SP-RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MIZ/SP-RING zinc finger, putative

Species:

Leishmania mexicana

UniProt:

E9B391_LEIMU

TriTrypDb:

LmxM.31.3070

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B391

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B391

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016925	protein sumoylation	7	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0019789	SUMO transferase activity	4	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0061665	SUMO ligase activity	5	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.523
CLV_C14_Caspase3-7	158	162	PF00656	0.586
CLV_C14_Caspase3-7	404	408	PF00656	0.428
CLV_NRD_NRD_1	13	15	PF00675	0.623
CLV_NRD_NRD_1	135	137	PF00675	0.557
CLV_NRD_NRD_1	192	194	PF00675	0.633
CLV_NRD_NRD_1	316	318	PF00675	0.437
CLV_NRD_NRD_1	424	426	PF00675	0.557
CLV_NRD_NRD_1	91	93	PF00675	0.510
CLV_PCSK_FUR_1	133	137	PF00082	0.608
CLV_PCSK_FUR_1	422	426	PF00082	0.624
CLV_PCSK_KEX2_1	13	15	PF00082	0.623
CLV_PCSK_KEX2_1	135	137	PF00082	0.498
CLV_PCSK_KEX2_1	192	194	PF00082	0.633
CLV_PCSK_KEX2_1	316	318	PF00082	0.434
CLV_PCSK_KEX2_1	422	424	PF00082	0.533
CLV_PCSK_KEX2_1	91	93	PF00082	0.413
CLV_PCSK_PC7_1	419	425	PF00082	0.514
CLV_PCSK_SKI1_1	353	357	PF00082	0.444
CLV_PCSK_SKI1_1	91	95	PF00082	0.488
DEG_COP1_1	407	417	PF00400	0.385
DEG_SPOP_SBC_1	172	176	PF00917	0.536
DEG_SPOP_SBC_1	178	182	PF00917	0.491
DEG_SPOP_SBC_1	378	382	PF00917	0.447
DEG_SPOP_SBC_1	93	97	PF00917	0.403
DOC_CKS1_1	18	23	PF01111	0.599
DOC_CYCLIN_RxL_1	348	360	PF00134	0.531
DOC_MAPK_gen_1	135	144	PF00069	0.545
DOC_PP4_FxxP_1	206	209	PF00568	0.496
DOC_PP4_FxxP_1	418	421	PF00568	0.431
DOC_SPAK_OSR1_1	387	391	PF12202	0.476
DOC_USP7_MATH_1	12	16	PF00917	0.784
DOC_USP7_MATH_1	178	182	PF00917	0.628
DOC_USP7_MATH_1	188	192	PF00917	0.681
DOC_USP7_MATH_1	202	206	PF00917	0.624
DOC_USP7_MATH_1	243	247	PF00917	0.577
DOC_USP7_MATH_1	271	275	PF00917	0.524
DOC_USP7_MATH_1	426	430	PF00917	0.641
DOC_USP7_MATH_1	450	454	PF00917	0.690
DOC_USP7_MATH_1	52	56	PF00917	0.436
DOC_WW_Pin1_4	17	22	PF00397	0.650
DOC_WW_Pin1_4	195	200	PF00397	0.691
DOC_WW_Pin1_4	216	221	PF00397	0.761
DOC_WW_Pin1_4	241	246	PF00397	0.617
DOC_WW_Pin1_4	5	10	PF00397	0.750
LIG_14-3-3_CanoR_1	13	23	PF00244	0.788
LIG_14-3-3_CanoR_1	290	298	PF00244	0.450
LIG_14-3-3_CanoR_1	91	100	PF00244	0.381
LIG_BIR_III_4	307	311	PF00653	0.432
LIG_BRCT_BRCA1_1	34	38	PF00533	0.524
LIG_deltaCOP1_diTrp_1	311	318	PF00928	0.362
LIG_deltaCOP1_diTrp_1	377	383	PF00928	0.393
LIG_FHA_1	113	119	PF00498	0.423
LIG_FHA_1	18	24	PF00498	0.610
LIG_FHA_1	331	337	PF00498	0.381
LIG_FHA_2	129	135	PF00498	0.653
LIG_FHA_2	146	152	PF00498	0.430
LIG_FHA_2	209	215	PF00498	0.676
LIG_Integrin_RGDW_4	309	312	PF00362	0.426
LIG_LIR_Apic_2	203	209	PF02991	0.496
LIG_LIR_Apic_2	416	421	PF02991	0.514
LIG_LIR_Gen_1	311	320	PF02991	0.356
LIG_LIR_Gen_1	35	44	PF02991	0.329
LIG_LIR_Gen_1	354	364	PF02991	0.573
LIG_LIR_Gen_1	67	73	PF02991	0.427
LIG_LIR_Nem_3	151	155	PF02991	0.618
LIG_LIR_Nem_3	311	315	PF02991	0.337
LIG_LIR_Nem_3	35	41	PF02991	0.395
LIG_LIR_Nem_3	360	364	PF02991	0.567
LIG_LIR_Nem_3	441	447	PF02991	0.574
LIG_Pex14_1	379	383	PF04695	0.424
