	80	PF00498	0.503
LIG_LIR_Gen_1	245	256	PF02991	0.582
LIG_LIR_Nem_3	147	152	PF02991	0.467
LIG_LIR_Nem_3	245	251	PF02991	0.581
LIG_LIR_Nem_3	34	38	PF02991	0.521
LIG_LIR_Nem_3	561	567	PF02991	0.552
LIG_LIR_Nem_3	704	710	PF02991	0.524
LIG_Pex14_2	584	588	PF04695	0.485
LIG_PROFILIN_1	512	518	PF00235	0.561
LIG_PTAP_UEV_1	490	495	PF05743	0.540
LIG_RPA_C_Fungi	372	384	PF08784	0.511
LIG_RPA_C_Plants	178	189	PF08784	0.571
LIG_SH2_NCK_1	358	362	PF00017	0.705
LIG_SH2_STAP1	131	135	PF00017	0.473
LIG_SH2_STAP1	217	221	PF00017	0.499
LIG_SH2_STAP1	686	690	PF00017	0.418
LIG_SH2_STAT3	567	570	PF00017	0.418
LIG_SH2_STAT3	689	692	PF00017	0.354
LIG_SH2_STAT5	142	145	PF00017	0.512
LIG_SH2_STAT5	689	692	PF00017	0.299
LIG_SH2_STAT5	724	727	PF00017	0.325
LIG_SH3_1	204	210	PF00018	0.575
LIG_SH3_1	98	104	PF00018	0.533
LIG_SH3_3	171	177	PF00018	0.620
LIG_SH3_3	204	210	PF00018	0.575
LIG_SH3_3	264	270	PF00018	0.582
LIG_SH3_3	392	398	PF00018	0.524
LIG_SH3_3	415	421	PF00018	0.722
LIG_SH3_3	431	437	PF00018	0.595
LIG_SH3_3	442	448	PF00018	0.644
LIG_SH3_3	452	458	PF00018	0.579
LIG_SH3_3	467	473	PF00018	0.589
LIG_SH3_3	475	481	PF00018	0.590
LIG_SH3_3	488	494	PF00018	0.619
LIG_SH3_3	502	508	PF00018	0.782
LIG_SH3_3	509	515	PF00018	0.587
LIG_SH3_3	531	537	PF00018	0.647
LIG_SH3_3	576	582	PF00018	0.418
LIG_SH3_3	603	609	PF00018	0.418
LIG_SH3_3	651	657	PF00018	0.379
LIG_SH3_3	98	104	PF00018	0.549
LIG_TRAF2_1	116	119	PF00917	0.411
LIG_TRFH_1	610	614	PF08558	0.379
LIG_UBA3_1	159	164	PF00899	0.455
LIG_WW_2	437	440	PF00397	0.529
LIG_WW_3	175	179	PF00397	0.600
LIG_WW_3	670	674	PF00397	0.286
MOD_CDC14_SPxK_1	353	356	PF00782	0.696
MOD_CDK_SPK_2	663	668	PF00069	0.315
MOD_CDK_SPxK_1	350	356	PF00069	0.687
MOD_CDK_SPxxK_3	610	617	PF00069	0.354
MOD_CK1_1	252	258	PF00069	0.525
MOD_CK1_1	396	402	PF00069	0.672
MOD_CK1_1	414	420	PF00069	0.507
MOD_CK1_1	524	530	PF00069	0.796
MOD_CK1_1	539	545	PF00069	0.566
MOD_CK1_1	64	70	PF00069	0.531
MOD_CK1_1	666	672	PF00069	0.366
MOD_CK1_1	75	81	PF00069	0.528
MOD_CK2_1	113	119	PF00069	0.436
MOD_CK2_1	255	261	PF00069	0.575
MOD_CK2_1	273	279	PF00069	0.445
MOD_CK2_1	314	320	PF00069	0.631
MOD_CK2_1	43	49	PF00069	0.531
MOD_CK2_1	55	61	PF00069	0.473
MOD_CK2_1	792	798	PF00069	0.480
MOD_Cter_Amidation	622	625	PF01082	0.418
MOD_GlcNHglycan	251	254	PF01048	0.556
MOD_GlcNHglycan	285	288	PF01048	0.563
MOD_GlcNHglycan	425	428	PF01048	0.725
MOD_GlcNHglycan	466	469	PF01048	0.608
MOD_GlcNHglycan	501	504	PF01048	0.789
MOD_GlcNHglycan	508	511	PF01048	0.702
MOD_GlcNHglycan	523	526	PF01048	0.821
MOD_GlcNHglycan	539	542	PF01048	0.581
MOD_GlcNHglycan	614	617	PF01048	0.385
MOD_GlcNHglycan	628	631	PF01048	0.255
MOD_GlcNHglycan	63	66	PF01048	0.514
MOD_GlcNHglycan	642	645	PF01048	0.432
MOD_GlcNHglycan	668	671	PF01048	0.395
MOD_GlcNHglycan	721	724	PF01048	0.418
MOD_GSK3_1	119	126	PF00069	0.381
MOD_GSK3_1	252	259	PF00069	0.457
MOD_GSK3_1	283	290	PF00069	0.555
MOD_GSK3_1	329	336	PF00069	0.591
MOD_GSK3_1	37	44	PF00069	0.521
MOD_GSK3_1	396	403	PF00069	0.654
MOD_GSK3_1	485	492	PF00069	0.676
MOD_GSK3_1	524	531	PF00069	0.706
MOD_GSK3_1	542	549	PF00069	0.586
MOD_GSK3_1	659	666	PF00069	0.258
MOD_GSK3_1	93	100	PF00069	0.553
MOD_LATS_1	732	738	PF00433	0.379
MOD_N-GLC_1	38	43	PF02516	0.510
MOD_N-GLC_1	659	664	PF02516	0.369
MOD_N-GLC_1	696	701	PF02516	0.237
MOD_NEK2_1	113	118	PF00069	0.407
MOD_NEK2_1	23	28	PF00069	0.534
MOD_NEK2_1	329	334	PF00069	0.557
MOD_NEK2_1	38	43	PF00069	0.501
MOD_NEK2_1	628	633	PF00069	0.400
MOD_NEK2_2	31	36	PF00069	0.515
MOD_NEK2_2	569	574	PF00069	0.418
MOD_PIKK_1	4	10	PF00454	0.436
MOD_PIKK_1	553	559	PF00454	0.356
MOD_PIKK_1	679	685	PF00454	0.325
MOD_PKA_1	294	300	PF00069	0.568
MOD_PKA_1	719	725	PF00069	0.418
MOD_PKA_2	111	117	PF00069	0.423
MOD_PKA_2	119	125	PF00069	0.374
MOD_PKA_2	249	255	PF00069	0.503
MOD_PKA_2	256	262	PF00069	0.455
MOD_PKA_2	31	37	PF00069	0.514
MOD_PKA_2	333	339	PF00069	0.610
MOD_PKA_2	672	678	PF00069	0.418
MOD_PKA_2	719	725	PF00069	0.418
MOD_PKA_2	747	753	PF00069	0.339
MOD_PKA_2	96	102	PF00069	0.578
MOD_PKB_1	281	289	PF00069	0.662
MOD_Plk_1	38	44	PF00069	0.509
MOD_Plk_1	659	665	PF00069	0.341
MOD_Plk_2-3	119	125	PF00069	0.468
MOD_Plk_4	209	215	PF00069	0.559
MOD_Plk_4	429	435	PF00069	0.522
MOD_ProDKin_1	203	209	PF00069	0.580
MOD_ProDKin_1	348	354	PF00069	0.678
MOD_ProDKin_1	359	365	PF00069	0.563
MOD_ProDKin_1	396	402	PF00069	0.672
MOD_ProDKin_1	411	417	PF00069	0.537
MOD_ProDKin_1	441	447	PF00069	0.648
MOD_ProDKin_1	524	530	PF00069	0.755
MOD_ProDKin_1	610	616	PF00069	0.379
MOD_ProDKin_1	650	656	PF00069	0.300
MOD_ProDKin_1	663	669	PF00069	0.267
MOD_ProDKin_1	97	103	PF00069	0.579
MOD_SUMO_rev_2	615	622	PF00179	0.392
TRG_DiLeu_BaEn_1	169	174	PF01217	0.668
TRG_DiLeu_BaEn_2	324	330	PF01217	0.566
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.650
TRG_ENDOCYTIC_2	217	220	PF00928	0.502
TRG_ER_diArg_1	12	14	PF00400	0.405
TRG_ER_diArg_1	177	180	PF00400	0.631
TRG_ER_diArg_1	188	191	PF00400	0.505
TRG_ER_diArg_1	238	241	PF00400	0.606
TRG_ER_diArg_1	280	283	PF00400	0.654
TRG_ER_diArg_1	291	294	PF00400	0.564
TRG_ER_diArg_1	321	324	PF00400	0.563
TRG_ER_diArg_1	624	626	PF00400	0.339
TRG_ER_diArg_1	717	720	PF00400	0.356
TRG_Pf-PMV_PEXEL_1	734	738	PF00026	0.418

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NTK5	Trypanosomatidae	32%	98%
A0A3Q8IJN1	Leishmania donovani	86%	100%
A4HKY6	Leishmania braziliensis	73%	100%
A4I8G7	Leishmania infantum	88%	100%
E9B3C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q4S9	Leishmania major	89%	100%