Rhodanese domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

As/Sb Reductase

Species:

Leishmania mexicana

UniProt:

E9B353_LEIMU

TriTrypDb:

LmxM.31.2740

Length:

127

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B353

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B353

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008794	arsenate reductase (glutaredoxin) activity	4	2
GO:0016491	oxidoreductase activity	2	2
GO:0030611	arsenate reductase activity	3	2
GO:0030613	oxidoreductase activity, acting on phosphorus or arsenic in donors	3	2
GO:0030614	oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	29	33	PF00656	0.549
CLV_NRD_NRD_1	66	68	PF00675	0.231
CLV_PCSK_SKI1_1	58	62	PF00082	0.313
CLV_PCSK_SKI1_1	88	92	PF00082	0.321
DOC_CYCLIN_RxL_1	58	66	PF00134	0.526
DOC_MAPK_DCC_7	95	105	PF00069	0.549
LIG_Actin_WH2_2	92	109	PF00022	0.520
LIG_BIR_II_1	1	5	PF00653	0.474
LIG_CtBP_PxDLS_1	9	13	PF00389	0.490
LIG_FHA_2	60	66	PF00498	0.526
LIG_LIR_Apic_2	5	9	PF02991	0.427
LIG_LIR_Gen_1	53	64	PF02991	0.461
LIG_LIR_Nem_3	111	117	PF02991	0.499
LIG_LIR_Nem_3	53	59	PF02991	0.478
LIG_NRBOX	11	17	PF00104	0.417
LIG_Pex14_1	110	114	PF04695	0.526
LIG_Rb_LxCxE_1	45	65	PF01857	0.482
LIG_SH2_PTP2	98	101	PF00017	0.490
LIG_SH2_STAP1	56	60	PF00017	0.491
LIG_SH2_STAT5	104	107	PF00017	0.462
LIG_SH2_STAT5	4	7	PF00017	0.350
LIG_SH2_STAT5	98	101	PF00017	0.492
LIG_SH3_3	77	83	PF00018	0.379
LIG_SUMO_SIM_anti_2	10	17	PF11976	0.461
LIG_SUMO_SIM_par_1	10	17	PF11976	0.461
MOD_CK1_1	45	51	PF00069	0.526
MOD_CK2_1	47	53	PF00069	0.494
MOD_CK2_1	59	65	PF00069	0.463
MOD_GSK3_1	45	52	PF00069	0.464
MOD_NEK2_1	59	64	PF00069	0.489
MOD_PKA_2	30	36	PF00069	0.549
MOD_Plk_4	2	8	PF00069	0.446
MOD_Plk_4	59	65	PF00069	0.502
MOD_Plk_4	75	81	PF00069	0.530
MOD_SUMO_for_1	7	10	PF00179	0.408
MOD_SUMO_rev_2	65	70	PF00179	0.526
TRG_DiLeu_BaEn_1	11	16	PF01217	0.419
TRG_ENDOCYTIC_2	117	120	PF00928	0.475
TRG_ENDOCYTIC_2	4	7	PF00928	0.349
TRG_ENDOCYTIC_2	56	59	PF00928	0.499
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.294

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDD0	Leptomonas seymouri	71%	100%
A0A0S4IHU2	Bodo saltans	38%	91%
A0A1X0NRP2	Trypanosomatidae	46%	86%
A0A3Q8IGZ4	Leishmania donovani	90%	100%
A0A3R7KPC6	Trypanosoma rangeli	54%	99%
A4HKR5	Leishmania braziliensis	83%	100%
A4I895	Leishmania infantum	91%	100%
Q8WZK3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	92%
V5AXX4	Trypanosoma cruzi	55%	100%