LeishMANIAdb
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Chloride channel protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Chloride channel protein
Gene product:
chloride channel protein, putative
Species:
Leishmania mexicana
UniProt:
E9B3C0_LEIMU
TriTrypDb:
LmxM.31.3370
Length:
884

Annotations

LeishMANIAdb annotations

Homologous to animal CLCN-group H+/Cl- exchangers.. The family seems to have duplicated in Kinetoplastida

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 19
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2

Expansion

Sequence features

E9B3C0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3C0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 19
GO:0005216 monoatomic ion channel activity 4 19
GO:0005244 voltage-gated monoatomic ion channel activity 4 19
GO:0005247 voltage-gated chloride channel activity 6 19
GO:0005253 monoatomic anion channel activity 5 19
GO:0005254 chloride channel activity 6 19
GO:0008308 voltage-gated monoatomic anion channel activity 5 19
GO:0008509 monoatomic anion transmembrane transporter activity 4 19
GO:0015075 monoatomic ion transmembrane transporter activity 3 19
GO:0015103 inorganic anion transmembrane transporter activity 4 19
GO:0015108 chloride transmembrane transporter activity 5 19
GO:0015267 channel activity 4 19
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 19
GO:0022803 passive transmembrane transporter activity 3 19
GO:0022832 voltage-gated channel activity 6 19
GO:0022836 gated channel activity 5 19
GO:0022857 transmembrane transporter activity 2 19

