ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B381_LEIMU

TriTrypDb:

LmxM.31.2990

Length:

758

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B381

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B381

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.484
CLV_C14_Caspase3-7	286	290	PF00656	0.562
CLV_C14_Caspase3-7	431	435	PF00656	0.630
CLV_C14_Caspase3-7	463	467	PF00656	0.574
CLV_C14_Caspase3-7	73	77	PF00656	0.491
CLV_NRD_NRD_1	25	27	PF00675	0.424
CLV_NRD_NRD_1	350	352	PF00675	0.422
CLV_NRD_NRD_1	375	377	PF00675	0.577
CLV_NRD_NRD_1	487	489	PF00675	0.681
CLV_NRD_NRD_1	681	683	PF00675	0.600
CLV_PCSK_KEX2_1	25	27	PF00082	0.424
CLV_PCSK_KEX2_1	350	352	PF00082	0.422
CLV_PCSK_KEX2_1	375	377	PF00082	0.568
CLV_PCSK_KEX2_1	683	685	PF00082	0.619
CLV_PCSK_PC1ET2_1	683	685	PF00082	0.615
CLV_PCSK_SKI1_1	103	107	PF00082	0.555
CLV_PCSK_SKI1_1	214	218	PF00082	0.578
CLV_PCSK_SKI1_1	219	223	PF00082	0.594
CLV_PCSK_SKI1_1	350	354	PF00082	0.530
CLV_PCSK_SKI1_1	369	373	PF00082	0.266
CLV_PCSK_SKI1_1	436	440	PF00082	0.531
CLV_PCSK_SKI1_1	488	492	PF00082	0.601
CLV_PCSK_SKI1_1	677	681	PF00082	0.642
CLV_Separin_Metazoa	294	298	PF03568	0.483
DEG_Nend_Nbox_1	1	3	PF02207	0.675
DEG_ODPH_VHL_1	206	217	PF01847	0.592
DEG_ODPH_VHL_1	394	407	PF01847	0.561
DEG_SCF_FBW7_1	353	358	PF00400	0.314
DEG_SCF_FBW7_1	615	621	PF00400	0.494
DEG_SPOP_SBC_1	652	656	PF00917	0.684
DOC_CKS1_1	352	357	PF01111	0.590
DOC_CKS1_1	615	620	PF01111	0.692
DOC_CYCLIN_RxL_1	132	142	PF00134	0.575
DOC_CYCLIN_RxL_1	674	681	PF00134	0.707
DOC_CYCLIN_yCln2_LP_2	198	204	PF00134	0.280
DOC_CYCLIN_yCln2_LP_2	325	331	PF00134	0.663
DOC_CYCLIN_yCln2_LP_2	448	454	PF00134	0.570
DOC_CYCLIN_yCln2_LP_2	586	592	PF00134	0.519
DOC_MAPK_gen_1	245	252	PF00069	0.439
DOC_MAPK_gen_1	417	426	PF00069	0.466
DOC_MAPK_gen_1	686	694	PF00069	0.643
DOC_MAPK_MEF2A_6	245	252	PF00069	0.441
DOC_MAPK_MEF2A_6	273	280	PF00069	0.495
DOC_MAPK_MEF2A_6	445	454	PF00069	0.540
DOC_PP1_RVXF_1	434	441	PF00149	0.536
DOC_PP1_RVXF_1	475	481	PF00149	0.626
DOC_PP1_RVXF_1	572	579	PF00149	0.455
DOC_PP1_SILK_1	91	96	PF00149	0.557
DOC_PP2B_LxvP_1	205	208	PF13499	0.442
DOC_PP2B_LxvP_1	448	451	PF13499	0.534
DOC_PP4_FxxP_1	352	355	PF00568	0.588
DOC_PP4_FxxP_1	444	447	PF00568	0.633
DOC_PP4_FxxP_1	558	561	PF00568	0.684
DOC_PP4_FxxP_1	741	744	PF00568	0.499
DOC_SPAK_OSR1_1	417	421	PF12202	0.598
DOC_SPAK_OSR1_1	62	66	PF12202	0.527
DOC_USP7_MATH_1	192	196	PF00917	0.655
DOC_USP7_MATH_1	209	213	PF00917	0.466
