Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B3B2_LEIMU

TriTrypDb:

LmxM.31.3290

Length:

240

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	6
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9B3B2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3B2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	87	93	PF00089	0.347
CLV_NRD_NRD_1	159	161	PF00675	0.351
CLV_PCSK_KEX2_1	159	161	PF00082	0.339
CLV_PCSK_KEX2_1	172	174	PF00082	0.445
CLV_PCSK_PC1ET2_1	172	174	PF00082	0.465
CLV_PCSK_SKI1_1	121	125	PF00082	0.342
CLV_PCSK_SKI1_1	160	164	PF00082	0.407
CLV_PCSK_SKI1_1	173	177	PF00082	0.407
DOC_CKS1_1	223	228	PF01111	0.646
DOC_CYCLIN_RxL_1	140	151	PF00134	0.567
DOC_CYCLIN_RxL_1	156	167	PF00134	0.577
DOC_WW_Pin1_4	222	227	PF00397	0.643
DOC_WW_Pin1_4	5	10	PF00397	0.573
LIG_14-3-3_CanoR_1	108	112	PF00244	0.541
LIG_14-3-3_CanoR_1	160	170	PF00244	0.576
LIG_BIR_II_1	1	5	PF00653	0.528
LIG_BRCT_BRCA1_1	87	91	PF00533	0.410
LIG_EH1_1	155	163	PF00400	0.552
LIG_FHA_1	174	180	PF00498	0.630
LIG_FHA_1	208	214	PF00498	0.705
LIG_FHA_2	178	184	PF00498	0.631
LIG_FHA_2	41	47	PF00498	0.353
LIG_GLEBS_BUB3_1	57	65	PF00400	0.425
LIG_LIR_Gen_1	130	141	PF02991	0.514
LIG_LIR_Gen_1	46	54	PF02991	0.270
LIG_LIR_Nem_3	130	136	PF02991	0.510
LIG_LIR_Nem_3	46	50	PF02991	0.263
LIG_SH2_CRK	133	137	PF00017	0.544
LIG_SH2_STAT5	42	45	PF00017	0.357
LIG_SH2_STAT5	85	88	PF00017	0.400
LIG_SH3_3	220	226	PF00018	0.633
LIG_SH3_3	96	102	PF00018	0.636
LIG_SUMO_SIM_par_1	142	149	PF11976	0.562
LIG_TRAF2_1	180	183	PF00917	0.617
LIG_TYR_ITIM	131	136	PF00017	0.525
LIG_WRC_WIRS_1	71	76	PF05994	0.333
MOD_CK1_1	152	158	PF00069	0.557
MOD_CK1_1	164	170	PF00069	0.643
MOD_CK1_1	3	9	PF00069	0.553
MOD_CK2_1	177	183	PF00069	0.636
MOD_GlcNHglycan	166	169	PF01048	0.404
MOD_GlcNHglycan	199	202	PF01048	0.477
MOD_GlcNHglycan	27	30	PF01048	0.722
MOD_GlcNHglycan	3	6	PF01048	0.707
MOD_GlcNHglycan	87	90	PF01048	0.491
MOD_GSK3_1	1	8	PF00069	0.552
MOD_GSK3_1	107	114	PF00069	0.688
MOD_GSK3_1	173	180	PF00069	0.633
MOD_GSK3_1	36	43	PF00069	0.390
MOD_N-GLC_1	152	157	PF02516	0.351
MOD_N-GLC_1	197	202	PF02516	0.438
MOD_NEK2_1	1	6	PF00069	0.555
MOD_NEK2_1	124	129	PF00069	0.512
MOD_NEK2_1	161	166	PF00069	0.567
MOD_NEK2_1	171	176	PF00069	0.631
MOD_PIKK_1	161	167	PF00454	0.563
MOD_PIKK_1	202	208	PF00454	0.720
MOD_PIKK_1	234	240	PF00454	0.747
MOD_PKA_2	107	113	PF00069	0.666
MOD_PKA_2	149	155	PF00069	0.632
MOD_PKA_2	202	208	PF00069	0.688
MOD_Plk_1	152	158	PF00069	0.551
MOD_Plk_4	107	113	PF00069	0.593
MOD_Plk_4	70	76	PF00069	0.268
MOD_ProDKin_1	222	228	PF00069	0.644
MOD_ProDKin_1	5	11	PF00069	0.572
TRG_DiLeu_BaEn_1	183	188	PF01217	0.598
TRG_DiLeu_BaEn_1	61	66	PF01217	0.418
TRG_DiLeu_LyEn_5	183	188	PF01217	0.655
TRG_ENDOCYTIC_2	133	136	PF00928	0.528
TRG_ENDOCYTIC_2	232	235	PF00928	0.645
TRG_ER_diArg_1	158	160	PF00400	0.550
TRG_NES_CRM1_1	22	36	PF08389	0.431
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.348
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIX5	Leptomonas seymouri	86%	100%
A0A0S4J8L9	Bodo saltans	55%	100%
A0A1X0NRU5	Trypanosomatidae	66%	100%
A0A3Q8IGH3	Leishmania donovani	94%	100%
A0A422P2X7	Trypanosoma rangeli	65%	100%
A4HKX4	Leishmania braziliensis	90%	100%
A4I8F4	Leishmania infantum	94%	100%
D0AAR7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
Q4Q4U3	Leishmania major	96%	100%
V5BVM8	Trypanosoma cruzi	67%	100%