Exonuclease-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease-like protein

Species:

Leishmania mexicana

UniProt:

E9B358_LEIMU

TriTrypDb:

LmxM.31.2790

Length:

347

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B358

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B358

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004518	nuclease activity	4	6
GO:0004527	exonuclease activity	5	6
GO:0005488	binding	1	6
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	185	187	PF00675	0.390
CLV_NRD_NRD_1	267	269	PF00675	0.351
CLV_NRD_NRD_1	337	339	PF00675	0.447
CLV_NRD_NRD_1	6	8	PF00675	0.695
CLV_PCSK_KEX2_1	185	187	PF00082	0.390
CLV_PCSK_KEX2_1	267	269	PF00082	0.351
CLV_PCSK_KEX2_1	337	339	PF00082	0.416
CLV_PCSK_KEX2_1	6	8	PF00082	0.695
DEG_SIAH_1	49	57	PF03145	0.620
DOC_PP2B_LxvP_1	68	71	PF13499	0.688
DOC_PP2B_LxvP_1	87	90	PF13499	0.442
DOC_PP4_FxxP_1	274	277	PF00568	0.590
DOC_USP7_MATH_1	10	14	PF00917	0.649
DOC_USP7_MATH_1	17	21	PF00917	0.677
DOC_USP7_MATH_1	79	83	PF00917	0.791
DOC_WW_Pin1_4	132	137	PF00397	0.584
DOC_WW_Pin1_4	19	24	PF00397	0.680
DOC_WW_Pin1_4	203	208	PF00397	0.478
DOC_WW_Pin1_4	26	31	PF00397	0.689
DOC_WW_Pin1_4	46	51	PF00397	0.666
DOC_WW_Pin1_4	5	10	PF00397	0.695
DOC_WW_Pin1_4	52	57	PF00397	0.588
LIG_14-3-3_CanoR_1	185	194	PF00244	0.590
LIG_14-3-3_CanoR_1	31	37	PF00244	0.689
LIG_14-3-3_CterR_2	342	347	PF00244	0.411
LIG_Actin_WH2_2	120	135	PF00022	0.590
LIG_Actin_WH2_2	59	75	PF00022	0.592
LIG_BIR_III_2	14	18	PF00653	0.663
LIG_BRCT_BRCA1_1	101	105	PF00533	0.463
LIG_deltaCOP1_diTrp_1	165	175	PF00928	0.540
LIG_FHA_1	31	37	PF00498	0.649
LIG_FHA_1	326	332	PF00498	0.590
LIG_FHA_1	63	69	PF00498	0.715
LIG_FHA_1	82	88	PF00498	0.458
LIG_FHA_2	118	124	PF00498	0.540
LIG_GBD_Chelix_1	211	219	PF00786	0.339
LIG_LIR_Gen_1	102	112	PF02991	0.400
LIG_LIR_Gen_1	198	207	PF02991	0.497
LIG_LIR_Gen_1	284	295	PF02991	0.590
LIG_LIR_Nem_3	102	108	PF02991	0.418
LIG_LIR_Nem_3	198	202	PF02991	0.497
LIG_LIR_Nem_3	206	211	PF02991	0.477
LIG_LIR_Nem_3	284	290	PF02991	0.503
LIG_LIR_Nem_3	49	54	PF02991	0.659
LIG_LYPXL_yS_3	292	295	PF13949	0.540
LIG_NRBOX	326	332	PF00104	0.590
LIG_Pex14_1	275	279	PF04695	0.540
LIG_Pex14_1	339	343	PF04695	0.614
LIG_Pex14_2	257	261	PF04695	0.482
LIG_SH2_CRK	218	222	PF00017	0.590
LIG_SH2_PTP2	178	181	PF00017	0.540
LIG_SH2_STAT5	178	181	PF00017	0.540
LIG_SH2_STAT6	270	274	PF00017	0.590
LIG_SH3_1	178	184	PF00018	0.540
LIG_SH3_2	181	186	PF14604	0.590
