Putative ABC transporter

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9B392_LEIMU

TriTrypDb:

Length:

704

Annotations

LeishMANIAdb annotations

ABC transporters probably involved in multidrug resistance. A member of this family confers vinblastine resistance to Leishmania enriettii.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

E9B392

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B392

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	1
GO:0005215	transporter activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0015399	primary active transmembrane transporter activity	4	12
GO:0016787	hydrolase activity	2	1
GO:0017076	purine nucleotide binding	4	12
GO:0022804	active transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	42	46	PF00656	0.788
CLV_C14_Caspase3-7	421	425	PF00656	0.552
CLV_C14_Caspase3-7	537	541	PF00656	0.538
CLV_C14_Caspase3-7	602	606	PF00656	0.562
CLV_MEL_PAP_1	290	296	PF00089	0.330
CLV_NRD_NRD_1	321	323	PF00675	0.313
CLV_NRD_NRD_1	509	511	PF00675	0.277
CLV_NRD_NRD_1	625	627	PF00675	0.346
CLV_PCSK_FUR_1	622	626	PF00082	0.414
CLV_PCSK_KEX2_1	624	626	PF00082	0.344

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM85	Leptomonas seymouri	30%	78%
A0A0N1PGA4	Leptomonas seymouri	80%	80%
A0A0S4IRM6	Bodo saltans	54%	85%
A0A0S4JF49	Bodo saltans	35%	93%
A0A0S4KKU1	Bodo saltans	25%	66%
A0A125QXJ1	Mesocricetus auratus	40%	84%
A0A1X0NRS8	Trypanosomatidae	66%	96%
A0A3R7MZT8	Trypanosoma rangeli	62%	94%
A0A3R7NYC2	Trypanosoma rangeli	26%	100%
A0A3S7X621	Leishmania donovani	95%	79%

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