Prefoldin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Prefoldin

Gene product:

prefoldin subunit, putative

Species:

Leishmania mexicana

UniProt:

E9B363_LEIMU

TriTrypDb:

LmxM.31.2840

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B363

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B363

Function

Biological processes
Term	Name	Level	Count
GO:0000122	negative regulation of transcription by RNA polymerase II	8	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010563	negative regulation of phosphorus metabolic process	6	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010921	regulation of phosphatase activity	5	1
GO:0010923	negative regulation of phosphatase activity	6	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0035303	regulation of dephosphorylation	7	1
GO:0035305	negative regulation of dephosphorylation	8	1
GO:0043086	negative regulation of catalytic activity	4	1
GO:0044092	negative regulation of molecular function	3	1
GO:0045892	negative regulation of DNA-templated transcription	7	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0045936	negative regulation of phosphate metabolic process	7	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0051336	regulation of hydrolase activity	4	1
GO:0051346	negative regulation of hydrolase activity	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902679	negative regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903507	negative regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	1
GO:0003712	transcription coregulator activity	2	1
GO:0003714	transcription corepressor activity	3	1
GO:0004857	enzyme inhibitor activity	3	1
GO:0005488	binding	1	1
GO:0019208	phosphatase regulator activity	3	1
GO:0019212	phosphatase inhibitor activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1
GO:0140110	transcription regulator activity	1	1
GO:0140678	molecular function inhibitor activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.666
CLV_NRD_NRD_1	101	103	PF00675	0.303
CLV_NRD_NRD_1	107	109	PF00675	0.303
CLV_NRD_NRD_1	275	277	PF00675	0.475
CLV_NRD_NRD_1	283	285	PF00675	0.532
CLV_NRD_NRD_1	345	347	PF00675	0.665
CLV_NRD_NRD_1	435	437	PF00675	0.788
CLV_NRD_NRD_1	463	465	PF00675	0.648
CLV_NRD_NRD_1	545	547	PF00675	0.563
CLV_NRD_NRD_1	55	57	PF00675	0.275
CLV_PCSK_FUR_1	52	56	PF00082	0.275
CLV_PCSK_FUR_1	543	547	PF00082	0.495
CLV_PCSK_KEX2_1	101	103	PF00082	0.303
CLV_PCSK_KEX2_1	107	109	PF00082	0.303
CLV_PCSK_KEX2_1	275	277	PF00082	0.475
CLV_PCSK_KEX2_1	283	285	PF00082	0.532
CLV_PCSK_KEX2_1	345	347	PF00082	0.575
CLV_PCSK_KEX2_1	463	465	PF00082	0.648
CLV_PCSK_KEX2_1	54	56	PF00082	0.278
CLV_PCSK_KEX2_1	545	547	PF00082	0.563
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.563
CLV_PCSK_PC7_1	543	549	PF00082	0.553
CLV_PCSK_SKI1_1	263	267	PF00082	0.513
CLV_PCSK_SKI1_1	412	416	PF00082	0.536
CLV_PCSK_SKI1_1	549	553	PF00082	0.583
CLV_PCSK_SKI1_1	55	59	PF00082	0.277
CLV_PCSK_SKI1_1	90	94	PF00082	0.252
DEG_APCC_DBOX_1	54	62	PF00400	0.476
DEG_COP1_1	309	318	PF00400	0.495
DEG_Nend_UBRbox_2	1	3	PF02207	0.461
DEG_SCF_FBW7_1	203	210	PF00400	0.682
DEG_SPOP_SBC_1	162	166	PF00917	0.564
DEG_SPOP_SBC_1	213	217	PF00917	0.677
DEG_SPOP_SBC_1	307	311	PF00917	0.460
DEG_SPOP_SBC_1	394	398	PF00917	0.664
