MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3C2_LEIMU

TriTrypDb:

LmxM.31.3390

Length:

600

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3C2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3C2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.723
CLV_C14_Caspase3-7	286	290	PF00656	0.589
CLV_NRD_NRD_1	132	134	PF00675	0.577
CLV_NRD_NRD_1	449	451	PF00675	0.475
CLV_NRD_NRD_1	540	542	PF00675	0.439
CLV_NRD_NRD_1	560	562	PF00675	0.586
CLV_PCSK_KEX2_1	132	134	PF00082	0.577
CLV_PCSK_KEX2_1	262	264	PF00082	0.638
CLV_PCSK_KEX2_1	449	451	PF00082	0.475
CLV_PCSK_KEX2_1	540	542	PF00082	0.439
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.597
CLV_PCSK_SKI1_1	218	222	PF00082	0.404
CLV_PCSK_SKI1_1	449	453	PF00082	0.369
CLV_PCSK_SKI1_1	485	489	PF00082	0.370
CLV_PCSK_SKI1_1	541	545	PF00082	0.478
DEG_APCC_DBOX_1	484	492	PF00400	0.331
DEG_APCC_DBOX_1	540	548	PF00400	0.477
DEG_Nend_UBRbox_2	1	3	PF02207	0.694
DEG_SCF_FBW7_1	94	99	PF00400	0.646
DEG_SPOP_SBC_1	113	117	PF00917	0.623
DEG_SPOP_SBC_1	339	343	PF00917	0.579
DOC_CKS1_1	211	216	PF01111	0.602
DOC_CYCLIN_yCln2_LP_2	267	273	PF00134	0.623
DOC_MAPK_gen_1	130	138	PF00069	0.519
DOC_MAPK_gen_1	540	548	PF00069	0.449
DOC_MAPK_gen_1	561	570	PF00069	0.559
DOC_MAPK_MEF2A_6	540	548	PF00069	0.439
DOC_MAPK_NFAT4_5	541	549	PF00069	0.456
DOC_PP2B_LxvP_1	410	413	PF13499	0.580
DOC_PP2B_LxvP_1	525	528	PF13499	0.438
DOC_USP7_MATH_1	112	116	PF00917	0.682
DOC_USP7_MATH_1	137	141	PF00917	0.588
DOC_USP7_MATH_1	155	159	PF00917	0.628
DOC_USP7_MATH_1	288	292	PF00917	0.566
DOC_USP7_MATH_1	311	315	PF00917	0.546
DOC_USP7_MATH_1	34	38	PF00917	0.700
DOC_USP7_MATH_1	429	433	PF00917	0.451
DOC_USP7_MATH_1	438	442	PF00917	0.512
DOC_USP7_MATH_1	454	458	PF00917	0.521
DOC_USP7_MATH_1	46	50	PF00917	0.718
DOC_USP7_MATH_1	54	58	PF00917	0.582
DOC_USP7_MATH_1	60	64	PF00917	0.628
DOC_USP7_MATH_1	94	98	PF00917	0.672
DOC_USP7_UBL2_3	262	266	PF12436	0.628
DOC_USP7_UBL2_3	549	553	PF12436	0.509
DOC_USP7_UBL2_3	558	562	PF12436	0.507
DOC_USP7_UBL2_3	569	573	PF12436	0.327
DOC_USP7_UBL2_3	594	598	PF12436	0.690
DOC_USP7_UBL2_3	86	90	PF12436	0.557
DOC_WW_Pin1_4	108	113	PF00397	0.711
DOC_WW_Pin1_4	115	120	PF00397	0.738
DOC_WW_Pin1_4	210	215	PF00397	0.570
DOC_WW_Pin1_4	344	349	PF00397	0.477
DOC_WW_Pin1_4	38	43	PF00397	0.775
DOC_WW_Pin1_4	385	390	PF00397	0.498
DOC_WW_Pin1_4	56	61	PF00397	0.748
DOC_WW_Pin1_4	90	95	PF00397	0.590
LIG_14-3-3_CanoR_1	132	137	PF00244	0.462
LIG_14-3-3_CanoR_1	337	344	PF00244	0.568
LIG_14-3-3_CanoR_1	516	525	PF00244	0.486
LIG_Actin_WH2_2	312	329	PF00022	0.507
LIG_Actin_WH2_2	426	442	PF00022	0.476
LIG_Actin_WH2_2	461	479	PF00022	0.555
LIG_BRCT_BRCA1_1	16	20	PF00533	0.547
LIG_BRCT_BRCA1_1	491	495	PF00533	0.369
LIG_Clathr_ClatBox_1	73	77	PF01394	0.547
LIG_EH1_1	530	538	PF00400	0.396
LIG_FHA_1	181	187	PF00498	0.573
LIG_FHA_1	302	308	PF00498	0.439
LIG_FHA_1	320	326	PF00498	0.481
LIG_FHA_1	463	469	PF00498	0.543
LIG_FHA_1	93	99	PF00498	0.654
LIG_FHA_2	115	121	PF00498	0.725
LIG_FHA_2	414	420	PF00498	0.525
LIG_LIR_Apic_2	422	426	PF02991	0.373
LIG_LIR_Gen_1	13	22	PF02991	0.541
LIG_LIR_Gen_1	304	311	PF02991	0.434
LIG_LIR_Gen_1	382	391	PF02991	0.485
LIG_LIR_Gen_1	492	503	PF02991	0.391
LIG_LIR_Gen_1	565	575	PF02991	0.560
LIG_LIR_Gen_1	68	78	PF02991	0.472
LIG_LIR_Nem_3	13	19	PF02991	0.483
LIG_LIR_Nem_3	304	308	PF02991	0.420
LIG_LIR_Nem_3	382	386	PF02991	0.459
LIG_LIR_Nem_3	415	420	PF02991	0.404
LIG_LIR_Nem_3	446	451	PF02991	0.482
LIG_LIR_Nem_3	565	570	PF02991	0.562
LIG_LIR_Nem_3	68	73	PF02991	0.459
LIG_MYND_3	166	170	PF01753	0.550
LIG_Pex14_2	16	20	PF04695	0.531
LIG_Pex14_2	401	405	PF04695	0.499
LIG_PTB_Apo_2	77	84	PF02174	0.604
LIG_REV1ctd_RIR_1	81	90	PF16727	0.603
LIG_RPA_C_Fungi	488	500	PF08784	0.440
LIG_SH2_CRK	336	340	PF00017	0.435
LIG_SH2_CRK	423	427	PF00017	0.348
LIG_SH2_SRC	237	240	PF00017	0.623
LIG_SH2_SRC	383	386	PF00017	0.458
LIG_SH2_STAP1	12	16	PF00017	0.517
LIG_SH2_STAP1	317	321	PF00017	0.521
LIG_SH2_STAT3	141	144	PF00017	0.624
LIG_SH2_STAT3	276	279	PF00017	0.597
LIG_SH2_STAT5	12	15	PF00017	0.482
LIG_SH2_STAT5	241	244	PF00017	0.505
LIG_SH2_STAT5	251	254	PF00017	0.458
LIG_SH2_STAT5	383	386	PF00017	0.335
LIG_SH2_STAT5	420	423	PF00017	0.432
LIG_SH3_3	120	126	PF00018	0.610
LIG_SH3_3	161	167	PF00018	0.533
LIG_SH3_3	208	214	PF00018	0.486
LIG_SH3_3	383	389	PF00018	0.456
LIG_SH3_3	40	46	PF00018	0.654
LIG_SH3_3	88	94	PF00018	0.584
LIG_SUMO_SIM_par_1	460	465	PF11976	0.495
LIG_TRAF2_1	25	28	PF00917	0.705
LIG_TRAF2_1	329	332	PF00917	0.414
LIG_TRAF2_1	349	352	PF00917	0.495
LIG_TRAF2_1	416	419	PF00917	0.410
LIG_TRFH_1	219	223	PF08558	0.410
LIG_TYR_ITIM	334	339	PF00017	0.395
LIG_TYR_ITIM	381	386	PF00017	0.301
LIG_UBA3_1	267	275	PF00899	0.589
LIG_UBA3_1	544	549	PF00899	0.454
LIG_WRC_WIRS_1	402	407	PF05994	0.525
LIG_WRC_WIRS_1	414	419	PF05994	0.531
MOD_CK1_1	115	121	PF00069	0.668
MOD_CK1_1	32	38	PF00069	0.759
MOD_CK1_1	340	346	PF00069	0.611
MOD_CK1_1	457	463	PF00069	0.448
MOD_CK1_1	65	71	PF00069	0.525
MOD_CK1_1	97	103	PF00069	0.707
MOD_CK2_1	413	419	PF00069	0.400
MOD_GlcNHglycan	189	192	PF01048	0.517
MOD_GlcNHglycan	279	282	PF01048	0.493
