GTP-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

GTP-binding protein

Gene product:

Miro-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9B3A4_LEIMU

TriTrypDb:

LmxM.31.3210

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9B3A4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3A4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0003924	GTPase activity	7	3
GO:0016462	pyrophosphatase activity	5	3
GO:0016787	hydrolase activity	2	3
GO:0016817	hydrolase activity, acting on acid anhydrides	3	3
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	3
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	3
GO:0000166	nucleotide binding	3	2
GO:0005488	binding	1	2
GO:0005525	GTP binding	5	2
GO:0017076	purine nucleotide binding	4	2
GO:0019001	guanyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032561	guanyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.595
CLV_C14_Caspase3-7	64	68	PF00656	0.472
CLV_C14_Caspase3-7	95	99	PF00656	0.321
CLV_NRD_NRD_1	211	213	PF00675	0.392
CLV_NRD_NRD_1	59	61	PF00675	0.425
CLV_PCSK_KEX2_1	211	213	PF00082	0.415
CLV_PCSK_KEX2_1	59	61	PF00082	0.401
CLV_PCSK_KEX2_1	71	73	PF00082	0.368
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.425
CLV_PCSK_SKI1_1	187	191	PF00082	0.403
CLV_PCSK_SKI1_1	60	64	PF00082	0.465
CLV_PCSK_SKI1_1	71	75	PF00082	0.469
CLV_Separin_Metazoa	208	212	PF03568	0.413
DOC_MAPK_gen_1	211	218	PF00069	0.463
DOC_MAPK_gen_1	69	77	PF00069	0.350
DOC_MAPK_MEF2A_6	69	77	PF00069	0.437
DOC_PP1_RVXF_1	57	64	PF00149	0.472
DOC_USP7_MATH_1	13	17	PF00917	0.308
DOC_USP7_MATH_1	148	152	PF00917	0.567
DOC_USP7_MATH_1	92	96	PF00917	0.321
DOC_USP7_UBL2_3	109	113	PF12436	0.391
DOC_USP7_UBL2_3	167	171	PF12436	0.608
DOC_WW_Pin1_4	149	154	PF00397	0.559
LIG_Actin_WH2_2	96	111	PF00022	0.421
LIG_BIR_II_1	1	5	PF00653	0.495
LIG_BIR_III_4	130	134	PF00653	0.601
LIG_BRCT_BRCA1_1	182	186	PF00533	0.471
LIG_FHA_1	119	125	PF00498	0.472
LIG_FHA_1	20	26	PF00498	0.452
LIG_FHA_1	37	43	PF00498	0.345
LIG_FHA_1	68	74	PF00498	0.465
LIG_FHA_2	175	181	PF00498	0.450
LIG_FHA_2	45	51	PF00498	0.437
LIG_Pex14_1	118	122	PF04695	0.352
LIG_Pex14_2	186	190	PF04695	0.388
LIG_SH3_3	100	106	PF00018	0.340
LIG_SH3_3	134	140	PF00018	0.502
LIG_SH3_3	160	166	PF00018	0.527
LIG_SH3_3	7	13	PF00018	0.323
MOD_CK1_1	16	22	PF00069	0.311
MOD_CK1_1	81	87	PF00069	0.472
MOD_CK2_1	44	50	PF00069	0.437
MOD_GlcNHglycan	15	18	PF01048	0.352
MOD_GlcNHglycan	25	28	PF01048	0.445
MOD_GlcNHglycan	63	66	PF01048	0.442
MOD_GlcNHglycan	79	83	PF01048	0.352
MOD_GSK3_1	13	20	PF00069	0.368
MOD_GSK3_1	50	57	PF00069	0.472
MOD_N-GLC_1	124	129	PF02516	0.572
MOD_N-GLC_1	54	59	PF02516	0.460
MOD_NEK2_1	193	198	PF00069	0.514
MOD_PKA_2	28	34	PF00069	0.499
MOD_Plk_1	113	119	PF00069	0.472
MOD_Plk_1	175	181	PF00069	0.450
MOD_Plk_4	113	119	PF00069	0.472
MOD_Plk_4	193	199	PF00069	0.515
MOD_ProDKin_1	149	155	PF00069	0.573
MOD_SUMO_rev_2	64	70	PF00179	0.472
TRG_DiLeu_BaEn_3	3	9	PF01217	0.478
TRG_DiLeu_BaEn_4	205	211	PF01217	0.493
TRG_ER_diArg_1	210	212	PF00400	0.430
TRG_ER_diArg_1	59	61	PF00400	0.468
TRG_NES_CRM1_1	128	141	PF08389	0.599
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD06	Leptomonas seymouri	83%	100%
A0A0S4JFN8	Bodo saltans	49%	100%
A0A1X0NRS7	Trypanosomatidae	54%	100%
A0A3Q8IH30	Leishmania donovani	97%	100%
A0A3R7MSK5	Trypanosoma rangeli	56%	100%
A4HKW6	Leishmania braziliensis	92%	100%
A4I8E6	Leishmania infantum	96%	100%
D0AAS7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
Q381A3	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	55%	100%
Q4Q4V1	Leishmania major	97%	100%
Q4R4K5	Macaca fascicularis	28%	100%
Q567Y6	Danio rerio	29%	100%
Q5E9J4	Bos taurus	26%	100%
Q5FVJ7	Rattus norvegicus	28%	100%
Q5M8K8	Xenopus tropicalis	28%	100%
Q9DAI2	Mus musculus	28%	100%
Q9H7X7	Homo sapiens	29%	100%
V5BR15	Trypanosoma cruzi	57%	100%