Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF778), putative

Species:

Leishmania mexicana

UniProt:

E9B367_LEIMU

TriTrypDb:

LmxM.31.2880

Length:

587

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B367

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B367

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	394	398	PF00656	0.567
CLV_C14_Caspase3-7	417	421	PF00656	0.489
CLV_NRD_NRD_1	284	286	PF00675	0.289
CLV_NRD_NRD_1	321	323	PF00675	0.289
CLV_NRD_NRD_1	324	326	PF00675	0.289
CLV_NRD_NRD_1	385	387	PF00675	0.349
CLV_NRD_NRD_1	553	555	PF00675	0.462
CLV_PCSK_FUR_1	319	323	PF00082	0.289
CLV_PCSK_FUR_1	382	386	PF00082	0.209
CLV_PCSK_KEX2_1	284	286	PF00082	0.302
CLV_PCSK_KEX2_1	321	323	PF00082	0.289
CLV_PCSK_KEX2_1	324	326	PF00082	0.289
CLV_PCSK_KEX2_1	384	386	PF00082	0.351
CLV_PCSK_KEX2_1	553	555	PF00082	0.461
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.314
CLV_PCSK_SKI1_1	312	316	PF00082	0.297
CLV_PCSK_SKI1_1	537	541	PF00082	0.289
DEG_APCC_DBOX_1	233	241	PF00400	0.488
DOC_ANK_TNKS_1	438	445	PF00023	0.489
DOC_CDC14_PxL_1	114	122	PF14671	0.737
DOC_CYCLIN_RxL_1	129	140	PF00134	0.721
DOC_CYCLIN_RxL_1	532	543	PF00134	0.567
DOC_MAPK_DCC_7	307	316	PF00069	0.489
DOC_MAPK_FxFP_2	152	155	PF00069	0.565
DOC_MAPK_gen_1	189	199	PF00069	0.409
DOC_MAPK_MEF2A_6	192	201	PF00069	0.409
DOC_PP1_RVXF_1	155	162	PF00149	0.409
DOC_PP1_RVXF_1	535	541	PF00149	0.489
DOC_PP2B_LxvP_1	134	137	PF13499	0.724
DOC_PP4_FxxP_1	152	155	PF00568	0.565
DOC_USP7_MATH_1	174	178	PF00917	0.424
DOC_USP7_MATH_1	246	250	PF00917	0.490
DOC_USP7_MATH_1	25	29	PF00917	0.665
DOC_USP7_MATH_1	276	280	PF00917	0.486
DOC_USP7_MATH_1	403	407	PF00917	0.567
DOC_USP7_MATH_1	442	446	PF00917	0.495
DOC_USP7_MATH_1	501	505	PF00917	0.612
DOC_USP7_MATH_1	521	525	PF00917	0.508
DOC_USP7_UBL2_3	485	489	PF12436	0.567
DOC_WW_Pin1_4	122	127	PF00397	0.704
DOC_WW_Pin1_4	17	22	PF00397	0.705
DOC_WW_Pin1_4	213	218	PF00397	0.471
DOC_WW_Pin1_4	252	257	PF00397	0.495
DOC_WW_Pin1_4	268	273	PF00397	0.489
DOC_WW_Pin1_4	3	8	PF00397	0.819
DOC_WW_Pin1_4	323	328	PF00397	0.567
DOC_WW_Pin1_4	372	377	PF00397	0.492
DOC_WW_Pin1_4	445	450	PF00397	0.489
DOC_WW_Pin1_4	483	488	PF00397	0.494
DOC_WW_Pin1_4	499	504	PF00397	0.454
DOC_WW_Pin1_4	50	55	PF00397	0.742
DOC_WW_Pin1_4	506	511	PF00397	0.495
DOC_WW_Pin1_4	95	100	PF00397	0.727
LIG_14-3-3_CanoR_1	157	162	PF00244	0.409
LIG_14-3-3_CanoR_1	178	183	PF00244	0.480
LIG_14-3-3_CanoR_1	266	272	PF00244	0.471
LIG_14-3-3_CanoR_1	288	296	PF00244	0.528
LIG_14-3-3_CanoR_1	63	70	PF00244	0.630
LIG_BIR_III_2	518	522	PF00653	0.567
LIG_BIR_III_4	395	399	PF00653	0.567
LIG_BRCT_BRCA1_1	159	163	PF00533	0.489
LIG_BRCT_BRCA1_1	270	274	PF00533	0.567
LIG_BRCT_BRCA1_1	457	461	PF00533	0.489
LIG_deltaCOP1_diTrp_1	528	540	PF00928	0.556
LIG_eIF4E_1	579	585	PF01652	0.371
LIG_FHA_1	224	230	PF00498	0.514
LIG_FHA_1	268	274	PF00498	0.567
LIG_FHA_1	301	307	PF00498	0.489
LIG_FHA_1	378	384	PF00498	0.599
LIG_FHA_1	432	438	PF00498	0.489
LIG_FHA_2	106	112	PF00498	0.651
LIG_FHA_2	138	144	PF00498	0.747
LIG_Integrin_RGD_1	550	552	PF01839	0.381
LIG_LIR_Apic_2	160	164	PF02991	0.489
LIG_LIR_Gen_1	414	424	PF02991	0.491
LIG_LIR_Gen_1	457	466	PF02991	0.489
LIG_LIR_Gen_1	568	579	PF02991	0.440
LIG_LIR_Nem_3	160	166	PF02991	0.469
LIG_LIR_Nem_3	414	419	PF02991	0.491
LIG_LIR_Nem_3	457	462	PF02991	0.504
LIG_LIR_Nem_3	530	536	PF02991	0.409
LIG_LIR_Nem_3	568	574	PF02991	0.510
LIG_MYND_1	100	104	PF01753	0.708
LIG_NRBOX	345	351	PF00104	0.504
LIG_PDZ_Class_2	582	587	PF00595	0.490
LIG_Pex14_2	154	158	PF04695	0.675
LIG_Pex14_2	582	586	PF04695	0.420
LIG_SH2_STAP1	387	391	PF00017	0.514
LIG_SH2_STAT5	180	183	PF00017	0.509
LIG_SH2_STAT5	187	190	PF00017	0.472
LIG_SH2_STAT5	581	584	PF00017	0.399
LIG_SH3_2	484	489	PF14604	0.567
LIG_SH3_3	123	129	PF00018	0.821
LIG_SH3_3	217	223	PF00018	0.412
LIG_SH3_3	250	256	PF00018	0.601
LIG_SH3_3	269	275	PF00018	0.389
LIG_SH3_3	373	379	PF00018	0.562
LIG_SH3_3	39	45	PF00018	0.653
LIG_SH3_3	4	10	PF00018	0.660
LIG_SH3_3	478	484	PF00018	0.567
LIG_SH3_3	504	510	PF00018	0.438
LIG_SUMO_SIM_anti_2	195	201	PF11976	0.409
LIG_SUMO_SIM_par_1	190	198	PF11976	0.567
LIG_SUMO_SIM_par_1	216	221	PF11976	0.409
LIG_TRAF2_1	408	411	PF00917	0.567
LIG_TRAF2_1	527	530	PF00917	0.506
LIG_WRC_WIRS_1	179	184	PF05994	0.489
LIG_WW_3	281	285	PF00397	0.469
MOD_CDC14_SPxK_1	486	489	PF00782	0.514
MOD_CDK_SPK_2	17	22	PF00069	0.642
MOD_CDK_SPK_2	6	11	PF00069	0.693
MOD_CDK_SPxK_1	483	489	PF00069	0.533
MOD_CDK_SPxxK_3	125	132	PF00069	0.719
MOD_CK1_1	105	111	PF00069	0.739
MOD_CK1_1	17	23	PF00069	0.682
MOD_CK1_1	221	227	PF00069	0.491
MOD_CK1_1	232	238	PF00069	0.506
MOD_CK1_1	241	247	PF00069	0.427
MOD_CK1_1	257	263	PF00069	0.506
MOD_CK1_1	356	362	PF00069	0.559
MOD_CK1_1	445	451	PF00069	0.489
MOD_CK1_1	457	463	PF00069	0.489
MOD_CK1_1	479	485	PF00069	0.492
MOD_CK1_1	493	499	PF00069	0.500
MOD_CK1_1	509	515	PF00069	0.449
MOD_CK1_1	524	530	PF00069	0.538
MOD_CK1_1	563	569	PF00069	0.331
MOD_CK1_1	6	12	PF00069	0.800
MOD_CK1_1	65	71	PF00069	0.691
MOD_CK1_1	94	100	PF00069	0.818
MOD_CK2_1	137	143	PF00069	0.756
MOD_CK2_1	169	175	PF00069	0.489
MOD_CK2_1	25	31	PF00069	0.662
MOD_CK2_1	404	410	PF00069	0.494
MOD_CK2_1	524	530	PF00069	0.525
MOD_Cter_Amidation	319	322	PF01082	0.289
MOD_DYRK1A_RPxSP_1	268	272	PF00069	0.435
MOD_GlcNHglycan	121	125	PF01048	0.523
MOD_GlcNHglycan	16	19	PF01048	0.646
MOD_GlcNHglycan	219	223	PF01048	0.341
MOD_GlcNHglycan	245	249	PF01048	0.310
MOD_GlcNHglycan	258	262	PF01048	0.327
MOD_GlcNHglycan	290	293	PF01048	0.249
MOD_GlcNHglycan	297	300	PF01048	0.216
MOD_GlcNHglycan	35	38	PF01048	0.498
MOD_GlcNHglycan	400	403	PF01048	0.278
MOD_GlcNHglycan	407	410	PF01048	0.271
MOD_GlcNHglycan	440	443	PF01048	0.298
MOD_GlcNHglycan	478	481	PF01048	0.285
MOD_GlcNHglycan	492	495	PF01048	0.319
MOD_GlcNHglycan	499	502	PF01048	0.236
MOD_GlcNHglycan	503	506	PF01048	0.249
MOD_GlcNHglycan	565	568	PF01048	0.349
MOD_GlcNHglycan	64	67	PF01048	0.633
MOD_GlcNHglycan	73	76	PF01048	0.481
MOD_GlcNHglycan	93	96	PF01048	0.626
MOD_GSK3_1	13	20	PF00069	0.685
MOD_GSK3_1	174	181	PF00069	0.502
MOD_GSK3_1	207	214	PF00069	0.470
MOD_GSK3_1	21	28	PF00069	0.715
MOD_GSK3_1	221	228	PF00069	0.485
MOD_GSK3_1	244	251	PF00069	0.502
MOD_GSK3_1	350	357	PF00069	0.489
MOD_GSK3_1	362	369	PF00069	0.489
MOD_GSK3_1	386	393	PF00069	0.595
MOD_GSK3_1	40	47	PF00069	0.825
MOD_GSK3_1	438	445	PF00069	0.489
MOD_GSK3_1	475	482	PF00069	0.514
MOD_GSK3_1	493	500	PF00069	0.525
MOD_GSK3_1	509	516	PF00069	0.460
MOD_GSK3_1	58	65	PF00069	0.677
MOD_GSK3_1	84	91	PF00069	0.699
MOD_GSK3_1	94	101	PF00069	0.674
MOD_N-GLC_1	431	436	PF02516	0.289
MOD_N-GLC_1	47	52	PF02516	0.450
MOD_N-GLC_1	91	96	PF02516	0.604
MOD_NEK2_1	120	125	PF00069	0.760
MOD_NEK2_1	14	19	PF00069	0.713
MOD_NEK2_1	182	187	PF00069	0.489
MOD_NEK2_1	225	230	PF00069	0.505
MOD_NEK2_1	238	243	PF00069	0.417
MOD_NEK2_1	315	320	PF00069	0.499
MOD_NEK2_1	431	436	PF00069	0.489
MOD_NEK2_1	540	545	PF00069	0.567
MOD_NEK2_1	58	63	PF00069	0.706
MOD_PIKK_1	232	238	PF00454	0.567
MOD_PIKK_1	300	306	PF00454	0.567
MOD_PIKK_1	329	335	PF00454	0.567
MOD_PIKK_1	470	476	PF00454	0.504
MOD_PK_1	192	198	PF00069	0.567
MOD_PKA_2	267	273	PF00069	0.528
MOD_PKA_2	320	326	PF00069	0.567
MOD_PKA_2	438	444	PF00069	0.491
MOD_PKA_2	62	68	PF00069	0.650
MOD_Plk_1	110	116	PF00069	0.623
MOD_Plk_1	182	188	PF00069	0.489
MOD_Plk_1	431	437	PF00069	0.489
MOD_Plk_2-3	390	396	PF00069	0.514
MOD_Plk_4	157	163	PF00069	0.567
MOD_Plk_4	182	188	PF00069	0.489
MOD_Plk_4	260	266	PF00069	0.438
MOD_Plk_4	540	546	PF00069	0.567
MOD_Plk_4	565	571	PF00069	0.440
MOD_ProDKin_1	122	128	PF00069	0.702
MOD_ProDKin_1	17	23	PF00069	0.706
MOD_ProDKin_1	213	219	PF00069	0.471
MOD_ProDKin_1	252	258	PF00069	0.495
MOD_ProDKin_1	268	274	PF00069	0.489
MOD_ProDKin_1	3	9	PF00069	0.821
MOD_ProDKin_1	323	329	PF00069	0.567
MOD_ProDKin_1	372	378	PF00069	0.492
MOD_ProDKin_1	445	451	PF00069	0.489
MOD_ProDKin_1	483	489	PF00069	0.494
MOD_ProDKin_1	499	505	PF00069	0.454
MOD_ProDKin_1	50	56	PF00069	0.743
MOD_ProDKin_1	506	512	PF00069	0.495
MOD_ProDKin_1	95	101	PF00069	0.728
MOD_SUMO_rev_2	184	194	PF00179	0.489
TRG_DiLeu_BaEn_1	414	419	PF01217	0.514
TRG_DiLeu_BaEn_4	414	420	PF01217	0.514
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.489
TRG_ENDOCYTIC_2	416	419	PF00928	0.489
TRG_ENDOCYTIC_2	579	582	PF00928	0.401
TRG_ER_diArg_1	265	268	PF00400	0.594
TRG_ER_diArg_1	283	285	PF00400	0.435
TRG_ER_diArg_1	319	322	PF00400	0.495
TRG_ER_diArg_1	385	387	PF00400	0.546
TRG_ER_diArg_1	553	555	PF00400	0.655
TRG_NLS_MonoExtN_4	382	388	PF00514	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1M3	Leptomonas seymouri	55%	76%
A0A3S7X5W7	Leishmania donovani	86%	99%
A4HKS9	Leishmania braziliensis	70%	100%
A4I8A8	Leishmania infantum	86%	99%
Q4Q4Y7	Leishmania major	86%	100%