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 43 47 PF00656 0.559
CLV_C14_Caspase3-7 726 730 PF00656 0.407
CLV_C14_Caspase3-7 746 750 PF00656 0.519
CLV_C14_Caspase3-7 761 765 PF00656 0.338
CLV_MEL_PAP_1 854 860 PF00089 0.433
CLV_MEL_PAP_1 88 94 PF00089 0.316
CLV_NRD_NRD_1 22 24 PF00675 0.435
CLV_NRD_NRD_1 517 519 PF00675 0.397
CLV_NRD_NRD_1 72 74 PF00675 0.309
CLV_PCSK_KEX2_1 22 24 PF00082 0.466
CLV_PCSK_KEX2_1 517 519 PF00082 0.397
CLV_PCSK_KEX2_1 71 73 PF00082 0.317
CLV_PCSK_KEX2_1 779 781 PF00082 0.548
CLV_PCSK_PC1ET2_1 779 781 PF00082 0.581
CLV_PCSK_SKI1_1 433 437 PF00082 0.251
CLV_PCSK_SKI1_1 477 481 PF00082 0.510
CLV_PCSK_SKI1_1 512 516 PF00082 0.433
DEG_APCC_DBOX_1 711 719 PF00400 0.209
DEG_MDM2_SWIB_1 361 368 PF02201 0.314
DOC_CDC14_PxL_1 839 847 PF14671 0.310
DOC_CKS1_1 14 19 PF01111 0.622
DOC_CKS1_1 462 467 PF01111 0.387
DOC_CYCLIN_RxL_1 429 439 PF00134 0.466
DOC_CYCLIN_RxL_1 509 519 PF00134 0.293
DOC_CYCLIN_yCln2_LP_2 412 418 PF00134 0.347
DOC_MAPK_gen_1 474 484 PF00069 0.221
DOC_MAPK_MEF2A_6 103 110 PF00069 0.438
DOC_MAPK_MEF2A_6 476 484 PF00069 0.235
DOC_MAPK_MEF2A_6 595 604 PF00069 0.273
DOC_MAPK_MEF2A_6 690 699 PF00069 0.314
DOC_MAPK_MEF2A_6 712 721 PF00069 0.266
DOC_MAPK_NFAT4_5 103 111 PF00069 0.397
DOC_MAPK_NFAT4_5 712 720 PF00069 0.243
DOC_PP1_RVXF_1 105 112 PF00149 0.246
DOC_PP1_RVXF_1 180 187 PF00149 0.310
DOC_PP1_RVXF_1 337 343 PF00149 0.476
DOC_PP1_RVXF_1 510 516 PF00149 0.250
DOC_PP1_RVXF_1 593 599 PF00149 0.240
DOC_PP1_RVXF_1 855 861 PF00149 0.346
DOC_PP2B_LxvP_1 212 215 PF13499 0.298
DOC_PP4_FxxP_1 14 17 PF00568 0.606
DOC_PP4_FxxP_1 296 299 PF00568 0.220
DOC_PP4_FxxP_1 318 321 PF00568 0.273
DOC_PP4_FxxP_1 570 573 PF00568 0.276
DOC_USP7_MATH_1 217 221 PF00917 0.431
DOC_USP7_MATH_1 609 613 PF00917 0.514
DOC_USP7_MATH_1 650 654 PF00917 0.364
DOC_USP7_MATH_1 8 12 PF00917 0.692
DOC_USP7_MATH_1 803 807 PF00917 0.269
DOC_WW_Pin1_4 13 18 PF00397 0.628
DOC_WW_Pin1_4 317 322 PF00397 0.273
DOC_WW_Pin1_4 461 466 PF00397 0.427
DOC_WW_Pin1_4 503 508 PF00397 0.264
DOC_WW_Pin1_4 665 670 PF00397 0.250
LIG_14-3-3_CanoR_1 145 154 PF00244 0.449
LIG_14-3-3_CanoR_1 182 187 PF00244 0.433
LIG_14-3-3_CanoR_1 281 286 PF00244 0.233
LIG_14-3-3_CanoR_1 517 525 PF00244 0.250
LIG_14-3-3_CanoR_1 595 599 PF00244 0.273
LIG_14-3-3_CanoR_1 829 835 PF00244 0.287
LIG_14-3-3_CanoR_1 857 861 PF00244 0.402
LIG_14-3-3_CanoR_1 96 106 PF00244 0.596
LIG_Actin_WH2_2 766 781 PF00022 0.318
LIG_APCC_ABBA_1 810 815 PF00400 0.252
LIG_APCC_ABBAyCdc20_2 477 483 PF00400 0.218
LIG_BIR_II_1 1 5 PF00653 0.648
LIG_BRCT_BRCA1_1 10 14 PF00533 0.607
LIG_BRCT_BRCA1_1 423 427 PF00533 0.413
LIG_Clathr_ClatBox_1 326 330 PF01394 0.273
LIG_EH1_1 158 166 PF00400 0.321
LIG_EH1_1 237 245 PF00400 0.409
LIG_eIF4E_1 508 514 PF01652 0.249
LIG_FHA_1 175 181 PF00498 0.344
LIG_FHA_1 393 399 PF00498 0.284
LIG_FHA_1 404 410 PF00498 0.310
LIG_FHA_1 462 468 PF00498 0.337
LIG_FHA_1 595 601 PF00498 0.280
LIG_FHA_1 606 612 PF00498 0.411
LIG_FHA_1 665 671 PF00498 0.289
LIG_FHA_1 846 852 PF00498 0.358
LIG_FHA_2 388 394 PF00498 0.364
LIG_FHA_2 65 71 PF00498 0.603
LIG_FHA_2 659 665 PF00498 0.293
LIG_FHA_2 669 675 PF00498 0.293
LIG_FHA_2 772 778 PF00498 0.292
LIG_GBD_Chelix_1 244 252 PF00786 0.310
LIG_LIR_Apic_2 11 17 PF02991 0.605
LIG_LIR_Apic_2 294 299 PF02991 0.220
LIG_LIR_Apic_2 315 321 PF02991 0.273
LIG_LIR_Apic_2 455 461 PF02991 0.240
LIG_LIR_Gen_1 183 194 PF02991 0.369
LIG_LIR_Gen_1 290 299 PF02991 0.279
