Tox-GHH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B372_LEIMU

TriTrypDb:

LmxM.31.2920

Length:

727

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 6
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9B372

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B372

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.555
CLV_NRD_NRD_1	202	204	PF00675	0.542
CLV_NRD_NRD_1	256	258	PF00675	0.678
CLV_NRD_NRD_1	297	299	PF00675	0.643
CLV_NRD_NRD_1	309	311	PF00675	0.598
CLV_NRD_NRD_1	356	358	PF00675	0.634
CLV_NRD_NRD_1	538	540	PF00675	0.522
CLV_NRD_NRD_1	561	563	PF00675	0.774
CLV_NRD_NRD_1	603	605	PF00675	0.658
CLV_NRD_NRD_1	81	83	PF00675	0.636
CLV_PCSK_KEX2_1	202	204	PF00082	0.542
CLV_PCSK_KEX2_1	297	299	PF00082	0.678
CLV_PCSK_KEX2_1	309	311	PF00082	0.675
CLV_PCSK_KEX2_1	355	357	PF00082	0.668
CLV_PCSK_KEX2_1	537	539	PF00082	0.515
CLV_PCSK_KEX2_1	603	605	PF00082	0.636
CLV_PCSK_KEX2_1	723	725	PF00082	0.438
CLV_PCSK_KEX2_1	80	82	PF00082	0.627
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.676
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.479
CLV_PCSK_PC7_1	293	299	PF00082	0.716
CLV_PCSK_SKI1_1	351	355	PF00082	0.658
CLV_PCSK_SKI1_1	48	52	PF00082	0.575
CLV_PCSK_SKI1_1	538	542	PF00082	0.611
CLV_PCSK_SKI1_1	570	574	PF00082	0.584
CLV_PCSK_SKI1_1	60	64	PF00082	0.430
CLV_PCSK_SKI1_1	720	724	PF00082	0.455
DEG_Nend_UBRbox_1	1	4	PF02207	0.418
DEG_SCF_FBW7_1	133	139	PF00400	0.321
DOC_CKS1_1	133	138	PF01111	0.425
DOC_CKS1_1	98	103	PF01111	0.401
DOC_MAPK_gen_1	2	11	PF00069	0.386
DOC_MAPK_gen_1	355	365	PF00069	0.360
DOC_MAPK_gen_1	586	594	PF00069	0.475
DOC_MAPK_gen_1	623	633	PF00069	0.329
DOC_MAPK_MEF2A_6	2	11	PF00069	0.388
DOC_MAPK_MEF2A_6	333	341	PF00069	0.436
DOC_MAPK_MEF2A_6	497	506	PF00069	0.316
DOC_MAPK_RevD_3	681	697	PF00069	0.331
DOC_PP1_RVXF_1	201	208	PF00149	0.239
DOC_PP1_RVXF_1	536	543	PF00149	0.311
DOC_PP2B_LxvP_1	146	149	PF13499	0.264
DOC_PP4_FxxP_1	32	35	PF00568	0.268
DOC_USP7_MATH_1	136	140	PF00917	0.282
DOC_USP7_MATH_1	54	58	PF00917	0.415
DOC_USP7_MATH_1	552	556	PF00917	0.432
DOC_USP7_MATH_1	561	565	PF00917	0.368
DOC_USP7_UBL2_3	295	299	PF12436	0.422
DOC_WW_Pin1_4	132	137	PF00397	0.362
DOC_WW_Pin1_4	496	501	PF00397	0.310
DOC_WW_Pin1_4	550	555	PF00397	0.410
DOC_WW_Pin1_4	97	102	PF00397	0.375
LIG_14-3-3_CanoR_1	309	314	PF00244	0.491
LIG_14-3-3_CanoR_1	342	350	PF00244	0.468
LIG_14-3-3_CanoR_1	478	484	PF00244	0.483
LIG_14-3-3_CanoR_1	60	70	PF00244	0.310
LIG_14-3-3_CanoR_1	670	679	PF00244	0.391
LIG_14-3-3_CanoR_1	718	723	PF00244	0.740
LIG_14-3-3_CterR_2	724	727	PF00244	0.629
LIG_Actin_WH2_2	327	344	PF00022	0.412
LIG_BIR_III_4	183	187	PF00653	0.295
LIG_BRCT_BRCA1_1	24	28	PF00533	0.388
LIG_BRCT_BRCA1_1	360	364	PF00533	0.376
LIG_deltaCOP1_diTrp_1	260	266	PF00928	0.319
LIG_FHA_1	40	46	PF00498	0.395
LIG_FHA_1	451	457	PF00498	0.406
LIG_FHA_1	480	486	PF00498	0.399
LIG_FHA_1	497	503	PF00498	0.206
LIG_FHA_1	525	531	PF00498	0.320
LIG_FHA_1	605	611	PF00498	0.381
LIG_FHA_1	626	632	PF00498	0.354
LIG_FHA_1	649	655	PF00498	0.386
LIG_FHA_1	705	711	PF00498	0.663
LIG_FHA_1	98	104	PF00498	0.410
LIG_FHA_2	224	230	PF00498	0.530
LIG_FHA_2	263	269	PF00498	0.355
LIG_FHA_2	322	328	PF00498	0.365
LIG_FHA_2	392	398	PF00498	0.321
LIG_FHA_2	447	453	PF00498	0.227
LIG_FHA_2	529	535	PF00498	0.292
LIG_LIR_Apic_2	704	709	PF02991	0.718
LIG_LIR_Gen_1	123	133	PF02991	0.368
LIG_LIR_Gen_1	260	271	PF02991	0.373
LIG_LIR_Gen_1	394	404	PF02991	0.342
LIG_LIR_Gen_1	425	436	PF02991	0.398
LIG_LIR_Gen_1	518	525	PF02991	0.365
LIG_LIR_Gen_1	658	666	PF02991	0.308
LIG_LIR_Gen_1	67	78	PF02991	0.404
LIG_LIR_Gen_1	84	94	PF02991	0.248
LIG_LIR_Nem_3	260	266	PF02991	0.323
LIG_LIR_Nem_3	394	399	PF02991	0.319
LIG_LIR_Nem_3	425	431	PF02991	0.416
LIG_LIR_Nem_3	518	523	PF02991	0.368
LIG_LIR_Nem_3	600	605	PF02991	0.422
LIG_LIR_Nem_3	658	663	PF02991	0.298
LIG_LIR_Nem_3	67	73	PF02991	0.287
LIG_LIR_Nem_3	84	90	PF02991	0.269
LIG_LYPXL_S_1	286	290	PF13949	0.525
LIG_LYPXL_yS_3	287	290	PF13949	0.328
LIG_NRBOX	678	684	PF00104	0.411
LIG_Pex14_2	28	32	PF04695	0.373
LIG_PTB_Apo_2	72	79	PF02174	0.325
LIG_PTB_Phospho_1	72	78	PF10480	0.322
LIG_RPA_C_Fungi	665	677	PF08784	0.341
LIG_SH2_CRK	428	432	PF00017	0.517
LIG_SH2_CRK	706	710	PF00017	0.671
LIG_SH2_CRK	99	103	PF00017	0.367
LIG_SH2_GRB2like	70	73	PF00017	0.311
LIG_SH2_NCK_1	396	400	PF00017	0.406
LIG_SH2_SRC	278	281	PF00017	0.432
LIG_SH2_SRC	396	399	PF00017	0.391
LIG_SH2_SRC	70	73	PF00017	0.311
LIG_SH2_STAP1	278	282	PF00017	0.478
LIG_SH2_STAP1	520	524	PF00017	0.445
LIG_SH2_STAT5	109	112	PF00017	0.472
LIG_SH2_STAT5	206	209	PF00017	0.386
LIG_SH2_STAT5	253	256	PF00017	0.552
LIG_SH2_STAT5	378	381	PF00017	0.378
LIG_SH2_STAT5	608	611	PF00017	0.324
LIG_SH2_STAT5	70	73	PF00017	0.446
LIG_SH2_STAT5	706	709	PF00017	0.672
LIG_SH2_STAT5	78	81	PF00017	0.560
LIG_SH2_STAT5	99	102	PF00017	0.513
LIG_SH3_3	41	47	PF00018	0.489
LIG_SH3_3	634	640	PF00018	0.353
LIG_SH3_3	95	101	PF00018	0.398
LIG_SH3_4	573	580	PF00018	0.372
LIG_SUMO_SIM_anti_2	159	165	PF11976	0.343
LIG_SUMO_SIM_anti_2	482	488	PF11976	0.486
LIG_SUMO_SIM_anti_2	5	10	PF11976	0.398
LIG_SUMO_SIM_anti_2	616	622	PF11976	0.222
LIG_SUMO_SIM_anti_2	653	658	PF11976	0.324
LIG_SUMO_SIM_par_1	48	53	PF11976	0.341
LIG_SUMO_SIM_par_1	606	614	PF11976	0.296
LIG_SUMO_SIM_par_1	639	645	PF11976	0.378
LIG_SUMO_SIM_par_1	653	658	PF11976	0.305
LIG_TYR_ITIM	426	431	PF00017	0.541
LIG_TYR_ITIM	68	73	PF00017	0.368
LIG_TYR_ITSM	392	399	PF00017	0.412
MOD_CK1_1	132	138	PF00069	0.429
MOD_CK1_1	153	159	PF00069	0.477
MOD_CK1_1	381	387	PF00069	0.369
MOD_CK1_1	407	413	PF00069	0.507
MOD_CK1_1	493	499	PF00069	0.426
MOD_CK1_1	629	635	PF00069	0.336
MOD_CK1_1	64	70	PF00069	0.465
MOD_CK1_1	669	675	PF00069	0.441
MOD_CK2_1	182	188	PF00069	0.440
MOD_CK2_1	262	268	PF00069	0.595
MOD_CK2_1	321	327	PF00069	0.416
MOD_CK2_1	438	444	PF00069	0.557
MOD_CK2_1	629	635	PF00069	0.443
MOD_Cter_Amidation	255	258	PF01082	0.523
MOD_GlcNHglycan	183	187	PF01048	0.550
MOD_GlcNHglycan	192	195	PF01048	0.365
MOD_GlcNHglycan	334	337	PF01048	0.710
MOD_GlcNHglycan	440	443	PF01048	0.618
MOD_GlcNHglycan	55	59	PF01048	0.546
MOD_GlcNHglycan	92	95	PF01048	0.401
MOD_GSK3_1	107	114	PF00069	0.464
MOD_GSK3_1	132	139	PF00069	0.444
MOD_GSK3_1	18	25	PF00069	0.507
MOD_GSK3_1	262	269	PF00069	0.470
MOD_GSK3_1	337	344	PF00069	0.609
MOD_GSK3_1	378	385	PF00069	0.368
MOD_GSK3_1	446	453	PF00069	0.382
MOD_GSK3_1	524	531	PF00069	0.313
MOD_GSK3_1	615	622	PF00069	0.386
MOD_GSK3_1	625	632	PF00069	0.446
MOD_GSK3_1	665	672	PF00069	0.386
MOD_GSK3_1	718	725	PF00069	0.608
MOD_GSK3_1	9	16	PF00069	0.525
MOD_N-GLC_1	112	117	PF02516	0.482
MOD_N-GLC_1	223	228	PF02516	0.623
MOD_N-GLC_1	351	356	PF02516	0.657
MOD_N-GLC_1	446	451	PF02516	0.363
MOD_N-GLC_1	718	723	PF02516	0.449
MOD_NEK2_1	112	117	PF00069	0.451
MOD_NEK2_1	129	134	PF00069	0.439
MOD_NEK2_1	13	18	PF00069	0.593
MOD_NEK2_1	141	146	PF00069	0.398
MOD_NEK2_1	190	195	PF00069	0.500
MOD_NEK2_1	266	271	PF00069	0.471
MOD_NEK2_1	337	342	PF00069	0.562
MOD_NEK2_1	446	451	PF00069	0.361
MOD_NEK2_1	485	490	PF00069	0.511
MOD_NEK2_1	524	529	PF00069	0.347
MOD_NEK2_1	62	67	PF00069	0.336
MOD_NEK2_1	665	670	PF00069	0.440
MOD_NEK2_2	262	267	PF00069	0.560
MOD_NEK2_2	391	396	PF00069	0.329
MOD_NEK2_2	598	603	PF00069	0.666
MOD_PIKK_1	141	147	PF00454	0.534
MOD_PIKK_1	18	24	PF00454	0.505
MOD_PIKK_1	342	348	PF00454	0.662
MOD_PIKK_1	407	413	PF00454	0.386
