Piwi domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B374_LEIMU

TriTrypDb:

LmxM.31.2940

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B374

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B374

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	484	488	PF00656	0.374
CLV_NRD_NRD_1	129	131	PF00675	0.603
CLV_NRD_NRD_1	397	399	PF00675	0.565
CLV_NRD_NRD_1	464	466	PF00675	0.414
CLV_NRD_NRD_1	567	569	PF00675	0.665
CLV_NRD_NRD_1	75	77	PF00675	0.514
CLV_PCSK_KEX2_1	210	212	PF00082	0.315
CLV_PCSK_KEX2_1	396	398	PF00082	0.560
CLV_PCSK_KEX2_1	536	538	PF00082	0.475
CLV_PCSK_KEX2_1	569	571	PF00082	0.694
CLV_PCSK_KEX2_1	75	77	PF00082	0.537
CLV_PCSK_PC1ET2_1	210	212	PF00082	0.315
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.475
CLV_PCSK_PC1ET2_1	569	571	PF00082	0.694
CLV_PCSK_SKI1_1	110	114	PF00082	0.555
CLV_PCSK_SKI1_1	134	138	PF00082	0.418
CLV_PCSK_SKI1_1	152	156	PF00082	0.467
CLV_PCSK_SKI1_1	16	20	PF00082	0.612
CLV_PCSK_SKI1_1	376	380	PF00082	0.512
CLV_PCSK_SKI1_1	521	525	PF00082	0.488
DEG_Nend_UBRbox_1	1	4	PF02207	0.584
DEG_ODPH_VHL_1	257	270	PF01847	0.260
DOC_CYCLIN_yCln2_LP_2	14	20	PF00134	0.699
DOC_MAPK_DCC_7	10	20	PF00069	0.717
DOC_MAPK_gen_1	167	176	PF00069	0.456
DOC_MAPK_gen_1	440	449	PF00069	0.315
DOC_MAPK_gen_1	465	472	PF00069	0.389
DOC_MAPK_gen_1	536	543	PF00069	0.424
DOC_MAPK_gen_1	75	83	PF00069	0.513
DOC_MAPK_JIP1_4	598	604	PF00069	0.714
DOC_MAPK_MEF2A_6	152	160	PF00069	0.389
DOC_MAPK_MEF2A_6	536	545	PF00069	0.421
DOC_MAPK_MEF2A_6	87	95	PF00069	0.530
DOC_MAPK_RevD_3	93	107	PF00069	0.476
DOC_PP1_RVXF_1	508	515	PF00149	0.496
DOC_PP1_RVXF_1	558	565	PF00149	0.424
DOC_PP1_SILK_1	223	228	PF00149	0.391
DOC_PP1_SILK_1	431	436	PF00149	0.389
DOC_PP2B_LxvP_1	410	413	PF13499	0.512
DOC_PP4_FxxP_1	495	498	PF00568	0.455
DOC_SPAK_OSR1_1	66	70	PF12202	0.547
DOC_USP7_MATH_1	306	310	PF00917	0.612
DOC_USP7_MATH_1	506	510	PF00917	0.528
DOC_USP7_MATH_2	498	504	PF00917	0.494
DOC_USP7_UBL2_3	102	106	PF12436	0.437
DOC_USP7_UBL2_3	507	511	PF12436	0.628
DOC_WW_Pin1_4	228	233	PF00397	0.315
DOC_WW_Pin1_4	350	355	PF00397	0.592
DOC_WW_Pin1_4	442	447	PF00397	0.315
LIG_14-3-3_CanoR_1	177	183	PF00244	0.429
LIG_14-3-3_CanoR_1	227	232	PF00244	0.334
LIG_14-3-3_CanoR_1	576	586	PF00244	0.514
LIG_14-3-3_CanoR_1	66	72	PF00244	0.428
LIG_14-3-3_CanoR_1	75	83	PF00244	0.484
LIG_BIR_III_2	478	482	PF00653	0.444
