AMPK1_CBM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein, putative

Species:

Leishmania mexicana

UniProt:

E9B384_LEIMU

TriTrypDb:

LmxM.31.3010

Length:

880

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

E9B384

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B384

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.300
CLV_NRD_NRD_1	24	26	PF00675	0.466
CLV_NRD_NRD_1	579	581	PF00675	0.424
CLV_NRD_NRD_1	677	679	PF00675	0.420
CLV_NRD_NRD_1	7	9	PF00675	0.648
CLV_PCSK_KEX2_1	677	679	PF00082	0.440
CLV_PCSK_KEX2_1	681	683	PF00082	0.551
CLV_PCSK_KEX2_1	7	9	PF00082	0.647
CLV_PCSK_KEX2_1	727	729	PF00082	0.626
CLV_PCSK_KEX2_1	81	83	PF00082	0.584
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.607
CLV_PCSK_PC1ET2_1	727	729	PF00082	0.630
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.509
CLV_PCSK_PC7_1	677	683	PF00082	0.540
CLV_PCSK_SKI1_1	32	36	PF00082	0.483
CLV_PCSK_SKI1_1	531	535	PF00082	0.510
CLV_PCSK_SKI1_1	546	550	PF00082	0.415
CLV_PCSK_SKI1_1	628	632	PF00082	0.446
CLV_PCSK_SKI1_1	722	726	PF00082	0.472
CLV_PCSK_SKI1_1	740	744	PF00082	0.460
CLV_PCSK_SKI1_1	801	805	PF00082	0.537
DEG_APCC_DBOX_1	24	32	PF00400	0.586
DEG_SCF_FBW7_1	805	812	PF00400	0.582
DOC_ANK_TNKS_1	340	347	PF00023	0.328
DOC_CDC14_PxL_1	124	132	PF14671	0.328
DOC_CDC14_PxL_1	143	151	PF14671	0.347
DOC_CKS1_1	438	443	PF01111	0.419
DOC_CKS1_1	600	605	PF01111	0.368
DOC_CYCLIN_yCln2_LP_2	631	637	PF00134	0.425
DOC_MAPK_gen_1	25	36	PF00069	0.498
DOC_MAPK_MEF2A_6	59	68	PF00069	0.448
DOC_PP2B_LxvP_1	331	334	PF13499	0.316
DOC_USP7_MATH_1	117	121	PF00917	0.378
DOC_USP7_MATH_1	393	397	PF00917	0.605
DOC_USP7_MATH_1	555	559	PF00917	0.559
DOC_USP7_MATH_1	809	813	PF00917	0.603
DOC_USP7_MATH_1	859	863	PF00917	0.686
DOC_USP7_UBL2_3	198	202	PF12436	0.540
DOC_USP7_UBL2_3	581	585	PF12436	0.588
DOC_WW_Pin1_4	389	394	PF00397	0.510
DOC_WW_Pin1_4	406	411	PF00397	0.362
DOC_WW_Pin1_4	437	442	PF00397	0.381
DOC_WW_Pin1_4	483	488	PF00397	0.456
DOC_WW_Pin1_4	516	521	PF00397	0.396
DOC_WW_Pin1_4	539	544	PF00397	0.544
DOC_WW_Pin1_4	586	591	PF00397	0.535
DOC_WW_Pin1_4	599	604	PF00397	0.467
DOC_WW_Pin1_4	612	617	PF00397	0.364
DOC_WW_Pin1_4	687	692	PF00397	0.592
DOC_WW_Pin1_4	709	714	PF00397	0.394
DOC_WW_Pin1_4	80	85	PF00397	0.452
DOC_WW_Pin1_4	805	810	PF00397	0.425
DOC_WW_Pin1_4	829	834	PF00397	0.575
DOC_WW_Pin1_4	854	859	PF00397	0.576
LIG_14-3-3_CanoR_1	131	136	PF00244	0.328
LIG_14-3-3_CanoR_1	387	393	PF00244	0.426
LIG_14-3-3_CanoR_1	680	688	PF00244	0.393
LIG_Actin_WH2_2	16	31	PF00022	0.321
LIG_Actin_WH2_2	66	83	PF00022	0.471
LIG_AP2alpha_2	498	500	PF02296	0.449
LIG_BIR_II_1	1	5	PF00653	0.691
LIG_BIR_III_2	841	845	PF00653	0.587
LIG_BRCT_BRCA1_1	133	137	PF00533	0.328
LIG_BRCT_BRCA1_1	298	302	PF00533	0.396
LIG_Clathr_ClatBox_1	180	184	PF01394	0.394
LIG_Clathr_ClatBox_1	51	55	PF01394	0.506
LIG_Clathr_ClatBox_1	63	67	PF01394	0.472
LIG_FHA_1	108	114	PF00498	0.340
LIG_FHA_1	152	158	PF00498	0.319
LIG_FHA_1	276	282	PF00498	0.542
LIG_FHA_1	309	315	PF00498	0.354
LIG_FHA_1	328	334	PF00498	0.181
LIG_FHA_1	410	416	PF00498	0.403
LIG_FHA_1	491	497	PF00498	0.486
LIG_FHA_1	533	539	PF00498	0.448
LIG_FHA_1	545	551	PF00498	0.428
LIG_FHA_1	559	565	PF00498	0.342
LIG_FHA_1	595	601	PF00498	0.454
LIG_FHA_1	654	660	PF00498	0.519
LIG_FHA_1	718	724	PF00498	0.528
LIG_FHA_1	72	78	PF00498	0.487
LIG_FHA_1	789	795	PF00498	0.419
LIG_FHA_1	81	87	PF00498	0.385
LIG_FHA_1	819	825	PF00498	0.554
LIG_FHA_2	139	145	PF00498	0.449
LIG_FHA_2	504	510	PF00498	0.448
LIG_FHA_2	600	606	PF00498	0.372
LIG_FHA_2	697	703	PF00498	0.435
LIG_FHA_2	762	768	PF00498	0.521
LIG_FHA_2	791	797	PF00498	0.408
LIG_Integrin_isoDGR_2	5	7	PF01839	0.685
LIG_LIR_Apic_2	284	289	PF02991	0.457
LIG_LIR_Gen_1	103	113	PF02991	0.416
LIG_LIR_Gen_1	134	143	PF02991	0.328
LIG_LIR_Gen_1	235	246	PF02991	0.570
LIG_LIR_Gen_1	396	403	PF02991	0.503
LIG_LIR_Gen_1	40	51	PF02991	0.372
LIG_LIR_Gen_1	430	441	PF02991	0.434
LIG_LIR_Gen_1	574	582	PF02991	0.430
LIG_LIR_Gen_1	693	703	PF02991	0.505
LIG_LIR_Gen_1	779	789	PF02991	0.469
LIG_LIR_Nem_3	103	108	PF02991	0.437
LIG_LIR_Nem_3	119	124	PF02991	0.390
LIG_LIR_Nem_3	134	140	PF02991	0.302
LIG_LIR_Nem_3	141	146	PF02991	0.328
LIG_LIR_Nem_3	235	241	PF02991	0.595
LIG_LIR_Nem_3	285	291	PF02991	0.395
LIG_LIR_Nem_3	337	343	PF02991	0.345
LIG_LIR_Nem_3	396	400	PF02991	0.493
LIG_LIR_Nem_3	40	46	PF02991	0.380
LIG_LIR_Nem_3	430	436	PF02991	0.455
LIG_LIR_Nem_3	469	474	PF02991	0.494
LIG_LIR_Nem_3	479	485	PF02991	0.373
LIG_LIR_Nem_3	498	503	PF02991	0.289
LIG_LIR_Nem_3	517	521	PF02991	0.383
LIG_LIR_Nem_3	574	579	PF02991	0.406
LIG_LIR_Nem_3	587	591	PF02991	0.454
LIG_LIR_Nem_3	693	698	PF02991	0.478
LIG_LIR_Nem_3	779	785	PF02991	0.470
LIG_LIR_Nem_3	806	810	PF02991	0.427
LIG_LYPXL_S_1	287	291	PF13949	0.449
LIG_LYPXL_yS_3	146	149	PF13949	0.363
LIG_LYPXL_yS_3	288	291	PF13949	0.449
LIG_MAD2	801	809	PF02301	0.283
LIG_PDZ_Class_2	875	880	PF00595	0.576
LIG_PTB_Apo_2	425	432	PF02174	0.550
LIG_RPA_C_Fungi	228	240	PF08784	0.530
LIG_SH2_CRK	340	344	PF00017	0.328
LIG_SH2_CRK	43	47	PF00017	0.502
LIG_SH2_CRK	588	592	PF00017	0.560
LIG_SH2_CRK	807	811	PF00017	0.427
LIG_SH2_GRB2like	426	429	PF00017	0.555
LIG_SH2_NCK_1	397	401	PF00017	0.468
LIG_SH2_NCK_1	588	592	PF00017	0.519
LIG_SH2_NCK_1	614	618	PF00017	0.400
LIG_SH2_SRC	286	289	PF00017	0.488
LIG_SH2_SRC	426	429	PF00017	0.486
LIG_SH2_STAP1	338	342	PF00017	0.344
LIG_SH2_STAP1	39	43	PF00017	0.444
LIG_SH2_STAT5	238	241	PF00017	0.528
LIG_SH2_STAT5	286	289	PF00017	0.449
LIG_SH2_STAT5	326	329	PF00017	0.324
LIG_SH2_STAT5	332	335	PF00017	0.316
LIG_SH2_STAT5	342	345	PF00017	0.273
LIG_SH2_STAT5	408	411	PF00017	0.427
LIG_SH2_STAT5	426	429	PF00017	0.380
LIG_SH2_STAT5	435	438	PF00017	0.376
LIG_SH2_STAT5	45	48	PF00017	0.391
LIG_SH2_STAT5	470	473	PF00017	0.424
LIG_SH2_STAT5	588	591	PF00017	0.440
LIG_SH2_STAT5	599	602	PF00017	0.418
LIG_SH2_STAT5	609	612	PF00017	0.406
LIG_SH2_STAT5	614	617	PF00017	0.398
LIG_SH2_STAT5	760	763	PF00017	0.430
LIG_SH2_STAT5	792	795	PF00017	0.448
LIG_SH2_STAT5	807	810	PF00017	0.412
LIG_SH3_3	144	150	PF00018	0.343
LIG_SH3_3	155	161	PF00018	0.218
LIG_SH3_3	438	444	PF00018	0.428
LIG_SH3_3	493	499	PF00018	0.568
LIG_SH3_3	597	603	PF00018	0.585
LIG_SH3_3	731	737	PF00018	0.485
LIG_SH3_3	742	748	PF00018	0.397
LIG_SH3_5	334	338	PF00018	0.363
LIG_SUMO_SIM_anti_2	493	498	PF11976	0.609
LIG_SUMO_SIM_anti_2	61	67	PF11976	0.449
LIG_SUMO_SIM_par_1	179	184	PF11976	0.436
LIG_SUMO_SIM_par_1	260	265	PF11976	0.537
LIG_SUMO_SIM_par_1	311	317	PF11976	0.345
LIG_SUMO_SIM_par_1	490	498	PF11976	0.362
LIG_SUMO_SIM_par_1	560	565	PF11976	0.280
LIG_SUMO_SIM_par_1	61	67	PF11976	0.386
LIG_SUMO_SIM_par_1	644	650	PF11976	0.428
LIG_SUMO_SIM_par_1	655	660	PF11976	0.401
LIG_TRAF2_1	375	378	PF00917	0.681
LIG_TYR_ITAM	573	591	PF00017	0.398
LIG_TYR_ITIM	805	810	PF00017	0.425
LIG_WRC_WIRS_1	118	123	PF05994	0.386
LIG_WRC_WIRS_1	140	145	PF05994	0.305
LIG_WRC_WIRS_1	51	56	PF05994	0.462
MOD_CDK_SPK_2	406	411	PF00069	0.356
MOD_CDK_SPxK_1	437	443	PF00069	0.512
MOD_CDK_SPxK_1	516	522	PF00069	0.398
MOD_CDK_SPxK_1	709	715	PF00069	0.396
MOD_CDK_SPxK_1	805	811	PF00069	0.426
MOD_CDK_SPxxK_3	539	546	PF00069	0.495
MOD_CK1_1	142	148	PF00069	0.385
MOD_CK1_1	355	361	PF00069	0.449
MOD_CK1_1	439	445	PF00069	0.557
MOD_CK1_1	532	538	PF00069	0.447
MOD_CK1_1	558	564	PF00069	0.440
MOD_CK1_1	683	689	PF00069	0.603
MOD_CK1_1	690	696	PF00069	0.509
MOD_CK1_1	849	855	PF00069	0.783
MOD_CK1_1	862	868	PF00069	0.640
MOD_CK1_1	869	875	PF00069	0.718
MOD_CK2_1	138	144	PF00069	0.363
MOD_CK2_1	27	33	PF00069	0.457
MOD_CK2_1	485	491	PF00069	0.581
MOD_CK2_1	550	556	PF00069	0.364
MOD_CK2_1	66	72	PF00069	0.379
MOD_CK2_1	761	767	PF00069	0.594
MOD_CK2_1	790	796	PF00069	0.312
MOD_CK2_1	809	815	PF00069	0.292
MOD_CK2_1	862	868	PF00069	0.759
MOD_CK2_1	871	877	PF00069	0.658
MOD_Cter_Amidation	5	8	PF01082	0.689
MOD_GlcNHglycan	294	297	PF01048	0.363
MOD_GlcNHglycan	487	490	PF01048	0.560
MOD_GlcNHglycan	591	594	PF01048	0.589
MOD_GlcNHglycan	667	670	PF01048	0.525
MOD_GlcNHglycan	852	855	PF01048	0.564
MOD_GlcNHglycan	865	868	PF01048	0.465
MOD_GSK3_1	107	114	PF00069	0.378
MOD_GSK3_1	138	145	PF00069	0.437
MOD_GSK3_1	292	299	PF00069	0.391
MOD_GSK3_1	308	315	PF00069	0.315
MOD_GSK3_1	348	355	PF00069	0.449
MOD_GSK3_1	389	396	PF00069	0.475
MOD_GSK3_1	402	409	PF00069	0.427
MOD_GSK3_1	683	690	PF00069	0.517
MOD_GSK3_1	703	710	PF00069	0.223
MOD_GSK3_1	761	768	PF00069	0.518
MOD_GSK3_1	790	797	PF00069	0.537
MOD_GSK3_1	805	812	PF00069	0.465
MOD_GSK3_1	842	849	PF00069	0.716
MOD_GSK3_1	850	857	PF00069	0.693
MOD_GSK3_1	859	866	PF00069	0.624
MOD_GSK3_1	867	874	PF00069	0.727
MOD_N-GLC_1	138	143	PF02516	0.363
MOD_N-GLC_1	308	313	PF02516	0.332
MOD_N-GLC_1	393	398	PF02516	0.463
MOD_N-GLC_1	476	481	PF02516	0.524
MOD_N-GLC_1	594	599	PF02516	0.455
MOD_N-GLC_2	416	418	PF02516	0.472
MOD_NEK2_1	282	287	PF00069	0.537
MOD_NEK2_1	327	332	PF00069	0.344
MOD_NEK2_1	436	441	PF00069	0.399
MOD_NEK2_1	452	457	PF00069	0.441
MOD_NEK2_1	66	71	PF00069	0.354
MOD_NEK2_1	803	808	PF00069	0.492
MOD_NEK2_1	848	853	PF00069	0.725
MOD_NEK2_1	861	866	PF00069	0.575
MOD_NEK2_1	871	876	PF00069	0.609
MOD_NEK2_1	89	94	PF00069	0.386
MOD_PIKK_1	555	561	PF00454	0.536
MOD_PKA_1	680	686	PF00069	0.539
MOD_PKA_2	276	282	PF00069	0.545
MOD_PKB_1	678	686	PF00069	0.358
MOD_Plk_1	138	144	PF00069	0.363
MOD_Plk_1	32	38	PF00069	0.476
MOD_Plk_1	402	408	PF00069	0.452
MOD_Plk_1	429	435	PF00069	0.568
MOD_Plk_1	476	482	PF00069	0.484