MOD_GlcNHglycan	289	293	PF01048	0.458
MOD_GlcNHglycan	327	330	PF01048	0.454
MOD_GlcNHglycan	366	369	PF01048	0.470
MOD_GlcNHglycan	469	472	PF01048	0.554
MOD_GlcNHglycan	54	57	PF01048	0.676
MOD_GlcNHglycan	8	11	PF01048	0.500
MOD_GlcNHglycan	99	102	PF01048	0.625
MOD_GSK3_1	108	115	PF00069	0.732
MOD_GSK3_1	150	157	PF00069	0.714
MOD_GSK3_1	187	194	PF00069	0.421
MOD_GSK3_1	30	37	PF00069	0.768
MOD_GSK3_1	338	345	PF00069	0.668
MOD_GSK3_1	52	59	PF00069	0.725
MOD_GSK3_1	547	554	PF00069	0.539
MOD_GSK3_1	6	13	PF00069	0.510
MOD_GSK3_1	90	97	PF00069	0.535
MOD_N-GLC_1	187	192	PF02516	0.473
MOD_N-GLC_1	30	35	PF02516	0.784
MOD_N-GLC_1	311	316	PF02516	0.542
MOD_N-GLC_1	364	369	PF02516	0.489
MOD_NEK2_1	14	19	PF00069	0.521
MOD_NEK2_1	187	192	PF00069	0.518
MOD_NEK2_1	338	343	PF00069	0.615
MOD_NEK2_1	400	405	PF00069	0.454
MOD_NEK2_1	439	444	PF00069	0.525
MOD_NEK2_1	462	467	PF00069	0.501
MOD_NEK2_1	489	494	PF00069	0.464
MOD_NEK2_2	10	15	PF00069	0.451
MOD_OFUCOSY	189	195	PF10250	0.537
MOD_PIKK_1	516	522	PF00454	0.467
MOD_PIKK_1	556	562	PF00454	0.456
MOD_PIKK_1	62	68	PF00454	0.547
MOD_PK_1	132	138	PF00069	0.568
MOD_PKA_1	132	138	PF00069	0.533
MOD_PKA_2	132	138	PF00069	0.628
MOD_Plk_1	311	317	PF00069	0.496
MOD_Plk_1	319	325	PF00069	0.483
MOD_Plk_1	364	370	PF00069	0.426
MOD_Plk_2-3	551	557	PF00069	0.536
MOD_Plk_4	137	143	PF00069	0.534
MOD_Plk_4	15	21	PF00069	0.624
MOD_Plk_4	155	161	PF00069	0.634
MOD_Plk_4	457	463	PF00069	0.500
MOD_Plk_4	563	569	PF00069	0.550
MOD_ProDKin_1	108	114	PF00069	0.715
MOD_ProDKin_1	115	121	PF00069	0.735
MOD_ProDKin_1	210	216	PF00069	0.571
MOD_ProDKin_1	344	350	PF00069	0.471
MOD_ProDKin_1	38	44	PF00069	0.776
MOD_ProDKin_1	385	391	PF00069	0.498
MOD_ProDKin_1	56	62	PF00069	0.740
MOD_ProDKin_1	90	96	PF00069	0.605
MOD_SUMO_for_1	552	555	PF00179	0.502
MOD_SUMO_rev_2	551	559	PF00179	0.543
MOD_SUMO_rev_2	591	600	PF00179	0.595
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.589
TRG_ENDOCYTIC_2	336	339	PF00928	0.410
TRG_ENDOCYTIC_2	383	386	PF00928	0.339
TRG_ER_diArg_1	448	450	PF00400	0.492
TRG_ER_diArg_1	539	541	PF00400	0.450
TRG_Pf-PMV_PEXEL_1	509	513	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4F3	Leptomonas seymouri	80%	99%
A0A0S4JDR3	Bodo saltans	30%	100%
A0A1X0NRU6	Trypanosomatidae	36%	100%
A0A3R7P3B0	Trypanosoma rangeli	37%	100%
A0A3S5H7T1	Leishmania donovani	97%	100%
A4HKY4	Leishmania braziliensis	92%	100%
A4I8G3	Leishmania infantum	97%	100%
D0AAQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q4T3	Leishmania major	98%	100%
V5B5Q7	Trypanosoma cruzi	38%	100%