CPSF_A domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B352_LEIMU

TriTrypDb:

LmxM.31.2730

Length:

1004

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B352

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B352

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.432
CLV_C14_Caspase3-7	296	300	PF00656	0.500
CLV_C14_Caspase3-7	501	505	PF00656	0.402
CLV_C14_Caspase3-7	860	864	PF00656	0.488
CLV_C14_Caspase3-7	946	950	PF00656	0.422
CLV_C14_Caspase3-7	986	990	PF00656	0.475
CLV_NRD_NRD_1	423	425	PF00675	0.480
CLV_NRD_NRD_1	490	492	PF00675	0.310
CLV_PCSK_KEX2_1	110	112	PF00082	0.363
CLV_PCSK_KEX2_1	177	179	PF00082	0.479
CLV_PCSK_KEX2_1	423	425	PF00082	0.624
CLV_PCSK_KEX2_1	761	763	PF00082	0.371
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.385
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.457
CLV_PCSK_PC1ET2_1	761	763	PF00082	0.371
CLV_PCSK_SKI1_1	138	142	PF00082	0.363
CLV_PCSK_SKI1_1	156	160	PF00082	0.235
CLV_PCSK_SKI1_1	450	454	PF00082	0.437
CLV_PCSK_SKI1_1	492	496	PF00082	0.351
CLV_PCSK_SKI1_1	566	570	PF00082	0.345
CLV_PCSK_SKI1_1	616	620	PF00082	0.389
CLV_PCSK_SKI1_1	735	739	PF00082	0.455
CLV_PCSK_SKI1_1	762	766	PF00082	0.370
CLV_PCSK_SKI1_1	871	875	PF00082	0.571
CLV_PCSK_SKI1_1	907	911	PF00082	0.328
DEG_APCC_DBOX_1	734	742	PF00400	0.373
DEG_SCF_FBW7_1	697	702	PF00400	0.390
DOC_ANK_TNKS_1	368	375	PF00023	0.443
DOC_CKS1_1	634	639	PF01111	0.483
DOC_CKS1_1	875	880	PF01111	0.355
DOC_CYCLIN_RxL_1	602	613	PF00134	0.387
DOC_MAPK_DCC_7	421	430	PF00069	0.537
DOC_MAPK_gen_1	150	159	PF00069	0.333
DOC_MAPK_gen_1	421	430	PF00069	0.427
DOC_MAPK_gen_1	675	684	PF00069	0.419
DOC_MAPK_gen_1	732	741	PF00069	0.375
DOC_MAPK_gen_1	874	883	PF00069	0.384
DOC_MAPK_MEF2A_6	421	430	PF00069	0.422
DOC_MAPK_MEF2A_6	732	741	PF00069	0.463
DOC_MAPK_MEF2A_6	831	838	PF00069	0.344
DOC_MAPK_MEF2A_6	952	960	PF00069	0.369
DOC_MIT_MIM_1	151	160	PF04212	0.317
DOC_PP1_RVXF_1	258	264	PF00149	0.351
DOC_PP1_RVXF_1	905	911	PF00149	0.382
DOC_PP4_FxxP_1	540	543	PF00568	0.320
DOC_PP4_MxPP_1	812	815	PF00568	0.373
DOC_USP7_MATH_1	129	133	PF00917	0.336
DOC_USP7_MATH_1	298	302	PF00917	0.578
DOC_USP7_MATH_1	316	320	PF00917	0.573
DOC_USP7_MATH_1	344	348	PF00917	0.666
DOC_USP7_MATH_1	401	405	PF00917	0.566
DOC_USP7_MATH_1	463	467	PF00917	0.574
DOC_USP7_MATH_1	787	791	PF00917	0.429
DOC_USP7_MATH_1	855	859	PF00917	0.650
DOC_USP7_MATH_1	945	949	PF00917	0.435
DOC_USP7_MATH_2	855	861	PF00917	0.534
DOC_WW_Pin1_4	276	281	PF00397	0.425
DOC_WW_Pin1_4	51	56	PF00397	0.526
DOC_WW_Pin1_4	574	579	PF00397	0.381
DOC_WW_Pin1_4	633	638	PF00397	0.474
DOC_WW_Pin1_4	695	700	PF00397	0.543
DOC_WW_Pin1_4	851	856	PF00397	0.636
DOC_WW_Pin1_4	864	869	PF00397	0.625
DOC_WW_Pin1_4	874	879	PF00397	0.337
LIG_14-3-3_CanoR_1	215	220	PF00244	0.449
