Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP109

Species:

Leishmania mexicana

UniProt:

E9B357_LEIMU

TriTrypDb:

LmxM.31.2780

Length:

1095

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0031080	nuclear pore outer ring	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9B357

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B357

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	389	393	PF00656	0.524
CLV_NRD_NRD_1	2	4	PF00675	0.593
CLV_NRD_NRD_1	312	314	PF00675	0.439
CLV_NRD_NRD_1	5	7	PF00675	0.522
CLV_NRD_NRD_1	621	623	PF00675	0.566
CLV_PCSK_FUR_1	3	7	PF00082	0.587
CLV_PCSK_KEX2_1	312	314	PF00082	0.487
CLV_PCSK_KEX2_1	4	6	PF00082	0.561
CLV_PCSK_KEX2_1	621	623	PF00082	0.566
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.619
CLV_PCSK_SKI1_1	115	119	PF00082	0.499
CLV_PCSK_SKI1_1	5	9	PF00082	0.532
CLV_PCSK_SKI1_1	590	594	PF00082	0.406
CLV_PCSK_SKI1_1	613	617	PF00082	0.512
CLV_PCSK_SKI1_1	752	756	PF00082	0.510
CLV_PCSK_SKI1_1	933	937	PF00082	0.492
CLV_Separin_Metazoa	834	838	PF03568	0.436
DEG_Nend_UBRbox_3	1	3	PF02207	0.630
DEG_SCF_FBW7_1	243	250	PF00400	0.460
DEG_SPOP_SBC_1	1075	1079	PF00917	0.695
DOC_CYCLIN_RxL_1	610	619	PF00134	0.444
DOC_CYCLIN_RxL_1	930	940	PF00134	0.501
DOC_MAPK_gen_1	3	9	PF00069	0.585
DOC_MAPK_gen_1	590	598	PF00069	0.446
DOC_MAPK_gen_1	711	721	PF00069	0.453
DOC_MAPK_MEF2A_6	161	168	PF00069	0.655
DOC_MAPK_MEF2A_6	367	375	PF00069	0.529
DOC_MAPK_MEF2A_6	920	929	PF00069	0.366
DOC_PP1_RVXF_1	113	120	PF00149	0.510
DOC_PP1_RVXF_1	284	290	PF00149	0.458
DOC_PP2B_LxvP_1	49	52	PF13499	0.610
DOC_PP2B_LxvP_1	651	654	PF13499	0.411
DOC_PP2B_LxvP_1	765	768	PF13499	0.457
DOC_PP2B_LxvP_1	773	776	PF13499	0.396
DOC_PP2B_LxvP_1	974	977	PF13499	0.620
DOC_PP4_FxxP_1	721	724	PF00568	0.408
DOC_USP7_MATH_1	1015	1019	PF00917	0.672
DOC_USP7_MATH_1	1071	1075	PF00917	0.726
DOC_USP7_MATH_1	1076	1080	PF00917	0.646
DOC_USP7_MATH_1	1084	1088	PF00917	0.565
DOC_USP7_MATH_1	232	236	PF00917	0.543
DOC_USP7_MATH_1	24	28	PF00917	0.584
DOC_USP7_MATH_1	247	251	PF00917	0.706
DOC_USP7_MATH_1	278	282	PF00917	0.641
DOC_USP7_MATH_1	333	337	PF00917	0.672
DOC_USP7_MATH_1	341	345	PF00917	0.613
DOC_USP7_MATH_1	393	397	PF00917	0.618
DOC_USP7_MATH_1	467	471	PF00917	0.724
DOC_USP7_MATH_1	50	54	PF00917	0.580
DOC_USP7_MATH_1	554	558	PF00917	0.449
DOC_USP7_MATH_1	656	660	PF00917	0.504
DOC_USP7_MATH_1	665	669	PF00917	0.348
DOC_USP7_MATH_1	81	85	PF00917	0.558
DOC_USP7_MATH_1	823	827	PF00917	0.514
DOC_WW_Pin1_4	1078	1083	PF00397	0.704
DOC_WW_Pin1_4	136	141	PF00397	0.606
DOC_WW_Pin1_4	179	184	PF00397	0.535
DOC_WW_Pin1_4	243	248	PF00397	0.586
DOC_WW_Pin1_4	276	281	PF00397	0.574
DOC_WW_Pin1_4	413	418	PF00397	0.513
DOC_WW_Pin1_4	637	642	PF00397	0.407
DOC_WW_Pin1_4	670	675	PF00397	0.528
DOC_WW_Pin1_4	868	873	PF00397	0.464
DOC_WW_Pin1_4	90	95	PF00397	0.540
DOC_WW_Pin1_4	912	917	PF00397	0.547
LIG_14-3-3_CanoR_1	1057	1062	PF00244	0.595
LIG_14-3-3_CanoR_1	254	258	PF00244	0.627
LIG_14-3-3_CanoR_1	5	10	PF00244	0.539
LIG_14-3-3_CanoR_1	510	516	PF00244	0.504
LIG_14-3-3_CanoR_1	542	552	PF00244	0.509
LIG_14-3-3_CanoR_1	597	605	PF00244	0.355
LIG_14-3-3_CanoR_1	933	943	PF00244	0.607
LIG_Actin_WH2_2	577	595	PF00022	0.444
LIG_Actin_WH2_2	777	794	PF00022	0.432
LIG_APCC_ABBA_1	373	378	PF00400	0.492
LIG_BIR_III_4	392	396	PF00653	0.559
LIG_Clathr_ClatBox_1	163	167	PF01394	0.518
LIG_FHA_1	112	118	PF00498	0.506
LIG_FHA_1	180	186	PF00498	0.509
LIG_FHA_1	210	216	PF00498	0.480
LIG_FHA_1	269	275	PF00498	0.506
LIG_FHA_1	345	351	PF00498	0.565
LIG_FHA_1	407	413	PF00498	0.623
LIG_FHA_1	575	581	PF00498	0.358
LIG_FHA_1	600	606	PF00498	0.485
LIG_FHA_1	671	677	PF00498	0.353
LIG_FHA_1	845	851	PF00498	0.314
LIG_FHA_1	872	878	PF00498	0.532
LIG_FHA_1	946	952	PF00498	0.549
LIG_FHA_2	387	393	PF00498	0.580
LIG_FHA_2	70	76	PF00498	0.638
LIG_FHA_2	913	919	PF00498	0.555
LIG_GBD_Chelix_1	928	936	PF00786	0.327
LIG_LIR_Gen_1	339	350	PF02991	0.551
LIG_LIR_Gen_1	574	584	PF02991	0.321
LIG_LIR_Gen_1	689	699	PF02991	0.432
LIG_LIR_Gen_1	715	725	PF02991	0.436
LIG_LIR_Gen_1	830	840	PF02991	0.453
LIG_LIR_Gen_1	896	904	PF02991	0.347
LIG_LIR_Nem_3	293	299	PF02991	0.442
LIG_LIR_Nem_3	557	563	PF02991	0.419
LIG_LIR_Nem_3	574	579	PF02991	0.297
LIG_LIR_Nem_3	684	688	PF02991	0.438
LIG_LIR_Nem_3	689	694	PF02991	0.509
LIG_LIR_Nem_3	715	720	PF02991	0.433
LIG_LIR_Nem_3	896	901	PF02991	0.337
LIG_NRBOX	535	541	PF00104	0.509
LIG_NRBOX	786	792	PF00104	0.433
LIG_NRBOX	931	937	PF00104	0.499
LIG_PCNA_yPIPBox_3	16	29	PF02747	0.609
LIG_PCNA_yPIPBox_3	528	540	PF02747	0.445
LIG_Pex14_1	713	717	PF04695	0.436
LIG_Pex14_2	717	721	PF04695	0.397
LIG_SH2_CRK	407	411	PF00017	0.556
LIG_SH2_CRK	537	541	PF00017	0.453
LIG_SH2_CRK	560	564	PF00017	0.389
LIG_SH2_CRK	683	687	PF00017	0.421
LIG_SH2_CRK	852	856	PF00017	0.460
LIG_SH2_NCK_1	801	805	PF00017	0.418
LIG_SH2_PTP2	685	688	PF00017	0.447
LIG_SH2_PTP2	898	901	PF00017	0.425
LIG_SH2_SRC	904	907	PF00017	0.384
LIG_SH2_STAP1	1038	1042	PF00017	0.556
LIG_SH2_STAP1	430	434	PF00017	0.450
LIG_SH2_STAP1	576	580	PF00017	0.412
LIG_SH2_STAP1	904	908	PF00017	0.383
LIG_SH2_STAT3	430	433	PF00017	0.472
LIG_SH2_STAT5	458	461	PF00017	0.522
LIG_SH2_STAT5	576	579	PF00017	0.272
LIG_SH2_STAT5	685	688	PF00017	0.445
LIG_SH2_STAT5	801	804	PF00017	0.426
LIG_SH2_STAT5	898	901	PF00017	0.366
LIG_SH2_STAT5	931	934	PF00017	0.479
LIG_SH3_3	269	275	PF00018	0.460
LIG_SH3_3	34	40	PF00018	0.606
LIG_SH3_3	376	382	PF00018	0.497
LIG_SH3_3	585	591	PF00018	0.345
LIG_SH3_3	866	872	PF00018	0.455
LIG_SH3_3	953	959	PF00018	0.676
LIG_SUMO_SIM_anti_2	210	215	PF11976	0.412
LIG_SUMO_SIM_par_1	162	167	PF11976	0.581
LIG_TRAF2_1	72	75	PF00917	0.629
LIG_TYR_ITIM	405	410	PF00017	0.478
LIG_TYR_ITIM	558	563	PF00017	0.395
LIG_TYR_ITIM	681	686	PF00017	0.401
LIG_TYR_ITIM	850	855	PF00017	0.436
LIG_WRC_WIRS_1	25	30	PF05994	0.589
LIG_WRC_WIRS_1	459	464	PF05994	0.355
LIG_WRC_WIRS_1	894	899	PF05994	0.375
MOD_CK1_1	1018	1024	PF00069	0.681
MOD_CK1_1	1074	1080	PF00069	0.648
MOD_CK1_1	1087	1093	PF00069	0.686
MOD_CK1_1	156	162	PF00069	0.590
MOD_CK1_1	300	306	PF00069	0.439
MOD_CK1_1	336	342	PF00069	0.668
MOD_CK1_1	344	350	PF00069	0.508
MOD_CK1_1	366	372	PF00069	0.409
MOD_CK1_1	471	477	PF00069	0.734
MOD_CK1_1	490	496	PF00069	0.507
MOD_CK1_1	574	580	PF00069	0.363
MOD_CK1_1	599	605	PF00069	0.575
MOD_CK1_1	871	877	PF00069	0.300
MOD_CK1_1	912	918	PF00069	0.548
MOD_CK1_1	934	940	PF00069	0.530
MOD_CK2_1	1060	1066	PF00069	0.725
MOD_CK2_1	232	238	PF00069	0.570
MOD_CK2_1	314	320	PF00069	0.683
MOD_CK2_1	509	515	PF00069	0.421
MOD_CK2_1	626	632	PF00069	0.548
MOD_CK2_1	69	75	PF00069	0.643
MOD_CK2_1	800	806	PF00069	0.460
MOD_CK2_1	993	999	PF00069	0.632
MOD_GlcNHglycan	1003	1006	PF01048	0.634
MOD_GlcNHglycan	1015	1018	PF01048	0.592
MOD_GlcNHglycan	1025	1028	PF01048	0.793
MOD_GlcNHglycan	1068	1071	PF01048	0.689
MOD_GlcNHglycan	1073	1076	PF01048	0.709
MOD_GlcNHglycan	1086	1089	PF01048	0.782
MOD_GlcNHglycan	119	122	PF01048	0.446
MOD_GlcNHglycan	247	250	PF01048	0.688
MOD_GlcNHglycan	280	283	PF01048	0.666
MOD_GlcNHglycan	316	319	PF01048	0.671
MOD_GlcNHglycan	336	339	PF01048	0.456
MOD_GlcNHglycan	395	398	PF01048	0.640
MOD_GlcNHglycan	449	452	PF01048	0.553
MOD_GlcNHglycan	470	473	PF01048	0.646
MOD_GlcNHglycan	489	492	PF01048	0.344
MOD_GlcNHglycan	511	514	PF01048	0.429
MOD_GlcNHglycan	545	548	PF01048	0.504
MOD_GlcNHglycan	572	576	PF01048	0.389
MOD_GlcNHglycan	637	640	PF01048	0.560
MOD_GlcNHglycan	663	666	PF01048	0.394
MOD_GlcNHglycan	802	805	PF01048	0.630
MOD_GlcNHglycan	83	86	PF01048	0.610
MOD_GlcNHglycan	838	841	PF01048	0.477
MOD_GlcNHglycan	860	863	PF01048	0.428
MOD_GlcNHglycan	912	915	PF01048	0.543
MOD_GlcNHglycan	936	939	PF01048	0.493
MOD_GlcNHglycan	961	966	PF01048	0.683
MOD_GlcNHglycan	974	977	PF01048	0.626
MOD_GlcNHglycan	982	985	PF01048	0.556
MOD_GlcNHglycan	995	998	PF01048	0.519
MOD_GSK3_1	1015	1022	PF00069	0.596
MOD_GSK3_1	1056	1063	PF00069	0.674
MOD_GSK3_1	1066	1073	PF00069	0.691
MOD_GSK3_1	107	114	PF00069	0.534
MOD_GSK3_1	1074	1081	PF00069	0.631
MOD_GSK3_1	1084	1091	PF00069	0.480
MOD_GSK3_1	243	250	PF00069	0.593
MOD_GSK3_1	336	343	PF00069	0.630
MOD_GSK3_1	362	369	PF00069	0.549
MOD_GSK3_1	467	474	PF00069	0.649
MOD_GSK3_1	475	482	PF00069	0.698
MOD_GSK3_1	483	490	PF00069	0.480
MOD_GSK3_1	494	501	PF00069	0.480
MOD_GSK3_1	543	550	PF00069	0.475
MOD_GSK3_1	621	628	PF00069	0.523
MOD_GSK3_1	661	668	PF00069	0.464
MOD_GSK3_1	873	880	PF00069	0.449
MOD_GSK3_1	927	934	PF00069	0.625
MOD_GSK3_1	95	102	PF00069	0.550
MOD_NEK2_1	193	198	PF00069	0.540
MOD_NEK2_1	345	350	PF00069	0.468
MOD_NEK2_1	355	360	PF00069	0.438
MOD_NEK2_1	386	391	PF00069	0.390
MOD_NEK2_1	447	452	PF00069	0.574
MOD_NEK2_1	483	488	PF00069	0.573
MOD_NEK2_1	509	514	PF00069	0.430
MOD_NEK2_1	616	621	PF00069	0.475
MOD_NEK2_1	635	640	PF00069	0.539
MOD_NEK2_1	681	686	PF00069	0.325
MOD_NEK2_1	936	941	PF00069	0.632
MOD_NEK2_1	95	100	PF00069	0.582
MOD_NEK2_1	979	984	PF00069	0.623
MOD_NEK2_2	730	735	PF00069	0.389
MOD_PIKK_1	326	332	PF00454	0.674
MOD_PIKK_1	336	342	PF00454	0.741
MOD_PIKK_1	345	351	PF00454	0.454
MOD_PIKK_1	445	451	PF00454	0.502
MOD_PIKK_1	69	75	PF00454	0.593
MOD_PIKK_1	844	850	PF00454	0.394
MOD_PK_1	621	627	PF00069	0.543
MOD_PKA_1	5	11	PF00069	0.544
MOD_PKA_1	621	627	PF00069	0.560
MOD_PKA_2	1056	1062	PF00069	0.587
MOD_PKA_2	1066	1072	PF00069	0.709
MOD_PKA_2	233	239	PF00069	0.616
MOD_PKA_2	253	259	PF00069	0.623
MOD_PKA_2	262	268	PF00069	0.468
MOD_PKA_2	5	11	PF00069	0.544
MOD_PKA_2	509	515	PF00069	0.429
MOD_PKA_2	596	602	PF00069	0.385
MOD_PKA_2	621	627	PF00069	0.563
MOD_PKA_2	713	719	PF00069	0.443
MOD_PKA_2	836	842	PF00069	0.502
MOD_PKB_1	3	11	PF00069	0.590
MOD_Plk_1	156	162	PF00069	0.553
MOD_Plk_1	193	199	PF00069	0.654
MOD_Plk_1	209	215	PF00069	0.399
MOD_Plk_1	261	267	PF00069	0.429
MOD_Plk_1	571	577	PF00069	0.285
MOD_Plk_1	656	662	PF00069	0.480
MOD_Plk_1	877	883	PF00069	0.440
MOD_Plk_1	961	967	PF00069	0.601
MOD_Plk_4	1057	1063	PF00069	0.648
MOD_Plk_4	209	215	PF00069	0.451
MOD_Plk_4	24	30	PF00069	0.605
MOD_Plk_4	253	259	PF00069	0.623
MOD_Plk_4	290	296	PF00069	0.405
MOD_Plk_4	300	306	PF00069	0.366
MOD_Plk_4	366	372	PF00069	0.531
MOD_Plk_4	458	464	PF00069	0.538
MOD_Plk_4	483	489	PF00069	0.651
MOD_Plk_4	574	580	PF00069	0.375
MOD_Plk_4	611	617	PF00069	0.472
MOD_Plk_4	621	627	PF00069	0.543
MOD_Plk_4	681	687	PF00069	0.430
MOD_Plk_4	713	719	PF00069	0.443
MOD_Plk_4	750	756	PF00069	0.564
MOD_Plk_4	927	933	PF00069	0.476
MOD_ProDKin_1	1078	1084	PF00069	0.704
MOD_ProDKin_1	136	142	PF00069	0.606
MOD_ProDKin_1	179	185	PF00069	0.546
MOD_ProDKin_1	243	249	PF00069	0.585
MOD_ProDKin_1	276	282	PF00069	0.562
MOD_ProDKin_1	413	419	PF00069	0.502
MOD_ProDKin_1	637	643	PF00069	0.395
MOD_ProDKin_1	670	676	PF00069	0.522
MOD_ProDKin_1	868	874	PF00069	0.454
MOD_ProDKin_1	90	96	PF00069	0.548
MOD_ProDKin_1	912	918	PF00069	0.548
MOD_SUMO_for_1	463	466	PF00179	0.398
MOD_SUMO_rev_2	745	754	PF00179	0.526
MOD_SUMO_rev_2	939	949	PF00179	0.576
TRG_DiLeu_BaEn_1	715	720	PF01217	0.459
TRG_DiLeu_BaEn_2	674	680	PF01217	0.371
TRG_DiLeu_BaEn_2	749	755	PF01217	0.390
TRG_DiLeu_BaLyEn_6	558	563	PF01217	0.437
TRG_DiLeu_BaLyEn_6	789	794	PF01217	0.248
TRG_DiLeu_BaLyEn_6	812	817	PF01217	0.414
TRG_DiLeu_BaLyEn_6	974	979	PF01217	0.627
TRG_ENDOCYTIC_2	407	410	PF00928	0.476
TRG_ENDOCYTIC_2	537	540	PF00928	0.450
TRG_ENDOCYTIC_2	560	563	PF00928	0.388
TRG_ENDOCYTIC_2	576	579	PF00928	0.321
TRG_ENDOCYTIC_2	683	686	PF00928	0.425
TRG_ENDOCYTIC_2	833	836	PF00928	0.436
TRG_ENDOCYTIC_2	852	855	PF00928	0.427
TRG_ENDOCYTIC_2	898	901	PF00928	0.368
TRG_ER_diArg_1	3	6	PF00400	0.570
TRG_ER_diArg_1	620	622	PF00400	0.528
TRG_NLS_MonoCore_2	2	7	PF00514	0.594
TRG_NLS_MonoExtN_4	3	8	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	5	10	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML2	Leptomonas seymouri	53%	100%
A0A3S5ISF7	Trypanosoma rangeli	23%	100%
A0A3S7X5V5	Leishmania donovani	91%	100%
A4HKR9	Leishmania braziliensis	79%	100%
A4I899	Leishmania infantum	90%	100%
Q4Q4Z7	Leishmania major	90%	100%