Dynein axonemal assembly factor 4

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CS domain/TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania mexicana

UniProt:

E9B364_LEIMU

TriTrypDb:

LmxM.31.2850

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0042995	cell projection	2	11
GO:0043005	neuron projection	4	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0120293	dynein axonemal particle	5	11
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B364

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B364

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0007399	nervous system development	4	11
GO:0009987	cellular process	1	11
GO:0032502	developmental process	1	11
GO:0048731	system development	3	11
GO:0048856	anatomical structure development	2	11
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0036158	outer dynein arm assembly	7	1
GO:0036159	inner dynein arm assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0070286	axonemal dynein complex assembly	6	1
GO:0071840	cellular component organization or biogenesis	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	511	515	PF00656	0.687
CLV_C14_Caspase3-7	68	72	PF00656	0.571
CLV_NRD_NRD_1	106	108	PF00675	0.476
CLV_NRD_NRD_1	134	136	PF00675	0.578
CLV_NRD_NRD_1	372	374	PF00675	0.366
CLV_NRD_NRD_1	551	553	PF00675	0.503
CLV_NRD_NRD_1	555	557	PF00675	0.489
CLV_PCSK_FUR_1	549	553	PF00082	0.622
CLV_PCSK_KEX2_1	106	108	PF00082	0.465
CLV_PCSK_KEX2_1	133	135	PF00082	0.575
CLV_PCSK_KEX2_1	313	315	PF00082	0.431
CLV_PCSK_KEX2_1	336	338	PF00082	0.424
CLV_PCSK_KEX2_1	372	374	PF00082	0.366
CLV_PCSK_KEX2_1	551	553	PF00082	0.573
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.541
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.420
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.424
CLV_PCSK_PC7_1	129	135	PF00082	0.533
CLV_PCSK_SKI1_1	100	104	PF00082	0.544
CLV_PCSK_SKI1_1	134	138	PF00082	0.546
CLV_PCSK_SKI1_1	419	423	PF00082	0.551
DEG_SCF_FBW7_1	225	232	PF00400	0.678
DEG_SCF_FBW7_2	349	356	PF00400	0.511
DEG_SPOP_SBC_1	216	220	PF00917	0.571
DEG_SPOP_SBC_1	229	233	PF00917	0.673
DOC_CKS1_1	226	231	PF01111	0.691
DOC_CKS1_1	235	240	PF01111	0.562
DOC_MAPK_gen_1	23	32	PF00069	0.487
DOC_MAPK_gen_1	272	281	PF00069	0.602
DOC_MAPK_gen_1	477	487	PF00069	0.549
DOC_MAPK_MEF2A_6	242	251	PF00069	0.543
DOC_MAPK_MEF2A_6	26	34	PF00069	0.495
DOC_PP4_FxxP_1	258	261	PF00568	0.716
DOC_USP7_MATH_1	187	191	PF00917	0.545
DOC_USP7_MATH_1	211	215	PF00917	0.654
DOC_USP7_MATH_1	216	220	PF00917	0.616
DOC_USP7_MATH_1	229	233	PF00917	0.576
DOC_USP7_MATH_1	261	265	PF00917	0.604
DOC_USP7_UBL2_3	23	27	PF12436	0.501
DOC_USP7_UBL2_3	583	587	PF12436	0.467
