LeishMANIAdb
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Phosphatidate cytidylyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphatidate cytidylyltransferase
Gene product:
phosphatidate cytidylyltransferase-like protein
Species:
Leishmania mexicana
UniProt:
E9B366_LEIMU
TriTrypDb:
LmxM.31.2870
Length:
498

Annotations

LeishMANIAdb annotations

Related to bacterial cytidyltransferase enzymes. Relatively conserved architecture, with the expection of an insertion of 2 helices.. Might have been acquired by horizontal gene transfer in the ancestors of Kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005886 plasma membrane 3 1

Expansion

Sequence features

E9B366
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B366

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 7
GO:0006644 phospholipid metabolic process 4 7
GO:0006650 glycerophospholipid metabolic process 5 7
GO:0006793 phosphorus metabolic process 3 7
GO:0006796 phosphate-containing compound metabolic process 4 7
GO:0008152 metabolic process 1 7
GO:0008610 lipid biosynthetic process 4 7
GO:0008654 phospholipid biosynthetic process 5 7
GO:0009058 biosynthetic process 2 7
GO:0009987 cellular process 1 7
GO:0016024 CDP-diacylglycerol biosynthetic process 6 7
GO:0019637 organophosphate metabolic process 3 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0044249 cellular biosynthetic process 3 7
GO:0044255 cellular lipid metabolic process 3 7
GO:0045017 glycerolipid biosynthetic process 4 7
GO:0046341 CDP-diacylglycerol metabolic process 6 7
GO:0046474 glycerophospholipid biosynthetic process 5 7
GO:0046486 glycerolipid metabolic process 4 7
GO:0071704 organic substance metabolic process 2 7
GO:0090407 organophosphate biosynthetic process 4 7
GO:1901576 organic substance biosynthetic process 3 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0004605 phosphatidate cytidylyltransferase activity 6 8
GO:0016740 transferase activity 2 10
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 10
GO:0016779 nucleotidyltransferase activity 4 10
GO:0070567 cytidylyltransferase activity 5 8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 463 467 PF00656 0.458
CLV_NRD_NRD_1 345 347 PF00675 0.405
CLV_NRD_NRD_1 492 494 PF00675 0.357
CLV_PCSK_KEX2_1 186 188 PF00082 0.348
CLV_PCSK_KEX2_1 347 349 PF00082 0.432
CLV_PCSK_KEX2_1 443 445 PF00082 0.242
CLV_PCSK_KEX2_1 492 494 PF00082 0.357
CLV_PCSK_KEX2_1 70 72 PF00082 0.394
CLV_PCSK_PC1ET2_1 186 188 PF00082 0.348
CLV_PCSK_PC1ET2_1 347 349 PF00082 0.432
CLV_PCSK_PC1ET2_1 443 445 PF00082 0.242
CLV_PCSK_PC1ET2_1 70 72 PF00082 0.412
CLV_PCSK_SKI1_1 238 242 PF00082 0.411
CLV_PCSK_SKI1_1 29 33 PF00082 0.328
CLV_PCSK_SKI1_1 316 320 PF00082 0.344
CLV_PCSK_SKI1_1 348 352 PF00082 0.432
CLV_PCSK_SKI1_1 358 362 PF00082 0.389
CLV_PCSK_SKI1_1 493 497 PF00082 0.364
CLV_PCSK_SKI1_1 71 75 PF00082 0.395
DEG_APCC_DBOX_1 19 27 PF00400 0.675
DEG_MDM2_SWIB_1 272 280 PF02201 0.276
DEG_Nend_UBRbox_2 1 3 PF02207 0.657
DEG_SCF_TRCP1_1 488 494 PF00400 0.542
DOC_CKS1_1 280 285 PF01111 0.341
DOC_CYCLIN_RxL_1 355 363 PF00134 0.574
DOC_CYCLIN_yCln2_LP_2 470 476 PF00134 0.525
DOC_CYCLIN_yCln2_LP_2 89 95 PF00134 0.559
DOC_MAPK_gen_1 70 77 PF00069 0.580
DOC_MAPK_MEF2A_6 221 228 PF00069 0.703
DOC_MAPK_MEF2A_6 464 472 PF00069 0.442
DOC_MAPK_MEF2A_6 70 79 PF00069 0.581
DOC_PP1_RVXF_1 135 142 PF00149 0.393
DOC_PP4_FxxP_1 403 406 PF00568 0.241
DOC_PP4_FxxP_1 453 456 PF00568 0.510
DOC_USP7_MATH_1 217 221 PF00917 0.632
DOC_USP7_MATH_1 373 377 PF00917 0.447
DOC_USP7_MATH_1 414 418 PF00917 0.202
DOC_USP7_MATH_1 478 482 PF00917 0.371
DOC_USP7_UBL2_3 347 351 PF12436 0.557
DOC_USP7_UBL2_3 70 74 PF12436 0.597
DOC_WW_Pin1_4 107 112 PF00397 0.766
DOC_WW_Pin1_4 12 17 PF00397 0.664
DOC_WW_Pin1_4 279 284 PF00397 0.428
DOC_WW_Pin1_4 360 365 PF00397 0.569
DOC_WW_Pin1_4 369 374 PF00397 0.412
DOC_WW_Pin1_4 88 93 PF00397 0.743
LIG_14-3-3_CanoR_1 480 486 PF00244 0.545
LIG_14-3-3_CanoR_1 492 496 PF00244 0.563
LIG_14-3-3_CanoR_1 5 11 PF00244 0.626
LIG_Actin_WH2_2 430 445 PF00022 0.282
LIG_Clathr_ClatBox_1 156 160 PF01394 0.341
LIG_Clathr_ClatBox_1 78 82 PF01394 0.664
LIG_FHA_1 26 32 PF00498 0.313
LIG_FHA_1 279 285 PF00498 0.228
LIG_FHA_1 5 11 PF00498 0.636
LIG_FHA_2 220 226 PF00498 0.654
LIG_GSK3_LRP6_1 107 112 PF00069 0.637
LIG_LIR_Apic_2 121 126 PF02991 0.615
LIG_LIR_Apic_2 450 456 PF02991 0.467
LIG_LIR_Gen_1 131 139 PF02991 0.467
LIG_LIR_Gen_1 160 171 PF02991 0.306
LIG_LIR_Gen_1 245 255 PF02991 0.629
LIG_LIR_Gen_1 261 272 PF02991 0.387
LIG_LIR_Gen_1 412 423 PF02991 0.287
LIG_LIR_Gen_1 55 64 PF02991 0.231
LIG_LIR_Nem_3 131 136 PF02991 0.453
LIG_LIR_Nem_3 158 164 PF02991 0.347
LIG_LIR_Nem_3 261 267 PF02991 0.590
LIG_LIR_Nem_3 270 275 PF02991 0.326
LIG_LIR_Nem_3 323 328 PF02991 0.598
LIG_LIR_Nem_3 390 394 PF02991 0.379
LIG_LIR_Nem_3 412 418 PF02991 0.256
LIG_LIR_Nem_3 55 60 PF02991 0.305
LIG_LIR_Nem_3 65 69 PF02991 0.259
LIG_NRBOX 437 443 PF00104 0.189
LIG_PDZ_Class_2 493 498 PF00595 0.568
LIG_Pex14_2 272 276 PF04695 0.276
LIG_Pex14_2 396 400 PF04695 0.252
LIG_Pex14_2 56 60 PF04695 0.281
LIG_SH2_CRK 123 127 PF00017 0.599
LIG_SH2_CRK 133 137 PF00017 0.279
LIG_SH2_NCK_1 329 333 PF00017 0.478
LIG_SH2_STAT5 149 152 PF00017 0.403
LIG_SH2_STAT5 162 165 PF00017 0.279
LIG_SH2_STAT5 246 249 PF00017 0.660
LIG_SH3_1 105 111 PF00018 0.690
LIG_SH3_1 123 129 PF00018 0.611
LIG_SH3_3 100 106 PF00018 0.621
LIG_SH3_3 114 120 PF00018 0.668
LIG_SH3_3 123 129 PF00018 0.606
LIG_SH3_3 289 295 PF00018 0.384
LIG_SH3_3 89 95 PF00018 0.758
LIG_SUMO_SIM_par_1 155 160 PF11976 0.455
LIG_SUMO_SIM_par_1 167 172 PF11976 0.320
LIG_SUMO_SIM_par_1 28 35 PF11976 0.177
LIG_UBA3_1 437 443 PF00899 0.276
LIG_WRC_WIRS_1 53 58 PF05994 0.357
MOD_CDC14_SPxK_1 15 18 PF00782 0.608
MOD_CDC14_SPxK_1 372 375 PF00782 0.442
MOD_CDK_SPxK_1 12 18 PF00069 0.613
MOD_CDK_SPxK_1 369 375 PF00069 0.442
MOD_CK1_1 44 50 PF00069 0.506
MOD_CK1_1 481 487 PF00069 0.562
MOD_CK2_1 217 223 PF00069 0.767
MOD_CMANNOS 397 400 PF00535 0.177
MOD_DYRK1A_RPxSP_1 369 373 PF00069 0.510
MOD_GlcNHglycan 193 196 PF01048 0.452
MOD_GlcNHglycan 230 234 PF01048 0.463
MOD_GlcNHglycan 352 356 PF01048 0.320
MOD_GlcNHglycan 43 46 PF01048 0.515
MOD_GlcNHglycan 488 491 PF01048 0.475
MOD_GSK3_1 186 193 PF00069 0.687
MOD_GSK3_1 21 28 PF00069 0.683
MOD_GSK3_1 369 376 PF00069 0.442
MOD_GSK3_1 52 59 PF00069 0.464
MOD_GSK3_1 77 84 PF00069 0.712
MOD_N-GLC_1 373 378 PF02516 0.325
MOD_NEK2_1 297 302 PF00069 0.372
MOD_NEK2_1 41 46 PF00069 0.436
MOD_NEK2_1 437 442 PF00069 0.260
MOD_NEK2_1 56 61 PF00069 0.174
MOD_NEK2_1 81 86 PF00069 0.725
MOD_NEK2_2 52 57 PF00069 0.203
MOD_PIKK_1 186 192 PF00454 0.726
MOD_PKA_1 186 192 PF00069 0.551
MOD_PKA_2 186 192 PF00069 0.601
MOD_PKA_2 4 10 PF00069 0.577
MOD_PKA_2 491 497 PF00069 0.560
MOD_Plk_1 224 230 PF00069 0.739
MOD_Plk_1 373 379 PF00069 0.543
MOD_Plk_1 81 87 PF00069 0.657
MOD_Plk_4 297 303 PF00069 0.300
MOD_Plk_4 437 443 PF00069 0.234
MOD_Plk_4 52 58 PF00069 0.365
MOD_Plk_4 94 100 PF00069 0.635
MOD_ProDKin_1 107 113 PF00069 0.767
MOD_ProDKin_1 12 18 PF00069 0.666
MOD_ProDKin_1 279 285 PF00069 0.428
MOD_ProDKin_1 360 366 PF00069 0.571
MOD_ProDKin_1 369 375 PF00069 0.412
MOD_ProDKin_1 88 94 PF00069 0.741
MOD_SUMO_for_1 179 182 PF00179 0.594
MOD_SUMO_for_1 234 237 PF00179 0.723
TRG_DiLeu_BaEn_1 152 157 PF01217 0.325
TRG_DiLeu_BaEn_1 352 357 PF01217 0.542
TRG_ENDOCYTIC_2 133 136 PF00928 0.375
TRG_ENDOCYTIC_2 162 165 PF00928 0.372
TRG_ENDOCYTIC_2 325 328 PF00928 0.610
TRG_ENDOCYTIC_2 399 402 PF00928 0.298
TRG_ER_diArg_1 18 21 PF00400 0.708
TRG_ER_diArg_1 345 348 PF00400 0.596
TRG_NLS_MonoExtN_4 345 350 PF00514 0.577
TRG_Pf-PMV_PEXEL_1 348 352 PF00026 0.424

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEC8 Leptomonas seymouri 64% 100%
A0A1X0NT53 Trypanosomatidae 31% 100%
A0A3Q8IDC1 Leishmania donovani 89% 100%
A0A422NZP0 Trypanosoma rangeli 32% 100%
A4HKS8 Leishmania braziliensis 68% 96%
E9AHM2 Leishmania infantum 89% 100%
Q4Q4Y8 Leishmania major 86% 98%
V5AXY5 Trypanosoma cruzi 32% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS