Roc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ras family, putative

Species:

Leishmania mexicana

UniProt:

E9B388_LEIMU

TriTrypDb:

LmxM.31.3050

Length:

825

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B388

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B388

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0036094	small molecule binding	2	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003824	catalytic activity	1	1
GO:0003924	GTPase activity	7	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	267	269	PF00675	0.565
CLV_NRD_NRD_1	340	342	PF00675	0.541
CLV_NRD_NRD_1	444	446	PF00675	0.514
CLV_NRD_NRD_1	467	469	PF00675	0.565
CLV_NRD_NRD_1	63	65	PF00675	0.376
CLV_NRD_NRD_1	668	670	PF00675	0.503
CLV_NRD_NRD_1	79	81	PF00675	0.343
CLV_NRD_NRD_1	813	815	PF00675	0.532
CLV_PCSK_FUR_1	811	815	PF00082	0.555
CLV_PCSK_KEX2_1	267	269	PF00082	0.565
CLV_PCSK_KEX2_1	339	341	PF00082	0.487
CLV_PCSK_KEX2_1	467	469	PF00082	0.535
CLV_PCSK_KEX2_1	63	65	PF00082	0.397
CLV_PCSK_KEX2_1	668	670	PF00082	0.503
CLV_PCSK_KEX2_1	811	813	PF00082	0.531
CLV_PCSK_PC1ET2_1	339	341	PF00082	0.487
CLV_PCSK_SKI1_1	13	17	PF00082	0.565
CLV_PCSK_SKI1_1	139	143	PF00082	0.342
CLV_PCSK_SKI1_1	183	187	PF00082	0.343
CLV_PCSK_SKI1_1	455	459	PF00082	0.432
CLV_PCSK_SKI1_1	573	577	PF00082	0.499
CLV_PCSK_SKI1_1	65	69	PF00082	0.364
CLV_PCSK_SKI1_1	813	817	PF00082	0.558
DEG_APCC_DBOX_1	449	457	PF00400	0.367
DEG_APCC_DBOX_1	610	618	PF00400	0.467
DEG_Nend_UBRbox_1	1	4	PF02207	0.772
DEG_ODPH_VHL_1	541	554	PF01847	0.412
DEG_SPOP_SBC_1	239	243	PF00917	0.756
DEG_SPOP_SBC_1	24	28	PF00917	0.737
DEG_SPOP_SBC_1	248	252	PF00917	0.537
DEG_SPOP_SBC_1	96	100	PF00917	0.343
DOC_CKS1_1	416	421	PF01111	0.453
DOC_CKS1_1	532	537	PF01111	0.518
DOC_CYCLIN_yCln2_LP_2	233	239	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	416	422	PF00134	0.479
DOC_CYCLIN_yCln2_LP_2	487	493	PF00134	0.377
DOC_MAPK_DCC_7	46	56	PF00069	0.647
DOC_MAPK_DCC_7	570	580	PF00069	0.311
DOC_MAPK_gen_1	167	175	PF00069	0.245
DOC_MAPK_gen_1	339	346	PF00069	0.483
DOC_MAPK_gen_1	539	546	PF00069	0.398
DOC_MAPK_gen_1	548	556	PF00069	0.391
DOC_MAPK_gen_1	570	580	PF00069	0.499
DOC_MAPK_gen_1	609	616	PF00069	0.447
DOC_MAPK_gen_1	63	69	PF00069	0.345
DOC_MAPK_MEF2A_6	339	348	PF00069	0.475
DOC_MAPK_MEF2A_6	548	556	PF00069	0.489
DOC_PP1_RVXF_1	453	459	PF00149	0.375
