NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH dehydrogenase subunit NI8M, putative

Species:

Leishmania mexicana

UniProt:

E9B3A0_LEIMU

TriTrypDb:

LmxM.31.3170

Length:

165

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0005747	mitochondrial respiratory chain complex I	4	1
GO:0030964	NADH dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045271	respiratory chain complex I	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:0098803	respiratory chain complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990204	oxidoreductase complex	3	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

E9B3A0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B3A0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016491	oxidoreductase activity	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_APCC_DBOX_1	32	40	PF00400	0.480
DOC_MAPK_DCC_7	33	41	PF00069	0.468
DOC_MAPK_MEF2A_6	33	41	PF00069	0.468
DOC_PP4_FxxP_1	55	58	PF00568	0.491
DOC_USP7_MATH_1	115	119	PF00917	0.684
DOC_WW_Pin1_4	129	134	PF00397	0.453
DOC_WW_Pin1_4	5	10	PF00397	0.474
DOC_WW_Pin1_4	62	67	PF00397	0.493
LIG_14-3-3_CanoR_1	101	110	PF00244	0.564
LIG_BIR_II_1	1	5	PF00653	0.505
LIG_EH_1	42	46	PF12763	0.519
LIG_FHA_1	124	130	PF00498	0.659
LIG_FHA_1	13	19	PF00498	0.489
LIG_FHA_1	140	146	PF00498	0.662
LIG_FHA_1	45	51	PF00498	0.530
LIG_FHA_1	6	12	PF00498	0.486
LIG_FHA_2	47	53	PF00498	0.493
LIG_FHA_2	63	69	PF00498	0.526
LIG_FHA_2	76	82	PF00498	0.549
LIG_LIR_Apic_2	15	20	PF02991	0.453
LIG_LIR_Apic_2	52	58	PF02991	0.495
LIG_MYND_1	152	156	PF01753	0.696
LIG_Pex14_1	3	7	PF04695	0.483
LIG_SH2_GRB2like	61	64	PF00017	0.474
LIG_SH2_STAP1	121	125	PF00017	0.553
LIG_SH2_STAT5	121	124	PF00017	0.551
LIG_SH2_STAT5	61	64	PF00017	0.493
LIG_SH3_3	108	114	PF00018	0.662
LIG_SH3_3	128	134	PF00018	0.582
LIG_SH3_3	142	148	PF00018	0.648
LIG_SH3_3	17	23	PF00018	0.474
LIG_TRAF2_1	49	52	PF00917	0.516
LIG_TRAF2_1	77	80	PF00917	0.565
LIG_WRC_WIRS_1	116	121	PF05994	0.551
LIG_WRC_WIRS_1	45	50	PF05994	0.518
MOD_CK2_1	46	52	PF00069	0.506
MOD_CK2_1	75	81	PF00069	0.542
MOD_GSK3_1	115	122	PF00069	0.543
MOD_N-GLC_1	62	67	PF02516	0.493
MOD_Plk_1	51	57	PF00069	0.501
MOD_Plk_4	12	18	PF00069	0.463
MOD_ProDKin_1	129	135	PF00069	0.458
MOD_ProDKin_1	5	11	PF00069	0.469
MOD_ProDKin_1	62	68	PF00069	0.496
MOD_SUMO_for_1	127	130	PF00179	0.678
TRG_DiLeu_BaEn_3	80	86	PF01217	0.493
TRG_ER_diArg_1	3	6	PF00400	0.494
TRG_NES_CRM1_1	40	52	PF08389	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y2	Leptomonas seymouri	97%	100%
A0A0S4JUU5	Bodo saltans	82%	100%
A0A1X0NS35	Trypanosomatidae	92%	100%
A0A3S7X619	Leishmania donovani	99%	100%
A0A422NYP1	Trypanosoma rangeli	88%	100%
A4HKW2	Leishmania braziliensis	98%	100%
A4I8E2	Leishmania infantum	99%	100%
D0AAT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	91%	100%
Q4Q4V5	Leishmania major	99%	100%
V5BLE5	Trypanosoma cruzi	92%	100%