LeishMANIAdb
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60S ribosomal protein L27

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
60S ribosomal protein L27
Gene product:
ribosomal protein L27, putative
Species:
Leishmania mexicana
UniProt:
E9B350_LEIMU
TriTrypDb:
LmxM.31.2710
Length:
134

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 24
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 13
GO:0032991 protein-containing complex 1 14
GO:0043226 organelle 2 14
GO:0043228 non-membrane-bounded organelle 3 14
GO:0043229 intracellular organelle 3 14
GO:0043232 intracellular non-membrane-bounded organelle 4 14
GO:0110165 cellular anatomical entity 1 14
GO:1990904 ribonucleoprotein complex 2 14
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1
GO:0015934 large ribosomal subunit 4 1
GO:0022625 cytosolic large ribosomal subunit 5 1
GO:0044391 ribosomal subunit 3 1
GO:0016020 membrane 2 1

Expansion

Sequence features

E9B350
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B350

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 14
GO:0006518 peptide metabolic process 4 14
GO:0006807 nitrogen compound metabolic process 2 14
GO:0008152 metabolic process 1 14
GO:0009058 biosynthetic process 2 14
GO:0009059 macromolecule biosynthetic process 4 14
GO:0009987 cellular process 1 14
GO:0019538 protein metabolic process 3 14
GO:0034641 cellular nitrogen compound metabolic process 3 14
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 14
GO:0043043 peptide biosynthetic process 5 14
GO:0043170 macromolecule metabolic process 3 14
GO:0043603 amide metabolic process 3 14
GO:0043604 amide biosynthetic process 4 14
GO:0044237 cellular metabolic process 2 14
GO:0044238 primary metabolic process 2 14
GO:0044249 cellular biosynthetic process 3 14
GO:0044260 obsolete cellular macromolecule metabolic process 3 14
GO:0044271 cellular nitrogen compound biosynthetic process 4 14
GO:0071704 organic substance metabolic process 2 14
GO:1901564 organonitrogen compound metabolic process 3 14
GO:1901566 organonitrogen compound biosynthetic process 4 14
GO:1901576 organic substance biosynthetic process 3 14
Molecular functions
Term Name Level Count
GO:0003735 structural constituent of ribosome 2 14
GO:0005198 structural molecule activity 1 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 64 66 PF00675 0.286
CLV_PCSK_FUR_1 107 111 PF00082 0.342
CLV_PCSK_KEX2_1 104 106 PF00082 0.373
CLV_PCSK_KEX2_1 109 111 PF00082 0.364
CLV_PCSK_KEX2_1 64 66 PF00082 0.301
CLV_PCSK_PC1ET2_1 104 106 PF00082 0.377
CLV_PCSK_PC1ET2_1 109 111 PF00082 0.377
CLV_PCSK_PC7_1 105 111 PF00082 0.342
CLV_PCSK_SKI1_1 113 117 PF00082 0.329
CLV_PCSK_SKI1_1 3 7 PF00082 0.470
CLV_PCSK_SKI1_1 40 44 PF00082 0.532
CLV_PCSK_SKI1_1 78 82 PF00082 0.304
DEG_APCC_DBOX_1 39 47 PF00400 0.537
DOC_MAPK_gen_1 3 13 PF00069 0.351
DOC_MAPK_gen_1 64 72 PF00069 0.486
DOC_MAPK_gen_1 91 99 PF00069 0.486
DOC_MAPK_HePTP_8 62 74 PF00069 0.486
DOC_MAPK_MEF2A_6 64 72 PF00069 0.486
DOC_PP4_FxxP_1 4 7 PF00568 0.465
DOC_USP7_MATH_1 122 126 PF00917 0.577
DOC_USP7_UBL2_3 47 51 PF12436 0.452
LIG_14-3-3_CanoR_1 64 72 PF00244 0.492
LIG_BRCT_BRCA1_1 124 128 PF00533 0.577
LIG_LIR_Apic_2 2 7 PF02991 0.595
LIG_PDZ_Class_2 129 134 PF00595 0.486
LIG_REV1ctd_RIR_1 126 134 PF16727 0.486
LIG_SUMO_SIM_par_1 9 14 PF11976 0.520
LIG_UBA3_1 42 51 PF00899 0.474
MOD_CK1_1 100 106 PF00069 0.489
MOD_CK1_1 58 64 PF00069 0.486
MOD_GSK3_1 26 33 PF00069 0.620
MOD_N-GLC_1 97 102 PF02516 0.286
MOD_PIKK_1 63 69 PF00454 0.486
MOD_PKA_2 63 69 PF00069 0.480
MOD_Plk_4 122 128 PF00069 0.572
TRG_ER_diArg_1 131 134 PF00400 0.520

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I8B0 Leptomonas seymouri 95% 100%
A0A0S4JTD6 Bodo saltans 77% 86%
A0A0S4JTD7 Bodo saltans 77% 86%
A0A0S4KKR9 Bodo saltans 75% 100%
A0A1D8PFG4 Candida albicans (strain SC5314 / ATCC MYA-2876) 40% 99%
A0A1X0NRX5 Trypanosomatidae 83% 100%
A0A3Q8IDB1 Leishmania donovani 97% 100%
A0A3S5ISF6 Trypanosoma rangeli 80% 100%
A1XQU5 Sus scrofa 47% 99%
A4HKR2 Leishmania braziliensis 93% 100%
A4I890 Leishmania infantum 97% 100%
D0AAG2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 80% 79%
E9B348 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
O14388 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 42% 99%
O74538 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 44% 99%
P0C2H6 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 42% 99%
P0C2H7 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 42% 99%
P0DJ19 Tetrahymena thermophila 39% 93%
P41101 Solanum tuberosum 42% 97%
P51419 Arabidopsis thaliana 41% 99%
P61353 Homo sapiens 47% 99%
P61354 Rattus norvegicus 47% 99%
P61355 Gallus gallus 47% 99%
P61356 Bos taurus 47% 99%
P61357 Cervus nippon 47% 99%
P61358 Mus musculus 47% 99%
P61359 Hippocampus comes 49% 99%
P91914 Caenorhabditis elegans 42% 99%
Q02984 Pyrobotrys stellata 40% 100%
Q05462 Pisum sativum 43% 99%
Q4Q504 Leishmania major 98% 100%
Q4R8Z4 Macaca fascicularis 47% 99%
Q55BE6 Dictyostelium discoideum 44% 93%
Q7ZV82 Danio rerio 48% 99%
Q8LCL3 Arabidopsis thaliana 41% 99%
Q90YU1 Ictalurus punctatus 46% 99%
Q9P843 Candida albicans 40% 99%
Q9SKX8 Arabidopsis thaliana 41% 99%
Q9XSU7 Canis lupus familiaris 46% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS