Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lipase (class 3), putative

Species:

Leishmania mexicana

UniProt:

E9B3B9_LEIMU

TriTrypDb:

LmxM.31.3360

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3B9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3B9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0009056	catabolic process	2	1
GO:0016042	lipid catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016298	lipase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.712
CLV_C14_Caspase3-7	670	674	PF00656	0.470
CLV_C14_Caspase3-7	87	91	PF00656	0.638
CLV_NRD_NRD_1	140	142	PF00675	0.630
CLV_NRD_NRD_1	294	296	PF00675	0.591
CLV_NRD_NRD_1	406	408	PF00675	0.574
CLV_NRD_NRD_1	421	423	PF00675	0.383
CLV_NRD_NRD_1	576	578	PF00675	0.582
CLV_NRD_NRD_1	61	63	PF00675	0.539
CLV_NRD_NRD_1	632	634	PF00675	0.530
CLV_NRD_NRD_1	728	730	PF00675	0.452
CLV_NRD_NRD_1	769	771	PF00675	0.537
CLV_PCSK_KEX2_1	12	14	PF00082	0.658
CLV_PCSK_KEX2_1	139	141	PF00082	0.630
CLV_PCSK_KEX2_1	279	281	PF00082	0.447
CLV_PCSK_KEX2_1	296	298	PF00082	0.496
CLV_PCSK_KEX2_1	406	408	PF00082	0.574
CLV_PCSK_KEX2_1	421	423	PF00082	0.383
CLV_PCSK_KEX2_1	576	578	PF00082	0.582
CLV_PCSK_KEX2_1	61	63	PF00082	0.539
CLV_PCSK_KEX2_1	632	634	PF00082	0.419
CLV_PCSK_KEX2_1	727	729	PF00082	0.499
CLV_PCSK_KEX2_1	769	771	PF00082	0.537
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.641
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.562
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.384
CLV_PCSK_PC7_1	135	141	PF00082	0.616
CLV_PCSK_SKI1_1	421	425	PF00082	0.456
CLV_PCSK_SKI1_1	459	463	PF00082	0.353
CLV_PCSK_SKI1_1	565	569	PF00082	0.536
CLV_PCSK_SKI1_1	576	580	PF00082	0.709
CLV_PCSK_SKI1_1	618	622	PF00082	0.485
CLV_PCSK_SKI1_1	729	733	PF00082	0.418
CLV_Separin_Metazoa	766	770	PF03568	0.481
DEG_APCC_DBOX_1	664	672	PF00400	0.512
DEG_APCC_DBOX_1	727	735	PF00400	0.444
DEG_Nend_Nbox_1	1	3	PF02207	0.573
DEG_SPOP_SBC_1	183	187	PF00917	0.588
DEG_SPOP_SBC_1	205	209	PF00917	0.731
DEG_SPOP_SBC_1	38	42	PF00917	0.522
DEG_SPOP_SBC_1	85	89	PF00917	0.726
DOC_CDC14_PxL_1	126	134	PF14671	0.586
DOC_CDC14_PxL_1	753	761	PF14671	0.508
DOC_CKS1_1	150	155	PF01111	0.740
DOC_CYCLIN_yClb5_NLxxxL_5	759	768	PF00134	0.284
DOC_CYCLIN_yCln2_LP_2	732	738	PF00134	0.420
DOC_MAPK_gen_1	632	640	PF00069	0.295
DOC_MAPK_gen_1	727	736	PF00069	0.442
DOC_MAPK_HePTP_8	630	642	PF00069	0.284
DOC_MAPK_MEF2A_6	632	640	PF00069	0.295
DOC_MAPK_MEF2A_6	727	736	PF00069	0.442
DOC_PP1_RVXF_1	650	657	PF00149	0.505
DOC_PP2B_LxvP_1	154	157	PF13499	0.683
DOC_PP2B_LxvP_1	713	716	PF13499	0.380
DOC_PP2B_LxvP_1	732	735	PF13499	0.426
DOC_PP4_FxxP_1	269	272	PF00568	0.572
DOC_USP7_MATH_1	117	121	PF00917	0.592
DOC_USP7_MATH_1	158	162	PF00917	0.759
DOC_USP7_MATH_1	177	181	PF00917	0.490
DOC_USP7_MATH_1	205	209	PF00917	0.717
DOC_USP7_MATH_1	229	233	PF00917	0.629
DOC_USP7_MATH_1	307	311	PF00917	0.447
DOC_USP7_MATH_1	341	345	PF00917	0.529
DOC_USP7_MATH_1	38	42	PF00917	0.522
DOC_USP7_MATH_1	597	601	PF00917	0.719
DOC_USP7_MATH_1	606	610	PF00917	0.512
DOC_USP7_MATH_1	703	707	PF00917	0.620
DOC_USP7_MATH_1	86	90	PF00917	0.670
DOC_WW_Pin1_4	100	105	PF00397	0.663
DOC_WW_Pin1_4	149	154	PF00397	0.782
DOC_WW_Pin1_4	225	230	PF00397	0.817
DOC_WW_Pin1_4	343	348	PF00397	0.573
DOC_WW_Pin1_4	39	44	PF00397	0.567
DOC_WW_Pin1_4	466	471	PF00397	0.399
DOC_WW_Pin1_4	500	505	PF00397	0.223
DOC_WW_Pin1_4	60	65	PF00397	0.454
DOC_WW_Pin1_4	782	787	PF00397	0.569
LIG_14-3-3_CanoR_1	314	318	PF00244	0.514
LIG_14-3-3_CanoR_1	439	443	PF00244	0.394
LIG_14-3-3_CanoR_1	459	465	PF00244	0.334
LIG_14-3-3_CanoR_1	46	55	PF00244	0.552
LIG_14-3-3_CanoR_1	530	539	PF00244	0.449
LIG_14-3-3_CanoR_1	576	582	PF00244	0.538
LIG_Actin_WH2_2	429	445	PF00022	0.422
LIG_AP2alpha_2	262	264	PF02296	0.580
LIG_APCC_ABBA_1	640	645	PF00400	0.301
LIG_FHA_1	149	155	PF00498	0.713
LIG_FHA_1	219	225	PF00498	0.745
LIG_FHA_1	276	282	PF00498	0.513
LIG_FHA_1	314	320	PF00498	0.532
LIG_FHA_1	455	461	PF00498	0.477
LIG_FHA_1	536	542	PF00498	0.406
LIG_FHA_1	615	621	PF00498	0.392
LIG_FHA_2	246	252	PF00498	0.647
LIG_FHA_2	40	46	PF00498	0.558
LIG_FHA_2	467	473	PF00498	0.334
LIG_FHA_2	496	502	PF00498	0.419
LIG_GSK3_LRP6_1	149	154	PF00069	0.742
LIG_LIR_Apic_2	267	272	PF02991	0.569
LIG_LIR_Apic_2	27	31	PF02991	0.514
LIG_LIR_Apic_2	63	68	PF02991	0.551
LIG_LIR_Gen_1	273	282	PF02991	0.525
LIG_LIR_Gen_1	447	456	PF02991	0.498
LIG_LIR_Gen_1	478	489	PF02991	0.339
LIG_LIR_Gen_1	554	563	PF02991	0.359
LIG_LIR_Gen_1	773	782	PF02991	0.344
LIG_LIR_Nem_3	124	129	PF02991	0.504
LIG_LIR_Nem_3	273	277	PF02991	0.537
LIG_LIR_Nem_3	447	452	PF02991	0.486
LIG_LIR_Nem_3	478	484	PF02991	0.339
LIG_LIR_Nem_3	49	55	PF02991	0.520
LIG_LIR_Nem_3	534	539	PF02991	0.449
LIG_LIR_Nem_3	554	559	PF02991	0.334
LIG_LIR_Nem_3	773	778	PF02991	0.326
LIG_LYPXL_yS_3	756	759	PF13949	0.515
LIG_NRBOX	554	560	PF00104	0.449
LIG_NRBOX	763	769	PF00104	0.405
LIG_PCNA_yPIPBox_3	552	565	PF02747	0.361
LIG_Pex14_2	122	126	PF04695	0.501
LIG_PTAP_UEV_1	587	592	PF05743	0.625
LIG_SH2_CRK	35	39	PF00017	0.534
LIG_SH2_CRK	382	386	PF00017	0.381
LIG_SH2_CRK	481	485	PF00017	0.334
LIG_SH2_CRK	679	683	PF00017	0.650
LIG_SH2_GRB2like	481	484	PF00017	0.334
LIG_SH2_NCK_1	106	110	PF00017	0.491
LIG_SH2_NCK_1	377	381	PF00017	0.355
LIG_SH2_NCK_1	65	69	PF00017	0.569
LIG_SH2_NCK_1	679	683	PF00017	0.650
LIG_SH2_SRC	481	484	PF00017	0.334
LIG_SH2_SRC	65	68	PF00017	0.564
LIG_SH2_STAP1	302	306	PF00017	0.453
LIG_SH2_STAP1	377	381	PF00017	0.374
LIG_SH2_STAP1	440	444	PF00017	0.396
LIG_SH2_STAP1	481	485	PF00017	0.334
LIG_SH2_STAP1	515	519	PF00017	0.353
LIG_SH2_STAT3	302	305	PF00017	0.462
LIG_SH2_STAT5	106	109	PF00017	0.647
LIG_SH2_STAT5	239	242	PF00017	0.634
LIG_SH2_STAT5	373	376	PF00017	0.368
LIG_SH2_STAT5	390	393	PF00017	0.405
LIG_SH2_STAT5	408	411	PF00017	0.443
LIG_SH2_STAT5	55	58	PF00017	0.515
LIG_SH2_STAT5	560	563	PF00017	0.378
LIG_SH2_STAT5	71	74	PF00017	0.618
LIG_SH2_STAT5	760	763	PF00017	0.404
LIG_SH3_3	147	153	PF00018	0.731
LIG_SH3_3	585	591	PF00018	0.627
LIG_SH3_3	743	749	PF00018	0.421
LIG_SUMO_SIM_anti_2	743	750	PF11976	0.539
LIG_SUMO_SIM_par_1	472	479	PF11976	0.303
LIG_SUMO_SIM_par_1	743	750	PF11976	0.407
LIG_TRAF2_1	682	685	PF00917	0.655
LIG_WRC_WIRS_1	123	128	PF05994	0.503
LIG_WRC_WIRS_1	461	466	PF05994	0.334
LIG_WW_3	13	17	PF00397	0.628
MOD_CDK_SPK_2	343	348	PF00069	0.592
MOD_CDK_SPK_2	39	44	PF00069	0.556
MOD_CDK_SPxxK_3	39	46	PF00069	0.563
MOD_CK1_1	121	127	PF00069	0.653
MOD_CK1_1	187	193	PF00069	0.783
MOD_CK1_1	228	234	PF00069	0.786
MOD_CK1_1	275	281	PF00069	0.538
MOD_CK1_1	310	316	PF00069	0.526
MOD_CK1_1	335	341	PF00069	0.515
MOD_CK1_1	346	352	PF00069	0.678
MOD_CK1_1	438	444	PF00069	0.394
MOD_CK1_1	534	540	PF00069	0.416
MOD_CK1_1	570	576	PF00069	0.543
MOD_CK1_1	586	592	PF00069	0.629
MOD_CK1_1	60	66	PF00069	0.559
MOD_CK1_1	600	606	PF00069	0.479
MOD_CK1_1	686	692	PF00069	0.678
MOD_CK1_1	706	712	PF00069	0.489
MOD_CK1_1	99	105	PF00069	0.667
MOD_CK2_1	205	211	PF00069	0.734
MOD_CK2_1	229	235	PF00069	0.629
MOD_CK2_1	245	251	PF00069	0.614
MOD_CK2_1	390	396	PF00069	0.434
MOD_CK2_1	514	520	PF00069	0.305
MOD_CK2_1	70	76	PF00069	0.704
MOD_GlcNHglycan	107	110	PF01048	0.588
MOD_GlcNHglycan	187	190	PF01048	0.759
MOD_GlcNHglycan	208	211	PF01048	0.749
MOD_GlcNHglycan	274	277	PF01048	0.587
MOD_GlcNHglycan	337	340	PF01048	0.462
MOD_GlcNHglycan	588	591	PF01048	0.629
MOD_GlcNHglycan	594	597	PF01048	0.654
MOD_GlcNHglycan	599	602	PF01048	0.681
MOD_GlcNHglycan	608	611	PF01048	0.503
MOD_GlcNHglycan	648	651	PF01048	0.449
MOD_GlcNHglycan	72	75	PF01048	0.704
MOD_GlcNHglycan	723	726	PF01048	0.589
MOD_GlcNHglycan	98	101	PF01048	0.643
MOD_GSK3_1	100	107	PF00069	0.623
MOD_GSK3_1	117	124	PF00069	0.654
MOD_GSK3_1	183	190	PF00069	0.776
MOD_GSK3_1	195	202	PF00069	0.611
MOD_GSK3_1	225	232	PF00069	0.745
MOD_GSK3_1	333	340	PF00069	0.567
MOD_GSK3_1	342	349	PF00069	0.611
MOD_GSK3_1	460	467	PF00069	0.334
MOD_GSK3_1	53	60	PF00069	0.523
MOD_GSK3_1	531	538	PF00069	0.353
MOD_GSK3_1	582	589	PF00069	0.609
MOD_GSK3_1	600	607	PF00069	0.702
MOD_GSK3_1	614	621	PF00069	0.342
MOD_GSK3_1	66	73	PF00069	0.787
MOD_GSK3_1	770	777	PF00069	0.405
MOD_GSK3_1	780	787	PF00069	0.563
MOD_GSK3_1	92	99	PF00069	0.730
MOD_N-GLC_1	720	725	PF02516	0.389
MOD_N-GLC_2	168	170	PF02516	0.627
MOD_NEK2_1	122	127	PF00069	0.573
MOD_NEK2_1	184	189	PF00069	0.650
MOD_NEK2_1	333	338	PF00069	0.514
MOD_NEK2_1	464	469	PF00069	0.343
MOD_NEK2_1	514	519	PF00069	0.333
MOD_NEK2_1	528	533	PF00069	0.353
MOD_NEK2_1	541	546	PF00069	0.275
MOD_NEK2_1	568	573	PF00069	0.508
MOD_NEK2_1	57	62	PF00069	0.534
MOD_NEK2_1	616	621	PF00069	0.370
MOD_NEK2_1	654	659	PF00069	0.359
MOD_NEK2_1	736	741	PF00069	0.524
MOD_NEK2_2	390	395	PF00069	0.537
MOD_NEK2_2	53	58	PF00069	0.497
MOD_PIKK_1	346	352	PF00454	0.656
MOD_PIKK_1	531	537	PF00454	0.393
MOD_PK_1	774	780	PF00069	0.516
MOD_PKA_1	140	146	PF00069	0.678
MOD_PKA_2	140	146	PF00069	0.634
MOD_PKA_2	313	319	PF00069	0.508
MOD_PKA_2	438	444	PF00069	0.394
MOD_PKA_2	464	470	PF00069	0.334
MOD_PKA_2	57	63	PF00069	0.527
MOD_PKA_2	680	686	PF00069	0.617
MOD_PKA_2	96	102	PF00069	0.500
MOD_PKB_1	295	303	PF00069	0.604
MOD_PKB_1	44	52	PF00069	0.566
MOD_Plk_1	229	235	PF00069	0.562
MOD_Plk_1	297	303	PF00069	0.600
MOD_Plk_1	683	689	PF00069	0.663
MOD_Plk_1	706	712	PF00069	0.488
MOD_Plk_4	118	124	PF00069	0.738
MOD_Plk_4	514	520	PF00069	0.350
MOD_Plk_4	551	557	PF00069	0.345
MOD_Plk_4	570	576	PF00069	0.554
MOD_Plk_4	577	583	PF00069	0.621
MOD_Plk_4	66	72	PF00069	0.590
MOD_Plk_4	715	721	PF00069	0.461
MOD_Plk_4	755	761	PF00069	0.431
MOD_ProDKin_1	100	106	PF00069	0.672
MOD_ProDKin_1	149	155	PF00069	0.780
MOD_ProDKin_1	225	231	PF00069	0.812
MOD_ProDKin_1	343	349	PF00069	0.573
MOD_ProDKin_1	39	45	PF00069	0.566
MOD_ProDKin_1	466	472	PF00069	0.399
MOD_ProDKin_1	500	506	PF00069	0.223
MOD_ProDKin_1	60	66	PF00069	0.454
MOD_ProDKin_1	782	788	PF00069	0.572
TRG_DiLeu_BaEn_1	396	401	PF01217	0.430
TRG_DiLeu_BaEn_1	428	433	PF01217	0.478
TRG_DiLeu_BaEn_1	743	748	PF01217	0.516
TRG_DiLeu_BaLyEn_6	524	529	PF01217	0.399
TRG_DiLeu_BaLyEn_6	633	638	PF01217	0.537
TRG_DiLeu_BaLyEn_6	649	654	PF01217	0.296
TRG_DiLeu_BaLyEn_6	708	713	PF01217	0.558
TRG_ENDOCYTIC_2	481	484	PF00928	0.334
TRG_ENDOCYTIC_2	515	518	PF00928	0.334
TRG_ENDOCYTIC_2	756	759	PF00928	0.515
TRG_ER_diArg_1	132	135	PF00400	0.624
TRG_ER_diArg_1	138	141	PF00400	0.597
TRG_ER_diArg_1	294	297	PF00400	0.615
TRG_ER_diArg_1	406	408	PF00400	0.562
TRG_ER_diArg_1	420	422	PF00400	0.385
TRG_ER_diArg_1	575	577	PF00400	0.579
TRG_ER_diArg_1	632	634	PF00400	0.570
TRG_ER_diArg_1	727	729	PF00400	0.503
TRG_ER_diArg_1	768	770	PF00400	0.602
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	422	427	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	669	673	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	762	766	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U7	Leptomonas seymouri	54%	98%
A0A3S7X618	Leishmania donovani	91%	100%
A4HKY1	Leishmania braziliensis	79%	100%
A4I8G1	Leishmania infantum	92%	100%
Q4Q4T6	Leishmania major	91%	100%