DOC_PP1_RVXF_1	51	57	PF00149	0.613
DOC_PP1_RVXF_1	551	557	PF00149	0.389
DOC_PP2B_LxvP_1	233	236	PF13499	0.622
DOC_PP2B_LxvP_1	716	719	PF13499	0.622
DOC_PP2B_LxvP_1	749	752	PF13499	0.481
DOC_PP4_FxxP_1	458	461	PF00568	0.392
DOC_PP4_FxxP_1	574	577	PF00568	0.310
DOC_USP7_MATH_1	237	241	PF00917	0.763
DOC_USP7_MATH_1	24	28	PF00917	0.673
DOC_USP7_MATH_1	249	253	PF00917	0.498
DOC_USP7_MATH_1	642	646	PF00917	0.453
DOC_USP7_MATH_2	490	496	PF00917	0.488
DOC_USP7_UBL2_3	208	212	PF12436	0.431
DOC_WW_Pin1_4	415	420	PF00397	0.437
DOC_WW_Pin1_4	531	536	PF00397	0.432
DOC_WW_Pin1_4	638	643	PF00397	0.515
DOC_WW_Pin1_4	754	759	PF00397	0.597
DOC_WW_Pin1_4	818	823	PF00397	0.724
LIG_14-3-3_CanoR_1	253	263	PF00244	0.491
LIG_14-3-3_CanoR_1	349	356	PF00244	0.462
LIG_14-3-3_CanoR_1	404	410	PF00244	0.465
LIG_14-3-3_CanoR_1	668	672	PF00244	0.475
LIG_14-3-3_CanoR_1	720	726	PF00244	0.553
LIG_14-3-3_CanoR_1	97	104	PF00244	0.426
LIG_APCC_ABBA_1	623	628	PF00400	0.374
LIG_APCC_ABBAyCdc20_2	622	628	PF00400	0.374
LIG_BRCT_BRCA1_1	25	29	PF00533	0.539
LIG_BRCT_BRCA1_1	494	498	PF00533	0.517
LIG_BRCT_BRCA1_1	820	824	PF00533	0.557
LIG_BRCT_BRCA1_1	84	88	PF00533	0.443
LIG_deltaCOP1_diTrp_1	561	567	PF00928	0.393
LIG_EH1_1	341	349	PF00400	0.477
LIG_FHA_1	131	137	PF00498	0.365
LIG_FHA_1	722	728	PF00498	0.573
LIG_FHA_1	775	781	PF00498	0.688
LIG_FHA_1	97	103	PF00498	0.343
LIG_FHA_2	187	193	PF00498	0.343
LIG_FHA_2	780	786	PF00498	0.571
LIG_LIR_Apic_2	522	527	PF02991	0.393
LIG_LIR_Gen_1	112	123	PF02991	0.258
LIG_LIR_Gen_1	140	150	PF02991	0.338
LIG_LIR_Gen_1	351	360	PF02991	0.495
LIG_LIR_Gen_1	411	420	PF02991	0.475
LIG_LIR_Gen_1	495	506	PF02991	0.491
LIG_LIR_Gen_1	555	563	PF02991	0.397
LIG_LIR_Nem_3	112	118	PF02991	0.289
LIG_LIR_Nem_3	140	145	PF02991	0.338
LIG_LIR_Nem_3	174	179	PF02991	0.340
LIG_LIR_Nem_3	411	415	PF02991	0.447
LIG_LIR_Nem_3	495	501	PF02991	0.475
LIG_LIR_Nem_3	555	559	PF02991	0.380
LIG_LIR_Nem_3	561	567	PF02991	0.359
LIG_LIR_Nem_3	662	666	PF02991	0.383
LIG_MYND_1	527	531	PF01753	0.403
LIG_PCNA_yPIPBox_3	566	575	PF02747	0.436
LIG_Pex14_1	378	382	PF04695	0.361
LIG_Pex14_2	142	146	PF04695	0.343
LIG_REV1ctd_RIR_1	86	93	PF16727	0.401
LIG_SH2_CRK	572	576	PF00017	0.426
LIG_SH2_CRK	663	667	PF00017	0.397
LIG_SH2_CRK	753	757	PF00017	0.596
LIG_SH2_SRC	525	528	PF00017	0.518
LIG_SH2_SRC	581	584	PF00017	0.651