DOC_USP7_MATH_1	301	305	PF00917	0.484
DOC_USP7_MATH_1	355	359	PF00917	0.631
DOC_USP7_MATH_1	363	367	PF00917	0.545
DOC_USP7_MATH_1	460	464	PF00917	0.580
DOC_USP7_MATH_1	482	486	PF00917	0.679
DOC_USP7_MATH_1	611	615	PF00917	0.632
DOC_USP7_MATH_1	709	713	PF00917	0.569
DOC_WW_Pin1_4	197	202	PF00397	0.559
DOC_WW_Pin1_4	351	356	PF00397	0.539
DOC_WW_Pin1_4	483	488	PF00397	0.687
DOC_WW_Pin1_4	512	517	PF00397	0.609
DOC_WW_Pin1_4	614	619	PF00397	0.630
LIG_14-3-3_CanoR_1	138	142	PF00244	0.596
LIG_14-3-3_CanoR_1	231	238	PF00244	0.642
LIG_14-3-3_CanoR_1	25	29	PF00244	0.651
LIG_14-3-3_CanoR_1	383	390	PF00244	0.540
LIG_14-3-3_CanoR_1	412	417	PF00244	0.460
LIG_Actin_WH2_2	122	140	PF00022	0.583
LIG_Actin_WH2_2	198	216	PF00022	0.584
LIG_APCC_ABBA_1	604	609	PF00400	0.594
LIG_BRCT_BRCA1_1	110	114	PF00533	0.469
LIG_BRCT_BRCA1_1	127	131	PF00533	0.351
LIG_BRCT_BRCA1_1	414	418	PF00533	0.443
LIG_BRCT_BRCA1_1	629	633	PF00533	0.487
LIG_BRCT_BRCA1_1	696	700	PF00533	0.635
LIG_BRCT_BRCA1_1	77	81	PF00533	0.417
LIG_CtBP_PxDLS_1	583	587	PF00389	0.547
LIG_deltaCOP1_diTrp_1	235	243	PF00928	0.626
LIG_EH1_1	80	88	PF00400	0.508
LIG_eIF4E_1	674	680	PF01652	0.716
LIG_FHA_1	29	35	PF00498	0.545
LIG_FHA_1	383	389	PF00498	0.491
LIG_FHA_1	402	408	PF00498	0.240
LIG_FHA_1	427	433	PF00498	0.690
LIG_FHA_1	45	51	PF00498	0.323
LIG_FHA_1	619	625	PF00498	0.518
LIG_FHA_1	689	695	PF00498	0.468
LIG_FHA_2	289	295	PF00498	0.355
LIG_FHA_2	429	435	PF00498	0.576
LIG_FHA_2	705	711	PF00498	0.562
LIG_HP1_1	201	205	PF01393	0.534
LIG_LIR_Apic_2	740	744	PF02991	0.590
LIG_LIR_Gen_1	111	121	PF02991	0.563
LIG_LIR_Gen_1	354	364	PF02991	0.514
LIG_LIR_Gen_1	379	388	PF02991	0.453
LIG_LIR_Gen_1	44	53	PF02991	0.264
LIG_LIR_Gen_1	564	572	PF02991	0.517
LIG_LIR_Gen_1	8	16	PF02991	0.532
LIG_LIR_Nem_3	111	117	PF02991	0.489
LIG_LIR_Nem_3	254	259	PF02991	0.549
LIG_LIR_Nem_3	321	325	PF02991	0.619
LIG_LIR_Nem_3	354	359	PF02991	0.533
LIG_LIR_Nem_3	379	384	PF02991	0.425
LIG_LIR_Nem_3	44	49	PF02991	0.259
LIG_LIR_Nem_3	564	569	PF02991	0.546
LIG_LIR_Nem_3	585	591	PF02991	0.496
LIG_LIR_Nem_3	747	752	PF02991	0.505
LIG_LIR_Nem_3	8	13	PF02991	0.530
LIG_LYPXL_yS_3	588	591	PF13949	0.500
LIG_NRBOX	81	87	PF00104	0.462
LIG_PDZ_Class_2	753	758	PF00595	0.520
LIG_Pex14_1	440	444	PF04695	0.606
LIG_REV1ctd_RIR_1	129	139	PF16727	0.478
LIG_SH2_CRK	364	368	PF00017	0.480
LIG_SH2_CRK	381	385	PF00017	0.336
LIG_SH2_NCK_1	539	543	PF00017	0.642
LIG_SH2_PTP2	10	13	PF00017	0.569
LIG_SH2_STAP1	153	157	PF00017	0.469
