Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B355_LEIMU

TriTrypDb:

LmxM.31.2760

Length:

871

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B355

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B355

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.552
CLV_C14_Caspase3-7	403	407	PF00656	0.742
CLV_C14_Caspase3-7	42	46	PF00656	0.767
CLV_C14_Caspase3-7	591	595	PF00656	0.720
CLV_C14_Caspase3-7	650	654	PF00656	0.778
CLV_NRD_NRD_1	216	218	PF00675	0.572
CLV_NRD_NRD_1	28	30	PF00675	0.838
CLV_NRD_NRD_1	354	356	PF00675	0.352
CLV_NRD_NRD_1	432	434	PF00675	0.606
CLV_NRD_NRD_1	48	50	PF00675	0.705
CLV_NRD_NRD_1	501	503	PF00675	0.570
CLV_NRD_NRD_1	7	9	PF00675	0.737
CLV_NRD_NRD_1	784	786	PF00675	0.713
CLV_NRD_NRD_1	855	857	PF00675	0.699
CLV_PCSK_KEX2_1	216	218	PF00082	0.576
CLV_PCSK_KEX2_1	27	29	PF00082	0.848
CLV_PCSK_KEX2_1	354	356	PF00082	0.352
CLV_PCSK_KEX2_1	432	434	PF00082	0.606
CLV_PCSK_KEX2_1	48	50	PF00082	0.705
CLV_PCSK_KEX2_1	501	503	PF00082	0.585
CLV_PCSK_KEX2_1	508	510	PF00082	0.579
CLV_PCSK_KEX2_1	784	786	PF00082	0.713
CLV_PCSK_KEX2_1	855	857	PF00082	0.598
CLV_PCSK_KEX2_1	89	91	PF00082	0.660
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.672
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.660
CLV_PCSK_SKI1_1	216	220	PF00082	0.570
CLV_PCSK_SKI1_1	517	521	PF00082	0.643
CLV_PCSK_SKI1_1	9	13	PF00082	0.732
CLV_Separin_Metazoa	413	417	PF03568	0.707
CLV_Separin_Metazoa	698	702	PF03568	0.573
DEG_APCC_DBOX_1	169	177	PF00400	0.643
DEG_COP1_1	342	352	PF00400	0.559
DEG_SCF_FBW7_1	11	18	PF00400	0.835
DEG_SCF_TRCP1_1	439	444	PF00400	0.600
DEG_SIAH_1	139	147	PF03145	0.638
DEG_SPOP_SBC_1	145	149	PF00917	0.646
DEG_SPOP_SBC_1	15	19	PF00917	0.728
DEG_SPOP_SBC_1	447	451	PF00917	0.542
DEG_SPOP_SBC_1	826	830	PF00917	0.610
DOC_CKS1_1	102	107	PF01111	0.758
DOC_CKS1_1	12	17	PF01111	0.835
DOC_CKS1_1	176	181	PF01111	0.751
DOC_CKS1_1	198	203	PF01111	0.696
DOC_CYCLIN_RxL_1	3	14	PF00134	0.741
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.732
DOC_CYCLIN_yCln2_LP_2	759	765	PF00134	0.534
DOC_MAPK_gen_1	492	500	PF00069	0.490
DOC_PP2B_LxvP_1	305	308	PF13499	0.573
DOC_USP7_MATH_1	106	110	PF00917	0.709
DOC_USP7_MATH_1	146	150	PF00917	0.700
DOC_USP7_MATH_1	15	19	PF00917	0.791
DOC_USP7_MATH_1	161	165	PF00917	0.705
DOC_USP7_MATH_1	192	196	PF00917	0.608
DOC_USP7_MATH_1	233	237	PF00917	0.556
DOC_USP7_MATH_1	532	536	PF00917	0.741
DOC_USP7_MATH_1	538	542	PF00917	0.745
DOC_USP7_MATH_1	588	592	PF00917	0.669
DOC_USP7_MATH_1	607	611	PF00917	0.846
DOC_USP7_MATH_1	634	638	PF00917	0.759
DOC_USP7_MATH_1	749	753	PF00917	0.768
DOC_USP7_MATH_1	75	79	PF00917	0.810
DOC_USP7_MATH_1	789	793	PF00917	0.777
DOC_USP7_MATH_1	804	808	PF00917	0.647
DOC_USP7_MATH_1	826	830	PF00917	0.824
DOC_WW_Pin1_4	101	106	PF00397	0.795
DOC_WW_Pin1_4	11	16	PF00397	0.736
DOC_WW_Pin1_4	112	117	PF00397	0.683
DOC_WW_Pin1_4	129	134	PF00397	0.733
DOC_WW_Pin1_4	175	180	PF00397	0.698
DOC_WW_Pin1_4	197	202	PF00397	0.804
DOC_WW_Pin1_4	22	27	PF00397	0.732
DOC_WW_Pin1_4	296	301	PF00397	0.758
DOC_WW_Pin1_4	327	332	PF00397	0.529
DOC_WW_Pin1_4	43	48	PF00397	0.676
DOC_WW_Pin1_4	563	568	PF00397	0.820
DOC_WW_Pin1_4	573	578	PF00397	0.774
DOC_WW_Pin1_4	584	589	PF00397	0.689
DOC_WW_Pin1_4	595	600	PF00397	0.748
DOC_WW_Pin1_4	624	629	PF00397	0.738
DOC_WW_Pin1_4	665	670	PF00397	0.822
DOC_WW_Pin1_4	791	796	PF00397	0.686
LIG_14-3-3_CanoR_1	170	174	PF00244	0.546
LIG_14-3-3_CanoR_1	21	26	PF00244	0.839
LIG_14-3-3_CanoR_1	37	47	PF00244	0.752
LIG_14-3-3_CanoR_1	432	436	PF00244	0.723
LIG_14-3-3_CanoR_1	48	54	PF00244	0.590
LIG_14-3-3_CanoR_1	481	490	PF00244	0.573
LIG_14-3-3_CanoR_1	501	505	PF00244	0.350
LIG_14-3-3_CanoR_1	608	612	PF00244	0.763
LIG_14-3-3_CanoR_1	664	669	PF00244	0.660
LIG_14-3-3_CanoR_1	684	690	PF00244	0.707
LIG_14-3-3_CanoR_1	701	705	PF00244	0.571
LIG_14-3-3_CanoR_1	784	788	PF00244	0.657
LIG_14-3-3_CanoR_1	797	804	PF00244	0.647
LIG_14-3-3_CanoR_1	806	813	PF00244	0.749
LIG_Actin_WH2_2	417	434	PF00022	0.693
LIG_Actin_WH2_2	686	703	PF00022	0.575
LIG_APCC_ABBA_1	208	213	PF00400	0.641
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_BIR_III_2	653	657	PF00653	0.554
LIG_BIR_III_4	594	598	PF00653	0.784
LIG_BRCT_BRCA1_1	114	118	PF00533	0.707
LIG_BRCT_BRCA1_1	768	772	PF00533	0.727
LIG_BRCT_BRCA1_1	775	779	PF00533	0.690
LIG_CSL_BTD_1	305	308	PF09270	0.496
LIG_CtBP_PxDLS_1	307	311	PF00389	0.460
LIG_FHA_1	183	189	PF00498	0.693
LIG_FHA_1	200	206	PF00498	0.678
LIG_FHA_1	331	337	PF00498	0.548
LIG_FHA_1	448	454	PF00498	0.757
LIG_FHA_1	520	526	PF00498	0.761
LIG_FHA_1	587	593	PF00498	0.633
LIG_FHA_1	808	814	PF00498	0.846
LIG_FHA_1	829	835	PF00498	0.561
LIG_FHA_2	170	176	PF00498	0.823
LIG_FHA_2	246	252	PF00498	0.553
LIG_FHA_2	40	46	PF00498	0.775
LIG_FHA_2	401	407	PF00498	0.697
LIG_FHA_2	415	421	PF00498	0.452
LIG_FHA_2	467	473	PF00498	0.454
LIG_FHA_2	60	66	PF00498	0.490
LIG_FHA_2	707	713	PF00498	0.740
LIG_FHA_2	74	80	PF00498	0.747
LIG_FHA_2	820	826	PF00498	0.626
LIG_GBD_Chelix_1	356	364	PF00786	0.355
LIG_GBD_Chelix_1	474	482	PF00786	0.690
LIG_LIR_Gen_1	358	369	PF02991	0.527
LIG_LIR_Gen_1	456	466	PF02991	0.623
LIG_LIR_LC3C_4	206	210	PF02991	0.495
LIG_LIR_Nem_3	358	364	PF02991	0.525
LIG_LIR_Nem_3	835	839	PF02991	0.639
LIG_PDZ_Class_1	866	871	PF00595	0.720
LIG_RPA_C_Fungi	489	501	PF08784	0.566
LIG_SH2_CRK	547	551	PF00017	0.521
LIG_SH2_NCK_1	13	17	PF00017	0.733
LIG_SH2_STAP1	853	857	PF00017	0.704
LIG_SH2_STAT3	476	479	PF00017	0.694
LIG_SH2_STAT5	13	16	PF00017	0.842
LIG_SH2_STAT5	54	57	PF00017	0.634
LIG_SH2_STAT5	708	711	PF00017	0.605
LIG_SH3_2	524	529	PF14604	0.718
LIG_SH3_3	130	136	PF00018	0.689
LIG_SH3_3	176	182	PF00018	0.654
LIG_SH3_3	195	201	PF00018	0.709
LIG_SH3_3	206	212	PF00018	0.601
LIG_SH3_3	518	524	PF00018	0.683
LIG_SH3_3	587	593	PF00018	0.619
LIG_SH3_3	626	632	PF00018	0.760
LIG_SH3_3	710	716	PF00018	0.719
LIG_SH3_3	759	765	PF00018	0.562
LIG_SH3_3	843	849	PF00018	0.783
LIG_SUMO_SIM_par_1	828	835	PF11976	0.551
LIG_TRAF2_1	423	426	PF00917	0.683
LIG_TRAF2_1	469	472	PF00917	0.615
LIG_TRAF2_1	503	506	PF00917	0.612
LIG_TRAF2_1	741	744	PF00917	0.548
LIG_Vh1_VBS_1	310	328	PF01044	0.581
MOD_CDC14_SPxK_1	25	28	PF00782	0.794
MOD_CDC14_SPxK_1	46	49	PF00782	0.655
MOD_CDC14_SPxK_1	794	797	PF00782	0.550
MOD_CDK_SPK_2	132	137	PF00069	0.737
MOD_CDK_SPK_2	22	27	PF00069	0.842
MOD_CDK_SPK_2	43	48	PF00069	0.676
MOD_CDK_SPK_2	563	568	PF00069	0.540
MOD_CDK_SPxK_1	22	28	PF00069	0.790
MOD_CDK_SPxK_1	43	49	PF00069	0.672
MOD_CDK_SPxK_1	624	630	PF00069	0.725
MOD_CDK_SPxK_1	791	797	PF00069	0.552
MOD_CDK_SPxxK_3	132	139	PF00069	0.740
MOD_CDK_SPxxK_3	22	29	PF00069	0.846
MOD_CK1_1	107	113	PF00069	0.731
MOD_CK1_1	132	138	PF00069	0.816
MOD_CK1_1	2	8	PF00069	0.767
MOD_CK1_1	203	209	PF00069	0.772
MOD_CK1_1	39	45	PF00069	0.713
MOD_CK1_1	437	443	PF00069	0.752
MOD_CK1_1	448	454	PF00069	0.632
MOD_CK1_1	456	462	PF00069	0.507
MOD_CK1_1	566	572	PF00069	0.737
MOD_CK1_1	573	579	PF00069	0.742
MOD_CK1_1	582	588	PF00069	0.696
MOD_CK1_1	598	604	PF00069	0.784
MOD_CK1_1	639	645	PF00069	0.641
MOD_CK1_1	667	673	PF00069	0.838
MOD_CK1_1	688	694	PF00069	0.691
MOD_CK1_1	732	738	PF00069	0.613
MOD_CK1_1	775	781	PF00069	0.760
MOD_CK1_1	805	811	PF00069	0.790
MOD_CK1_1	818	824	PF00069	0.802
MOD_CK1_1	828	834	PF00069	0.688
MOD_CK2_1	169	175	PF00069	0.821
MOD_CK2_1	245	251	PF00069	0.597
MOD_CK2_1	414	420	PF00069	0.484
MOD_CK2_1	466	472	PF00069	0.570
MOD_CK2_1	490	496	PF00069	0.577
MOD_CK2_1	500	506	PF00069	0.562
MOD_CK2_1	59	65	PF00069	0.790
MOD_CK2_1	706	712	PF00069	0.703
MOD_CK2_1	73	79	PF00069	0.587
MOD_CK2_1	775	781	PF00069	0.684
MOD_DYRK1A_RPxSP_1	586	590	PF00069	0.557
MOD_GlcNHglycan	140	143	PF01048	0.793
MOD_GlcNHglycan	148	151	PF01048	0.688
MOD_GlcNHglycan	190	193	PF01048	0.711
MOD_GlcNHglycan	274	277	PF01048	0.731
MOD_GlcNHglycan	293	296	PF01048	0.507
MOD_GlcNHglycan	38	41	PF01048	0.711
MOD_GlcNHglycan	397	400	PF01048	0.581
MOD_GlcNHglycan	4	7	PF01048	0.700
MOD_GlcNHglycan	439	442	PF01048	0.771
MOD_GlcNHglycan	450	453	PF01048	0.637
MOD_GlcNHglycan	530	533	PF01048	0.707
MOD_GlcNHglycan	540	543	PF01048	0.673
MOD_GlcNHglycan	559	562	PF01048	0.685
MOD_GlcNHglycan	570	573	PF01048	0.719
MOD_GlcNHglycan	582	585	PF01048	0.805
MOD_GlcNHglycan	615	618	PF01048	0.747
MOD_GlcNHglycan	638	641	PF01048	0.691
MOD_GlcNHglycan	73	76	PF01048	0.757
MOD_GlcNHglycan	737	741	PF01048	0.723
MOD_GSK3_1	11	18	PF00069	0.678
MOD_GSK3_1	125	132	PF00069	0.697
MOD_GSK3_1	144	151	PF00069	0.728
MOD_GSK3_1	161	168	PF00069	0.755
MOD_GSK3_1	184	191	PF00069	0.686
MOD_GSK3_1	193	200	PF00069	0.649
MOD_GSK3_1	306	313	PF00069	0.704
MOD_GSK3_1	326	333	PF00069	0.378
MOD_GSK3_1	39	46	PF00069	0.725
MOD_GSK3_1	437	444	PF00069	0.723
MOD_GSK3_1	456	463	PF00069	0.602
MOD_GSK3_1	49	56	PF00069	0.621
MOD_GSK3_1	528	535	PF00069	0.787
MOD_GSK3_1	566	573	PF00069	0.742
MOD_GSK3_1	580	587	PF00069	0.789
MOD_GSK3_1	603	610	PF00069	0.812
MOD_GSK3_1	624	631	PF00069	0.703
MOD_GSK3_1	664	671	PF00069	0.753
MOD_GSK3_1	672	679	PF00069	0.751
MOD_GSK3_1	700	707	PF00069	0.787
MOD_GSK3_1	71	78	PF00069	0.856
MOD_GSK3_1	725	732	PF00069	0.687
MOD_GSK3_1	768	775	PF00069	0.735
MOD_GSK3_1	789	796	PF00069	0.701
MOD_GSK3_1	802	809	PF00069	0.815
MOD_GSK3_1	815	822	PF00069	0.747
MOD_GSK3_1	828	835	PF00069	0.810
MOD_N-GLC_1	152	157	PF02516	0.670
MOD_N-GLC_1	773	778	PF02516	0.655
MOD_N-GLC_1	818	823	PF02516	0.840
MOD_NEK2_1	152	157	PF00069	0.740
MOD_NEK2_1	270	275	PF00069	0.501
MOD_NEK2_1	319	324	PF00069	0.649
MOD_NEK2_1	414	419	PF00069	0.519
MOD_NEK2_1	431	436	PF00069	0.621
MOD_NEK2_1	490	495	PF00069	0.544
MOD_NEK2_1	579	584	PF00069	0.852
MOD_NEK2_1	700	705	PF00069	0.667
MOD_NEK2_1	827	832	PF00069	0.618
MOD_PIKK_1	203	209	PF00454	0.726
MOD_PIKK_1	414	420	PF00454	0.431
MOD_PIKK_1	467	473	PF00454	0.746
MOD_PIKK_1	598	604	PF00454	0.837