LIG_14-3-3_CanoR_1	441	445	PF00244	0.436
LIG_14-3-3_CanoR_1	675	680	PF00244	0.504
LIG_14-3-3_CanoR_1	73	82	PF00244	0.438
LIG_14-3-3_CanoR_1	762	771	PF00244	0.372
LIG_14-3-3_CanoR_1	804	812	PF00244	0.438
LIG_14-3-3_CanoR_1	845	851	PF00244	0.481
LIG_14-3-3_CanoR_1	920	929	PF00244	0.340
LIG_14-3-3_CanoR_1	952	960	PF00244	0.427
LIG_BIR_II_1	1	5	PF00653	0.545
LIG_BIR_III_2	865	869	PF00653	0.358
LIG_BRCT_BRCA1_1	536	540	PF00533	0.542
LIG_CSL_BTD_1	915	918	PF09270	0.411
LIG_deltaCOP1_diTrp_1	599	603	PF00928	0.380
LIG_DLG_GKlike_1	795	803	PF00625	0.313
LIG_FHA_1	170	176	PF00498	0.481
LIG_FHA_1	220	226	PF00498	0.502
LIG_FHA_1	267	273	PF00498	0.554
LIG_FHA_1	474	480	PF00498	0.393
LIG_FHA_1	696	702	PF00498	0.424
LIG_FHA_1	717	723	PF00498	0.377
LIG_FHA_1	75	81	PF00498	0.402
LIG_FHA_1	763	769	PF00498	0.400
LIG_FHA_1	83	89	PF00498	0.332
LIG_FHA_1	865	871	PF00498	0.594
LIG_FHA_1	951	957	PF00498	0.363
LIG_FHA_2	14	20	PF00498	0.467
LIG_FHA_2	243	249	PF00498	0.582
LIG_FHA_2	451	457	PF00498	0.482
LIG_FHA_2	610	616	PF00498	0.381
LIG_FHA_2	747	753	PF00498	0.268
LIG_FHA_2	847	853	PF00498	0.571
LIG_IRF3_LxIS_1	570	577	PF10401	0.443
LIG_LIR_Apic_2	537	543	PF02991	0.350
LIG_LIR_Apic_2	544	548	PF02991	0.343
LIG_LIR_Gen_1	228	237	PF02991	0.331
LIG_LIR_Gen_1	569	579	PF02991	0.357
LIG_LIR_Gen_1	595	606	PF02991	0.360
LIG_LIR_Gen_1	683	693	PF02991	0.351
LIG_LIR_Gen_1	923	932	PF02991	0.423
LIG_LIR_Nem_3	228	233	PF02991	0.340
LIG_LIR_Nem_3	482	486	PF02991	0.312
LIG_LIR_Nem_3	569	574	PF02991	0.322
LIG_LIR_Nem_3	595	601	PF02991	0.377
LIG_LIR_Nem_3	683	688	PF02991	0.410
LIG_LIR_Nem_3	923	929	PF02991	0.310
LIG_MYND_1	276	280	PF01753	0.542
LIG_NRBOX	795	801	PF00104	0.428
LIG_Pex14_1	993	997	PF04695	0.423
LIG_Rb_LxCxE_1	707	724	PF01857	0.328
LIG_SH2_CRK	253	257	PF00017	0.518
LIG_SH2_CRK	34	38	PF00017	0.424
LIG_SH2_CRK	483	487	PF00017	0.284
LIG_SH2_CRK	571	575	PF00017	0.422
LIG_SH2_CRK	635	639	PF00017	0.402
LIG_SH2_CRK	997	1001	PF00017	0.398
LIG_SH2_NCK_1	286	290	PF00017	0.521
LIG_SH2_NCK_1	295	299	PF00017	0.577
LIG_SH2_PTP2	139	142	PF00017	0.352
LIG_SH2_PTP2	685	688	PF00017	0.328
LIG_SH2_SRC	286	289	PF00017	0.517
LIG_SH2_SRC	295	298	PF00017	0.574
LIG_SH2_SRC	545	548	PF00017	0.373
LIG_SH2_SRC	685	688	PF00017	0.328
LIG_SH2_SRC	928	931	PF00017	0.341
LIG_SH2_STAP1	286	290	PF00017	0.553
LIG_SH2_STAP1	571	575	PF00017	0.422
LIG_SH2_STAP1	840	844	PF00017	0.319
LIG_SH2_STAT5	139	142	PF00017	0.369
LIG_SH2_STAT5	545	548	PF00017	0.350
LIG_SH2_STAT5	571	574	PF00017	0.302
LIG_SH2_STAT5	635	638	PF00017	0.346
LIG_SH2_STAT5	685	688	PF00017	0.405
LIG_SH2_STAT5	721	724	PF00017	0.403
LIG_SH2_STAT5	81	84	PF00017	0.321
LIG_SH2_STAT5	928	931	PF00017	0.380
LIG_SH3_3	34	40	PF00018	0.410
LIG_SH3_3	507	513	PF00018	0.413
LIG_SH3_3	52	58	PF00018	0.419
LIG_SH3_3	547	553	PF00018	0.345
LIG_SH3_3	591	597	PF00018	0.510
LIG_SH3_3	768	774	PF00018	0.389
LIG_SH3_3	872	878	PF00018	0.364
LIG_SH3_3	879	885	PF00018	0.319
LIG_SH3_3	912	918	PF00018	0.422
LIG_SUMO_SIM_anti_2	188	195	PF11976	0.424
LIG_SUMO_SIM_anti_2	41	49	PF11976	0.337
LIG_SUMO_SIM_anti_2	953	960	PF11976	0.336
LIG_SUMO_SIM_par_1	188	195	PF11976	0.310
LIG_SUMO_SIM_par_1	41	49	PF11976	0.341
LIG_SxIP_EBH_1	661	675	PF03271	0.520
LIG_TRAF2_1	39	42	PF00917	0.380
LIG_TRAF2_1	466	469	PF00917	0.542
LIG_TRAF2_1	618	621	PF00917	0.498
LIG_TYR_ITIM	995	1000	PF00017	0.400
LIG_UBA3_1	44	50	PF00899	0.366
LIG_UBA3_1	809	816	PF00899	0.390
LIG_WRC_WIRS_1	216	221	PF05994	0.372
LIG_WW_3	578	582	PF00397	0.455
MOD_CDK_SPxK_1	633	639	PF00069	0.408
MOD_CDK_SPxxK_3	574	581	PF00069	0.502
MOD_CDK_SPxxK_3	864	871	PF00069	0.376
MOD_CK1_1	166	172	PF00069	0.527
MOD_CK1_1	266	272	PF00069	0.458
MOD_CK1_1	349	355	PF00069	0.705
MOD_CK1_1	49	55	PF00069	0.553
MOD_CK1_1	798	804	PF00069	0.307
MOD_CK1_1	90	96	PF00069	0.565
MOD_CK1_1	954	960	PF00069	0.418
MOD_CK2_1	298	304	PF00069	0.680
MOD_CK2_1	450	456	PF00069	0.501
MOD_CK2_1	462	468	PF00069	0.527
MOD_CK2_1	512	518	PF00069	0.393
MOD_CK2_1	609	615	PF00069	0.415
MOD_CK2_1	717	723	PF00069	0.430
MOD_CK2_1	746	752	PF00069	0.285
MOD_CK2_1	776	782	PF00069	0.334
MOD_CK2_1	787	793	PF00069	0.375
MOD_CK2_1	816	822	PF00069	0.443
MOD_CK2_1	851	857	PF00069	0.601
MOD_CMANNOS	202	205	PF00535	0.344
MOD_Cter_Amidation	489	492	PF01082	0.297
MOD_GlcNHglycan	131	134	PF01048	0.331
MOD_GlcNHglycan	165	168	PF01048	0.354
MOD_GlcNHglycan	202	205	PF01048	0.412
MOD_GlcNHglycan	309	312	PF01048	0.683
MOD_GlcNHglycan	318	321	PF01048	0.699
MOD_GlcNHglycan	348	351	PF01048	0.666
MOD_GlcNHglycan	355	358	PF01048	0.484
MOD_GlcNHglycan	51	54	PF01048	0.471
MOD_GlcNHglycan	554	557	PF01048	0.448
MOD_GlcNHglycan	651	654	PF01048	0.628
MOD_GlcNHglycan	800	803	PF01048	0.389
MOD_GlcNHglycan	857	860	PF01048	0.567
MOD_GSK3_1	110	117	PF00069	0.436
MOD_GSK3_1	14	21	PF00069	0.509
MOD_GSK3_1	200	207	PF00069	0.388
MOD_GSK3_1	215	222	PF00069	0.232
MOD_GSK3_1	276	283	PF00069	0.439
MOD_GSK3_1	298	305	PF00069	0.622
MOD_GSK3_1	349	356	PF00069	0.583
MOD_GSK3_1	459	466	PF00069	0.462
MOD_GSK3_1	663	670	PF00069	0.597
MOD_GSK3_1	695	702	PF00069	0.449
MOD_GSK3_1	82	89	PF00069	0.454
MOD_GSK3_1	851	858	PF00069	0.599
MOD_GSK3_1	916	923	PF00069	0.370
MOD_GSK3_1	930	937	PF00069	0.294
MOD_GSK3_1	950	957	PF00069	0.405
MOD_LATS_1	213	219	PF00433	0.375
MOD_LATS_1	410	416	PF00433	0.486
MOD_N-GLC_1	122	127	PF02516	0.354
MOD_N-GLC_1	474	479	PF02516	0.394
MOD_N-GLC_1	74	79	PF02516	0.426
MOD_N-GLC_2	363	365	PF02516	0.412
MOD_NEK2_1	263	268	PF00069	0.447
MOD_NEK2_1	27	32	PF00069	0.384
MOD_NEK2_1	353	358	PF00069	0.475
MOD_NEK2_2	440	445	PF00069	0.496
MOD_PIKK_1	699	705	PF00454	0.523
MOD_PIKK_1	920	926	PF00454	0.442
MOD_PIKK_1	977	983	PF00454	0.269
MOD_PK_1	18	24	PF00069	0.456
MOD_PKA_1	110	116	PF00069	0.466
MOD_PKA_2	110	116	PF00069	0.466
MOD_PKA_2	214	220	PF00069	0.513
MOD_PKA_2	440	446	PF00069	0.432
MOD_PKA_2	803	809	PF00069	0.428
MOD_PKA_2	919	925	PF00069	0.446
MOD_PKA_2	951	957	PF00069	0.445
MOD_Plk_1	122	128	PF00069	0.349
MOD_Plk_1	143	149	PF00069	0.428
MOD_Plk_1	18	24	PF00069	0.422
MOD_Plk_1	402	408	PF00069	0.505
MOD_Plk_1	474	480	PF00069	0.374
MOD_Plk_1	517	523	PF00069	0.360
MOD_Plk_1	83	89	PF00069	0.370
MOD_Plk_1	954	960	PF00069	0.357
MOD_Plk_2-3	746	752	PF00069	0.264
MOD_Plk_2-3	943	949	PF00069	0.516
MOD_Plk_4	122	128	PF00069	0.328
MOD_Plk_4	225	231	PF00069	0.396
MOD_Plk_4	242	248	PF00069	0.461
MOD_Plk_4	349	355	PF00069	0.590
MOD_Plk_4	541	547	PF00069	0.444
MOD_Plk_4	566	572	PF00069	0.328
MOD_Plk_4	64	70	PF00069	0.407
MOD_Plk_4	717	723	PF00069	0.520
MOD_Plk_4	795	801	PF00069	0.446
MOD_Plk_4	954	960	PF00069	0.413
MOD_ProDKin_1	276	282	PF00069	0.437
MOD_ProDKin_1	51	57	PF00069	0.513
MOD_ProDKin_1	574	580	PF00069	0.395
MOD_ProDKin_1	633	639	PF00069	0.485
MOD_ProDKin_1	695	701	PF00069	0.535
MOD_ProDKin_1	851	857	PF00069	0.642
MOD_ProDKin_1	864	870	PF00069	0.610
MOD_ProDKin_1	874	880	PF00069	0.334
MOD_SUMO_rev_2	300	310	PF00179	0.601
MOD_SUMO_rev_2	415	420	PF00179	0.404
MOD_SUMO_rev_2	646	650	PF00179	0.376
TRG_DiLeu_BaEn_1	188	193	PF01217	0.381
TRG_DiLeu_BaEn_1	734	739	PF01217	0.450
TRG_DiLeu_BaEn_1	955	960	PF01217	0.490
TRG_DiLeu_BaEn_3	41	47	PF01217	0.386
TRG_DiLeu_BaEn_4	447	453	PF01217	0.512
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.481
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.372
TRG_DiLeu_BaLyEn_6	904	909	PF01217	0.420
TRG_DiLeu_LyEn_5	696	701	PF01217	0.387
TRG_ENDOCYTIC_2	139	142	PF00928	0.336
TRG_ENDOCYTIC_2	34	37	PF00928	0.440
TRG_ENDOCYTIC_2	483	486	PF00928	0.284
TRG_ENDOCYTIC_2	571	574	PF00928	0.302
TRG_ENDOCYTIC_2	598	601	PF00928	0.335
TRG_ENDOCYTIC_2	635	638	PF00928	0.368
TRG_ENDOCYTIC_2	685	688	PF00928	0.328
TRG_ENDOCYTIC_2	928	931	PF00928	0.380
TRG_ENDOCYTIC_2	997	1000	PF00928	0.596
TRG_ER_diArg_1	423	425	PF00400	0.581
TRG_ER_diArg_1	488	491	PF00400	0.303
TRG_ER_FFAT_1	292	301	PF00635	0.563
TRG_Pf-PMV_PEXEL_1	369	373	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	907	912	PF00026	0.371

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Z6	Leptomonas seymouri	62%	95%
A0A1X0NRM5	Trypanosomatidae	39%	100%
A0A3S7X5X2	Leishmania donovani	88%	97%
A0A422NZR3	Trypanosoma rangeli	40%	100%
A4HKR4	Leishmania braziliensis	80%	99%
A4I894	Leishmania infantum	88%	97%
D0AAG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q502	Leishmania major	89%	100%