Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B368_LEIMU

TriTrypDb:

LmxM.31.2885

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B368

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B368

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.721
CLV_C14_Caspase3-7	217	221	PF00656	0.673
CLV_NRD_NRD_1	326	328	PF00675	0.563
CLV_NRD_NRD_1	346	348	PF00675	0.616
CLV_NRD_NRD_1	349	351	PF00675	0.598
CLV_PCSK_FUR_1	324	328	PF00082	0.612
CLV_PCSK_FUR_1	347	351	PF00082	0.626
CLV_PCSK_KEX2_1	326	328	PF00082	0.556
CLV_PCSK_KEX2_1	348	350	PF00082	0.631
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.631
CLV_PCSK_PC7_1	322	328	PF00082	0.615
CLV_PCSK_SKI1_1	365	369	PF00082	0.545
CLV_PCSK_SKI1_1	55	59	PF00082	0.467
DEG_APCC_DBOX_1	298	306	PF00400	0.504
DOC_ANK_TNKS_1	196	203	PF00023	0.588
DOC_PP1_RVXF_1	101	108	PF00149	0.642
DOC_PP2B_PxIxI_1	43	49	PF00149	0.491
DOC_PP4_FxxP_1	50	53	PF00568	0.490
DOC_USP7_MATH_1	141	145	PF00917	0.621
DOC_USP7_MATH_1	156	160	PF00917	0.617
DOC_USP7_MATH_1	186	190	PF00917	0.588
DOC_USP7_MATH_1	213	217	PF00917	0.658
DOC_USP7_MATH_1	221	225	PF00917	0.602
DOC_USP7_MATH_1	287	291	PF00917	0.441
DOC_USP7_MATH_1	314	318	PF00917	0.641
DOC_USP7_MATH_1	357	361	PF00917	0.662
DOC_USP7_MATH_1	375	379	PF00917	0.627
DOC_USP7_MATH_1	434	438	PF00917	0.608
DOC_USP7_MATH_1	85	89	PF00917	0.671
DOC_WW_Pin1_4	112	117	PF00397	0.545
DOC_WW_Pin1_4	158	163	PF00397	0.734
DOC_WW_Pin1_4	88	93	PF00397	0.696
LIG_14-3-3_CanoR_1	299	303	PF00244	0.501
LIG_14-3-3_CanoR_1	329	338	PF00244	0.611
LIG_14-3-3_CanoR_1	74	80	PF00244	0.693
LIG_APCC_ABBA_1	234	239	PF00400	0.411
LIG_BIR_III_4	84	88	PF00653	0.664
LIG_BRCT_BRCA1_1	188	192	PF00533	0.642
LIG_FHA_1	15	21	PF00498	0.544
LIG_FHA_1	240	246	PF00498	0.380
LIG_FHA_1	408	414	PF00498	0.647
LIG_FHA_1	76	82	PF00498	0.686
LIG_FHA_1	84	90	PF00498	0.633
LIG_FHA_2	215	221	PF00498	0.521
LIG_GBD_Chelix_1	173	181	PF00786	0.476
LIG_LIR_Gen_1	104	113	PF02991	0.629
LIG_LIR_Gen_1	3	9	PF02991	0.477
LIG_LIR_Nem_3	104	110	PF02991	0.635
LIG_LIR_Nem_3	3	8	PF02991	0.479
LIG_LIR_Nem_3	361	367	PF02991	0.458
LIG_LIR_Nem_3	78	82	PF02991	0.627
LIG_LYPXL_yS_3	79	82	PF13949	0.645
LIG_NRBOX	304	310	PF00104	0.527
LIG_PDZ_Class_1	434	439	PF00595	0.550
LIG_Pex14_2	107	111	PF04695	0.627
LIG_PTAP_UEV_1	152	157	PF05743	0.492
LIG_SH2_PTP2	5	8	PF00017	0.463
LIG_SH2_SRC	59	62	PF00017	0.299
LIG_SH2_STAP1	16	20	PF00017	0.512
LIG_SH2_STAP1	61	65	PF00017	0.441
LIG_SH2_STAT5	16	19	PF00017	0.437
LIG_SH2_STAT5	183	186	PF00017	0.527
LIG_SH2_STAT5	334	337	PF00017	0.483
LIG_SH2_STAT5	435	438	PF00017	0.485
LIG_SH2_STAT5	5	8	PF00017	0.437
LIG_SH2_STAT5	59	62	PF00017	0.306
LIG_SH3_1	150	156	PF00018	0.487
LIG_SH3_2	342	347	PF14604	0.661
LIG_SH3_3	150	156	PF00018	0.523
LIG_SH3_3	339	345	PF00018	0.570
LIG_SH3_3	428	434	PF00018	0.631
LIG_SH3_3	86	92	PF00018	0.703
LIG_SUMO_SIM_par_1	284	291	PF11976	0.486
LIG_TRAF2_1	126	129	PF00917	0.572
LIG_TRAF2_1	91	94	PF00917	0.542
LIG_WW_3	226	230	PF00397	0.680
MOD_CK1_1	161	167	PF00069	0.704
MOD_CK1_1	216	222	PF00069	0.721
MOD_CK1_1	230	236	PF00069	0.552
MOD_CK1_1	83	89	PF00069	0.734
MOD_CK2_1	88	94	PF00069	0.671
MOD_GlcNHglycan	156	159	PF01048	0.735
MOD_GlcNHglycan	189	192	PF01048	0.672
MOD_GlcNHglycan	223	226	PF01048	0.721
MOD_GlcNHglycan	229	232	PF01048	0.539
MOD_GlcNHglycan	248	251	PF01048	0.266
MOD_GlcNHglycan	312	315	PF01048	0.615
MOD_GlcNHglycan	377	380	PF01048	0.592
MOD_GlcNHglycan	422	425	PF01048	0.726
MOD_GlcNHglycan	62	65	PF01048	0.645
MOD_GSK3_1	129	136	PF00069	0.603
MOD_GSK3_1	154	161	PF00069	0.762
MOD_GSK3_1	235	242	PF00069	0.364
MOD_GSK3_1	310	317	PF00069	0.561
MOD_GSK3_1	371	378	PF00069	0.569
MOD_GSK3_1	401	408	PF00069	0.572
MOD_N-GLC_1	130	135	PF02516	0.610
MOD_NEK2_1	169	174	PF00069	0.482
MOD_NEK2_1	177	182	PF00069	0.340
MOD_NEK2_1	264	269	PF00069	0.417
MOD_NEK2_1	288	293	PF00069	0.400
MOD_NEK2_1	31	36	PF00069	0.413
MOD_NEK2_1	318	323	PF00069	0.507
MOD_NEK2_1	9	14	PF00069	0.367
MOD_NEK2_2	298	303	PF00069	0.518
MOD_NEK2_2	85	90	PF00069	0.637
MOD_PIKK_1	329	335	PF00454	0.590
MOD_PKA_1	365	371	PF00069	0.550
MOD_PKA_2	298	304	PF00069	0.493
MOD_PKA_2	401	407	PF00069	0.692
MOD_PKB_1	327	335	PF00069	0.595
MOD_Plk_1	101	107	PF00069	0.644
MOD_Plk_1	130	136	PF00069	0.661
MOD_Plk_1	141	147	PF00069	0.711
MOD_Plk_4	1	7	PF00069	0.505
MOD_Plk_4	230	236	PF00069	0.523
MOD_Plk_4	314	320	PF00069	0.693
MOD_Plk_4	336	342	PF00069	0.616
MOD_Plk_4	384	390	PF00069	0.594
MOD_Plk_4	85	91	PF00069	0.731
MOD_ProDKin_1	112	118	PF00069	0.539
MOD_ProDKin_1	158	164	PF00069	0.727
MOD_ProDKin_1	88	94	PF00069	0.702
MOD_SUMO_rev_2	233	243	PF00179	0.449
MOD_SUMO_rev_2	358	367	PF00179	0.600
TRG_DiLeu_BaEn_2	383	389	PF01217	0.404
TRG_ENDOCYTIC_2	5	8	PF00928	0.463
TRG_ENDOCYTIC_2	79	82	PF00928	0.666
TRG_ER_diArg_1	111	114	PF00400	0.558
TRG_ER_diArg_1	324	327	PF00400	0.612
TRG_ER_diArg_1	346	349	PF00400	0.621
TRG_NLS_MonoCore_2	346	351	PF00514	0.622
TRG_NLS_MonoExtC_3	347	353	PF00514	0.545
TRG_NLS_MonoExtN_4	345	352	PF00514	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IME3	Leptomonas seymouri	53%	100%
A0A1X0NTD1	Trypanosomatidae	28%	100%
A0A3S7X601	Leishmania donovani	87%	99%
A0A422NZX0	Trypanosoma rangeli	31%	100%
A4HKT0	Leishmania braziliensis	79%	99%
A4I8A9	Leishmania infantum	88%	99%
D0AAI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4Q4Y6	Leishmania major	87%	100%
V5DE70	Trypanosoma cruzi	28%	100%