Cytoplasmic dynein 2 light intermediate chain 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein light intermediate chain, putative

Species:

Leishmania mexicana

UniProt:

E9B3A6_LEIMU

TriTrypDb:

LmxM.31.3230

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005868	cytoplasmic dynein complex	4	11
GO:0005875	microtubule associated complex	2	11
GO:0005929	cilium	4	10
GO:0030286	dynein complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	10
GO:1902494	catalytic complex	2	11
GO:0005815	microtubule organizing center	2	4
GO:0005930	axoneme	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0036064	ciliary basal body	3	1

Expansion

Sequence features

E9B3A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3A6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0010970	transport along microtubule	4	11
GO:0030705	cytoskeleton-dependent intracellular transport	4	11
GO:0031503	protein-containing complex localization	2	11
GO:0035721	intraciliary retrograde transport	4	11
GO:0035735	intraciliary transport involved in cilium assembly	4	11
GO:0042073	intraciliary transport	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0099111	microtubule-based transport	4	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0045504	dynein heavy chain binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.435
CLV_MEL_PAP_1	202	208	PF00089	0.449
CLV_NRD_NRD_1	138	140	PF00675	0.439
CLV_NRD_NRD_1	200	202	PF00675	0.342
CLV_NRD_NRD_1	29	31	PF00675	0.623
CLV_NRD_NRD_1	382	384	PF00675	0.576
CLV_NRD_NRD_1	400	402	PF00675	0.314
CLV_NRD_NRD_1	411	413	PF00675	0.417
CLV_NRD_NRD_1	7	9	PF00675	0.600
CLV_PCSK_KEX2_1	124	126	PF00082	0.674
CLV_PCSK_KEX2_1	138	140	PF00082	0.360
CLV_PCSK_KEX2_1	200	202	PF00082	0.305
CLV_PCSK_KEX2_1	240	242	PF00082	0.414
CLV_PCSK_KEX2_1	29	31	PF00082	0.623
CLV_PCSK_KEX2_1	382	384	PF00082	0.491
CLV_PCSK_PC1ET2_1	124	126	PF00082	0.698
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.414
CLV_PCSK_SKI1_1	124	128	PF00082	0.615
CLV_PCSK_SKI1_1	223	227	PF00082	0.443
CLV_PCSK_SKI1_1	79	83	PF00082	0.568
DEG_APCC_DBOX_1	240	248	PF00400	0.344
DOC_CKS1_1	166	171	PF01111	0.311
DOC_MAPK_DCC_7	243	252	PF00069	0.298
DOC_MAPK_gen_1	294	301	PF00069	0.438
DOC_MAPK_MEF2A_6	243	252	PF00069	0.296
DOC_MAPK_MEF2A_6	319	326	PF00069	0.441
DOC_PP4_FxxP_1	304	307	PF00568	0.370
DOC_PP4_FxxP_1	392	395	PF00568	0.430
DOC_USP7_MATH_1	10	14	PF00917	0.754
DOC_USP7_MATH_1	137	141	PF00917	0.508
DOC_USP7_MATH_1	215	219	PF00917	0.397
DOC_USP7_MATH_1	317	321	PF00917	0.390
DOC_USP7_MATH_1	337	341	PF00917	0.400
DOC_USP7_MATH_1	419	423	PF00917	0.549
DOC_USP7_MATH_1	98	102	PF00917	0.411
DOC_WW_Pin1_4	1	6	PF00397	0.646
DOC_WW_Pin1_4	165	170	PF00397	0.321
DOC_WW_Pin1_4	217	222	PF00397	0.373
DOC_WW_Pin1_4	24	29	PF00397	0.571
DOC_WW_Pin1_4	39	44	PF00397	0.700
DOC_WW_Pin1_4	50	55	PF00397	0.561
LIG_14-3-3_CanoR_1	109	115	PF00244	0.518
LIG_14-3-3_CanoR_1	125	134	PF00244	0.606
LIG_14-3-3_CanoR_1	138	146	PF00244	0.335
LIG_14-3-3_CanoR_1	205	213	PF00244	0.494
LIG_14-3-3_CanoR_1	260	269	PF00244	0.240
LIG_AP2alpha_2	378	380	PF02296	0.488
LIG_Clathr_ClatBox_1	323	327	PF01394	0.419
LIG_deltaCOP1_diTrp_1	354	360	PF00928	0.419
LIG_FHA_1	102	108	PF00498	0.320
LIG_FHA_1	127	133	PF00498	0.420
LIG_FHA_1	194	200	PF00498	0.316
LIG_FHA_1	247	253	PF00498	0.296
LIG_FHA_1	261	267	PF00498	0.366
LIG_FHA_1	51	57	PF00498	0.560
LIG_FHA_1	68	74	PF00498	0.449
LIG_FHA_1	76	82	PF00498	0.431
LIG_FHA_1	89	95	PF00498	0.324
LIG_FHA_2	128	134	PF00498	0.438
LIG_FHA_2	313	319	PF00498	0.496
LIG_FHA_2	32	38	PF00498	0.617
LIG_LIR_Apic_2	302	307	PF02991	0.396
LIG_LIR_Apic_2	354	359	PF02991	0.387
LIG_LIR_Apic_2	389	395	PF02991	0.439
LIG_LIR_Gen_1	157	167	PF02991	0.445
LIG_LIR_Gen_1	329	339	PF02991	0.378
LIG_LIR_Gen_1	72	81	PF02991	0.408
LIG_LIR_LC3C_4	90	95	PF02991	0.451
LIG_LIR_Nem_3	157	162	PF02991	0.426
LIG_LIR_Nem_3	292	298	PF02991	0.442
LIG_LIR_Nem_3	329	334	PF02991	0.332
LIG_LIR_Nem_3	72	77	PF02991	0.402
LIG_Pex14_1	356	360	PF04695	0.409
LIG_Pex14_2	304	308	PF04695	0.347
LIG_Pex14_2	360	364	PF04695	0.431
LIG_Rb_pABgroove_1	379	387	PF01858	0.441
LIG_SH2_NCK_1	385	389	PF00017	0.418
LIG_SH2_STAT5	111	114	PF00017	0.454
LIG_SH2_STAT5	275	278	PF00017	0.352
LIG_SH2_STAT5	312	315	PF00017	0.463
LIG_SH3_2	25	30	PF14604	0.597
LIG_SH3_3	163	169	PF00018	0.315
LIG_SH3_3	22	28	PF00018	0.611
LIG_SH3_3	304	310	PF00018	0.433
LIG_SUMO_SIM_anti_2	249	254	PF11976	0.405
LIG_SUMO_SIM_anti_2	89	97	PF11976	0.351
LIG_SUMO_SIM_par_1	322	327	PF11976	0.351
LIG_TRAF2_1	183	186	PF00917	0.470
LIG_TRAF2_1	288	291	PF00917	0.413
LIG_TRAF2_1	35	38	PF00917	0.662
LIG_WRC_WIRS_1	111	116	PF05994	0.545
MOD_CDC14_SPxK_1	27	30	PF00782	0.587
MOD_CDC14_SPxK_1	42	45	PF00782	0.812
MOD_CDK_SPK_2	24	29	PF00069	0.485
MOD_CDK_SPxK_1	217	223	PF00069	0.375
MOD_CDK_SPxK_1	24	30	PF00069	0.584
MOD_CDK_SPxK_1	39	45	PF00069	0.813
MOD_CDK_SPxxK_3	1	8	PF00069	0.679
MOD_CK1_1	101	107	PF00069	0.432
MOD_CK1_1	113	119	PF00069	0.517
MOD_CK1_1	207	213	PF00069	0.461
MOD_CK1_1	32	38	PF00069	0.691
MOD_CK1_1	415	421	PF00069	0.420
MOD_CK2_1	285	291	PF00069	0.382
MOD_CK2_1	31	37	PF00069	0.788
MOD_CK2_1	312	318	PF00069	0.421
MOD_GlcNHglycan	118	121	PF01048	0.575
MOD_GlcNHglycan	244	247	PF01048	0.321
MOD_GlcNHglycan	318	322	PF01048	0.510
MOD_GlcNHglycan	98	101	PF01048	0.364
MOD_GSK3_1	109	116	PF00069	0.431
MOD_GSK3_1	242	249	PF00069	0.340
MOD_GSK3_1	285	292	PF00069	0.337
MOD_GSK3_1	29	36	PF00069	0.740
MOD_GSK3_1	415	422	PF00069	0.425
MOD_GSK3_1	44	51	PF00069	0.601
MOD_GSK3_1	82	89	PF00069	0.467
MOD_GSK3_1	98	105	PF00069	0.461
MOD_N-GLC_1	116	121	PF02516	0.577
MOD_N-GLC_1	299	304	PF02516	0.370
MOD_N-GLC_1	337	342	PF02516	0.462
MOD_N-GLC_1	419	424	PF02516	0.549
MOD_N-GLC_1	75	80	PF02516	0.487
MOD_NEK2_1	132	137	PF00069	0.419
MOD_NEK2_1	242	247	PF00069	0.350
MOD_NEK2_1	269	274	PF00069	0.310
MOD_NEK2_1	299	304	PF00069	0.370
MOD_PIKK_1	154	160	PF00454	0.391
MOD_PIKK_1	207	213	PF00454	0.513
MOD_PIKK_1	260	266	PF00454	0.319
MOD_PIKK_1	44	50	PF00454	0.624
MOD_PK_1	82	88	PF00069	0.357
MOD_PKA_1	29	35	PF00069	0.618
MOD_PKA_1	412	418	PF00069	0.505
MOD_PKA_2	137	143	PF00069	0.464
MOD_PKA_2	204	210	PF00069	0.454
MOD_PKA_2	242	248	PF00069	0.346
MOD_PKA_2	29	35	PF00069	0.574
MOD_PKA_2	327	333	PF00069	0.419
MOD_PKA_2	44	50	PF00069	0.487
MOD_Plk_1	132	138	PF00069	0.396
MOD_Plk_1	299	305	PF00069	0.380
MOD_Plk_1	317	323	PF00069	0.349
MOD_Plk_1	337	343	PF00069	0.438
MOD_Plk_1	82	88	PF00069	0.577
MOD_Plk_1	89	95	PF00069	0.461
MOD_Plk_2-3	327	333	PF00069	0.364
MOD_Plk_4	102	108	PF00069	0.292
MOD_Plk_4	193	199	PF00069	0.332
MOD_Plk_4	246	252	PF00069	0.301
MOD_Plk_4	327	333	PF00069	0.419
MOD_Plk_4	89	95	PF00069	0.401
MOD_ProDKin_1	1	7	PF00069	0.645
MOD_ProDKin_1	165	171	PF00069	0.319
MOD_ProDKin_1	217	223	PF00069	0.375
MOD_ProDKin_1	24	30	PF00069	0.574
MOD_ProDKin_1	39	45	PF00069	0.702
MOD_ProDKin_1	50	56	PF00069	0.558
MOD_SUMO_rev_2	235	242	PF00179	0.435
MOD_SUMO_rev_2	4	10	PF00179	0.684
TRG_ENDOCYTIC_2	111	114	PF00928	0.522
TRG_ER_diArg_1	199	201	PF00400	0.404
TRG_ER_diArg_1	241	244	PF00400	0.323
TRG_ER_diArg_1	28	30	PF00400	0.614
TRG_ER_diArg_1	381	383	PF00400	0.634
TRG_NLS_Bipartite_1	401	416	PF00514	0.435
TRG_NLS_MonoExtN_4	123	128	PF00514	0.588
TRG_NLS_MonoExtN_4	237	244	PF00514	0.420
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.381
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.683
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAN3	Leptomonas seymouri	82%	99%
A0A0S4JG99	Bodo saltans	53%	100%
A0A1X0NS84	Trypanosomatidae	51%	100%
A0A3R7P067	Trypanosoma rangeli	54%	100%
A0A3S5H7T0	Leishmania donovani	93%	100%
A4HKW8	Leishmania braziliensis	83%	100%
A4I8E8	Leishmania infantum	93%	100%
D0AAS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
Q32KV4	Bos taurus	27%	100%
Q4Q4U9	Leishmania major	94%	100%
Q6AY43	Rattus norvegicus	27%	100%
Q7SXY4	Danio rerio	28%	100%
Q7XA07	Chlamydomonas reinhardtii	22%	100%
Q8K0T2	Mus musculus	27%	100%
Q8TCX1	Homo sapiens	26%	100%