Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9B3A1_LEIMU

TriTrypDb:

LmxM.31.3180

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B3A1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3A1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	604	608	PF00656	0.396
CLV_NRD_NRD_1	222	224	PF00675	0.482
CLV_NRD_NRD_1	292	294	PF00675	0.584
CLV_NRD_NRD_1	396	398	PF00675	0.452
CLV_PCSK_KEX2_1	12	14	PF00082	0.567
CLV_PCSK_KEX2_1	222	224	PF00082	0.482
CLV_PCSK_KEX2_1	291	293	PF00082	0.586
CLV_PCSK_KEX2_1	395	397	PF00082	0.537
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.567
CLV_PCSK_PC7_1	288	294	PF00082	0.547
CLV_PCSK_SKI1_1	12	16	PF00082	0.511
CLV_PCSK_SKI1_1	169	173	PF00082	0.415
CLV_PCSK_SKI1_1	222	226	PF00082	0.384
CLV_PCSK_SKI1_1	299	303	PF00082	0.513
CLV_PCSK_SKI1_1	328	332	PF00082	0.381
CLV_PCSK_SKI1_1	336	340	PF00082	0.361
CLV_PCSK_SKI1_1	428	432	PF00082	0.525
CLV_PCSK_SKI1_1	499	503	PF00082	0.419
CLV_PCSK_SKI1_1	51	55	PF00082	0.374
CLV_PCSK_SKI1_1	522	526	PF00082	0.604
CLV_PCSK_SKI1_1	536	540	PF00082	0.326
CLV_PCSK_SKI1_1	574	578	PF00082	0.506
CLV_PCSK_SKI1_1	615	619	PF00082	0.422
CLV_PCSK_SKI1_1	627	631	PF00082	0.603
CLV_Separin_Metazoa	333	337	PF03568	0.377
CLV_Separin_Metazoa	612	616	PF03568	0.339
DEG_APCC_DBOX_1	327	335	PF00400	0.389
DEG_APCC_DBOX_1	38	46	PF00400	0.507
DEG_APCC_DBOX_1	498	506	PF00400	0.415
DEG_APCC_DBOX_1	614	622	PF00400	0.431
DOC_CDC14_PxL_1	411	419	PF14671	0.511
DOC_CKS1_1	282	287	PF01111	0.588
DOC_CKS1_1	658	663	PF01111	0.548
DOC_CYCLIN_RxL_1	325	333	PF00134	0.465
DOC_CYCLIN_RxL_1	401	410	PF00134	0.424
DOC_CYCLIN_RxL_1	499	507	PF00134	0.411
DOC_CYCLIN_RxL_1	68	78	PF00134	0.462
DOC_CYCLIN_yClb5_NLxxxL_5	71	79	PF00134	0.454
DOC_MAPK_MEF2A_6	169	176	PF00069	0.416
DOC_MAPK_MEF2A_6	412	419	PF00069	0.592
DOC_MAPK_MEF2A_6	495	504	PF00069	0.422
DOC_MAPK_MEF2A_6	552	561	PF00069	0.461
DOC_MAPK_NFAT4_5	169	177	PF00069	0.379
DOC_MAPK_NFAT4_5	499	507	PF00069	0.247
DOC_MAPK_NFAT4_5	552	560	PF00069	0.398
DOC_PP1_RVXF_1	316	323	PF00149	0.472
DOC_PP1_RVXF_1	402	409	PF00149	0.409
DOC_PP4_FxxP_1	341	344	PF00568	0.455
DOC_USP7_MATH_1	364	368	PF00917	0.618
DOC_USP7_MATH_1	605	609	PF00917	0.431
DOC_WW_Pin1_4	105	110	PF00397	0.464
DOC_WW_Pin1_4	2	7	PF00397	0.609
DOC_WW_Pin1_4	226	231	PF00397	0.471
DOC_WW_Pin1_4	281	286	PF00397	0.638
DOC_WW_Pin1_4	432	437	PF00397	0.529
DOC_WW_Pin1_4	456	461	PF00397	0.308
DOC_WW_Pin1_4	476	481	PF00397	0.427
DOC_WW_Pin1_4	545	550	PF00397	0.344
DOC_WW_Pin1_4	599	604	PF00397	0.423
DOC_WW_Pin1_4	657	662	PF00397	0.516
LIG_14-3-3_CanoR_1	120	124	PF00244	0.392
LIG_14-3-3_CanoR_1	141	151	PF00244	0.398
LIG_14-3-3_CanoR_1	395	400	PF00244	0.496
LIG_14-3-3_CanoR_1	503	512	PF00244	0.345
LIG_14-3-3_CanoR_1	627	632	PF00244	0.389
LIG_Actin_WH2_2	69	84	PF00022	0.394
LIG_APCC_ABBA_1	310	315	PF00400	0.461
LIG_BIR_III_4	271	275	PF00653	0.646
LIG_BRCT_BRCA1_1	220	224	PF00533	0.422
LIG_deltaCOP1_diTrp_1	295	301	PF00928	0.472
LIG_eIF4E_1	175	181	PF01652	0.443
LIG_FHA_1	109	115	PF00498	0.340
LIG_FHA_1	120	126	PF00498	0.434
LIG_FHA_1	13	19	PF00498	0.471
LIG_FHA_1	143	149	PF00498	0.395
LIG_FHA_1	180	186	PF00498	0.431
LIG_FHA_1	192	198	PF00498	0.348
LIG_FHA_1	227	233	PF00498	0.516
LIG_FHA_1	238	244	PF00498	0.376
LIG_FHA_1	26	32	PF00498	0.552
LIG_FHA_1	3	9	PF00498	0.588
LIG_FHA_1	457	463	PF00498	0.390
LIG_FHA_1	486	492	PF00498	0.422
LIG_FHA_1	571	577	PF00498	0.502
LIG_FHA_1	580	586	PF00498	0.387
LIG_FHA_1	587	593	PF00498	0.313
LIG_FHA_1	76	82	PF00498	0.409
LIG_FHA_2	162	168	PF00498	0.483
LIG_FHA_2	282	288	PF00498	0.603
LIG_FHA_2	33	39	PF00498	0.525
LIG_FHA_2	602	608	PF00498	0.474
LIG_LIR_Gen_1	111	118	PF02991	0.366
LIG_LIR_Gen_1	551	562	PF02991	0.446
LIG_LIR_Nem_3	111	115	PF02991	0.539
LIG_LIR_Nem_3	126	131	PF02991	0.366
LIG_LIR_Nem_3	295	301	PF02991	0.538
LIG_LIR_Nem_3	3	7	PF02991	0.550
LIG_LIR_Nem_3	409	414	PF02991	0.506
LIG_LIR_Nem_3	551	557	PF02991	0.383
LIG_NRBOX	501	507	PF00104	0.404
LIG_PCNA_TLS_4	169	176	PF02747	0.416
LIG_Pex14_2	130	134	PF04695	0.363
LIG_Pex14_2	64	68	PF04695	0.417
LIG_SH2_NCK_1	92	96	PF00017	0.240
LIG_SH2_STAP1	387	391	PF00017	0.556
LIG_SH2_STAP1	92	96	PF00017	0.240
LIG_SH2_STAT5	102	105	PF00017	0.316
LIG_SH2_STAT5	175	178	PF00017	0.440
LIG_SH2_STAT5	250	253	PF00017	0.498
LIG_SH2_STAT5	4	7	PF00017	0.599
LIG_SH2_STAT5	554	557	PF00017	0.362
LIG_SH2_STAT5	587	590	PF00017	0.306
LIG_SH2_STAT5	92	95	PF00017	0.402
LIG_SH3_3	274	280	PF00018	0.672
LIG_SUMO_SIM_anti_2	147	153	PF11976	0.436
LIG_SUMO_SIM_par_1	487	493	PF11976	0.321
LIG_SUMO_SIM_par_1	589	594	PF11976	0.412
LIG_TRAF2_1	136	139	PF00917	0.501
LIG_TRAF2_1	490	493	PF00917	0.416
LIG_TRAF2_1	529	532	PF00917	0.539
LIG_UBA3_1	170	177	PF00899	0.339
LIG_UBA3_1	75	82	PF00899	0.385
MOD_CDK_SPK_2	226	231	PF00069	0.461
MOD_CDK_SPxxK_3	281	288	PF00069	0.633
MOD_CDK_SPxxK_3	545	552	PF00069	0.414
MOD_CK1_1	108	114	PF00069	0.439
MOD_CK1_1	26	32	PF00069	0.423
MOD_CK1_1	365	371	PF00069	0.723
MOD_CK1_1	548	554	PF00069	0.415
MOD_CK2_1	161	167	PF00069	0.439
MOD_CK2_1	281	287	PF00069	0.609
MOD_CK2_1	32	38	PF00069	0.475
MOD_CK2_1	487	493	PF00069	0.420
MOD_CK2_1	663	669	PF00069	0.639
MOD_CMANNOS	322	325	PF00535	0.486
MOD_GlcNHglycan	103	106	PF01048	0.426
MOD_GlcNHglycan	199	203	PF01048	0.461
MOD_GlcNHglycan	206	209	PF01048	0.401
MOD_GlcNHglycan	28	31	PF01048	0.447
MOD_GlcNHglycan	348	351	PF01048	0.510
MOD_GlcNHglycan	364	367	PF01048	0.555
MOD_GlcNHglycan	420	423	PF01048	0.430
MOD_GlcNHglycan	595	598	PF01048	0.436
MOD_GlcNHglycan	607	610	PF01048	0.327
MOD_GSK3_1	101	108	PF00069	0.433
MOD_GSK3_1	179	186	PF00069	0.439
MOD_GSK3_1	214	221	PF00069	0.454
MOD_GSK3_1	365	372	PF00069	0.575
MOD_GSK3_1	456	463	PF00069	0.300
MOD_GSK3_1	510	517	PF00069	0.388
MOD_GSK3_1	587	594	PF00069	0.344
MOD_GSK3_1	60	67	PF00069	0.324
MOD_GSK3_1	601	608	PF00069	0.418
MOD_GSK3_1	8	15	PF00069	0.566
MOD_LATS_1	10	16	PF00433	0.539
MOD_NEK2_1	31	36	PF00069	0.553
MOD_NEK2_1	316	321	PF00069	0.401
MOD_NEK2_1	406	411	PF00069	0.489
MOD_NEK2_1	504	509	PF00069	0.366
MOD_NEK2_1	511	516	PF00069	0.411
MOD_NEK2_1	579	584	PF00069	0.321
MOD_NEK2_1	586	591	PF00069	0.339
MOD_NEK2_1	593	598	PF00069	0.326
MOD_NEK2_1	75	80	PF00069	0.504
MOD_NEK2_1	90	95	PF00069	0.276
MOD_PIKK_1	32	38	PF00454	0.554
MOD_PIKK_1	389	395	PF00454	0.375
MOD_PIKK_1	441	447	PF00454	0.443
MOD_PIKK_1	663	669	PF00454	0.628
MOD_PKA_1	12	18	PF00069	0.574
MOD_PKA_1	395	401	PF00069	0.496
MOD_PKA_2	119	125	PF00069	0.379
MOD_PKA_2	12	18	PF00069	0.574
MOD_PKA_2	236	242	PF00069	0.410
MOD_PKA_2	395	401	PF00069	0.496
MOD_PKA_2	514	520	PF00069	0.487
MOD_PKA_2	570	576	PF00069	0.409
MOD_PKB_1	49	57	PF00069	0.365
MOD_Plk_1	286	292	PF00069	0.606
MOD_Plk_1	389	395	PF00069	0.375
MOD_Plk_1	51	57	PF00069	0.355
MOD_Plk_4	119	125	PF00069	0.379
MOD_Plk_4	147	153	PF00069	0.436
MOD_Plk_4	246	252	PF00069	0.478
MOD_Plk_4	587	593	PF00069	0.408
MOD_ProDKin_1	105	111	PF00069	0.458
MOD_ProDKin_1	2	8	PF00069	0.602
MOD_ProDKin_1	226	232	PF00069	0.466
MOD_ProDKin_1	281	287	PF00069	0.636
MOD_ProDKin_1	432	438	PF00069	0.524
MOD_ProDKin_1	456	462	PF00069	0.303
MOD_ProDKin_1	476	482	PF00069	0.422
MOD_ProDKin_1	545	551	PF00069	0.343
MOD_ProDKin_1	599	605	PF00069	0.422
MOD_ProDKin_1	657	663	PF00069	0.528
MOD_SUMO_rev_2	570	576	PF00179	0.409
TRG_DiLeu_BaEn_1	167	172	PF01217	0.364
TRG_DiLeu_BaEn_1	373	378	PF01217	0.445
TRG_DiLeu_BaEn_1	492	497	PF01217	0.398
TRG_DiLeu_BaEn_3	296	302	PF01217	0.362
TRG_DiLeu_BaLyEn_6	166	171	PF01217	0.354
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.461
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.371
TRG_DiLeu_BaLyEn_6	415	420	PF01217	0.407
TRG_DiLeu_BaLyEn_6	500	505	PF01217	0.365
TRG_DiLeu_BaLyEn_6	557	562	PF01217	0.385
TRG_ENDOCYTIC_2	131	134	PF00928	0.359
TRG_ENDOCYTIC_2	411	414	PF00928	0.517
TRG_ENDOCYTIC_2	554	557	PF00928	0.426
TRG_ER_diArg_1	18	21	PF00400	0.583
TRG_ER_diArg_1	222	224	PF00400	0.482
TRG_ER_diArg_1	290	293	PF00400	0.590
TRG_ER_diArg_1	394	397	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.350
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.373
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	328	333	PF00026	0.396
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTY7	Leptomonas seymouri	37%	100%
A0A3S7X637	Leishmania donovani	88%	100%
A4HKW3	Leishmania braziliensis	76%	100%
A4I8E3	Leishmania infantum	88%	100%
Q4Q4V4	Leishmania major	87%	100%