MOD_Plk_1	490	496	PF00069	0.531
MOD_Plk_1	66	72	PF00069	0.369
MOD_Plk_1	707	713	PF00069	0.455
MOD_Plk_1	867	873	PF00069	0.722
MOD_Plk_2-3	209	215	PF00069	0.525
MOD_Plk_2-3	312	318	PF00069	0.449
MOD_Plk_2-3	490	496	PF00069	0.416
MOD_Plk_2-3	50	56	PF00069	0.504
MOD_Plk_2-3	776	782	PF00069	0.337
MOD_Plk_4	282	288	PF00069	0.532
MOD_Plk_4	327	333	PF00069	0.333
MOD_Plk_4	379	385	PF00069	0.497
MOD_Plk_4	476	482	PF00069	0.489
MOD_Plk_4	571	577	PF00069	0.412
MOD_Plk_4	765	771	PF00069	0.596
MOD_ProDKin_1	389	395	PF00069	0.516
MOD_ProDKin_1	406	412	PF00069	0.364
MOD_ProDKin_1	437	443	PF00069	0.387
MOD_ProDKin_1	483	489	PF00069	0.460
MOD_ProDKin_1	516	522	PF00069	0.398
MOD_ProDKin_1	539	545	PF00069	0.539
MOD_ProDKin_1	586	592	PF00069	0.540
MOD_ProDKin_1	599	605	PF00069	0.460
MOD_ProDKin_1	612	618	PF00069	0.364
MOD_ProDKin_1	687	693	PF00069	0.584
MOD_ProDKin_1	709	715	PF00069	0.396
MOD_ProDKin_1	80	86	PF00069	0.442
MOD_ProDKin_1	805	811	PF00069	0.426
MOD_ProDKin_1	829	835	PF00069	0.578
MOD_ProDKin_1	854	860	PF00069	0.580
MOD_SUMO_for_1	58	61	PF00179	0.551
MOD_SUMO_for_1	770	773	PF00179	0.491
MOD_SUMO_rev_2	524	533	PF00179	0.472
MOD_SUMO_rev_2	53	60	PF00179	0.542
MOD_SUMO_rev_2	733	742	PF00179	0.519
TRG_DiLeu_BaEn_3	251	257	PF01217	0.567
TRG_DiLeu_BaLyEn_6	641	646	PF01217	0.284
TRG_ENDOCYTIC_2	146	149	PF00928	0.344
TRG_ENDOCYTIC_2	168	171	PF00928	0.395
TRG_ENDOCYTIC_2	238	241	PF00928	0.528
TRG_ENDOCYTIC_2	288	291	PF00928	0.413
TRG_ENDOCYTIC_2	340	343	PF00928	0.334
TRG_ENDOCYTIC_2	397	400	PF00928	0.469
TRG_ENDOCYTIC_2	43	46	PF00928	0.372
TRG_ENDOCYTIC_2	435	438	PF00928	0.394
TRG_ENDOCYTIC_2	576	579	PF00928	0.404
TRG_ENDOCYTIC_2	588	591	PF00928	0.420
TRG_ENDOCYTIC_2	609	612	PF00928	0.436
TRG_ENDOCYTIC_2	807	810	PF00928	0.426
TRG_ER_diArg_1	676	678	PF00400	0.405
TRG_NES_CRM1_1	50	61	PF08389	0.466
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.328

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME5	Leptomonas seymouri	78%	90%
A0A0S4II95	Bodo saltans	53%	100%
A0A1X0NRQ9	Trypanosomatidae	61%	91%
A0A3Q8IDD1	Leishmania donovani	93%	100%
A0A422NYS0	Trypanosoma rangeli	59%	96%
A4HKU6	Leishmania braziliensis	79%	100%
A4I8C5	Leishmania infantum	94%	100%
D0AAU7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	91%
Q4Q4X1	Leishmania major	91%	100%
V5BQQ6	Trypanosoma cruzi	62%	96%