LIG_BIR_III_4	289	293	PF00653	0.480
LIG_BRCT_BRCA1_1	63	67	PF00533	0.566
LIG_FHA_1	22	28	PF00498	0.663
LIG_FHA_1	260	266	PF00498	0.315
LIG_FHA_1	360	366	PF00498	0.648
LIG_FHA_1	434	440	PF00498	0.476
LIG_FHA_1	582	588	PF00498	0.498
LIG_LIR_Apic_2	493	498	PF02991	0.446
LIG_LIR_Apic_2	593	599	PF02991	0.593
LIG_LIR_Gen_1	323	334	PF02991	0.475
LIG_LIR_Gen_1	406	417	PF02991	0.682
LIG_LIR_LC3C_4	377	381	PF02991	0.480
LIG_LIR_Nem_3	294	299	PF02991	0.435
LIG_LIR_Nem_3	323	329	PF02991	0.486
LIG_LIR_Nem_3	487	492	PF02991	0.315
LIG_LIR_Nem_3	517	523	PF02991	0.454
LIG_NRBOX	140	146	PF00104	0.433
LIG_Pex14_2	386	390	PF04695	0.551
LIG_PTB_Apo_2	40	47	PF02174	0.448
LIG_SH2_CRK	229	233	PF00017	0.334
LIG_SH2_CRK	341	345	PF00017	0.534
LIG_SH2_CRK	596	600	PF00017	0.603
LIG_SH2_GRB2like	242	245	PF00017	0.435
LIG_SH2_GRB2like	399	402	PF00017	0.546
LIG_SH2_GRB2like	92	95	PF00017	0.299
LIG_SH2_NCK_1	596	600	PF00017	0.603
LIG_SH2_PTP2	469	472	PF00017	0.435
LIG_SH2_SRC	242	245	PF00017	0.186
LIG_SH2_SRC	92	95	PF00017	0.383
LIG_SH2_STAP1	341	345	PF00017	0.490
LIG_SH2_STAP1	63	67	PF00017	0.541
LIG_SH2_STAT3	578	581	PF00017	0.474
LIG_SH2_STAT5	229	232	PF00017	0.315
LIG_SH2_STAT5	242	245	PF00017	0.315
LIG_SH2_STAT5	409	412	PF00017	0.663
LIG_SH2_STAT5	469	472	PF00017	0.435
LIG_SH2_STAT5	531	534	PF00017	0.532
LIG_SH2_STAT5	596	599	PF00017	0.592
LIG_SH2_STAT5	92	95	PF00017	0.383
LIG_SH3_3	209	215	PF00018	0.186
LIG_SH3_3	253	259	PF00018	0.315
LIG_SH3_3	267	273	PF00018	0.396
LIG_SH3_3	440	446	PF00018	0.231
LIG_SH3_3	66	72	PF00018	0.429
LIG_SH3_3	78	84	PF00018	0.434
LIG_SUMO_SIM_anti_2	267	272	PF11976	0.458
LIG_SUMO_SIM_par_1	172	178	PF11976	0.560
LIG_SUMO_SIM_par_1	264	269	PF11976	0.292
LIG_TRAF2_1	147	150	PF00917	0.567
LIG_TRAF2_1	481	484	PF00917	0.377
LIG_TYR_ITIM	90	95	PF00017	0.369
LIG_UBA3_1	279	285	PF00899	0.518
LIG_UBA3_1	501	507	PF00899	0.522
LIG_WRC_WIRS_1	434	439	PF05994	0.391
MOD_CK1_1	178	184	PF00069	0.450
MOD_CK1_1	343	349	PF00069	0.596
MOD_CK1_1	39	45	PF00069	0.498
MOD_CK1_1	563	569	PF00069	0.581
MOD_CK1_1	580	586	PF00069	0.352
MOD_CK1_1	594	600	PF00069	0.596
MOD_CK1_1	74	80	PF00069	0.477
MOD_CK2_1	355	361	PF00069	0.667
MOD_CK2_1	541	547	PF00069	0.411
MOD_CK2_1	548	554	PF00069	0.497
MOD_Cter_Amidation	208	211	PF01082	0.315
MOD_Cter_Amidation	382	385	PF01082	0.589
MOD_GlcNHglycan	177	180	PF01048	0.515
MOD_GlcNHglycan	21	24	PF01048	0.573
MOD_GlcNHglycan	357	360	PF01048	0.684
MOD_GlcNHglycan	550	553	PF01048	0.501
MOD_GSK3_1	33	40	PF00069	0.474
MOD_GSK3_1	339	346	PF00069	0.586
MOD_GSK3_1	355	362	PF00069	0.430
MOD_GSK3_1	429	436	PF00069	0.389
MOD_GSK3_1	556	563	PF00069	0.542
MOD_GSK3_1	577	584	PF00069	0.481
MOD_GSK3_1	590	597	PF00069	0.570
MOD_GSK3_1	67	74	PF00069	0.403
MOD_N-GLC_1	259	264	PF02516	0.334
MOD_N-GLC_2	546	548	PF02516	0.479
MOD_NEK2_1	119	124	PF00069	0.455
MOD_NEK2_1	264	269	PF00069	0.296
MOD_NEK2_1	355	360	PF00069	0.642
MOD_NEK2_1	365	370	PF00069	0.601
MOD_NEK2_1	37	42	PF00069	0.499
MOD_NEK2_1	515	520	PF00069	0.446
MOD_NEK2_1	541	546	PF00069	0.426
MOD_NEK2_1	62	67	PF00069	0.551
MOD_NEK2_2	531	536	PF00069	0.540
MOD_NEK2_2	591	596	PF00069	0.574
MOD_PIKK_1	577	583	PF00454	0.462
MOD_PIKK_1	67	73	PF00454	0.541
MOD_PK_1	429	435	PF00069	0.389
MOD_PKA_2	346	352	PF00069	0.532
MOD_PKA_2	74	80	PF00069	0.495
MOD_PKB_1	568	576	PF00069	0.671
MOD_Plk_1	33	39	PF00069	0.459
MOD_Plk_1	429	435	PF00069	0.420
MOD_Plk_4	266	272	PF00069	0.503
MOD_Plk_4	27	33	PF00069	0.591
MOD_Plk_4	340	346	PF00069	0.590
MOD_Plk_4	429	435	PF00069	0.423
MOD_Plk_4	500	506	PF00069	0.487
MOD_Plk_4	591	597	PF00069	0.576
MOD_ProDKin_1	228	234	PF00069	0.315
MOD_ProDKin_1	350	356	PF00069	0.598
MOD_ProDKin_1	442	448	PF00069	0.315
MOD_SUMO_for_1	496	499	PF00179	0.588
TRG_DiLeu_BaEn_1	375	380	PF01217	0.410
TRG_DiLeu_BaEn_3	150	156	PF01217	0.509
TRG_DiLeu_BaLyEn_6	10	15	PF01217	0.638
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.462
TRG_DiLeu_BaLyEn_6	421	426	PF01217	0.462
TRG_ENDOCYTIC_2	242	245	PF00928	0.435
TRG_ENDOCYTIC_2	341	344	PF00928	0.542
TRG_ENDOCYTIC_2	409	412	PF00928	0.606
TRG_ENDOCYTIC_2	469	472	PF00928	0.435
TRG_ENDOCYTIC_2	92	95	PF00928	0.383
TRG_ER_diArg_1	308	311	PF00400	0.497
TRG_ER_diArg_1	396	398	PF00400	0.550
TRG_NLS_MonoExtC_3	283	288	PF00514	0.585
TRG_NLS_MonoExtN_4	130	135	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	152	157	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBK1	Leptomonas seymouri	70%	100%
A0A1X0NRN7	Trypanosomatidae	58%	99%
A0A3R7NSK8	Trypanosoma rangeli	59%	100%
A0A3S7X5W5	Leishmania donovani	95%	100%
A4HKT6	Leishmania braziliensis	86%	100%
A4I8B5	Leishmania infantum	95%	100%
D0AAI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	99%
Q9U1E2	Leishmania major	93%	100%
V5DE73	Trypanosoma cruzi	56%	100%