LIG_SH3_3	147	153	PF00018	0.590
LIG_SH3_3	178	184	PF00018	0.506
LIG_SH3_3	242	248	PF00018	0.500
LIG_SH3_3	274	280	PF00018	0.578
LIG_SH3_3	287	293	PF00018	0.472
LIG_SH3_3	31	37	PF00018	0.738
LIG_SH3_3	47	53	PF00018	0.774
LIG_SUMO_SIM_par_1	108	115	PF11976	0.540
LIG_TRAF2_2	9	14	PF00917	0.646
LIG_TYR_ITIM	216	221	PF00017	0.590
LIG_TYR_ITIM	290	295	PF00017	0.590
MOD_CDK_SPK_2	26	31	PF00069	0.647
MOD_CDK_SPK_2	52	57	PF00069	0.619
MOD_CK1_1	137	143	PF00069	0.585
MOD_CK1_1	19	25	PF00069	0.750
MOD_CK1_1	26	32	PF00069	0.775
MOD_CK1_1	81	87	PF00069	0.747
MOD_CK2_1	117	123	PF00069	0.540
MOD_CK2_1	151	157	PF00069	0.478
MOD_Cter_Amidation	4	7	PF01082	0.655
MOD_GlcNHglycan	101	104	PF01048	0.465
MOD_GlcNHglycan	117	120	PF01048	0.312
MOD_GlcNHglycan	187	190	PF01048	0.312
MOD_GlcNHglycan	19	22	PF01048	0.582
MOD_GlcNHglycan	228	231	PF01048	0.279
MOD_GlcNHglycan	87	90	PF01048	0.747
MOD_GlcNHglycan	93	96	PF01048	0.697
MOD_GSK3_1	111	118	PF00069	0.506
MOD_GSK3_1	134	141	PF00069	0.585
MOD_GSK3_1	185	192	PF00069	0.479
MOD_GSK3_1	19	26	PF00069	0.700
MOD_GSK3_1	5	12	PF00069	0.687
MOD_GSK3_1	74	81	PF00069	0.695
MOD_GSK3_1	91	98	PF00069	0.517
MOD_GSK3_1	99	106	PF00069	0.559
MOD_N-GLC_1	253	258	PF02516	0.312
MOD_NEK2_1	112	117	PF00069	0.482
MOD_NEK2_1	228	233	PF00069	0.526
MOD_NEK2_1	25	30	PF00069	0.641
MOD_NEK2_1	281	286	PF00069	0.505
MOD_NEK2_1	32	37	PF00069	0.659
MOD_NEK2_1	62	67	PF00069	0.603
MOD_OFUCOSY	100	107	PF10250	0.541
MOD_PIKK_1	82	88	PF00454	0.714
MOD_PKA_1	185	191	PF00069	0.544
MOD_PKA_1	337	343	PF00069	0.335
MOD_PKA_2	179	185	PF00069	0.506
MOD_PKA_2	30	36	PF00069	0.618
MOD_PKA_2	337	343	PF00069	0.527
MOD_Plk_1	156	162	PF00069	0.478
MOD_Plk_1	253	259	PF00069	0.478
MOD_Plk_1	323	329	PF00069	0.569
MOD_ProDKin_1	132	138	PF00069	0.584
MOD_ProDKin_1	19	25	PF00069	0.680
MOD_ProDKin_1	203	209	PF00069	0.478
MOD_ProDKin_1	26	32	PF00069	0.690
MOD_ProDKin_1	46	52	PF00069	0.664
MOD_ProDKin_1	5	11	PF00069	0.697
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.630
TRG_ENDOCYTIC_2	218	221	PF00928	0.546
TRG_ENDOCYTIC_2	271	274	PF00928	0.516
TRG_ENDOCYTIC_2	292	295	PF00928	0.557
TRG_ER_diArg_1	184	186	PF00400	0.590
TRG_ER_diArg_1	266	268	PF00400	0.551
TRG_ER_diArg_1	337	339	PF00400	0.450

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBJ5	Leptomonas seymouri	44%	85%
A4HKS0	Leishmania braziliensis	78%	100%
D0AAH2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	95%
V5BHY6	Trypanosoma cruzi	34%	100%