DOC_WW_Pin1_4	172	177	PF00397	0.705
DOC_WW_Pin1_4	181	186	PF00397	0.712
DOC_WW_Pin1_4	192	197	PF00397	0.427
DOC_WW_Pin1_4	212	217	PF00397	0.680
DOC_WW_Pin1_4	225	230	PF00397	0.715
DOC_WW_Pin1_4	234	239	PF00397	0.682
DOC_WW_Pin1_4	251	256	PF00397	0.455
DOC_WW_Pin1_4	281	286	PF00397	0.476
DOC_WW_Pin1_4	349	354	PF00397	0.482
DOC_WW_Pin1_4	596	601	PF00397	0.446
LIG_14-3-3_CanoR_1	419	428	PF00244	0.573
LIG_14-3-3_CanoR_1	94	99	PF00244	0.617
LIG_BRCT_BRCA1_1	230	234	PF00533	0.488
LIG_BRCT_BRCA1_1	62	66	PF00533	0.526
LIG_Clathr_ClatBox_1	48	52	PF01394	0.487
LIG_FHA_1	244	250	PF00498	0.515
LIG_FHA_1	480	486	PF00498	0.487
LIG_FHA_2	10	16	PF00498	0.487
LIG_FHA_2	125	131	PF00498	0.631
LIG_FHA_2	398	404	PF00498	0.559
LIG_FHA_2	420	426	PF00498	0.669
LIG_FHA_2	597	603	PF00498	0.448
LIG_LIR_Apic_2	257	261	PF02991	0.715
LIG_LIR_Gen_1	326	335	PF02991	0.532
LIG_LIR_Gen_1	36	45	PF02991	0.501
LIG_LIR_Gen_1	451	462	PF02991	0.574
LIG_LIR_Nem_3	274	279	PF02991	0.590
LIG_LIR_Nem_3	36	41	PF02991	0.508
LIG_LIR_Nem_3	360	365	PF02991	0.467
LIG_LIR_Nem_3	451	457	PF02991	0.468
LIG_MLH1_MIPbox_1	62	66	PF16413	0.525
LIG_RPA_C_Fungi	102	114	PF08784	0.473
LIG_SH2_CRK	276	280	PF00017	0.580
LIG_SH2_CRK	362	366	PF00017	0.441
LIG_SH2_CRK	454	458	PF00017	0.465
LIG_SH2_CRK	566	570	PF00017	0.423
LIG_SH2_GRB2like	601	604	PF00017	0.536
LIG_SH2_NCK_1	447	451	PF00017	0.439
LIG_SH2_STAP1	199	203	PF00017	0.553
LIG_SH2_STAP1	308	312	PF00017	0.398
LIG_SH2_STAP1	454	458	PF00017	0.442
LIG_SH2_STAP1	601	605	PF00017	0.443
LIG_SH2_STAT3	118	121	PF00017	0.619
LIG_SH2_STAT3	270	273	PF00017	0.672
LIG_SH2_STAT3	296	299	PF00017	0.523
LIG_SH2_STAT5	329	332	PF00017	0.540
LIG_SH2_STAT5	377	380	PF00017	0.466
LIG_SH2_STAT5	47	50	PF00017	0.344
LIG_SH2_STAT5	572	575	PF00017	0.460
LIG_SH2_STAT5	591	594	PF00017	0.502
LIG_SH2_STAT5	65	68	PF00017	0.328
LIG_SH3_3	223	229	PF00018	0.711
LIG_SH3_3	232	238	PF00018	0.654
LIG_SH3_3	38	44	PF00018	0.413
LIG_SUMO_SIM_anti_2	28	34	PF11976	0.441
LIG_SUMO_SIM_par_1	277	284	PF11976	0.576
LIG_SUMO_SIM_par_1	47	52	PF11976	0.348
LIG_TRAF2_1	534	537	PF00917	0.773
LIG_UBA3_1	17	23	PF00899	0.413
LIG_UBA3_1	53	61	PF00899	0.385
LIG_WW_1	196	199	PF00397	0.465
LIG_WW_1	44	47	PF00397	0.413
MOD_CDK_SPK_2	251	256	PF00069	0.596
MOD_CK1_1	172	178	PF00069	0.707
MOD_CK1_1	215	221	PF00069	0.688
MOD_CK1_1	233	239	PF00069	0.692
MOD_CK1_1	355	361	PF00069	0.506
MOD_CK1_1	60	66	PF00069	0.435
MOD_CK1_1	625	631	PF00069	0.573
MOD_CK2_1	124	130	PF00069	0.658
MOD_CK2_1	512	518	PF00069	0.683
MOD_CK2_1	526	532	PF00069	0.707
MOD_GlcNHglycan	181	184	PF01048	0.788
MOD_GlcNHglycan	199	202	PF01048	0.709
MOD_GlcNHglycan	205	208	PF01048	0.739
MOD_GlcNHglycan	325	328	PF01048	0.507
MOD_GlcNHglycan	384	387	PF01048	0.469
MOD_GlcNHglycan	454	457	PF01048	0.490
MOD_GlcNHglycan	532	535	PF01048	0.722
MOD_GlcNHglycan	560	564	PF01048	0.475
MOD_GlcNHglycan	574	577	PF01048	0.339
MOD_GlcNHglycan	624	627	PF01048	0.525
MOD_GSK3_1	124	131	PF00069	0.542
MOD_GSK3_1	177	184	PF00069	0.763
MOD_GSK3_1	203	210	PF00069	0.753
MOD_GSK3_1	211	218	PF00069	0.578
MOD_GSK3_1	225	232	PF00069	0.792
MOD_GSK3_1	243	250	PF00069	0.530
MOD_GSK3_1	277	284	PF00069	0.611
MOD_GSK3_1	340	347	PF00069	0.425
MOD_GSK3_1	5	12	PF00069	0.480
MOD_GSK3_1	526	533	PF00069	0.771
MOD_GSK3_1	539	546	PF00069	0.690
MOD_GSK3_1	56	63	PF00069	0.419
MOD_GSK3_1	89	96	PF00069	0.591
MOD_N-GLC_1	247	252	PF02516	0.651
MOD_N-GLC_1	323	328	PF02516	0.507
MOD_NEK2_1	18	23	PF00069	0.363
MOD_NEK2_1	323	328	PF00069	0.507
MOD_NEK2_1	344	349	PF00069	0.420
MOD_NEK2_2	187	192	PF00069	0.470
MOD_NEK2_2	308	313	PF00069	0.406
MOD_PIKK_1	124	130	PF00454	0.631
MOD_PIKK_1	295	301	PF00454	0.499
MOD_PIKK_1	355	361	PF00454	0.506
MOD_PIKK_1	479	485	PF00454	0.522
MOD_PIKK_1	60	66	PF00454	0.475
MOD_PK_1	277	283	PF00069	0.582
MOD_PK_1	94	100	PF00069	0.582
MOD_PKA_2	124	130	PF00069	0.592
MOD_PKA_2	271	277	PF00069	0.524
MOD_PKA_2	93	99	PF00069	0.587
MOD_Plk_1	247	253	PF00069	0.670
MOD_Plk_1	340	346	PF00069	0.417
MOD_Plk_1	450	456	PF00069	0.476
MOD_Plk_2-3	398	404	PF00069	0.610
MOD_Plk_4	230	236	PF00069	0.654
MOD_Plk_4	344	350	PF00069	0.429
MOD_Plk_4	543	549	PF00069	0.471
MOD_Plk_4	617	623	PF00069	0.463
MOD_ProDKin_1	172	178	PF00069	0.713
MOD_ProDKin_1	181	187	PF00069	0.708
MOD_ProDKin_1	192	198	PF00069	0.426
MOD_ProDKin_1	212	218	PF00069	0.680
MOD_ProDKin_1	225	231	PF00069	0.717
MOD_ProDKin_1	234	240	PF00069	0.678
MOD_ProDKin_1	251	257	PF00069	0.456
MOD_ProDKin_1	281	287	PF00069	0.474
MOD_ProDKin_1	349	355	PF00069	0.492
MOD_ProDKin_1	596	602	PF00069	0.446
MOD_SUMO_for_1	155	158	PF00179	0.516
MOD_SUMO_rev_2	381	385	PF00179	0.560
TRG_ENDOCYTIC_2	276	279	PF00928	0.582
TRG_ENDOCYTIC_2	329	332	PF00928	0.540
TRG_ENDOCYTIC_2	362	365	PF00928	0.451
TRG_ENDOCYTIC_2	454	457	PF00928	0.407
TRG_ENDOCYTIC_2	566	569	PF00928	0.405
TRG_ER_diArg_1	134	136	PF00400	0.604
TRG_ER_diArg_1	548	551	PF00400	0.515
TRG_Pf-PMV_PEXEL_1	135	140	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	337	341	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE30	Leptomonas seymouri	70%	100%
A0A0S4IMJ5	Bodo saltans	46%	100%
A0A1X0NRQ0	Trypanosomatidae	52%	100%
A0A3R7LBE5	Trypanosoma rangeli	49%	100%
A0A3S7X5V3	Leishmania donovani	92%	100%
A4HKS6	Leishmania braziliensis	83%	100%
A4I8A6	Leishmania infantum	92%	100%
D0AAH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	96%
Q4Q4Z0	Leishmania major	93%	100%
V5BMH6	Trypanosoma cruzi	51%	100%