AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3C3_LEIMU

TriTrypDb:

LmxM.31.3400

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 4
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9B3C3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3C3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.414
CLV_NRD_NRD_1	290	292	PF00675	0.587
CLV_PCSK_SKI1_1	104	108	PF00082	0.624
CLV_PCSK_SKI1_1	267	271	PF00082	0.621
CLV_PCSK_SKI1_1	305	309	PF00082	0.523
CLV_PCSK_SKI1_1	559	563	PF00082	0.441
CLV_PCSK_SKI1_1	86	90	PF00082	0.622
DEG_APCC_DBOX_1	558	566	PF00400	0.429
DEG_MDM2_SWIB_1	550	557	PF02201	0.492
DOC_ANK_TNKS_1	180	187	PF00023	0.436
DOC_CDC14_PxL_1	312	320	PF14671	0.394
DOC_CDC14_PxL_1	325	333	PF14671	0.402
DOC_CKS1_1	480	485	PF01111	0.388
DOC_CYCLIN_yClb1_LxF_4	69	74	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.386
DOC_MAPK_gen_1	68	74	PF00069	0.446
DOC_MAPK_JIP1_4	321	327	PF00069	0.388
DOC_MAPK_MEF2A_6	108	115	PF00069	0.407
DOC_MAPK_MEF2A_6	301	310	PF00069	0.395
DOC_MAPK_MEF2A_6	559	566	PF00069	0.393
DOC_MAPK_MEF2A_6	86	93	PF00069	0.411
DOC_MAPK_NFAT4_5	559	567	PF00069	0.419
DOC_PP1_RVXF_1	283	289	PF00149	0.388
DOC_PP1_RVXF_1	509	515	PF00149	0.366
DOC_PP1_RVXF_1	69	75	PF00149	0.396
DOC_PP2B_LxvP_1	397	400	PF13499	0.353
DOC_PP4_FxxP_1	531	534	PF00568	0.435
DOC_USP7_MATH_1	118	122	PF00917	0.383
DOC_USP7_MATH_1	131	135	PF00917	0.408
DOC_USP7_MATH_1	153	157	PF00917	0.427
DOC_USP7_MATH_1	261	265	PF00917	0.384
DOC_USP7_MATH_1	401	405	PF00917	0.413
DOC_USP7_MATH_1	41	45	PF00917	0.456
DOC_USP7_MATH_1	431	435	PF00917	0.235
DOC_USP7_MATH_2	52	58	PF00917	0.426
DOC_USP7_UBL2_3	301	305	PF12436	0.209
DOC_WW_Pin1_4	121	126	PF00397	0.374
DOC_WW_Pin1_4	479	484	PF00397	0.407
DOC_WW_Pin1_4	48	53	PF00397	0.430
LIG_14-3-3_CanoR_1	267	272	PF00244	0.389
LIG_14-3-3_CanoR_1	389	397	PF00244	0.431
LIG_14-3-3_CanoR_1	417	427	PF00244	0.468
LIG_14-3-3_CanoR_1	47	52	PF00244	0.475
LIG_14-3-3_CanoR_1	591	597	PF00244	0.701
LIG_14-3-3_CanoR_1	71	77	PF00244	0.433
LIG_Actin_WH2_2	458	473	PF00022	0.444
LIG_APCC_ABBA_1	489	494	PF00400	0.371
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_BRCT_BRCA1_1	592	596	PF00533	0.666
LIG_CtBP_PxDLS_1	161	165	PF00389	0.376
LIG_deltaCOP1_diTrp_1	527	531	PF00928	0.380
LIG_EH1_1	73	81	PF00400	0.410
LIG_FHA_1	17	23	PF00498	0.632
LIG_FHA_1	430	436	PF00498	0.362
LIG_FHA_1	480	486	PF00498	0.389
LIG_FHA_1	503	509	PF00498	0.419
LIG_FHA_1	56	62	PF00498	0.423
LIG_FHA_2	180	186	PF00498	0.375
LIG_FHA_2	244	250	PF00498	0.217
LIG_GBD_Chelix_1	172	180	PF00786	0.406
LIG_GBD_Chelix_1	557	565	PF00786	0.240
LIG_IBAR_NPY_1	135	137	PF08397	0.396
LIG_LIR_Apic_2	219	223	PF02991	0.364
LIG_LIR_Apic_2	530	534	PF02991	0.422
LIG_LIR_Gen_1	227	237	PF02991	0.355
LIG_LIR_Gen_1	262	272	PF02991	0.320
LIG_LIR_Gen_1	90	100	PF02991	0.409
LIG_LIR_Nem_3	227	232	PF02991	0.318
LIG_LIR_Nem_3	262	268	PF02991	0.319
LIG_LIR_Nem_3	457	461	PF02991	0.336
LIG_LIR_Nem_3	594	600	PF02991	0.646
LIG_LYPXL_S_1	314	318	PF13949	0.610
LIG_LYPXL_yS_3	315	318	PF13949	0.386
LIG_NRBOX	560	566	PF00104	0.252
LIG_PCNA_PIPBox_1	225	234	PF02747	0.365
LIG_Pex14_2	550	554	PF04695	0.506
LIG_Pex14_3	372	377	PF04695	0.354
LIG_SH2_CRK	589	593	PF00017	0.678
LIG_SH2_GRB2like	597	600	PF00017	0.647
LIG_SH2_NCK_1	359	363	PF00017	0.427
LIG_SH2_NCK_1	589	593	PF00017	0.756
LIG_SH2_PTP2	220	223	PF00017	0.380
LIG_SH2_SRC	220	223	PF00017	0.390
LIG_SH2_STAT3	137	140	PF00017	0.457
LIG_SH2_STAT3	333	336	PF00017	0.302
LIG_SH2_STAT5	220	223	PF00017	0.315
LIG_SH2_STAT5	231	234	PF00017	0.309
LIG_SH2_STAT5	352	355	PF00017	0.352
LIG_SH2_STAT5	575	578	PF00017	0.370
LIG_SH2_STAT5	580	583	PF00017	0.594
LIG_SH3_3	310	316	PF00018	0.359
LIG_SH3_3	471	477	PF00018	0.437
LIG_SUMO_SIM_anti_2	304	310	PF11976	0.267
LIG_SUMO_SIM_anti_2	434	439	PF11976	0.217
LIG_SUMO_SIM_par_1	214	219	PF11976	0.407
LIG_SUMO_SIM_par_1	434	439	PF11976	0.314
LIG_UBA3_1	268	276	PF00899	0.401
LIG_WRC_WIRS_1	385	390	PF05994	0.457
MOD_CK1_1	121	127	PF00069	0.431
MOD_CK1_1	156	162	PF00069	0.444
MOD_CK1_1	165	171	PF00069	0.378
MOD_CK1_1	281	287	PF00069	0.457
MOD_CK1_1	384	390	PF00069	0.420
MOD_CK1_1	4	10	PF00069	0.572
MOD_CK1_1	421	427	PF00069	0.452
MOD_CK1_1	536	542	PF00069	0.561
MOD_CK1_1	590	596	PF00069	0.747
MOD_CK2_1	48	54	PF00069	0.416
MOD_GlcNHglycan	167	170	PF01048	0.602
MOD_GlcNHglycan	27	30	PF01048	0.735
MOD_GlcNHglycan	353	356	PF01048	0.617
MOD_GlcNHglycan	390	393	PF01048	0.592
MOD_GlcNHglycan	405	408	PF01048	0.568
MOD_GlcNHglycan	420	423	PF01048	0.663
MOD_GSK3_1	126	133	PF00069	0.396
MOD_GSK3_1	25	32	PF00069	0.648
MOD_GSK3_1	380	387	PF00069	0.436
MOD_GSK3_1	41	48	PF00069	0.312
MOD_GSK3_1	576	583	PF00069	0.397
MOD_N-GLC_1	131	136	PF02516	0.659
MOD_N-GLC_1	162	167	PF02516	0.621
MOD_N-GLC_1	429	434	PF02516	0.615
MOD_NEK2_1	1	6	PF00069	0.623
MOD_NEK2_1	16	21	PF00069	0.456
MOD_NEK2_1	162	167	PF00069	0.386
MOD_NEK2_1	317	322	PF00069	0.382
MOD_NEK2_1	388	393	PF00069	0.384
MOD_NEK2_1	461	466	PF00069	0.396
MOD_NEK2_1	576	581	PF00069	0.445
MOD_NEK2_1	587	592	PF00069	0.752
MOD_PIKK_1	429	435	PF00454	0.401
MOD_PIKK_1	449	455	PF00454	0.252
MOD_PKA_2	118	124	PF00069	0.353
MOD_PKA_2	388	394	PF00069	0.420
MOD_PKA_2	416	422	PF00069	0.464
MOD_PKA_2	590	596	PF00069	0.694
MOD_PKA_2	70	76	PF00069	0.436
MOD_Plk_1	162	168	PF00069	0.378
MOD_Plk_2-3	502	508	PF00069	0.411
MOD_Plk_4	123	129	PF00069	0.425
MOD_Plk_4	195	201	PF00069	0.322
MOD_Plk_4	233	239	PF00069	0.388
MOD_Plk_4	267	273	PF00069	0.382
MOD_Plk_4	327	333	PF00069	0.302
MOD_Plk_4	431	437	PF00069	0.227
MOD_Plk_4	87	93	PF00069	0.340
MOD_ProDKin_1	121	127	PF00069	0.376
MOD_ProDKin_1	479	485	PF00069	0.404
MOD_ProDKin_1	48	54	PF00069	0.427
MOD_SUMO_rev_2	419	427	PF00179	0.345
TRG_DiLeu_BaEn_1	304	309	PF01217	0.316
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.355
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.215
TRG_ENDOCYTIC_2	229	232	PF00928	0.321
TRG_ENDOCYTIC_2	315	318	PF00928	0.357
TRG_ENDOCYTIC_2	575	578	PF00928	0.416
TRG_ENDOCYTIC_2	589	592	PF00928	0.627
TRG_ENDOCYTIC_2	597	600	PF00928	0.616
TRG_ER_diArg_1	116	119	PF00400	0.398
TRG_ER_diArg_1	5	8	PF00400	0.634
TRG_ER_FFAT_2	121	133	PF00635	0.466
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.636
TRG_Pf-PMV_PEXEL_1	459	463	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I361	Leptomonas seymouri	50%	100%
A0A0S4JGY4	Bodo saltans	25%	98%
A0A1X0NRX3	Trypanosomatidae	30%	100%
A0A3Q8IFS8	Leishmania donovani	90%	100%
A0A422P343	Trypanosoma rangeli	35%	100%
A4HKY5	Leishmania braziliensis	76%	100%
A4I8G4	Leishmania infantum	90%	100%
Q4Q4T2	Leishmania major	87%	100%
V5DMC3	Trypanosoma cruzi	31%	100%