LIG_LIR_Gen_1 363 373 PF02991 0.314
LIG_LIR_Gen_1 400 409 PF02991 0.436
LIG_LIR_Gen_1 483 492 PF02991 0.221
LIG_LIR_Gen_1 505 515 PF02991 0.270
LIG_LIR_Gen_1 597 605 PF02991 0.240
LIG_LIR_Gen_1 75 83 PF02991 0.515
LIG_LIR_Gen_1 806 814 PF02991 0.258
LIG_LIR_LC3C_4 597 602 PF02991 0.333
LIG_LIR_Nem_3 149 154 PF02991 0.465
LIG_LIR_Nem_3 183 189 PF02991 0.328
LIG_LIR_Nem_3 197 202 PF02991 0.255
LIG_LIR_Nem_3 290 296 PF02991 0.286
LIG_LIR_Nem_3 363 368 PF02991 0.279
LIG_LIR_Nem_3 400 404 PF02991 0.414
LIG_LIR_Nem_3 438 444 PF02991 0.517
LIG_LIR_Nem_3 483 488 PF02991 0.236
LIG_LIR_Nem_3 505 511 PF02991 0.261
LIG_LIR_Nem_3 597 601 PF02991 0.269
LIG_LIR_Nem_3 75 80 PF02991 0.505
LIG_LIR_Nem_3 766 771 PF02991 0.310
LIG_LIR_Nem_3 806 810 PF02991 0.253
LIG_LIR_Nem_3 828 834 PF02991 0.295
LIG_MYND_3 645 649 PF01753 0.284
LIG_NRBOX 201 207 PF00104 0.251
LIG_NRBOX 509 515 PF00104 0.310
LIG_NRBOX 618 624 PF00104 0.355
LIG_NRBOX 714 720 PF00104 0.238
LIG_PALB2_WD40_1 29 37 PF16756 0.588
LIG_Pex14_2 234 238 PF04695 0.409
LIG_Pex14_2 361 365 PF04695 0.314
LIG_Pex14_2 449 453 PF04695 0.365
LIG_SH2_CRK 401 405 PF00017 0.387
LIG_SH2_CRK 508 512 PF00017 0.221
LIG_SH2_GRB2like 228 231 PF00017 0.433
LIG_SH2_NCK_1 77 81 PF00017 0.484
LIG_SH2_PTP2 458 461 PF00017 0.333
LIG_SH2_PTP2 807 810 PF00017 0.277
LIG_SH2_SRC 228 231 PF00017 0.433
LIG_SH2_SRC 82 85 PF00017 0.566
LIG_SH2_STAP1 399 403 PF00017 0.310
LIG_SH2_STAT3 820 823 PF00017 0.267
LIG_SH2_STAT5 131 134 PF00017 0.355
LIG_SH2_STAT5 196 199 PF00017 0.306
LIG_SH2_STAT5 228 231 PF00017 0.409
LIG_SH2_STAT5 387 390 PF00017 0.301
LIG_SH2_STAT5 399 402 PF00017 0.245
LIG_SH2_STAT5 420 423 PF00017 0.266
LIG_SH2_STAT5 458 461 PF00017 0.294
LIG_SH2_STAT5 535 538 PF00017 0.264
LIG_SH2_STAT5 589 592 PF00017 0.287
LIG_SH2_STAT5 660 663 PF00017 0.361
LIG_SH2_STAT5 723 726 PF00017 0.291
LIG_SH2_STAT5 807 810 PF00017 0.262
LIG_SH2_STAT5 813 816 PF00017 0.240
LIG_SH2_STAT5 820 823 PF00017 0.207
LIG_SH2_STAT5 832 835 PF00017 0.228
LIG_SH3_3 229 235 PF00018 0.450
LIG_SH3_3 440 446 PF00018 0.432
LIG_SH3_3 462 468 PF00018 0.263
LIG_SH3_3 788 794 PF00018 0.298
LIG_Sin3_3 598 605 PF02671 0.333
LIG_SUMO_SIM_par_1 249 255 PF11976 0.261
LIG_SUMO_SIM_par_1 393 400 PF11976 0.349
LIG_SUMO_SIM_par_1 406 413 PF11976 0.266
LIG_TRAF2_1 167 170 PF00917 0.324
LIG_TRAF2_1 67 70 PF00917 0.501
LIG_UBA3_1 617 625 PF00899 0.335
LIG_WRC_WIRS_1 831 836 PF05994 0.317
MOD_CK1_1 146 152 PF00069 0.455
MOD_CK1_1 288 294 PF00069 0.217
MOD_CK1_1 316 322 PF00069 0.249
MOD_CK1_1 347 353 PF00069 0.266
MOD_CK1_1 360 366 PF00069 0.231
MOD_CK1_1 397 403 PF00069 0.345
MOD_CK1_1 516 522 PF00069 0.241
MOD_CK1_1 548 554 PF00069 0.281
MOD_CK1_1 594 600 PF00069 0.289
MOD_CK1_1 612 618 PF00069 0.188
MOD_CK1_1 668 674 PF00069 0.197
MOD_CK2_1 164 170 PF00069 0.531
MOD_CK2_1 387 393 PF00069 0.310
MOD_CK2_1 64 70 PF00069 0.533
MOD_CK2_1 668 674 PF00069 0.197
MOD_CK2_1 771 777 PF00069 0.346
MOD_CK2_1 95 101 PF00069 0.520
MOD_GlcNHglycan 1 4 PF01048 0.532
MOD_GlcNHglycan 10 13 PF01048 0.497
MOD_GlcNHglycan 161 164 PF01048 0.721
MOD_GlcNHglycan 166 169 PF01048 0.667
MOD_GlcNHglycan 17 20 PF01048 0.410
MOD_GlcNHglycan 170 173 PF01048 0.628
MOD_GlcNHglycan 186 189 PF01048 0.497
MOD_GlcNHglycan 215 218 PF01048 0.237
MOD_GlcNHglycan 219 222 PF01048 0.228
MOD_GlcNHglycan 254 257 PF01048 0.235
MOD_GlcNHglycan 287 290 PF01048 0.438
MOD_GlcNHglycan 306 309 PF01048 0.145
