Putative RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9B360_LEIMU

TriTrypDb:

LmxM.31.2810

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B360

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B360

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.510
CLV_NRD_NRD_1	24	26	PF00675	0.465
CLV_NRD_NRD_1	294	296	PF00675	0.400
CLV_NRD_NRD_1	326	328	PF00675	0.502
CLV_NRD_NRD_1	400	402	PF00675	0.399
CLV_NRD_NRD_1	61	63	PF00675	0.642
CLV_NRD_NRD_1	7	9	PF00675	0.585
CLV_PCSK_KEX2_1	140	142	PF00082	0.243
CLV_PCSK_KEX2_1	202	204	PF00082	0.502
CLV_PCSK_KEX2_1	250	252	PF00082	0.536
CLV_PCSK_KEX2_1	326	328	PF00082	0.531
CLV_PCSK_KEX2_1	400	402	PF00082	0.401
CLV_PCSK_KEX2_1	424	426	PF00082	0.491
CLV_PCSK_KEX2_1	63	65	PF00082	0.644
CLV_PCSK_KEX2_1	7	9	PF00082	0.585
CLV_PCSK_KEX2_1	82	84	PF00082	0.494
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.319
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.502
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.536
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.550
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.644
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.603
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.494
CLV_PCSK_SKI1_1	140	144	PF00082	0.250
CLV_PCSK_SKI1_1	326	330	PF00082	0.399
CLV_PCSK_SKI1_1	356	360	PF00082	0.242
CLV_PCSK_SKI1_1	40	44	PF00082	0.592
CLV_PCSK_SKI1_1	421	425	PF00082	0.553
CLV_PCSK_SKI1_1	8	12	PF00082	0.623
DOC_CYCLIN_RxL_1	114	125	PF00134	0.450
DOC_MAPK_gen_1	223	232	PF00069	0.535
DOC_MAPK_gen_1	400	406	PF00069	0.367
DOC_PP2B_LxvP_1	269	272	PF13499	0.433
DOC_USP7_MATH_1	10	14	PF00917	0.525
DOC_USP7_MATH_1	365	369	PF00917	0.461
DOC_USP7_MATH_1	429	433	PF00917	0.536
DOC_USP7_MATH_1	439	443	PF00917	0.602
DOC_USP7_MATH_1	444	448	PF00917	0.619
DOC_USP7_UBL2_3	249	253	PF12436	0.551
DOC_USP7_UBL2_3	3	7	PF12436	0.669
DOC_USP7_UBL2_3	31	35	PF12436	0.545
DOC_USP7_UBL2_3	36	40	PF12436	0.560
DOC_USP7_UBL2_3	55	59	PF12436	0.492
DOC_WW_Pin1_4	8	13	PF00397	0.535
LIG_14-3-3_CanoR_1	310	314	PF00244	0.424
LIG_14-3-3_CanoR_1	318	325	PF00244	0.386
LIG_14-3-3_CanoR_1	401	407	PF00244	0.370
LIG_Actin_WH2_2	410	426	PF00022	0.579
LIG_AP2alpha_2	217	219	PF02296	0.416
LIG_BIR_II_1	1	5	PF00653	0.615
LIG_BRCT_BRCA1_1	301	305	PF00533	0.421
LIG_CaM_IQ_9	411	427	PF13499	0.419
LIG_FHA_1	154	160	PF00498	0.462
LIG_FHA_1	191	197	PF00498	0.523
LIG_FHA_1	362	368	PF00498	0.536
LIG_FHA_2	121	127	PF00498	0.462
LIG_FHA_2	219	225	PF00498	0.456
LIG_FHA_2	317	323	PF00498	0.447
LIG_FHA_2	51	57	PF00498	0.713
LIG_Integrin_isoDGR_2	434	436	PF01839	0.397
LIG_LIR_Gen_1	134	144	PF02991	0.510
LIG_LIR_Gen_1	217	227	PF02991	0.398
LIG_LIR_Nem_3	134	139	PF02991	0.443
LIG_LIR_Nem_3	224	230	PF02991	0.427
LIG_LIR_Nem_3	368	374	PF02991	0.443
LIG_MLH1_MIPbox_1	301	305	PF16413	0.542
LIG_NRP_CendR_1	445	448	PF00754	0.578
LIG_Pex14_2	132	136	PF04695	0.450
LIG_PTB_Apo_2	298	305	PF02174	0.539
LIG_PTB_Phospho_1	298	304	PF10480	0.535
LIG_RPA_C_Fungi	425	437	PF08784	0.466
LIG_SH2_CRK	352	356	PF00017	0.302
LIG_SH2_STAT3	173	176	PF00017	0.533
LIG_SH2_STAT3	263	266	PF00017	0.430
LIG_SH2_STAT5	131	134	PF00017	0.423
LIG_SH2_STAT5	263	266	PF00017	0.382
LIG_SH2_STAT5	284	287	PF00017	0.415
LIG_SH2_STAT5	304	307	PF00017	0.195
LIG_SH2_STAT5	336	339	PF00017	0.512
LIG_SH2_STAT5	47	50	PF00017	0.635
LIG_SH3_3	212	218	PF00018	0.595
LIG_SH3_4	36	43	PF00018	0.595
LIG_TRAF2_1	123	126	PF00917	0.344
LIG_WRC_WIRS_1	403	408	PF05994	0.354
MOD_CK1_1	38	44	PF00069	0.601
MOD_CK1_1	438	444	PF00069	0.628
MOD_CK2_1	120	126	PF00069	0.304
MOD_CK2_1	316	322	PF00069	0.438
MOD_Cter_Amidation	293	296	PF01082	0.264
MOD_GlcNHglycan	136	139	PF01048	0.451
MOD_GlcNHglycan	153	156	PF01048	0.295
MOD_GlcNHglycan	162	165	PF01048	0.454
MOD_GlcNHglycan	180	184	PF01048	0.374
MOD_GlcNHglycan	242	245	PF01048	0.518
MOD_GlcNHglycan	273	276	PF01048	0.592
MOD_GlcNHglycan	411	414	PF01048	0.503
MOD_GlcNHglycan	437	440	PF01048	0.526
MOD_GlcNHglycan	66	69	PF01048	0.742
MOD_GSK3_1	127	134	PF00069	0.397
MOD_GSK3_1	147	154	PF00069	0.119
MOD_GSK3_1	190	197	PF00069	0.496
MOD_GSK3_1	218	225	PF00069	0.423
MOD_GSK3_1	231	238	PF00069	0.448
MOD_GSK3_1	361	368	PF00069	0.318
MOD_GSK3_1	435	442	PF00069	0.655
MOD_N-GLC_1	409	414	PF02516	0.367
MOD_NEK2_1	1	6	PF00069	0.452
MOD_NEK2_1	153	158	PF00069	0.298
MOD_NEK2_1	222	227	PF00069	0.417
MOD_NEK2_1	299	304	PF00069	0.426
MOD_NEK2_1	361	366	PF00069	0.423
MOD_NEK2_1	402	407	PF00069	0.367
MOD_NEK2_2	2	7	PF00069	0.644
MOD_NEK2_2	218	223	PF00069	0.406
MOD_NEK2_2	382	387	PF00069	0.388
MOD_NEK2_2	50	55	PF00069	0.680
MOD_PIKK_1	109	115	PF00454	0.444
MOD_PIKK_1	235	241	PF00454	0.525
MOD_PKA_1	249	255	PF00069	0.547
MOD_PKA_1	35	41	PF00069	0.616
MOD_PKA_1	58	64	PF00069	0.671
MOD_PKA_2	147	153	PF00069	0.362
MOD_PKA_2	222	228	PF00069	0.409
MOD_PKA_2	309	315	PF00069	0.413
MOD_PKA_2	429	435	PF00069	0.470
MOD_PKB_1	62	70	PF00069	0.752
MOD_Plk_1	179	185	PF00069	0.640
MOD_Plk_1	409	415	PF00069	0.373
MOD_Plk_1	75	81	PF00069	0.732
MOD_Plk_2-3	91	97	PF00069	0.603
MOD_Plk_4	127	133	PF00069	0.400
MOD_Plk_4	209	215	PF00069	0.629
MOD_Plk_4	391	397	PF00069	0.422
MOD_ProDKin_1	8	14	PF00069	0.529
MOD_SUMO_rev_2	182	191	PF00179	0.626
TRG_DiLeu_BaEn_2	110	116	PF01217	0.464
TRG_ENDOCYTIC_2	284	287	PF00928	0.403
TRG_ENDOCYTIC_2	352	355	PF00928	0.302
TRG_ENDOCYTIC_2	371	374	PF00928	0.302
TRG_ER_diArg_1	145	148	PF00400	0.314
TRG_ER_diArg_1	325	327	PF00400	0.520
TRG_ER_diArg_1	400	402	PF00400	0.385
TRG_ER_diArg_1	425	428	PF00400	0.498
TRG_ER_diArg_1	62	65	PF00400	0.687
TRG_ER_diLys_1	443	448	PF00400	0.594
TRG_NLS_Bipartite_1	7	21	PF00514	0.536
TRG_NLS_MonoCore_2	15	20	PF00514	0.522
TRG_NLS_MonoCore_2	246	251	PF00514	0.543
TRG_NLS_MonoExtC_3	246	251	PF00514	0.525
TRG_NLS_MonoExtN_4	16	21	PF00514	0.508
TRG_NLS_MonoExtN_4	247	254	PF00514	0.533
TRG_NLS_MonoExtN_4	31	38	PF00514	0.505
TRG_NLS_MonoExtN_4	421	428	PF00514	0.540
TRG_NLS_MonoExtN_4	59	66	PF00514	0.657
TRG_Pf-PMV_PEXEL_1	326	331	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M4	Leptomonas seymouri	84%	100%
A0A0S4IWT2	Bodo saltans	57%	100%
A0A1X0NSA9	Trypanosomatidae	63%	100%
A0A3Q8IG48	Leishmania donovani	96%	100%
A0A3R7N0S8	Trypanosoma rangeli	63%	100%
A4HKS2	Leishmania braziliensis	88%	100%
A4I8A2	Leishmania infantum	96%	100%
D0AAH4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
O74400	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	66%
Q4Q4Z4	Leishmania major	95%	100%
V5BDC2	Trypanosoma cruzi	64%	92%