LIG_SH2_STAP1	225	229	PF00017	0.617
LIG_SH2_STAT5	10	13	PF00017	0.569
LIG_SH2_STAT5	364	367	PF00017	0.465
LIG_SH2_STAT5	511	514	PF00017	0.615
LIG_SH2_STAT5	566	569	PF00017	0.503
LIG_SH2_STAT5	671	674	PF00017	0.649
LIG_SH2_STAT5	752	755	PF00017	0.415
LIG_SH3_3	205	211	PF00018	0.588
LIG_SH3_3	390	396	PF00018	0.606
LIG_SH3_3	516	522	PF00018	0.627
LIG_SH3_3	657	663	PF00018	0.696
LIG_SUMO_SIM_anti_2	200	206	PF11976	0.432
LIG_SUMO_SIM_anti_2	406	411	PF11976	0.528
LIG_SUMO_SIM_par_1	298	304	PF11976	0.478
LIG_SUMO_SIM_par_1	30	36	PF11976	0.527
LIG_SUMO_SIM_par_1	403	408	PF11976	0.501
LIG_SUMO_SIM_par_1	428	434	PF11976	0.645
LIG_TRAF2_1	290	293	PF00917	0.522
LIG_TRAF2_1	713	716	PF00917	0.555
LIG_TRFH_1	558	562	PF08558	0.606
LIG_TYR_ITIM	586	591	PF00017	0.493
LIG_UBA3_1	720	728	PF00899	0.628
LIG_WRC_WIRS_1	356	361	PF05994	0.340
MOD_CDK_SPK_2	483	488	PF00069	0.687
MOD_CDK_SPxK_1	483	489	PF00069	0.688
MOD_CK1_1	224	230	PF00069	0.476
MOD_CK1_1	330	336	PF00069	0.552
MOD_CK1_1	357	363	PF00069	0.545
MOD_CK1_1	514	520	PF00069	0.566
MOD_CK1_1	55	61	PF00069	0.424
MOD_CK1_1	614	620	PF00069	0.688
MOD_CK1_1	655	661	PF00069	0.608
MOD_CK1_1	75	81	PF00069	0.483
MOD_CK2_1	231	237	PF00069	0.558
MOD_CK2_1	287	293	PF00069	0.522
MOD_CK2_1	628	634	PF00069	0.474
MOD_CK2_1	704	710	PF00069	0.512
MOD_CK2_1	737	743	PF00069	0.579
MOD_CK2_1	9	15	PF00069	0.594
MOD_Cter_Amidation	734	737	PF01082	0.587
MOD_GlcNHglycan	334	337	PF01048	0.577
MOD_GlcNHglycan	397	400	PF01048	0.379
MOD_GlcNHglycan	5	8	PF01048	0.617
MOD_GlcNHglycan	516	519	PF01048	0.559
MOD_GlcNHglycan	563	566	PF01048	0.664
MOD_GlcNHglycan	625	628	PF01048	0.626
MOD_GlcNHglycan	655	658	PF01048	0.722
MOD_GlcNHglycan	710	714	PF01048	0.572
MOD_GSK3_1	108	115	PF00069	0.508
MOD_GSK3_1	116	123	PF00069	0.461
MOD_GSK3_1	137	144	PF00069	0.507
MOD_GSK3_1	20	27	PF00069	0.624
MOD_GSK3_1	351	358	PF00069	0.447
MOD_GSK3_1	401	408	PF00069	0.533
MOD_GSK3_1	426	433	PF00069	0.617
MOD_GSK3_1	52	59	PF00069	0.597
MOD_GSK3_1	526	533	PF00069	0.630
MOD_GSK3_1	607	614	PF00069	0.610
MOD_GSK3_1	623	630	PF00069	0.460
MOD_GSK3_1	651	658	PF00069	0.609
MOD_GSK3_1	700	707	PF00069	0.614
MOD_N-GLC_2	471	473	PF02516	0.602
MOD_N-GLC_2	54	56	PF02516	0.588
MOD_N-GLC_2	603	605	PF02516	0.576
MOD_NEK2_1	106	111	PF00069	0.568
MOD_NEK2_1	137	142	PF00069	0.488
MOD_NEK2_1	156	161	PF00069	0.348
MOD_NEK2_1	20	25	PF00069	0.586
MOD_NEK2_1	251	256	PF00069	0.486
MOD_NEK2_1	52	57	PF00069	0.464
MOD_NEK2_1	584	589	PF00069	0.518
MOD_NEK2_1	597	602	PF00069	0.491
MOD_NEK2_1	623	628	PF00069	0.632
MOD_NEK2_1	633	638	PF00069	0.621
MOD_NEK2_1	653	658	PF00069	0.629
MOD_NEK2_1	700	705	PF00069	0.649
MOD_NEK2_1	720	725	PF00069	0.288
MOD_NEK2_1	81	86	PF00069	0.382
MOD_OFUCOSY	298	305	PF10250	0.478
MOD_OFUCOSY	72	79	PF10250	0.477
MOD_PIKK_1	382	388	PF00454	0.540
MOD_PKA_2	137	143	PF00069	0.597
MOD_PKA_2	24	30	PF00069	0.634
MOD_PKA_2	382	388	PF00069	0.565
MOD_PKA_2	688	694	PF00069	0.638
MOD_Plk_1	112	118	PF00069	0.544
MOD_Plk_1	405	411	PF00069	0.484
MOD_Plk_1	584	590	PF00069	0.533
MOD_Plk_1	709	715	PF00069	0.547
MOD_Plk_2-3	108	114	PF00069	0.264
MOD_Plk_2-3	28	34	PF00069	0.564
MOD_Plk_2-3	428	434	PF00069	0.646
MOD_Plk_2-3	9	15	PF00069	0.617
MOD_Plk_4	15	21	PF00069	0.616
MOD_Plk_4	252	258	PF00069	0.438
MOD_Plk_4	318	324	PF00069	0.566
MOD_Plk_4	405	411	PF00069	0.444
MOD_Plk_4	41	47	PF00069	0.260
MOD_Plk_4	460	466	PF00069	0.508
MOD_Plk_4	592	598	PF00069	0.532
MOD_Plk_4	611	617	PF00069	0.463
MOD_Plk_4	628	634	PF00069	0.349
MOD_Plk_4	656	662	PF00069	0.573
MOD_Plk_4	81	87	PF00069	0.369
MOD_Plk_4	89	95	PF00069	0.389
MOD_ProDKin_1	197	203	PF00069	0.548
MOD_ProDKin_1	351	357	PF00069	0.538
MOD_ProDKin_1	483	489	PF00069	0.688
MOD_ProDKin_1	512	518	PF00069	0.607
MOD_ProDKin_1	614	620	PF00069	0.628
MOD_SUMO_rev_2	428	438	PF00179	0.549
MOD_SUMO_rev_2	697	703	PF00179	0.513
TRG_DiLeu_BaEn_1	716	721	PF01217	0.550
TRG_DiLeu_BaEn_2	246	252	PF01217	0.251
TRG_DiLeu_BaEn_2	47	53	PF01217	0.459
TRG_DiLeu_BaLyEn_6	586	591	PF01217	0.518
TRG_ENDOCYTIC_2	10	13	PF00928	0.526
TRG_ENDOCYTIC_2	153	156	PF00928	0.508
TRG_ENDOCYTIC_2	256	259	PF00928	0.538
TRG_ENDOCYTIC_2	322	325	PF00928	0.602
TRG_ENDOCYTIC_2	356	359	PF00928	0.599
TRG_ENDOCYTIC_2	364	367	PF00928	0.461
TRG_ENDOCYTIC_2	381	384	PF00928	0.340
TRG_ENDOCYTIC_2	566	569	PF00928	0.502
TRG_ENDOCYTIC_2	588	591	PF00928	0.500
TRG_ENDOCYTIC_2	97	100	PF00928	0.583
TRG_ER_diArg_1	349	351	PF00400	0.413
TRG_ER_diArg_1	682	685	PF00400	0.616
TRG_NES_CRM1_1	104	120	PF08389	0.568
TRG_NLS_MonoExtC_3	681	686	PF00514	0.637
TRG_Pf-PMV_PEXEL_1	683	687	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N0	Leptomonas seymouri	53%	89%
A0A1X0NTF1	Trypanosomatidae	30%	88%
A0A3Q8ILH1	Leishmania donovani	93%	100%
A0A422NYN9	Trypanosoma rangeli	30%	88%
A4HKU3	Leishmania braziliensis	81%	100%
A4I8C2	Leishmania infantum	93%	100%
D0AAV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	88%
Q4Q4X4	Leishmania major	91%	100%