MOD_GlcNHglycan 315 318 PF01048 0.216
MOD_GlcNHglycan 362 365 PF01048 0.446
MOD_GlcNHglycan 370 373 PF01048 0.450
MOD_GlcNHglycan 412 415 PF01048 0.387
MOD_GlcNHglycan 518 521 PF01048 0.554
MOD_GlcNHglycan 755 758 PF01048 0.714
MOD_GlcNHglycan 801 804 PF01048 0.478
MOD_GlcNHglycan 815 819 PF01048 0.449
MOD_GlcNHglycan 92 95 PF01048 0.263
MOD_GSK3_1 13 20 PF00069 0.673
MOD_GSK3_1 143 150 PF00069 0.342
MOD_GSK3_1 164 171 PF00069 0.452
MOD_GSK3_1 180 187 PF00069 0.441
MOD_GSK3_1 213 220 PF00069 0.250
MOD_GSK3_1 281 288 PF00069 0.233
MOD_GSK3_1 312 319 PF00069 0.240
MOD_GSK3_1 399 406 PF00069 0.240
MOD_GSK3_1 421 428 PF00069 0.441
MOD_GSK3_1 498 505 PF00069 0.248
MOD_GSK3_1 548 555 PF00069 0.312
MOD_GSK3_1 605 612 PF00069 0.417
MOD_GSK3_1 664 671 PF00069 0.275
MOD_GSK3_1 749 756 PF00069 0.513
MOD_GSK3_1 799 806 PF00069 0.346
MOD_GSK3_1 92 99 PF00069 0.700
MOD_N-GLC_1 147 152 PF02516 0.588
MOD_N-GLC_1 154 159 PF02516 0.593
MOD_N-GLC_1 368 373 PF02516 0.342
MOD_NEK2_1 154 159 PF00069 0.471
MOD_NEK2_1 164 169 PF00069 0.503
MOD_NEK2_1 184 189 PF00069 0.362
MOD_NEK2_1 205 210 PF00069 0.257
MOD_NEK2_1 252 257 PF00069 0.255
MOD_NEK2_1 285 290 PF00069 0.251
MOD_NEK2_1 451 456 PF00069 0.282
MOD_NEK2_1 502 507 PF00069 0.224
MOD_NEK2_1 513 518 PF00069 0.220
MOD_NEK2_1 545 550 PF00069 0.437
MOD_NEK2_1 656 661 PF00069 0.404
MOD_NEK2_1 686 691 PF00069 0.239
MOD_NEK2_1 845 850 PF00069 0.355
MOD_NEK2_2 17 22 PF00069 0.611
MOD_NEK2_2 631 636 PF00069 0.314
MOD_NEK2_2 650 655 PF00069 0.364
MOD_NEK2_2 830 835 PF00069 0.282
MOD_OFUCOSY 351 358 PF10250 0.295
MOD_PIKK_1 845 851 PF00454 0.251
MOD_PK_1 379 385 PF00069 0.217
MOD_PK_1 789 795 PF00069 0.271
MOD_PKA_2 146 152 PF00069 0.435
MOD_PKA_2 425 431 PF00069 0.500
MOD_PKA_2 516 522 PF00069 0.241
MOD_PKA_2 594 600 PF00069 0.273
MOD_PKA_2 856 862 PF00069 0.231
MOD_PKA_2 90 96 PF00069 0.672
MOD_PKB_1 145 153 PF00069 0.453
MOD_Plk_1 147 153 PF00069 0.426
MOD_Plk_1 154 160 PF00069 0.444
MOD_Plk_1 368 374 PF00069 0.314
MOD_Plk_1 379 385 PF00069 0.289
MOD_Plk_1 392 398 PF00069 0.297
MOD_Plk_1 609 615 PF00069 0.409
MOD_Plk_4 194 200 PF00069 0.379
MOD_Plk_4 268 274 PF00069 0.222
MOD_Plk_4 288 294 PF00069 0.320
MOD_Plk_4 357 363 PF00069 0.270
MOD_Plk_4 394 400 PF00069 0.253
MOD_Plk_4 403 409 PF00069 0.260
MOD_Plk_4 436 442 PF00069 0.461
MOD_Plk_4 548 554 PF00069 0.279
MOD_Plk_4 631 637 PF00069 0.248
MOD_Plk_4 668 674 PF00069 0.280
MOD_Plk_4 675 681 PF00069 0.248
MOD_Plk_4 84 90 PF00069 0.515
MOD_Plk_4 856 862 PF00069 0.252
MOD_ProDKin_1 13 19 PF00069 0.627
MOD_ProDKin_1 317 323 PF00069 0.273
MOD_ProDKin_1 461 467 PF00069 0.427
MOD_ProDKin_1 503 509 PF00069 0.264
MOD_ProDKin_1 665 671 PF00069 0.250
MOD_SUMO_rev_2 130 137 PF00179 0.367
MOD_SUMO_rev_2 639 645 PF00179 0.246
TRG_DiLeu_BaEn_1 84 89 PF01217 0.553
TRG_DiLeu_BaLyEn_6 104 109 PF01217 0.223
TRG_DiLeu_BaLyEn_6 509 514 PF01217 0.250
TRG_DiLeu_BaLyEn_6 561 566 PF01217 0.273
TRG_ENDOCYTIC_2 151 154 PF00928 0.515
TRG_ENDOCYTIC_2 401 404 PF00928 0.387
TRG_ENDOCYTIC_2 441 444 PF00928 0.482
TRG_ENDOCYTIC_2 508 511 PF00928 0.221
TRG_ENDOCYTIC_2 706 709 PF00928 0.209
TRG_ENDOCYTIC_2 77 80 PF00928 0.487
TRG_ENDOCYTIC_2 807 810 PF00928 0.270
TRG_ENDOCYTIC_2 831 834 PF00928 0.260
TRG_ER_diArg_1 144 147 PF00400 0.388
TRG_ER_diArg_1 21 23 PF00400 0.669
TRG_ER_diArg_1 430 433 PF00400 0.462
TRG_ER_diArg_1 71 73 PF00400 0.509
TRG_NES_CRM1_1 127 138 PF08389 0.353
TRG_NES_CRM1_1 714 726 PF08389 0.354

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHR6 Leptomonas seymouri 35% 76%
A0A0N1IJL2 Leptomonas seymouri 75% 100%
A0A0S4IKD3 Bodo saltans 24% 100%
A0A0S4IL39 Bodo saltans 22% 100%
A0A0S4JG93 Bodo saltans 47% 100%
A0A0S4JNP7 Bodo saltans 28% 100%
A0A0S4JSW7 Bodo saltans 26% 100%
A0A1X0NKT6 Trypanosomatidae 32% 92%
A0A1X0NSH7 Trypanosomatidae 54% 96%
A0A1X0P2R6 Trypanosomatidae 24% 100%
A0A3Q8IH43 Leishmania donovani 95% 100%
A0A3R7KRB4 Trypanosoma rangeli 52% 97%
A0A3S7WNV9 Leishmania donovani 36% 75%
A0A422NY59 Trypanosoma rangeli 24% 100%
A0A451EJ75 Leishmania donovani 24% 100%
A4H342 Leishmania braziliensis 24% 100%
A4H415 Leishmania braziliensis 33% 75%
A4HKY2 Leishmania braziliensis 87% 100%
A4HRD9 Leishmania infantum 24% 100%
A4HS98 Leishmania infantum 36% 75%
D0A4W6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 90%
D0AAR0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 96%
E9AC07 Leishmania major 24% 100%
E9AHM3 Leishmania infantum 95% 100%
E9AJA4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AK82 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 78%
O70496 Mus musculus 29% 100%
P21564 Torpedo marmorata 25% 100%
P35522 Tetronarce californica 26% 100%
P35525 Rattus norvegicus 24% 97%
P51788 Homo sapiens 24% 98%
P51793 Homo sapiens 25% 100%
P51794 Rattus norvegicus 25% 100%
P51798 Homo sapiens 29% 100%
P51799 Rattus norvegicus 29% 100%
P51801 Homo sapiens 25% 100%
P60300 Arabidopsis thaliana 27% 100%
P92941 Arabidopsis thaliana 27% 100%
P92942 Arabidopsis thaliana 31% 100%
P92943 Arabidopsis thaliana 27% 100%
Q4PKH3 Bos taurus 31% 100%
Q4Q4T5 Leishmania major 93% 99%
Q54AX6 Dictyostelium discoideum 28% 100%
Q61418 Mus musculus 26% 100%
Q75JF3 Dictyostelium discoideum 28% 100%
Q86AZ6 Dictyostelium discoideum 28% 100%
Q96282 Arabidopsis thaliana 29% 100%
Q9NF95 Leishmania major 36% 75%
Q9R0A1 Mus musculus 23% 97%
V5BPC2 Trypanosoma cruzi 28% 100%
V5BVK3 Trypanosoma cruzi 52% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS