Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3B7_LEIMU

TriTrypDb:

LmxM.31.3340

Length:

1112

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3B7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.688
CLV_C14_Caspase3-7	418	422	PF00656	0.510
CLV_C14_Caspase3-7	448	452	PF00656	0.590
CLV_C14_Caspase3-7	545	549	PF00656	0.566
CLV_NRD_NRD_1	1087	1089	PF00675	0.718
CLV_NRD_NRD_1	1099	1101	PF00675	0.596
CLV_NRD_NRD_1	13	15	PF00675	0.568
CLV_NRD_NRD_1	374	376	PF00675	0.553
CLV_NRD_NRD_1	529	531	PF00675	0.596
CLV_NRD_NRD_1	686	688	PF00675	0.605
CLV_NRD_NRD_1	820	822	PF00675	0.452
CLV_NRD_NRD_1	990	992	PF00675	0.638
CLV_PCSK_KEX2_1	1087	1089	PF00082	0.732
CLV_PCSK_KEX2_1	13	15	PF00082	0.463
CLV_PCSK_KEX2_1	374	376	PF00082	0.555
CLV_PCSK_KEX2_1	529	531	PF00082	0.573
CLV_PCSK_KEX2_1	610	612	PF00082	0.573
CLV_PCSK_KEX2_1	686	688	PF00082	0.605
CLV_PCSK_KEX2_1	990	992	PF00082	0.638
CLV_PCSK_PC1ET2_1	610	612	PF00082	0.573
CLV_PCSK_SKI1_1	1030	1034	PF00082	0.458
CLV_PCSK_SKI1_1	1049	1053	PF00082	0.624
CLV_PCSK_SKI1_1	1103	1107	PF00082	0.761
CLV_PCSK_SKI1_1	254	258	PF00082	0.552
CLV_PCSK_SKI1_1	337	341	PF00082	0.727
CLV_PCSK_SKI1_1	375	379	PF00082	0.530
CLV_PCSK_SKI1_1	505	509	PF00082	0.535
CLV_PCSK_SKI1_1	614	618	PF00082	0.498
CLV_PCSK_SKI1_1	957	961	PF00082	0.629
DEG_APCC_DBOX_1	1059	1067	PF00400	0.652
DEG_APCC_DBOX_1	504	512	PF00400	0.523
DEG_Nend_Nbox_1	1	3	PF02207	0.492
DEG_SCF_FBW7_1	573	580	PF00400	0.606
DEG_SPOP_SBC_1	312	316	PF00917	0.588
DEG_SPOP_SBC_1	709	713	PF00917	0.683
DOC_CKS1_1	1031	1036	PF01111	0.555
DOC_CKS1_1	574	579	PF01111	0.618
DOC_CYCLIN_RxL_1	28	36	PF00134	0.570
DOC_CYCLIN_RxL_1	385	396	PF00134	0.589
DOC_CYCLIN_yCln2_LP_2	430	436	PF00134	0.376
DOC_CYCLIN_yCln2_LP_2	870	873	PF00134	0.704
DOC_CYCLIN_yCln2_LP_2	909	912	PF00134	0.394
DOC_CYCLIN_yCln2_LP_2	948	954	PF00134	0.578
DOC_MAPK_gen_1	29	37	PF00069	0.538
DOC_MAPK_gen_1	821	830	PF00069	0.623
DOC_MAPK_MEF2A_6	1060	1068	PF00069	0.601
DOC_MAPK_MEF2A_6	277	286	PF00069	0.449
DOC_MAPK_MEF2A_6	29	37	PF00069	0.541
DOC_PP1_RVXF_1	670	677	PF00149	0.555
DOC_PP2B_LxvP_1	116	119	PF13499	0.598
DOC_PP2B_LxvP_1	430	433	PF13499	0.390
DOC_PP2B_LxvP_1	511	514	PF13499	0.591
DOC_PP2B_LxvP_1	870	873	PF13499	0.704
DOC_PP2B_LxvP_1	909	912	PF13499	0.394
DOC_PP2B_LxvP_1	948	951	PF13499	0.564
DOC_PP2B_PxIxI_1	566	572	PF00149	0.557
DOC_USP7_MATH_1	1025	1029	PF00917	0.667
DOC_USP7_MATH_1	1090	1094	PF00917	0.717
DOC_USP7_MATH_1	119	123	PF00917	0.642
DOC_USP7_MATH_1	153	157	PF00917	0.561
DOC_USP7_MATH_1	170	174	PF00917	0.498
DOC_USP7_MATH_1	282	286	PF00917	0.459
DOC_USP7_MATH_1	312	316	PF00917	0.633
DOC_USP7_MATH_1	330	334	PF00917	0.801
DOC_USP7_MATH_1	355	359	PF00917	0.581
DOC_USP7_MATH_1	406	410	PF00917	0.628
DOC_USP7_MATH_1	51	55	PF00917	0.704
DOC_USP7_MATH_1	512	516	PF00917	0.643
DOC_USP7_MATH_1	688	692	PF00917	0.642
DOC_USP7_MATH_1	709	713	PF00917	0.764
DOC_USP7_MATH_1	894	898	PF00917	0.750
DOC_WW_Pin1_4	1030	1035	PF00397	0.571
DOC_WW_Pin1_4	262	267	PF00397	0.639
DOC_WW_Pin1_4	290	295	PF00397	0.626
DOC_WW_Pin1_4	461	466	PF00397	0.573
DOC_WW_Pin1_4	468	473	PF00397	0.554
DOC_WW_Pin1_4	573	578	PF00397	0.607
DOC_WW_Pin1_4	689	694	PF00397	0.508
DOC_WW_Pin1_4	77	82	PF00397	0.670
LIG_14-3-3_CanoR_1	1039	1045	PF00244	0.682
LIG_14-3-3_CanoR_1	254	260	PF00244	0.536
LIG_14-3-3_CanoR_1	302	311	PF00244	0.588
LIG_14-3-3_CanoR_1	337	342	PF00244	0.764
LIG_14-3-3_CanoR_1	34	38	PF00244	0.588
LIG_14-3-3_CanoR_1	374	382	PF00244	0.568
LIG_14-3-3_CanoR_1	578	584	PF00244	0.557
LIG_14-3-3_CanoR_1	614	623	PF00244	0.479
LIG_14-3-3_CanoR_1	708	718	PF00244	0.726
LIG_14-3-3_CanoR_1	747	753	PF00244	0.478
LIG_14-3-3_CanoR_1	793	799	PF00244	0.513
LIG_14-3-3_CanoR_1	824	829	PF00244	0.584
LIG_Actin_WH2_2	21	36	PF00022	0.482
LIG_Actin_WH2_2	382	400	PF00022	0.587
LIG_Actin_WH2_2	621	637	PF00022	0.588
LIG_Actin_WH2_2	727	745	PF00022	0.415
LIG_Actin_WH2_2	765	781	PF00022	0.494
LIG_BIR_III_4	360	364	PF00653	0.582
LIG_Clathr_ClatBox_1	194	198	PF01394	0.602
LIG_EH1_1	497	505	PF00400	0.497
LIG_FHA_1	1002	1008	PF00498	0.707
LIG_FHA_1	469	475	PF00498	0.815
LIG_FHA_1	480	486	PF00498	0.544
LIG_FHA_1	568	574	PF00498	0.572
LIG_FHA_1	583	589	PF00498	0.517
LIG_FHA_1	737	743	PF00498	0.413
LIG_FHA_1	747	753	PF00498	0.416
LIG_FHA_1	785	791	PF00498	0.532
LIG_FHA_1	825	831	PF00498	0.513
LIG_FHA_1	857	863	PF00498	0.442
LIG_FHA_1	888	894	PF00498	0.521
LIG_FHA_1	969	975	PF00498	0.696
LIG_FHA_1	978	984	PF00498	0.627
LIG_FHA_2	578	584	PF00498	0.601
LIG_FHA_2	613	619	PF00498	0.507
LIG_FHA_2	725	731	PF00498	0.431
LIG_FHA_2	795	801	PF00498	0.550
LIG_FHA_2	958	964	PF00498	0.645
LIG_FHA_2	971	977	PF00498	0.680
LIG_GBD_Chelix_1	192	200	PF00786	0.521
LIG_HP1_1	282	286	PF01393	0.475
LIG_LIR_Apic_2	1028	1034	PF02991	0.667
LIG_LIR_Apic_2	156	160	PF02991	0.711
LIG_LIR_Apic_2	261	266	PF02991	0.647
LIG_LIR_Gen_1	737	746	PF02991	0.547
LIG_LIR_Gen_1	774	781	PF02991	0.516
LIG_LIR_Gen_1	808	816	PF02991	0.546
LIG_LIR_Gen_1	915	926	PF02991	0.543
LIG_LIR_Nem_3	1075	1079	PF02991	0.469
LIG_LIR_Nem_3	243	248	PF02991	0.500
LIG_LIR_Nem_3	519	524	PF02991	0.456
LIG_LIR_Nem_3	737	741	PF02991	0.515
LIG_LIR_Nem_3	76	82	PF02991	0.720
LIG_LIR_Nem_3	774	778	PF02991	0.491
LIG_LIR_Nem_3	808	813	PF02991	0.529
LIG_LIR_Nem_3	915	921	PF02991	0.541
LIG_LIR_Nem_3	95	101	PF02991	0.327
LIG_LYPXL_yS_3	1076	1079	PF13949	0.470
LIG_LYPXL_yS_3	394	397	PF13949	0.607
LIG_NRBOX	385	391	PF00104	0.571
LIG_NRBOX	583	589	PF00104	0.567
LIG_NRBOX	730	736	PF00104	0.458
LIG_NRBOX	88	94	PF00104	0.445
LIG_PCNA_yPIPBox_3	578	588	PF02747	0.450
LIG_Pex14_1	1031	1035	PF04695	0.720
LIG_Pex14_2	736	740	PF04695	0.536
LIG_Pex14_2	914	918	PF04695	0.550
LIG_SH2_CRK	1035	1039	PF00017	0.688
LIG_SH2_CRK	157	161	PF00017	0.722
LIG_SH2_CRK	521	525	PF00017	0.496
LIG_SH2_CRK	773	777	PF00017	0.412
LIG_SH2_SRC	221	224	PF00017	0.577
LIG_SH2_STAP1	506	510	PF00017	0.525
LIG_SH2_STAT3	662	665	PF00017	0.486
LIG_SH2_STAT5	1035	1038	PF00017	0.683
LIG_SH2_STAT5	157	160	PF00017	0.690
LIG_SH2_STAT5	221	224	PF00017	0.558
LIG_SH2_STAT5	263	266	PF00017	0.522
LIG_SH2_STAT5	52	55	PF00017	0.439
LIG_SH2_STAT5	646	649	PF00017	0.478
LIG_SH2_STAT5	662	665	PF00017	0.335
LIG_SH2_STAT5	82	85	PF00017	0.592
LIG_SH2_STAT5	935	938	PF00017	0.540
LIG_SH2_STAT5	98	101	PF00017	0.325
LIG_SH3_2	1034	1039	PF14604	0.718
LIG_SH3_2	472	477	PF14604	0.607
LIG_SH3_3	1031	1037	PF00018	0.669
LIG_SH3_3	469	475	PF00018	0.808
LIG_SH3_3	511	517	PF00018	0.610
LIG_SH3_3	866	872	PF00018	0.748
LIG_SH3_3	905	911	PF00018	0.581
LIG_SH3_3	993	999	PF00018	0.673
LIG_SUMO_SIM_anti_2	285	291	PF11976	0.591
LIG_SUMO_SIM_anti_2	827	832	PF11976	0.574
LIG_SUMO_SIM_par_1	192	198	PF11976	0.572
LIG_SUMO_SIM_par_1	950	956	PF11976	0.572
LIG_SUMO_SIM_par_1	998	1004	PF11976	0.608
LIG_TRAF2_1	40	43	PF00917	0.613
LIG_TRAF2_1	594	597	PF00917	0.607
LIG_TRAF2_1	617	620	PF00917	0.566
LIG_TYR_ITIM	392	397	PF00017	0.594
LIG_TYR_ITIM	96	101	PF00017	0.444
LIG_TYR_ITSM	517	524	PF00017	0.533
LIG_UBA3_1	587	595	PF00899	0.474
LIG_UBA3_1	752	757	PF00899	0.535
LIG_WRC_WIRS_1	222	227	PF05994	0.475
LIG_WRC_WIRS_1	735	740	PF05994	0.426
LIG_WRC_WIRS_1	772	777	PF05994	0.491
LIG_WW_3	1036	1040	PF00397	0.698
MOD_CDK_SPK_2	573	578	PF00069	0.607
MOD_CK1_1	1013	1019	PF00069	0.724
MOD_CK1_1	117	123	PF00069	0.567
MOD_CK1_1	258	264	PF00069	0.548
MOD_CK1_1	314	320	PF00069	0.669
MOD_CK1_1	333	339	PF00069	0.775
MOD_CK1_1	62	68	PF00069	0.756
MOD_CK1_1	691	697	PF00069	0.703
MOD_CK1_1	710	716	PF00069	0.722
MOD_CK1_1	80	86	PF00069	0.613
MOD_CK1_1	808	814	PF00069	0.471
MOD_CK1_1	851	857	PF00069	0.446
MOD_CK1_1	896	902	PF00069	0.779
MOD_CK1_1	968	974	PF00069	0.671
MOD_CK2_1	37	43	PF00069	0.605
MOD_CK2_1	461	467	PF00069	0.791
MOD_CK2_1	51	57	PF00069	0.502
MOD_CK2_1	532	538	PF00069	0.668
MOD_CK2_1	577	583	PF00069	0.610
MOD_CK2_1	612	618	PF00069	0.500
MOD_CK2_1	794	800	PF00069	0.551
MOD_CK2_1	961	967	PF00069	0.629
MOD_CK2_1	970	976	PF00069	0.676
MOD_Cter_Amidation	1085	1088	PF01082	0.778
MOD_GlcNHglycan	1015	1018	PF01048	0.770
MOD_GlcNHglycan	1027	1030	PF01048	0.627
MOD_GlcNHglycan	103	106	PF01048	0.376
MOD_GlcNHglycan	1053	1056	PF01048	0.685
MOD_GlcNHglycan	1088	1091	PF01048	0.741
MOD_GlcNHglycan	1092	1095	PF01048	0.748
MOD_GlcNHglycan	116	119	PF01048	0.503
MOD_GlcNHglycan	172	175	PF01048	0.690
MOD_GlcNHglycan	304	307	PF01048	0.515
MOD_GlcNHglycan	357	360	PF01048	0.583
MOD_GlcNHglycan	398	401	PF01048	0.652
MOD_GlcNHglycan	402	405	PF01048	0.706
MOD_GlcNHglycan	417	420	PF01048	0.547
MOD_GlcNHglycan	53	56	PF01048	0.707
MOD_GlcNHglycan	630	633	PF01048	0.610
MOD_GlcNHglycan	65	68	PF01048	0.755
MOD_GlcNHglycan	761	764	PF01048	0.465
MOD_GlcNHglycan	853	856	PF01048	0.465
MOD_GlcNHglycan	86	89	PF01048	0.516
MOD_GlcNHglycan	896	899	PF01048	0.768
MOD_GlcNHglycan	941	944	PF01048	0.547
MOD_GSK3_1	1086	1093	PF00069	0.703
MOD_GSK3_1	149	156	PF00069	0.606
MOD_GSK3_1	170	177	PF00069	0.706
MOD_GSK3_1	254	261	PF00069	0.496
MOD_GSK3_1	33	40	PF00069	0.496
MOD_GSK3_1	333	340	PF00069	0.691
MOD_GSK3_1	351	358	PF00069	0.417
MOD_GSK3_1	396	403	PF00069	0.571
MOD_GSK3_1	407	414	PF00069	0.739
MOD_GSK3_1	512	519	PF00069	0.559
MOD_GSK3_1	528	535	PF00069	0.511
MOD_GSK3_1	573	580	PF00069	0.608
MOD_GSK3_1	59	66	PF00069	0.729
MOD_GSK3_1	707	714	PF00069	0.709
MOD_GSK3_1	73	80	PF00069	0.721
MOD_GSK3_1	742	749	PF00069	0.520
MOD_GSK3_1	805	812	PF00069	0.413
MOD_GSK3_1	939	946	PF00069	0.536
MOD_GSK3_1	957	964	PF00069	0.611
MOD_N-GLC_1	290	295	PF02516	0.637
MOD_N-GLC_2	847	849	PF02516	0.585
MOD_NEK2_1	101	106	PF00069	0.556
MOD_NEK2_1	1040	1045	PF00069	0.564
MOD_NEK2_1	1051	1056	PF00069	0.540
MOD_NEK2_1	126	131	PF00069	0.469
MOD_NEK2_1	149	154	PF00069	0.583
MOD_NEK2_1	185	190	PF00069	0.560
MOD_NEK2_1	24	29	PF00069	0.537
MOD_NEK2_1	33	38	PF00069	0.534
MOD_NEK2_1	582	587	PF00069	0.539
MOD_NEK2_1	628	633	PF00069	0.476
MOD_NEK2_1	634	639	PF00069	0.474
MOD_NEK2_1	734	739	PF00069	0.469
MOD_NEK2_1	742	747	PF00069	0.486
MOD_NEK2_1	758	763	PF00069	0.349
MOD_NEK2_1	809	814	PF00069	0.566
MOD_NEK2_1	831	836	PF00069	0.633
MOD_NEK2_1	92	97	PF00069	0.565
MOD_NEK2_1	977	982	PF00069	0.616
MOD_PIKK_1	185	191	PF00454	0.629
MOD_PIKK_1	255	261	PF00454	0.552
MOD_PIKK_1	330	336	PF00454	0.752
MOD_PIKK_1	437	443	PF00454	0.594
MOD_PIKK_1	512	518	PF00454	0.566
MOD_PIKK_1	577	583	PF00454	0.567
MOD_PIKK_1	605	611	PF00454	0.495
MOD_PIKK_1	634	640	PF00454	0.567
MOD_PIKK_1	675	681	PF00454	0.529
MOD_PIKK_1	711	717	PF00454	0.764
MOD_PIKK_1	746	752	PF00454	0.544
MOD_PKA_1	1095	1101	PF00069	0.712
MOD_PKA_2	1013	1019	PF00069	0.750
MOD_PKA_2	1086	1092	PF00069	0.738
MOD_PKA_2	33	39	PF00069	0.592
MOD_PKA_2	528	534	PF00069	0.630
MOD_PKA_2	577	583	PF00069	0.567
MOD_PKA_2	634	640	PF00069	0.560
MOD_PKA_2	707	713	PF00069	0.685
MOD_PKA_2	742	748	PF00069	0.537
MOD_Plk_1	300	306	PF00069	0.581
MOD_Plk_1	490	496	PF00069	0.616
MOD_Plk_1	582	588	PF00069	0.540
MOD_Plk_1	766	772	PF00069	0.361
MOD_Plk_1	955	961	PF00069	0.625
MOD_Plk_4	282	288	PF00069	0.464
MOD_Plk_4	516	522	PF00069	0.574
MOD_Plk_4	771	777	PF00069	0.477
MOD_Plk_4	805	811	PF00069	0.484
MOD_ProDKin_1	1030	1036	PF00069	0.559
MOD_ProDKin_1	262	268	PF00069	0.633
MOD_ProDKin_1	290	296	PF00069	0.632
MOD_ProDKin_1	461	467	PF00069	0.579
MOD_ProDKin_1	468	474	PF00069	0.552
MOD_ProDKin_1	573	579	PF00069	0.609
MOD_ProDKin_1	689	695	PF00069	0.511
MOD_ProDKin_1	77	83	PF00069	0.658
MOD_SUMO_for_1	594	597	PF00179	0.607
MOD_SUMO_rev_2	1078	1085	PF00179	0.757
TRG_DiLeu_BaEn_1	109	114	PF01217	0.564
TRG_DiLeu_BaEn_1	583	588	PF01217	0.568
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.528
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.679
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.567
TRG_DiLeu_BaLyEn_6	506	511	PF01217	0.566
TRG_DiLeu_BaLyEn_6	921	926	PF01217	0.567
TRG_ENDOCYTIC_2	1076	1079	PF00928	0.470
TRG_ENDOCYTIC_2	245	248	PF00928	0.509
TRG_ENDOCYTIC_2	276	279	PF00928	0.523
TRG_ENDOCYTIC_2	394	397	PF00928	0.607
TRG_ENDOCYTIC_2	521	524	PF00928	0.493
TRG_ENDOCYTIC_2	773	776	PF00928	0.405
TRG_ENDOCYTIC_2	935	938	PF00928	0.540
TRG_ENDOCYTIC_2	98	101	PF00928	0.451
TRG_ER_diArg_1	12	14	PF00400	0.553
TRG_ER_diArg_1	374	376	PF00400	0.543
TRG_ER_diArg_1	528	530	PF00400	0.583
TRG_ER_diArg_1	685	687	PF00400	0.585
TRG_ER_diArg_1	989	991	PF00400	0.644
TRG_NES_CRM1_1	26	38	PF08389	0.520
TRG_NES_CRM1_1	661	675	PF08389	0.570
TRG_NLS_Bipartite_1	1087	1104	PF00514	0.770
TRG_NLS_MonoExtC_3	1099	1104	PF00514	0.479
TRG_NLS_MonoExtN_4	1097	1104	PF00514	0.555
TRG_NLS_MonoExtN_4	819	825	PF00514	0.324
TRG_Pf-PMV_PEXEL_1	544	548	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	614	618	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	821	825	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB94	Leptomonas seymouri	57%	100%
A0A0S4JFQ5	Bodo saltans	24%	100%
A0A1X0NTJ4	Trypanosomatidae	31%	100%
A0A3S7X650	Leishmania donovani	92%	100%
A0A422P2Y6	Trypanosoma rangeli	32%	100%
A4HKX9	Leishmania braziliensis	83%	99%
A4I8F9	Leishmania infantum	93%	100%
D0AAR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q4T8	Leishmania major	92%	100%
V5B5Q4	Trypanosoma cruzi	32%	100%