Leucine-rich repeat protein (LRRP)

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania mexicana

UniProt:

E9B399_LEIMU

TriTrypDb:

LmxM.31.3160

Length:

815

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0005930	axoneme	2	1

Expansion

Sequence features

E9B399

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B399

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.681
CLV_C14_Caspase3-7	273	277	PF00656	0.702
CLV_C14_Caspase3-7	307	311	PF00656	0.568
CLV_NRD_NRD_1	387	389	PF00675	0.384
CLV_NRD_NRD_1	501	503	PF00675	0.470
CLV_NRD_NRD_1	507	509	PF00675	0.484
CLV_NRD_NRD_1	514	516	PF00675	0.487
CLV_NRD_NRD_1	63	65	PF00675	0.673
CLV_NRD_NRD_1	691	693	PF00675	0.630
CLV_NRD_NRD_1	786	788	PF00675	0.739
CLV_PCSK_KEX2_1	371	373	PF00082	0.631
CLV_PCSK_KEX2_1	501	503	PF00082	0.470
CLV_PCSK_KEX2_1	507	509	PF00082	0.476
CLV_PCSK_KEX2_1	599	601	PF00082	0.750
CLV_PCSK_KEX2_1	63	65	PF00082	0.673
CLV_PCSK_KEX2_1	691	693	PF00082	0.639
CLV_PCSK_KEX2_1	737	739	PF00082	0.802
CLV_PCSK_KEX2_1	786	788	PF00082	0.739
CLV_PCSK_PC1ET2_1	371	373	PF00082	0.624
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.750
CLV_PCSK_PC1ET2_1	737	739	PF00082	0.802
CLV_PCSK_PC7_1	687	693	PF00082	0.591
CLV_PCSK_PC7_1	782	788	PF00082	0.732
CLV_PCSK_SKI1_1	137	141	PF00082	0.520
CLV_PCSK_SKI1_1	508	512	PF00082	0.547
CLV_PCSK_SKI1_1	679	683	PF00082	0.484
CLV_PCSK_SKI1_1	692	696	PF00082	0.520
CLV_PCSK_SKI1_1	810	814	PF00082	0.469
CLV_PCSK_SKI1_1	94	98	PF00082	0.739
DEG_APCC_DBOX_1	432	440	PF00400	0.341
DEG_Nend_Nbox_1	1	3	PF02207	0.555
DEG_SCF_FBW7_1	116	123	PF00400	0.617
DEG_SCF_FBW7_1	713	720	PF00400	0.685
DEG_SPOP_SBC_1	727	731	PF00917	0.683
DOC_CDC14_PxL_1	573	581	PF14671	0.488
DOC_CKS1_1	117	122	PF01111	0.621
DOC_CKS1_1	752	757	PF01111	0.688
DOC_CYCLIN_RxL_1	687	699	PF00134	0.500
DOC_CYCLIN_RxL_1	91	100	PF00134	0.680
DOC_CYCLIN_yCln2_LP_2	715	721	PF00134	0.502
DOC_MAPK_gen_1	176	185	PF00069	0.445
DOC_MAPK_gen_1	388	394	PF00069	0.604
DOC_MAPK_gen_1	459	469	PF00069	0.319
DOC_MAPK_MEF2A_6	176	185	PF00069	0.449
DOC_PP2B_LxvP_1	579	582	PF13499	0.669
DOC_PP2B_LxvP_1	715	718	PF13499	0.559
DOC_USP7_MATH_1	229	233	PF00917	0.765
DOC_USP7_MATH_1	277	281	PF00917	0.632
DOC_USP7_MATH_1	309	313	PF00917	0.809
DOC_USP7_MATH_1	594	598	PF00917	0.806
DOC_USP7_MATH_1	72	76	PF00917	0.648
DOC_USP7_MATH_1	727	731	PF00917	0.780
DOC_USP7_MATH_1	748	752	PF00917	0.733
DOC_USP7_UBL2_3	367	371	PF12436	0.530
DOC_USP7_UBL2_3	80	84	PF12436	0.750
DOC_USP7_UBL2_3	94	98	PF12436	0.591
DOC_WW_Pin1_4	109	114	PF00397	0.765
DOC_WW_Pin1_4	116	121	PF00397	0.699
DOC_WW_Pin1_4	137	142	PF00397	0.589
DOC_WW_Pin1_4	174	179	PF00397	0.571
DOC_WW_Pin1_4	194	199	PF00397	0.468
DOC_WW_Pin1_4	227	232	PF00397	0.625
DOC_WW_Pin1_4	251	256	PF00397	0.483
DOC_WW_Pin1_4	571	576	PF00397	0.688
DOC_WW_Pin1_4	590	595	PF00397	0.830
DOC_WW_Pin1_4	713	718	PF00397	0.771
DOC_WW_Pin1_4	744	749	PF00397	0.625
DOC_WW_Pin1_4	751	756	PF00397	0.641
LIG_14-3-3_CanoR_1	179	184	PF00244	0.437
LIG_14-3-3_CanoR_1	283	289	PF00244	0.533
LIG_14-3-3_CanoR_1	391	395	PF00244	0.383
LIG_14-3-3_CanoR_1	407	412	PF00244	0.554
LIG_14-3-3_CanoR_1	600	609	PF00244	0.765
LIG_14-3-3_CanoR_1	786	790	PF00244	0.733
LIG_14-3-3_CanoR_1	798	804	PF00244	0.518
LIG_AP2alpha_2	659	661	PF02296	0.387
LIG_Clathr_ClatBox_1	152	156	PF01394	0.423
LIG_FHA_1	317	323	PF00498	0.596
LIG_FHA_1	32	38	PF00498	0.749
LIG_FHA_1	420	426	PF00498	0.491
LIG_FHA_1	475	481	PF00498	0.453
LIG_FHA_1	563	569	PF00498	0.728
LIG_FHA_1	714	720	PF00498	0.741
LIG_FHA_2	21	27	PF00498	0.528
LIG_FHA_2	305	311	PF00498	0.517
LIG_FHA_2	350	356	PF00498	0.613
LIG_FHA_2	509	515	PF00498	0.505
LIG_FHA_2	666	672	PF00498	0.599
LIG_FHA_2	698	704	PF00498	0.669
LIG_FHA_2	786	792	PF00498	0.745
LIG_LIR_Apic_2	172	178	PF02991	0.560
LIG_LIR_Apic_2	335	341	PF02991	0.638
LIG_LIR_Gen_1	12	20	PF02991	0.657
LIG_LIR_Gen_1	121	132	PF02991	0.517
LIG_LIR_Gen_1	166	175	PF02991	0.447
LIG_LIR_Gen_1	26	37	PF02991	0.511
LIG_LIR_Gen_1	529	536	PF02991	0.491
LIG_LIR_Gen_1	659	669	PF02991	0.624
LIG_LIR_Gen_1	677	686	PF02991	0.563
LIG_LIR_Nem_3	12	16	PF02991	0.515
LIG_LIR_Nem_3	121	127	PF02991	0.617
LIG_LIR_Nem_3	166	170	PF02991	0.450
LIG_LIR_Nem_3	26	32	PF02991	0.561
LIG_LIR_Nem_3	342	347	PF02991	0.520
LIG_LIR_Nem_3	397	401	PF02991	0.631
LIG_LIR_Nem_3	529	533	PF02991	0.499
LIG_LIR_Nem_3	659	664	PF02991	0.636
LIG_LIR_Nem_3	677	683	PF02991	0.566
LIG_MAD2	35	43	PF02301	0.699
LIG_MYND_1	577	581	PF01753	0.487
LIG_NRBOX	453	459	PF00104	0.500
LIG_SH2_CRK	167	171	PF00017	0.561