LIG_SH2_SRC	71	74	PF00017	0.399
LIG_SH2_STAP1	265	269	PF00017	0.572
LIG_SH2_STAP1	387	391	PF00017	0.469
LIG_SH2_STAP1	412	416	PF00017	0.396
LIG_SH2_STAT3	14	17	PF00017	0.607
LIG_SH2_STAT5	134	137	PF00017	0.435
LIG_SH2_STAT5	14	17	PF00017	0.507
LIG_SH2_STAT5	304	307	PF00017	0.446
LIG_SH2_STAT5	382	385	PF00017	0.371
LIG_SH2_STAT5	431	434	PF00017	0.431
LIG_SH2_STAT5	448	451	PF00017	0.363
LIG_SH2_STAT5	525	528	PF00017	0.385
LIG_SH2_STAT5	748	751	PF00017	0.433
LIG_SH2_STAT5	786	789	PF00017	0.520
LIG_SH3_3	393	399	PF00018	0.477
LIG_SH3_3	503	509	PF00018	0.509
LIG_SH3_3	577	583	PF00018	0.548
LIG_SH3_3	669	675	PF00018	0.436
LIG_SUMO_SIM_anti_2	393	398	PF11976	0.409
LIG_SUMO_SIM_par_1	183	189	PF11976	0.443
LIG_SUMO_SIM_par_1	489	497	PF11976	0.451
LIG_SUMO_SIM_par_1	722	728	PF11976	0.573
LIG_TRAF2_1	124	127	PF00917	0.368
LIG_TRAF2_1	364	367	PF00917	0.498
LIG_TRAF2_1	603	606	PF00917	0.523
LIG_TRAF2_1	759	762	PF00917	0.699
LIG_TRFH_1	556	560	PF08558	0.364
LIG_TYR_ITIM	69	74	PF00017	0.399
LIG_UBA3_1	141	147	PF00899	0.328
LIG_UBA3_1	301	310	PF00899	0.475
LIG_UBA3_1	331	339	PF00899	0.466
LIG_WRC_WIRS_1	213	218	PF05994	0.437
MOD_CDC14_SPxK_1	757	760	PF00782	0.692
MOD_CDK_SPK_2	638	643	PF00069	0.515
MOD_CDK_SPxK_1	754	760	PF00069	0.649
MOD_CK1_1	128	134	PF00069	0.372
MOD_CK1_1	224	230	PF00069	0.564
MOD_CK1_1	240	246	PF00069	0.731
MOD_CK1_1	27	33	PF00069	0.719
MOD_CK1_1	277	283	PF00069	0.427
MOD_CK1_1	408	414	PF00069	0.473
MOD_CK1_1	634	640	PF00069	0.429
MOD_CK1_1	690	696	PF00069	0.538
MOD_CK1_1	738	744	PF00069	0.523
MOD_CK1_1	774	780	PF00069	0.742
MOD_CK2_1	146	152	PF00069	0.357
MOD_CK2_1	361	367	PF00069	0.413
MOD_CK2_1	431	437	PF00069	0.423
MOD_CK2_1	779	785	PF00069	0.581
MOD_CK2_1	89	95	PF00069	0.376
MOD_CK2_1	97	103	PF00069	0.279
MOD_GlcNHglycan	148	151	PF01048	0.365
MOD_GlcNHglycan	157	160	PF01048	0.313
MOD_GlcNHglycan	293	296	PF01048	0.410
MOD_GlcNHglycan	298	301	PF01048	0.356
MOD_GlcNHglycan	636	639	PF01048	0.517
MOD_GlcNHglycan	710	713	PF01048	0.553
MOD_GlcNHglycan	99	102	PF01048	0.405
MOD_GSK3_1	130	137	PF00069	0.343
MOD_GSK3_1	2	9	PF00069	0.720
MOD_GSK3_1	224	231	PF00069	0.527
MOD_GSK3_1	23	30	PF00069	0.639
MOD_GSK3_1	515	522	PF00069	0.541
MOD_GSK3_1	634	641	PF00069	0.489
MOD_GSK3_1	688	695	PF00069	0.518
MOD_GSK3_1	767	774	PF00069	0.756
MOD_N-GLC_1	224	229	PF02516	0.551
MOD_NEK2_1	155	160	PF00069	0.343
MOD_NEK2_1	186	191	PF00069	0.343
MOD_NEK2_1	238	243	PF00069	0.764
MOD_NEK2_1	274	279	PF00069	0.377
MOD_NEK2_1	29	34	PF00069	0.668
MOD_NEK2_1	405	410	PF00069	0.384
MOD_NEK2_1	515	520	PF00069	0.317
MOD_NEK2_1	721	726	PF00069	0.479
MOD_NEK2_1	735	740	PF00069	0.368
MOD_NEK2_1	798	803	PF00069	0.536
MOD_NEK2_1	89	94	PF00069	0.405
MOD_NEK2_2	75	80	PF00069	0.343
MOD_OFUCOSY	736	742	PF10250	0.518
MOD_PIKK_1	515	521	PF00454	0.582
MOD_PIKK_1	719	725	PF00454	0.571
MOD_PK_1	760	766	PF00069	0.794
MOD_PKA_2	326	332	PF00069	0.495
MOD_PKA_2	348	354	PF00069	0.532
MOD_PKA_2	610	616	PF00069	0.483
MOD_PKA_2	642	648	PF00069	0.563
MOD_PKA_2	667	673	PF00069	0.508
MOD_PKA_2	719	725	PF00069	0.498
MOD_PKA_2	96	102	PF00069	0.399
MOD_Plk_1	105	111	PF00069	0.480
MOD_Plk_1	137	143	PF00069	0.343
MOD_Plk_1	760	766	PF00069	0.736
MOD_Plk_2-3	492	498	PF00069	0.510
MOD_Plk_4	130	136	PF00069	0.344
MOD_Plk_4	390	396	PF00069	0.369
MOD_Plk_4	405	411	PF00069	0.493
MOD_Plk_4	576	582	PF00069	0.497
MOD_Plk_4	610	616	PF00069	0.483
MOD_Plk_4	631	637	PF00069	0.485
MOD_Plk_4	721	727	PF00069	0.497
MOD_ProDKin_1	415	421	PF00069	0.444
MOD_ProDKin_1	531	537	PF00069	0.434
MOD_ProDKin_1	638	644	PF00069	0.512
MOD_ProDKin_1	754	760	PF00069	0.612
MOD_ProDKin_1	818	824	PF00069	0.727
TRG_DiLeu_BaEn_1	390	395	PF01217	0.441
TRG_DiLeu_BaEn_1	483	488	PF01217	0.477
TRG_DiLeu_BaEn_1	728	733	PF01217	0.414
TRG_DiLeu_BaEn_2	137	143	PF01217	0.443
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.328
TRG_ENDOCYTIC_2	412	415	PF00928	0.393
TRG_ENDOCYTIC_2	572	575	PF00928	0.365
TRG_ENDOCYTIC_2	663	666	PF00928	0.390
TRG_ENDOCYTIC_2	71	74	PF00928	0.399
TRG_ENDOCYTIC_2	748	751	PF00928	0.433
TRG_ER_diArg_1	267	269	PF00400	0.581
TRG_ER_diArg_1	466	468	PF00400	0.516
TRG_ER_diArg_1	52	55	PF00400	0.549
TRG_ER_diArg_1	550	553	PF00400	0.454
TRG_ER_diArg_1	598	601	PF00400	0.567
TRG_ER_diArg_1	811	814	PF00400	0.555
TRG_NLS_MonoExtC_3	338	343	PF00514	0.480
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	814	818	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9V2	Leptomonas seymouri	78%	82%
A0A1X0NT83	Trypanosomatidae	49%	82%
A0A3S5H7S9	Leishmania donovani	95%	100%
A0A422NYM8	Trypanosoma rangeli	46%	84%
A4HKV0	Leishmania braziliensis	88%	100%
A4I8C9	Leishmania infantum	95%	100%
Q4Q4W7	Leishmania major	95%	100%
V5DM76	Trypanosoma cruzi	46%	94%