Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B380_LEIMU

TriTrypDb:

LmxM.31.2985

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 0
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B380

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B380

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	80	82	PF00675	0.412
CLV_PCSK_KEX2_1	80	82	PF00082	0.478
CLV_PCSK_SKI1_1	38	42	PF00082	0.462
CLV_PCSK_SKI1_1	69	73	PF00082	0.552
DEG_Nend_UBRbox_3	1	3	PF02207	0.511
DOC_CDC14_PxL_1	156	164	PF14671	0.385
DOC_MAPK_gen_1	174	184	PF00069	0.259
DOC_MAPK_MEF2A_6	104	112	PF00069	0.424
DOC_PP1_RVXF_1	85	91	PF00149	0.245
DOC_PP2B_PxIxI_1	105	111	PF00149	0.323
DOC_USP7_MATH_1	40	44	PF00917	0.427
DOC_USP7_UBL2_3	38	42	PF12436	0.383
LIG_14-3-3_CanoR_1	80	90	PF00244	0.429
LIG_BRCT_BRCA1_1	168	172	PF00533	0.313
LIG_FHA_1	145	151	PF00498	0.396
LIG_FHA_1	4	10	PF00498	0.516
LIG_FHA_1	54	60	PF00498	0.391
LIG_LIR_Apic_2	100	106	PF02991	0.438
LIG_LIR_Gen_1	169	176	PF02991	0.324
LIG_LIR_LC3C_4	6	9	PF02991	0.391
LIG_LIR_Nem_3	154	158	PF02991	0.462
LIG_LIR_Nem_3	169	175	PF02991	0.288
LIG_SH2_CRK	103	107	PF00017	0.452
LIG_SH2_CRK	170	174	PF00017	0.340
LIG_SH2_CRK	60	64	PF00017	0.351
LIG_SH2_SRC	118	121	PF00017	0.352
LIG_SH2_SRC	124	127	PF00017	0.343
LIG_SH2_STAP1	135	139	PF00017	0.357
LIG_SH2_STAT5	118	121	PF00017	0.418
LIG_SH2_STAT5	124	127	PF00017	0.343
LIG_SH2_STAT5	156	159	PF00017	0.542
LIG_SH2_STAT5	83	86	PF00017	0.510
LIG_SUMO_SIM_anti_2	180	187	PF11976	0.354
LIG_SUMO_SIM_par_1	5	10	PF11976	0.420
LIG_TRFH_1	156	160	PF08558	0.356
LIG_TYR_ITIM	122	127	PF00017	0.365
MOD_CK1_1	62	68	PF00069	0.445
MOD_CK2_1	160	166	PF00069	0.540
MOD_GlcNHglycan	162	165	PF01048	0.463
MOD_GSK3_1	140	147	PF00069	0.398
MOD_GSK3_1	184	191	PF00069	0.448
MOD_GSK3_1	3	10	PF00069	0.428
MOD_GSK3_1	47	54	PF00069	0.450
MOD_GSK3_1	95	102	PF00069	0.340
MOD_N-GLC_1	51	56	PF02516	0.524
MOD_NEK2_1	133	138	PF00069	0.526
MOD_NEK2_1	144	149	PF00069	0.380
MOD_NEK2_1	3	8	PF00069	0.511
MOD_PKA_2	140	146	PF00069	0.471
MOD_PKB_1	97	105	PF00069	0.428
MOD_Plk_1	131	137	PF00069	0.380
MOD_Plk_1	22	28	PF00069	0.565
MOD_Plk_2-3	22	28	PF00069	0.565
MOD_Plk_4	140	146	PF00069	0.529
MOD_Plk_4	151	157	PF00069	0.479
MOD_Plk_4	3	9	PF00069	0.374
MOD_Plk_4	59	65	PF00069	0.358
TRG_DiLeu_BaLyEn_6	103	108	PF01217	0.407
TRG_ENDOCYTIC_2	124	127	PF00928	0.470
TRG_ENDOCYTIC_2	155	158	PF00928	0.508
TRG_ENDOCYTIC_2	170	173	PF00928	0.283
TRG_ENDOCYTIC_2	60	63	PF00928	0.358
TRG_ER_diArg_1	87	90	PF00400	0.293
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NRP9	Trypanosomatidae	38%	99%
A0A3Q8IFP0	Leishmania donovani	92%	100%
A0A422NZW7	Trypanosoma rangeli	38%	99%
A4HKU2	Leishmania braziliensis	76%	100%
A4I8C1	Leishmania infantum	91%	100%
D0AAJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	99%
Q9U1D7	Leishmania major	89%	100%