LIG_Pex14_2	388	392	PF04695	0.459
LIG_SH2_CRK	352	356	PF00017	0.568
LIG_SH2_CRK	361	365	PF00017	0.514
LIG_SH2_CRK	372	376	PF00017	0.350
LIG_SH2_CRK	44	48	PF00017	0.474
LIG_SH2_CRK	444	448	PF00017	0.474
LIG_SH2_GRB2like	152	155	PF00017	0.598
LIG_SH2_NCK_1	361	365	PF00017	0.557
LIG_SH2_STAP1	152	156	PF00017	0.623
LIG_SH2_STAP1	361	365	PF00017	0.472
LIG_SH2_STAT5	155	158	PF00017	0.634
LIG_SH2_STAT5	345	348	PF00017	0.379
LIG_SH3_3	116	122	PF00018	0.367
LIG_SH3_3	196	202	PF00018	0.736
LIG_SH3_3	242	248	PF00018	0.727
LIG_SH3_3	79	85	PF00018	0.436
MOD_CK1_1	17	23	PF00069	0.600
MOD_CK1_1	176	182	PF00069	0.566
MOD_CK1_1	322	328	PF00069	0.382
MOD_CK1_1	408	414	PF00069	0.436
MOD_CK1_1	429	435	PF00069	0.585
MOD_CK2_1	128	134	PF00069	0.571
MOD_CK2_1	351	357	PF00069	0.483
MOD_CK2_1	360	366	PF00069	0.526
MOD_CK2_1	383	389	PF00069	0.304
MOD_CK2_1	93	99	PF00069	0.320
MOD_DYRK1A_RPxSP_1	216	220	PF00069	0.591
MOD_GlcNHglycan	182	185	PF01048	0.613
MOD_GlcNHglycan	428	431	PF01048	0.665
MOD_GlcNHglycan	440	443	PF01048	0.444
MOD_GlcNHglycan	448	451	PF01048	0.586
MOD_GSK3_1	172	179	PF00069	0.622
MOD_GSK3_1	243	250	PF00069	0.603
MOD_GSK3_1	318	325	PF00069	0.465
MOD_GSK3_1	32	39	PF00069	0.409
MOD_GSK3_1	379	386	PF00069	0.283
MOD_GSK3_1	426	433	PF00069	0.649
MOD_GSK3_1	446	453	PF00069	0.760
MOD_N-GLC_1	176	181	PF02516	0.679
MOD_N-GLC_1	322	327	PF02516	0.254
MOD_N-GLC_2	56	58	PF02516	0.231
MOD_N-GLC_2	74	76	PF02516	0.153
MOD_NEK2_1	173	178	PF00069	0.595
MOD_NEK2_1	281	286	PF00069	0.414
MOD_NEK2_1	318	323	PF00069	0.536
MOD_NEK2_1	351	356	PF00069	0.515
MOD_PIKK_1	14	20	PF00454	0.624
MOD_PIKK_1	145	151	PF00454	0.431
MOD_PIKK_1	247	253	PF00454	0.675
MOD_PIKK_1	271	277	PF00454	0.396
MOD_PIKK_1	432	438	PF00454	0.616
MOD_PIKK_1	450	456	PF00454	0.587
MOD_PKA_1	91	97	PF00069	0.369
MOD_PKA_2	12	18	PF00069	0.785
MOD_PKA_2	91	97	PF00069	0.369
MOD_Plk_1	202	208	PF00069	0.755
MOD_Plk_1	322	328	PF00069	0.342
MOD_Plk_1	36	42	PF00069	0.292
MOD_Plk_2-3	360	366	PF00069	0.480
MOD_Plk_4	182	188	PF00069	0.470
MOD_Plk_4	330	336	PF00069	0.352
MOD_Plk_4	408	414	PF00069	0.528
MOD_Plk_4	65	71	PF00069	0.426
MOD_ProDKin_1	17	23	PF00069	0.648
MOD_ProDKin_1	195	201	PF00069	0.692
MOD_ProDKin_1	216	222	PF00069	0.760
MOD_ProDKin_1	241	247	PF00069	0.617
MOD_ProDKin_1	5	11	PF00069	0.752
MOD_SUMO_for_1	225	228	PF00179	0.565
MOD_SUMO_for_1	291	294	PF00179	0.533
TRG_DiLeu_BaEn_1	27	32	PF01217	0.580
TRG_DiLeu_BaEn_3	27	33	PF01217	0.424
TRG_ENDOCYTIC_2	352	355	PF00928	0.550
TRG_ENDOCYTIC_2	361	364	PF00928	0.501
TRG_ENDOCYTIC_2	44	47	PF00928	0.429
TRG_ENDOCYTIC_2	444	447	PF00928	0.523
TRG_ER_diArg_1	192	195	PF00400	0.631
TRG_ER_diArg_1	315	317	PF00400	0.452
TRG_ER_diArg_1	421	424	PF00400	0.537
TRG_ER_diArg_1	91	93	PF00400	0.516
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P907	Leptomonas seymouri	67%	73%
A0A0S4IQ84	Bodo saltans	29%	77%
A0A1X0NSE9	Trypanosomatidae	41%	99%
A0A3R7NRN3	Trypanosoma rangeli	41%	100%
A0A3S7X626	Leishmania donovani	92%	100%
A4HKV3	Leishmania braziliensis	84%	100%
A4I8D2	Leishmania infantum	93%	100%
D0AAU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4Q4W4	Leishmania major	91%	100%
V5B5L3	Trypanosoma cruzi	42%	100%