LeishMANIAdb
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CNNM transmembrane domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
CNNM transmembrane domain-containing protein
Gene product:
Domain of unknown function DUF21, putative
Species:
Leishmania mexicana
UniProt:
E9B383_LEIMU
TriTrypDb:
LmxM.31.3000
Length:
402

Annotations

LeishMANIAdb annotations

Homologous to plant metal transporters (likely Mg2+ transporters)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

E9B383
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B383

Function

Biological processes
Term Name Level Count
GO:0010960 magnesium ion homeostasis 8 12
GO:0042592 homeostatic process 3 12
GO:0048878 chemical homeostasis 4 12
GO:0050801 monoatomic ion homeostasis 5 12
GO:0055065 obsolete metal ion homeostasis 7 12
GO:0055080 monoatomic cation homeostasis 6 12
GO:0065007 biological regulation 1 12
GO:0065008 regulation of biological quality 2 12
GO:0072507 obsolete divalent inorganic cation homeostasis 7 12
GO:0098771 inorganic ion homeostasis 6 12
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 337 341 PF00656 0.379
CLV_NRD_NRD_1 61 63 PF00675 0.266
CLV_NRD_NRD_1 64 66 PF00675 0.269
CLV_PCSK_FUR_1 62 66 PF00082 0.311
CLV_PCSK_KEX2_1 170 172 PF00082 0.489
CLV_PCSK_KEX2_1 253 255 PF00082 0.652
CLV_PCSK_KEX2_1 61 63 PF00082 0.274
CLV_PCSK_KEX2_1 64 66 PF00082 0.280
CLV_PCSK_PC1ET2_1 170 172 PF00082 0.527
CLV_PCSK_PC1ET2_1 253 255 PF00082 0.652
CLV_PCSK_SKI1_1 286 290 PF00082 0.592
CLV_PCSK_SKI1_1 64 68 PF00082 0.301
DEG_APCC_DBOX_1 170 178 PF00400 0.262
DEG_APCC_DBOX_1 63 71 PF00400 0.537
DEG_SPOP_SBC_1 335 339 PF00917 0.198
DOC_CDC14_PxL_1 302 310 PF14671 0.382
DOC_CYCLIN_yCln2_LP_2 8 14 PF00134 0.457
DOC_CYCLIN_yCln2_LP_2 98 104 PF00134 0.423
DOC_MAPK_DCC_7 301 310 PF00069 0.382
DOC_MAPK_gen_1 236 247 PF00069 0.292
DOC_MAPK_gen_1 301 310 PF00069 0.366
DOC_MAPK_gen_1 61 70 PF00069 0.474
DOC_MAPK_HePTP_8 58 70 PF00069 0.522
DOC_MAPK_MEF2A_6 301 310 PF00069 0.403
DOC_MAPK_MEF2A_6 61 70 PF00069 0.494
DOC_PP1_RVXF_1 153 160 PF00149 0.276
DOC_PP1_RVXF_1 284 291 PF00149 0.400
DOC_PP2B_LxvP_1 308 311 PF13499 0.399
DOC_PP2B_LxvP_1 8 11 PF13499 0.470
DOC_USP7_MATH_1 130 134 PF00917 0.388
DOC_USP7_MATH_1 199 203 PF00917 0.530
DOC_USP7_MATH_1 249 253 PF00917 0.420
DOC_USP7_MATH_1 335 339 PF00917 0.253
DOC_USP7_MATH_1 373 377 PF00917 0.394
DOC_USP7_MATH_1 52 56 PF00917 0.556
DOC_USP7_UBL2_3 45 49 PF12436 0.560
DOC_WW_Pin1_4 314 319 PF00397 0.372
DOC_WW_Pin1_4 326 331 PF00397 0.342
DOC_WW_Pin1_4 97 102 PF00397 0.467
LIG_14-3-3_CanoR_1 240 246 PF00244 0.377
LIG_14-3-3_CanoR_1 254 260 PF00244 0.368
LIG_14-3-3_CanoR_1 312 318 PF00244 0.362
LIG_Actin_WH2_2 223 238 PF00022 0.413
LIG_APCC_ABBA_1 243 248 PF00400 0.384
LIG_APCC_ABBA_1 267 272 PF00400 0.328
LIG_BIR_II_1 1 5 PF00653 0.469
LIG_Clathr_ClatBox_1 80 84 PF01394 0.338
LIG_EH1_1 136 144 PF00400 0.450
LIG_eIF4E_1 137 143 PF01652 0.450
LIG_FHA_1 134 140 PF00498 0.277
LIG_FHA_1 144 150 PF00498 0.298
LIG_FHA_1 16 22 PF00498 0.428
LIG_FHA_1 240 246 PF00498 0.363
LIG_FHA_1 259 265 PF00498 0.242
LIG_FHA_1 278 284 PF00498 0.173
LIG_FHA_1 363 369 PF00498 0.515
LIG_FHA_1 77 83 PF00498 0.338
LIG_FHA_1 86 92 PF00498 0.338
LIG_FHA_2 335 341 PF00498 0.392
LIG_FHA_2 359 365 PF00498 0.431
LIG_IRF3_LxIS_1 32 39 PF10401 0.416
LIG_LIR_Gen_1 136 145 PF02991 0.221
LIG_LIR_Gen_1 15 23 PF02991 0.452
LIG_LIR_LC3C_4 24 28 PF02991 0.450
LIG_LIR_LC3C_4 79 82 PF02991 0.396
LIG_LIR_Nem_3 136 140 PF02991 0.179
LIG_NRBOX 284 290 PF00104 0.401
LIG_SH2_CRK 5 9 PF00017 0.462
LIG_SH2_NCK_1 270 274 PF00017 0.379
LIG_SH2_SRC 186 189 PF00017 0.369
LIG_SH2_SRC 367 370 PF00017 0.517
LIG_SH2_STAT5 137 140 PF00017 0.379
LIG_SH2_STAT5 229 232 PF00017 0.387
LIG_SH2_STAT5 325 328 PF00017 0.415
LIG_SH2_STAT5 367 370 PF00017 0.492
LIG_SH3_1 303 309 PF00018 0.413
LIG_SH3_3 142 148 PF00018 0.432
LIG_SH3_3 270 276 PF00018 0.377
LIG_SH3_3 303 309 PF00018 0.355
LIG_SUMO_SIM_anti_2 108 114 PF11976 0.361
LIG_SUMO_SIM_anti_2 18 24 PF11976 0.418
LIG_SUMO_SIM_anti_2 352 359 PF11976 0.410
LIG_SUMO_SIM_anti_2 79 85 PF11976 0.360
LIG_SUMO_SIM_par_1 10 15 PF11976 0.432
LIG_SUMO_SIM_par_1 18 24 PF11976 0.369
LIG_SUMO_SIM_par_1 222 228 PF11976 0.365
LIG_SUMO_SIM_par_1 36 42 PF11976 0.339
LIG_SUMO_SIM_par_1 78 85 PF11976 0.344
LIG_TYR_ITIM 135 140 PF00017 0.385
LIG_WRC_WIRS_1 378 383 PF05994 0.493
LIG_WW_3 197 201 PF00397 0.527
MOD_CK1_1 133 139 PF00069 0.221
MOD_CK1_1 15 21 PF00069 0.467
MOD_CK1_1 203 209 PF00069 0.516
MOD_CK1_1 258 264 PF00069 0.418
MOD_CK1_1 277 283 PF00069 0.282
MOD_CK1_1 314 320 PF00069 0.360
MOD_CK1_1 362 368 PF00069 0.454
MOD_CK1_1 39 45 PF00069 0.350
MOD_CK1_1 85 91 PF00069 0.423
MOD_CK2_1 222 228 PF00069 0.358
MOD_CK2_1 97 103 PF00069 0.450
MOD_Cter_Amidation 59 62 PF01082 0.322
MOD_GlcNHglycan 132 135 PF01048 0.328
MOD_GlcNHglycan 164 167 PF01048 0.556
MOD_GlcNHglycan 313 316 PF01048 0.587
MOD_GlcNHglycan 349 352 PF01048 0.573
MOD_GlcNHglycan 84 87 PF01048 0.423
MOD_GSK3_1 143 150 PF00069 0.330
MOD_GSK3_1 199 206 PF00069 0.589
MOD_GSK3_1 258 265 PF00069 0.367
MOD_GSK3_1 358 365 PF00069 0.469
MOD_GSK3_1 373 380 PF00069 0.335
MOD_N-GLC_1 277 282 PF02516 0.540
MOD_N-GLC_1 384 389 PF02516 0.681
MOD_NEK2_1 143 148 PF00069 0.306
MOD_NEK2_1 255 260 PF00069 0.404
MOD_NEK2_1 36 41 PF00069 0.377
MOD_NEK2_2 241 246 PF00069 0.370
MOD_PIKK_1 214 220 PF00454 0.428
MOD_PIKK_1 277 283 PF00454 0.356
MOD_PKA_2 199 205 PF00069 0.568
MOD_PKA_2 239 245 PF00069 0.390
MOD_PKA_2 311 317 PF00069 0.387
MOD_Plk_1 12 18 PF00069 0.298
MOD_Plk_1 200 206 PF00069 0.538
MOD_Plk_1 277 283 PF00069 0.308
MOD_Plk_1 384 390 PF00069 0.476
MOD_Plk_4 105 111 PF00069 0.363
MOD_Plk_4 12 18 PF00069 0.254
MOD_Plk_4 133 139 PF00069 0.206
MOD_Plk_4 230 236 PF00069 0.347
MOD_Plk_4 255 261 PF00069 0.379
MOD_Plk_4 3 9 PF00069 0.375
MOD_Plk_4 373 379 PF00069 0.473
MOD_Plk_4 76 82 PF00069 0.319
MOD_ProDKin_1 314 320 PF00069 0.374
MOD_ProDKin_1 326 332 PF00069 0.344
MOD_ProDKin_1 97 103 PF00069 0.467
TRG_DiLeu_BaEn_1 284 289 PF01217 0.332
TRG_DiLeu_BaLyEn_6 283 288 PF01217 0.381
TRG_DiLeu_BaLyEn_6 303 308 PF01217 0.194
TRG_DiLeu_BaLyEn_6 62 67 PF01217 0.537
TRG_DiLeu_LyEn_5 89 94 PF01217 0.423
TRG_ENDOCYTIC_2 137 140 PF00928 0.358
TRG_ENDOCYTIC_2 270 273 PF00928 0.398
TRG_ENDOCYTIC_2 5 8 PF00928 0.461
TRG_ER_diArg_1 300 303 PF00400 0.376
TRG_ER_diArg_1 61 64 PF00400 0.493
TRG_NES_CRM1_1 89 103 PF08389 0.333

