DNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

minichromosome maintenance (MCM) complex subunit, putative

Species:

Leishmania mexicana

UniProt:

E9B377_LEIMU

TriTrypDb:

LmxM.31.2960

Length:

725

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0032991	protein-containing complex	1	11
GO:0042555	MCM complex	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

E9B377

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B377

Function

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Biological processes
Term	Name	Level	Count
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0000727	double-strand break repair via break-induced replication	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006259	DNA metabolic process	4	11
GO:0006268	DNA unwinding involved in DNA replication	9	1
GO:0006270	DNA replication initiation	5	11
GO:0006271	DNA strand elongation involved in DNA replication	6	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003678	DNA helicase activity	3	11
GO:0003697	single-stranded DNA binding	5	1
GO:0003824	catalytic activity	1	11
GO:0004386	helicase activity	2	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0008094	ATP-dependent activity, acting on DNA	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.528
CLV_C14_Caspase3-7	661	665	PF00656	0.488
CLV_NRD_NRD_1	126	128	PF00675	0.258
CLV_PCSK_FUR_1	491	495	PF00082	0.258
CLV_PCSK_KEX2_1	126	128	PF00082	0.258
CLV_PCSK_KEX2_1	28	30	PF00082	0.272
CLV_PCSK_KEX2_1	304	306	PF00082	0.497
CLV_PCSK_KEX2_1	493	495	PF00082	0.258
CLV_PCSK_KEX2_1	573	575	PF00082	0.310
CLV_PCSK_KEX2_1	6	8	PF00082	0.691

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P686	Leptomonas seymouri	34%	84%
A0A0N0P9H0	Leptomonas seymouri	31%	79%
A0A0N1I2J6	Leptomonas seymouri	33%	81%
A0A0N1I371	Leptomonas seymouri	91%	100%
A0A0N1PC47	Leptomonas seymouri	33%	91%
A0A0S4IVB8	Bodo saltans	33%	83%
A0A0S4IW18	Bodo saltans	32%	90%
A0A0S4IYQ3	Bodo saltans	29%	90%
A0A0S4J4D4	Bodo saltans	30%	78%
A0A0S4J5X8	Bodo saltans	31%	96%

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