MOD_PIKK_1	450	456	PF00454	0.544
MOD_PKA_1	309	315	PF00069	0.676
MOD_PKA_2	266	272	PF00069	0.496
MOD_PKA_2	300	306	PF00069	0.757
MOD_PKA_2	308	314	PF00069	0.669
MOD_PKA_2	341	347	PF00069	0.699
MOD_PKA_2	358	364	PF00069	0.462
MOD_PKA_2	561	567	PF00069	0.732
MOD_PKA_2	587	593	PF00069	0.609
MOD_PKA_2	669	675	PF00069	0.545
MOD_Plk_1	112	118	PF00069	0.520
MOD_Plk_1	446	452	PF00069	0.361
MOD_Plk_1	590	596	PF00069	0.526
MOD_Plk_1	615	621	PF00069	0.472
MOD_Plk_1	704	710	PF00069	0.636
MOD_Plk_1	718	724	PF00069	0.449
MOD_Plk_4	112	118	PF00069	0.494
MOD_Plk_4	136	142	PF00069	0.442
MOD_Plk_4	266	272	PF00069	0.527
MOD_Plk_4	382	388	PF00069	0.403
MOD_Plk_4	579	585	PF00069	0.480
MOD_Plk_4	590	596	PF00069	0.571
MOD_Plk_4	604	610	PF00069	0.343
MOD_Plk_4	615	621	PF00069	0.308
MOD_Plk_4	73	79	PF00069	0.484
MOD_Plk_4	83	89	PF00069	0.428
MOD_Plk_4	9	15	PF00069	0.510
MOD_ProDKin_1	132	138	PF00069	0.442
MOD_ProDKin_1	496	502	PF00069	0.373
MOD_ProDKin_1	550	556	PF00069	0.522
MOD_ProDKin_1	97	103	PF00069	0.463
MOD_SUMO_rev_2	193	199	PF00179	0.386
TRG_DiLeu_BaEn_1	124	129	PF01217	0.455
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.634
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.409
TRG_ENDOCYTIC_2	109	112	PF00928	0.420
TRG_ENDOCYTIC_2	126	129	PF00928	0.415
TRG_ENDOCYTIC_2	192	195	PF00928	0.440
TRG_ENDOCYTIC_2	278	281	PF00928	0.403
TRG_ENDOCYTIC_2	287	290	PF00928	0.318
TRG_ENDOCYTIC_2	396	399	PF00928	0.326
TRG_ENDOCYTIC_2	428	431	PF00928	0.465
TRG_ENDOCYTIC_2	520	523	PF00928	0.446
TRG_ENDOCYTIC_2	581	584	PF00928	0.581
TRG_ENDOCYTIC_2	660	663	PF00928	0.363
TRG_ENDOCYTIC_2	70	73	PF00928	0.343
TRG_ENDOCYTIC_2	99	102	PF00928	0.396
TRG_ER_diArg_1	1	4	PF00400	0.418
TRG_ER_diArg_1	202	204	PF00400	0.421
TRG_ER_diArg_1	355	357	PF00400	0.640
TRG_ER_diArg_1	537	539	PF00400	0.397
TRG_ER_diArg_1	602	604	PF00400	0.482
TRG_ER_diArg_1	80	82	PF00400	0.511
TRG_NLS_MonoExtC_3	296	301	PF00514	0.654
TRG_NLS_MonoExtN_4	295	302	PF00514	0.561
TRG_Pf-PMV_PEXEL_1	236	241	PF00026	0.634

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML4	Leptomonas seymouri	63%	100%
A0A0S4JLI3	Bodo saltans	34%	93%
A0A1X0NRQ2	Trypanosomatidae	42%	100%
A0A3R7KWB9	Trypanosoma rangeli	42%	100%
A0A3S7X607	Leishmania donovani	94%	100%
A4HKT4	Leishmania braziliensis	84%	100%
A4I8B3	Leishmania infantum	94%	100%
D0AAI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q9U1E4	Leishmania major	93%	100%
V5AXZ0	Trypanosoma cruzi	42%	100%