DEG_SPOP_SBC_1	423	427	PF00917	0.580
DOC_CKS1_1	351	356	PF01111	0.588
DOC_CYCLIN_RxL_1	543	555	PF00134	0.560
DOC_CYCLIN_yCln2_LP_2	302	308	PF00134	0.458
DOC_MAPK_gen_1	294	303	PF00069	0.434
DOC_MAPK_gen_1	436	443	PF00069	0.673
DOC_PP1_RVXF_1	99	106	PF00149	0.451
DOC_PP2B_LxvP_1	365	368	PF13499	0.629
DOC_PP4_MxPP_1	533	536	PF00568	0.615
DOC_USP7_MATH_1	155	159	PF00917	0.642
DOC_USP7_MATH_1	162	166	PF00917	0.640
DOC_USP7_MATH_1	175	179	PF00917	0.626
DOC_USP7_MATH_1	214	218	PF00917	0.749
DOC_USP7_MATH_1	308	312	PF00917	0.536
DOC_USP7_MATH_1	361	365	PF00917	0.613
DOC_USP7_MATH_1	366	370	PF00917	0.614
DOC_USP7_MATH_1	380	384	PF00917	0.482
DOC_USP7_MATH_1	395	399	PF00917	0.502
DOC_USP7_MATH_1	418	422	PF00917	0.752
DOC_USP7_MATH_1	423	427	PF00917	0.529
DOC_USP7_MATH_1	431	435	PF00917	0.589
DOC_USP7_MATH_1	462	466	PF00917	0.521
DOC_USP7_MATH_1	88	92	PF00917	0.477
DOC_USP7_UBL2_3	545	549	PF12436	0.593
DOC_WW_Pin1_4	151	156	PF00397	0.676
DOC_WW_Pin1_4	177	182	PF00397	0.669
DOC_WW_Pin1_4	203	208	PF00397	0.593
DOC_WW_Pin1_4	350	355	PF00397	0.589
DOC_WW_Pin1_4	467	472	PF00397	0.566
DOC_WW_Pin1_4	487	492	PF00397	0.598
LIG_14-3-3_CanoR_1	263	270	PF00244	0.578
LIG_14-3-3_CanoR_1	412	420	PF00244	0.535
LIG_14-3-3_CanoR_1	463	471	PF00244	0.521
LIG_14-3-3_CanoR_1	480	487	PF00244	0.613
LIG_14-3-3_CanoR_1	495	499	PF00244	0.576
LIG_14-3-3_CanoR_1	546	552	PF00244	0.552
LIG_14-3-3_CanoR_1	90	98	PF00244	0.400
LIG_BIR_III_2	373	377	PF00653	0.618
LIG_Clathr_ClatBox_1	244	248	PF01394	0.449
LIG_EH1_1	497	505	PF00400	0.594
LIG_EVH1_2	535	539	PF00568	0.497
LIG_FHA_1	108	114	PF00498	0.539
LIG_FHA_1	137	143	PF00498	0.401
LIG_FHA_1	370	376	PF00498	0.601
LIG_FHA_1	394	400	PF00498	0.624
LIG_FHA_1	43	49	PF00498	0.475
LIG_FHA_1	488	494	PF00498	0.636
LIG_FHA_1	495	501	PF00498	0.595
LIG_FHA_1	73	79	PF00498	0.475
LIG_FHA_2	11	17	PF00498	0.583
LIG_FHA_2	229	235	PF00498	0.612
LIG_FHA_2	238	244	PF00498	0.448
LIG_FHA_2	332	338	PF00498	0.693
LIG_FHA_2	351	357	PF00498	0.593
LIG_FHA_2	39	45	PF00498	0.529
LIG_FHA_2	497	503	PF00498	0.520
LIG_LIR_Gen_1	16	22	PF02991	0.398
LIG_LIR_Gen_1	222	230	PF02991	0.484
LIG_LIR_Gen_1	327	336	PF02991	0.491
LIG_LIR_Gen_1	38	46	PF02991	0.475
LIG_LIR_Nem_3	16	21	PF02991	0.403
LIG_LIR_Nem_3	222	226	PF02991	0.487
LIG_LIR_Nem_3	327	332	PF02991	0.502
LIG_LIR_Nem_3	38	42	PF02991	0.475
LIG_MYND_1	199	203	PF01753	0.563
LIG_MYND_1	304	308	PF01753	0.514
LIG_MYND_1	536	540	PF01753	0.575
LIG_PCNA_yPIPBox_3	135	145	PF02747	0.471
LIG_PDZ_Class_3	556	561	PF00595	0.569
LIG_PTAP_UEV_1	367	372	PF05743	0.530
LIG_SH2_CRK	351	355	PF00017	0.588
LIG_SH2_CRK	39	43	PF00017	0.475
LIG_SH2_STAP1	68	72	PF00017	0.495
LIG_SH2_STAT5	18	21	PF00017	0.514
LIG_SH2_STAT5	489	492	PF00017	0.595
LIG_SH2_STAT5	498	501	PF00017	0.692
LIG_SH3_3	298	304	PF00018	0.500
LIG_SH3_3	365	371	PF00018	0.622
LIG_SH3_3	531	537	PF00018	0.585
LIG_SH3_3	54	60	PF00018	0.475
LIG_SUMO_SIM_anti_2	77	84	PF11976	0.475
LIG_SUMO_SIM_par_1	240	248	PF11976	0.454
LIG_SUMO_SIM_par_1	77	84	PF11976	0.475
LIG_TRAF2_1	158	161	PF00917	0.770
LIG_WRC_WIRS_1	230	235	PF05994	0.480
MOD_CK1_1	165	171	PF00069	0.509
MOD_CK1_1	194	200	PF00069	0.680
MOD_CK1_1	324	330	PF00069	0.705
MOD_CK1_1	369	375	PF00069	0.602
MOD_CK1_1	397	403	PF00069	0.660