LIG_SH2_CRK	175	179	PF00017	0.574
LIG_SH2_CRK	29	33	PF00017	0.544
LIG_SH2_PTP2	124	127	PF00017	0.596
LIG_SH2_PTP2	680	683	PF00017	0.602
LIG_SH2_STAP1	29	33	PF00017	0.587
LIG_SH2_STAP1	530	534	PF00017	0.572
LIG_SH2_STAT3	340	343	PF00017	0.606
LIG_SH2_STAT3	539	542	PF00017	0.614
LIG_SH2_STAT5	124	127	PF00017	0.596
LIG_SH2_STAT5	338	341	PF00017	0.619
LIG_SH2_STAT5	344	347	PF00017	0.643
LIG_SH2_STAT5	504	507	PF00017	0.505
LIG_SH2_STAT5	578	581	PF00017	0.502
LIG_SH2_STAT5	680	683	PF00017	0.602
LIG_SH3_1	144	150	PF00018	0.599
LIG_SH3_1	578	584	PF00018	0.695
LIG_SH3_2	583	588	PF14604	0.747
LIG_SH3_3	111	117	PF00018	0.809
LIG_SH3_3	144	150	PF00018	0.604
LIG_SH3_3	217	223	PF00018	0.674
LIG_SH3_3	252	258	PF00018	0.485
LIG_SH3_3	262	268	PF00018	0.630
LIG_SH3_3	34	40	PF00018	0.695
LIG_SH3_3	547	553	PF00018	0.686
LIG_SH3_3	578	584	PF00018	0.739
LIG_SH3_3	757	763	PF00018	0.666
LIG_SUMO_SIM_anti_2	154	159	PF11976	0.532
LIG_SUMO_SIM_anti_2	668	674	PF11976	0.591
LIG_SUMO_SIM_par_1	151	156	PF11976	0.428
LIG_SUMO_SIM_par_1	256	263	PF11976	0.514
LIG_SUMO_SIM_par_1	475	485	PF11976	0.355
LIG_SUMO_SIM_par_1	706	712	PF11976	0.662
LIG_TRAF2_1	107	110	PF00917	0.708
LIG_TRAF2_1	493	496	PF00917	0.548
LIG_TRAF2_1	511	514	PF00917	0.498
LIG_WRC_WIRS_1	383	388	PF05994	0.440
LIG_WRC_WIRS_1	483	488	PF05994	0.435
LIG_WW_2	40	43	PF00397	0.699
LIG_WW_2	550	553	PF00397	0.709
LIG_WW_3	112	116	PF00397	0.566
MOD_CDK_SPK_2	174	179	PF00069	0.567
MOD_CDK_SPxK_1	109	115	PF00069	0.525
MOD_CDK_SPxxK_3	137	144	PF00069	0.592
MOD_CK1_1	151	157	PF00069	0.431
MOD_CK1_1	163	169	PF00069	0.483
MOD_CK1_1	192	198	PF00069	0.677
MOD_CK1_1	248	254	PF00069	0.762
MOD_CK1_1	260	266	PF00069	0.688
MOD_CK1_1	301	307	PF00069	0.639
MOD_CK1_1	593	599	PF00069	0.743
MOD_CK1_1	603	609	PF00069	0.658
MOD_CK1_1	619	625	PF00069	0.569
MOD_CK1_1	726	732	PF00069	0.741
MOD_CK1_1	75	81	PF00069	0.719
MOD_CK1_1	751	757	PF00069	0.609
MOD_CK2_1	20	26	PF00069	0.524
MOD_CK2_1	349	355	PF00069	0.540
MOD_CK2_1	431	437	PF00069	0.579
MOD_CK2_1	489	495	PF00069	0.552
MOD_CK2_1	508	514	PF00069	0.353
MOD_CK2_1	665	671	PF00069	0.601
MOD_CK2_1	697	703	PF00069	0.600
MOD_CK2_1	727	733	PF00069	0.801
MOD_CK2_1	785	791	PF00069	0.753
MOD_Cter_Amidation	369	372	PF01082	0.597
MOD_GlcNHglycan	12	16	PF01048	0.622
MOD_GlcNHglycan	191	194	PF01048	0.656
MOD_GlcNHglycan	250	253	PF01048	0.790
MOD_GlcNHglycan	279	282	PF01048	0.730
MOD_GlcNHglycan	29	32	PF01048	0.497
MOD_GlcNHglycan	517	520	PF01048	0.399
MOD_GlcNHglycan	53	56	PF01048	0.642
MOD_GlcNHglycan	557	561	PF01048	0.680
MOD_GlcNHglycan	596	599	PF01048	0.764
MOD_GlcNHglycan	618	621	PF01048	0.718
MOD_GlcNHglycan	624	627	PF01048	0.740
MOD_GlcNHglycan	632	635	PF01048	0.788
MOD_GlcNHglycan	66	69	PF01048	0.732
MOD_GlcNHglycan	719	722	PF01048	0.712
MOD_GlcNHglycan	725	728	PF01048	0.750
MOD_GlcNHglycan	740	743	PF01048	0.763
MOD_GlcNHglycan	87	90	PF01048	0.678
MOD_GSK3_1	116	123	PF00069	0.740
MOD_GSK3_1	16	23	PF00069	0.617
MOD_GSK3_1	189	196	PF00069	0.539
MOD_GSK3_1	27	34	PF00069	0.571
MOD_GSK3_1	390	397	PF00069	0.389
MOD_GSK3_1	431	438	PF00069	0.439
MOD_GSK3_1	47	54	PF00069	0.565
MOD_GSK3_1	522	529	PF00069	0.583
MOD_GSK3_1	588	595	PF00069	0.831
MOD_GSK3_1	599	606	PF00069	0.783
MOD_GSK3_1	622	629	PF00069	0.719
MOD_GSK3_1	713	720	PF00069	0.708
MOD_GSK3_1	72	79	PF00069	0.699
MOD_GSK3_1	723	730	PF00069	0.748
MOD_GSK3_1	744	751	PF00069	0.731
MOD_GSK3_1	781	788	PF00069	0.730
MOD_GSK3_1	97	104	PF00069	0.787
MOD_N-GLC_1	283	288	PF02516	0.791
MOD_N-GLC_1	444	449	PF02516	0.439
MOD_N-GLC_1	569	574	PF02516	0.735
MOD_N-GLC_1	799	804	PF02516	0.695
MOD_NEK2_1	16	21	PF00069	0.647
MOD_NEK2_1	237	242	PF00069	0.728
MOD_NEK2_1	298	303	PF00069	0.758
MOD_NEK2_1	316	321	PF00069	0.629
MOD_NEK2_1	449	454	PF00069	0.383
MOD_NEK2_1	474	479	PF00069	0.453
MOD_NEK2_1	482	487	PF00069	0.425
MOD_NEK2_1	630	635	PF00069	0.731
MOD_NEK2_1	719	724	PF00069	0.693
MOD_PIKK_1	301	307	PF00454	0.720
MOD_PIKK_1	316	322	PF00454	0.484
MOD_PIKK_1	339	345	PF00454	0.624
MOD_PIKK_1	349	355	PF00454	0.616
MOD_PIKK_1	431	437	PF00454	0.579
MOD_PIKK_1	563	569	PF00454	0.751
MOD_PIKK_1	748	754	PF00454	0.702
MOD_PIKK_1	97	103	PF00454	0.692
MOD_PK_1	179	185	PF00069	0.433
MOD_PK_1	605	611	PF00069	0.547
MOD_PKA_1	515	521	PF00069	0.386
MOD_PKA_1	599	605	PF00069	0.772
MOD_PKA_1	737	743	PF00069	0.767
MOD_PKA_2	282	288	PF00069	0.646
MOD_PKA_2	298	304	PF00069	0.687
MOD_PKA_2	379	385	PF00069	0.624
MOD_PKA_2	390	396	PF00069	0.690
MOD_PKA_2	599	605	PF00069	0.772
MOD_PKA_2	639	645	PF00069	0.583
MOD_PKA_2	737	743	PF00069	0.767
MOD_PKA_2	75	81	PF00069	0.778
MOD_PKA_2	781	787	PF00069	0.732
MOD_Plk_1	11	17	PF00069	0.636
MOD_Plk_1	237	243	PF00069	0.667
MOD_Plk_1	309	315	PF00069	0.665
MOD_Plk_1	569	575	PF00069	0.736
MOD_Plk_1	588	594	PF00069	0.499
MOD_Plk_1	799	805	PF00069	0.697
MOD_Plk_2-3	526	532	PF00069	0.591
MOD_Plk_2-3	703	709	PF00069	0.665
MOD_Plk_2-3	785	791	PF00069	0.712
MOD_Plk_4	120	126	PF00069	0.468
MOD_Plk_4	148	154	PF00069	0.461
MOD_Plk_4	163	169	PF00069	0.466
MOD_Plk_4	665	671	PF00069	0.489
MOD_Plk_4	679	685	PF00069	0.493
MOD_Plk_4	703	709	PF00069	0.665
MOD_Plk_4	756	762	PF00069	0.715
MOD_Plk_4	92	98	PF00069	0.668
MOD_ProDKin_1	109	115	PF00069	0.764
MOD_ProDKin_1	116	122	PF00069	0.686
MOD_ProDKin_1	137	143	PF00069	0.585
MOD_ProDKin_1	174	180	PF00069	0.564
MOD_ProDKin_1	194	200	PF00069	0.468
MOD_ProDKin_1	227	233	PF00069	0.628
MOD_ProDKin_1	251	257	PF00069	0.486
MOD_ProDKin_1	571	577	PF00069	0.680
MOD_ProDKin_1	590	596	PF00069	0.828
MOD_ProDKin_1	713	719	PF00069	0.775
MOD_ProDKin_1	744	750	PF00069	0.624
MOD_ProDKin_1	751	757	PF00069	0.641
MOD_SUMO_rev_2	286	296	PF00179	0.721
MOD_SUMO_rev_2	363	373	PF00179	0.642
MOD_SUMO_rev_2	513	518	PF00179	0.604
TRG_DiLeu_BaEn_2	214	220	PF01217	0.656
TRG_DiLeu_BaEn_2	656	662	PF01217	0.399
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.465
TRG_DiLeu_BaLyEn_6	518	523	PF01217	0.656
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.674
TRG_ENDOCYTIC_2	124	127	PF00928	0.585
TRG_ENDOCYTIC_2	129	132	PF00928	0.604
TRG_ENDOCYTIC_2	13	16	PF00928	0.638
TRG_ENDOCYTIC_2	167	170	PF00928	0.451
TRG_ENDOCYTIC_2	29	32	PF00928	0.434
TRG_ENDOCYTIC_2	344	347	PF00928	0.497
TRG_ENDOCYTIC_2	530	533	PF00928	0.488
TRG_ENDOCYTIC_2	680	683	PF00928	0.602
TRG_ER_diArg_1	500	502	PF00400	0.483
TRG_ER_diArg_1	63	65	PF00400	0.673
TRG_ER_diArg_1	691	693	PF00400	0.639
TRG_ER_diArg_1	771	774	PF00400	0.583
TRG_NLS_Bipartite_1	371	392	PF00514	0.372

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C3	Leptomonas seymouri	47%	97%
A0A1X0NTH1	Trypanosomatidae	32%	100%
A0A3Q8IHB8	Leishmania donovani	86%	100%
A0A422NYL4	Trypanosoma rangeli	32%	100%
A4HKW1	Leishmania braziliensis	73%	100%
A4I8E1	Leishmania infantum	86%	100%
Q4Q4V6	Leishmania major	84%	100%
V5BVG4	Trypanosoma cruzi	34%	100%