MOD_PIKK_1	668	674	PF00454	0.749
MOD_PKA_2	122	128	PF00069	0.621
MOD_PKA_2	138	144	PF00069	0.670
MOD_PKA_2	169	175	PF00069	0.570
MOD_PKA_2	2	8	PF00069	0.720
MOD_PKA_2	245	251	PF00069	0.556
MOD_PKA_2	36	42	PF00069	0.723
MOD_PKA_2	395	401	PF00069	0.558
MOD_PKA_2	431	437	PF00069	0.723
MOD_PKA_2	500	506	PF00069	0.679
MOD_PKA_2	528	534	PF00069	0.758
MOD_PKA_2	607	613	PF00069	0.821
MOD_PKA_2	700	706	PF00069	0.599
MOD_PKA_2	732	738	PF00069	0.760
MOD_PKA_2	783	789	PF00069	0.828
MOD_PKA_2	796	802	PF00069	0.696
MOD_PKA_2	805	811	PF00069	0.731
MOD_Plk_1	319	325	PF00069	0.645
MOD_Plk_2-3	169	175	PF00069	0.662
MOD_Plk_2-3	94	100	PF00069	0.557
MOD_Plk_4	114	120	PF00069	0.642
MOD_Plk_4	348	354	PF00069	0.523
MOD_Plk_4	768	774	PF00069	0.690
MOD_ProDKin_1	101	107	PF00069	0.795
MOD_ProDKin_1	11	17	PF00069	0.738
MOD_ProDKin_1	112	118	PF00069	0.684
MOD_ProDKin_1	129	135	PF00069	0.732
MOD_ProDKin_1	175	181	PF00069	0.696
MOD_ProDKin_1	197	203	PF00069	0.801
MOD_ProDKin_1	22	28	PF00069	0.734
MOD_ProDKin_1	296	302	PF00069	0.758
MOD_ProDKin_1	327	333	PF00069	0.530
MOD_ProDKin_1	43	49	PF00069	0.672
MOD_ProDKin_1	563	569	PF00069	0.820
MOD_ProDKin_1	573	579	PF00069	0.776
MOD_ProDKin_1	584	590	PF00069	0.683
MOD_ProDKin_1	595	601	PF00069	0.744
MOD_ProDKin_1	624	630	PF00069	0.739
MOD_ProDKin_1	665	671	PF00069	0.820
MOD_ProDKin_1	791	797	PF00069	0.688
MOD_SUMO_for_1	779	782	PF00179	0.522
TRG_DiLeu_BaEn_4	426	432	PF01217	0.593
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.647
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.662
TRG_DiLeu_BaLyEn_6	514	519	PF01217	0.613
TRG_DiLeu_BaLyEn_6	610	615	PF01217	0.759
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.729
TRG_ENDOCYTIC_2	361	364	PF00928	0.494
TRG_ER_diArg_1	136	139	PF00400	0.769
TRG_ER_diArg_1	216	218	PF00400	0.580
TRG_ER_diArg_1	26	29	PF00400	0.843
TRG_ER_diArg_1	353	355	PF00400	0.608
TRG_ER_diArg_1	431	433	PF00400	0.605
TRG_ER_diArg_1	435	438	PF00400	0.648
TRG_ER_diArg_1	47	49	PF00400	0.642
TRG_ER_diArg_1	500	502	PF00400	0.529
TRG_ER_diArg_1	515	518	PF00400	0.614
TRG_ER_diArg_1	783	785	PF00400	0.543
TRG_ER_diArg_1	855	857	PF00400	0.699
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	502	506	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1L2	Leptomonas seymouri	36%	100%
A0A3S5H7S7	Leishmania donovani	83%	100%
A4HKR7	Leishmania braziliensis	66%	100%
A4I897	Leishmania infantum	83%	99%
Q4Q4Z9	Leishmania major	83%	99%