MOD_CK1_1	422	428	PF00069	0.663
MOD_CK1_1	451	457	PF00069	0.563
MOD_CK1_1	482	488	PF00069	0.532
MOD_CK1_1	496	502	PF00069	0.467
MOD_CK2_1	10	16	PF00069	0.523
MOD_CK2_1	155	161	PF00069	0.671
MOD_CK2_1	229	235	PF00069	0.507
MOD_CK2_1	237	243	PF00069	0.465
MOD_CK2_1	382	388	PF00069	0.690
MOD_CK2_1	467	473	PF00069	0.614
MOD_Cter_Amidation	343	346	PF01082	0.496
MOD_Cter_Amidation	434	437	PF01082	0.487
MOD_Cter_Amidation	99	102	PF01082	0.275
MOD_GlcNHglycan	165	168	PF01048	0.627
MOD_GlcNHglycan	176	180	PF01048	0.602
MOD_GlcNHglycan	194	197	PF01048	0.605
MOD_GlcNHglycan	216	219	PF01048	0.670
MOD_GlcNHglycan	284	287	PF01048	0.546
MOD_GlcNHglycan	311	314	PF01048	0.591
MOD_GlcNHglycan	341	344	PF01048	0.530
MOD_GlcNHglycan	368	371	PF01048	0.620
MOD_GlcNHglycan	405	408	PF01048	0.659
MOD_GlcNHglycan	421	424	PF01048	0.511
MOD_GlcNHglycan	426	429	PF01048	0.660
MOD_GlcNHglycan	433	436	PF01048	0.598
MOD_GlcNHglycan	454	457	PF01048	0.518
MOD_GlcNHglycan	481	484	PF01048	0.610
MOD_GlcNHglycan	515	518	PF01048	0.638
MOD_GlcNHglycan	526	529	PF01048	0.568
MOD_GlcNHglycan	530	533	PF01048	0.610
MOD_GlcNHglycan	89	93	PF01048	0.275
MOD_GSK3_1	151	158	PF00069	0.566
MOD_GSK3_1	161	168	PF00069	0.689
MOD_GSK3_1	202	209	PF00069	0.647
MOD_GSK3_1	357	364	PF00069	0.684
MOD_GSK3_1	38	45	PF00069	0.529
MOD_GSK3_1	393	400	PF00069	0.579
MOD_GSK3_1	418	425	PF00069	0.643
MOD_GSK3_1	447	454	PF00069	0.603
MOD_GSK3_1	489	496	PF00069	0.654
MOD_GSK3_1	524	531	PF00069	0.540
MOD_N-GLC_1	292	297	PF02516	0.548
MOD_N-GLC_1	338	343	PF02516	0.617
MOD_N-GLC_1	72	77	PF02516	0.275
MOD_NEK2_1	192	197	PF00069	0.619
MOD_NEK2_1	221	226	PF00069	0.523
MOD_NEK2_1	42	47	PF00069	0.475
MOD_NEK2_1	493	498	PF00069	0.655
MOD_NEK2_1	72	77	PF00069	0.475
MOD_PIKK_1	156	162	PF00454	0.629
MOD_PIKK_1	462	468	PF00454	0.506
MOD_PIKK_1	90	96	PF00454	0.400
MOD_PKA_1	107	113	PF00069	0.486
MOD_PKA_1	547	553	PF00069	0.548
MOD_PKA_2	107	113	PF00069	0.486
MOD_PKA_2	144	150	PF00069	0.559
MOD_PKA_2	282	288	PF00069	0.552
MOD_PKA_2	462	468	PF00069	0.526
MOD_PKA_2	479	485	PF00069	0.616
MOD_PKA_2	494	500	PF00069	0.580
MOD_PKA_2	547	553	PF00069	0.550
MOD_Plk_1	221	227	PF00069	0.576
MOD_Plk_2-3	222	228	PF00069	0.471
MOD_Plk_2-3	237	243	PF00069	0.492
MOD_Plk_2-3	38	44	PF00069	0.529
MOD_Plk_4	165	171	PF00069	0.506
MOD_Plk_4	489	495	PF00069	0.654
MOD_Plk_4	547	553	PF00069	0.581
MOD_Plk_4	74	80	PF00069	0.475
MOD_ProDKin_1	151	157	PF00069	0.677
MOD_ProDKin_1	177	183	PF00069	0.667
MOD_ProDKin_1	203	209	PF00069	0.595
MOD_ProDKin_1	350	356	PF00069	0.588
MOD_ProDKin_1	467	473	PF00069	0.568
MOD_ProDKin_1	487	493	PF00069	0.598
MOD_SUMO_for_1	271	274	PF00179	0.484
TRG_ENDOCYTIC_2	18	21	PF00928	0.401
TRG_ENDOCYTIC_2	39	42	PF00928	0.475
TRG_ER_diArg_1	101	103	PF00400	0.500
TRG_ER_diArg_1	106	108	PF00400	0.508
TRG_ER_diArg_1	275	278	PF00400	0.483
TRG_ER_diArg_1	52	55	PF00400	0.475
TRG_NLS_MonoCore_2	544	549	PF00514	0.491
TRG_NLS_MonoExtC_3	544	549	PF00514	0.491
TRG_NLS_MonoExtN_4	543	550	PF00514	0.562
TRG_Pf-PMV_PEXEL_1	554	559	PF00026	0.592

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M6	Leptomonas seymouri	46%	100%
A0A3S7X5Y7	Leishmania donovani	83%	98%
A4HKS5	Leishmania braziliensis	69%	99%
A4I8A5	Leishmania infantum	83%	98%
Q4Q4Z1	Leishmania major	82%	100%