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8N1 Leptomonas seymouri 70% 100%
A0A0N1I1M9 Leptomonas seymouri 36% 95%
A0A0N1PDI6 Leptomonas seymouri 22% 67%
A0A0S4IPA6 Bodo saltans 25% 100%
A0A0S4IPI7 Bodo saltans 35% 81%
A0A0S4JSF9 Bodo saltans 25% 75%
A0A1X0NRR8 Trypanosomatidae 38% 92%
A0A1X0P1F1 Trypanosomatidae 23% 100%
A0A1X0PAL3 Trypanosomatidae 23% 71%
A0A3Q8IC75 Leishmania donovani 25% 100%
A0A3Q8IL77 Leishmania donovani 22% 66%
A0A3Q8ITK0 Leishmania donovani 96% 100%
A0A3R7LBY6 Trypanosoma rangeli 27% 100%
A0A422NS01 Trypanosoma rangeli 25% 71%
A0A422NYJ0 Trypanosoma rangeli 38% 86%
A4HAY2 Leishmania braziliensis 23% 68%
A4HIN7 Leishmania braziliensis 25% 100%
A4HKU5 Leishmania braziliensis 87% 100%
A4I5Y4 Leishmania infantum 25% 100%
A4I8C4 Leishmania infantum 96% 100%
A4IA41 Leishmania infantum 22% 66%
C9ZM59 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 72%
E9B177 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9B555 Leishmania mexicana (strain MHOM/GT/2001/U1103) 22% 66%
Q4Q2T0 Leishmania major 23% 66%
Q4Q4X2 Leishmania major 96% 100%
Q4Q6Y7 Leishmania major 24% 100%
Q4V3C7 Arabidopsis thaliana 29% 81%
Q67XQ0 Arabidopsis thaliana 29% 81%
Q8RY60 Arabidopsis thaliana 26% 76%
Q8VZI2 Arabidopsis thaliana 31% 95%
Q9LTD8 Arabidopsis thaliana 25% 80%
Q9ZQR4 Arabidopsis thaliana 26% 95%
Q9ZVS8 Arabidopsis thaliana 29% 81%
V5BKR5 Trypanosoma cruzi 24% 70%
V5DM70 Trypanosoma cruzi 38% 89%
V5DNW3 Trypanosoma cruzi 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS