PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinteoplast poly(A) polymerase complex 1 subunit, putative

Species:

Leishmania mexicana

UniProt:

E9B346_LEIMU

TriTrypDb:

LmxM.31.2670

Length:

790

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9B346

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B346

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0043631	RNA polyadenylation	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.574
CLV_C14_Caspase3-7	147	151	PF00656	0.508
CLV_C14_Caspase3-7	268	272	PF00656	0.750
CLV_C14_Caspase3-7	348	352	PF00656	0.503
CLV_C14_Caspase3-7	50	54	PF00656	0.515
CLV_C14_Caspase3-7	550	554	PF00656	0.650
CLV_C14_Caspase3-7	669	673	PF00656	0.531
CLV_NRD_NRD_1	170	172	PF00675	0.509
CLV_NRD_NRD_1	180	182	PF00675	0.469
CLV_NRD_NRD_1	216	218	PF00675	0.672
CLV_NRD_NRD_1	27	29	PF00675	0.612
CLV_NRD_NRD_1	31	33	PF00675	0.577
CLV_NRD_NRD_1	358	360	PF00675	0.497
CLV_NRD_NRD_1	479	481	PF00675	0.590
CLV_NRD_NRD_1	516	518	PF00675	0.473
CLV_NRD_NRD_1	524	526	PF00675	0.394
CLV_NRD_NRD_1	607	609	PF00675	0.539
CLV_NRD_NRD_1	715	717	PF00675	0.525
CLV_NRD_NRD_1	763	765	PF00675	0.523
CLV_NRD_NRD_1	88	90	PF00675	0.477
CLV_PCSK_FUR_1	168	172	PF00082	0.543
CLV_PCSK_FUR_1	603	607	PF00082	0.504
CLV_PCSK_KEX2_1	170	172	PF00082	0.493
CLV_PCSK_KEX2_1	180	182	PF00082	0.475
CLV_PCSK_KEX2_1	218	220	PF00082	0.658
CLV_PCSK_KEX2_1	293	295	PF00082	0.565
CLV_PCSK_KEX2_1	298	300	PF00082	0.511
CLV_PCSK_KEX2_1	31	33	PF00082	0.619
CLV_PCSK_KEX2_1	358	360	PF00082	0.587
CLV_PCSK_KEX2_1	390	392	PF00082	0.390
CLV_PCSK_KEX2_1	408	410	PF00082	0.465
CLV_PCSK_KEX2_1	479	481	PF00082	0.469
CLV_PCSK_KEX2_1	516	518	PF00082	0.414
CLV_PCSK_KEX2_1	605	607	PF00082	0.575
CLV_PCSK_KEX2_1	720	722	PF00082	0.557
CLV_PCSK_KEX2_1	762	764	PF00082	0.509
CLV_PCSK_KEX2_1	87	89	PF00082	0.489
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.732
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.565
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.511
CLV_PCSK_PC1ET2_1	390	392	PF00082	0.390
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.465
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.525
CLV_PCSK_PC7_1	214	220	PF00082	0.699
CLV_PCSK_PC7_1	294	300	PF00082	0.540
CLV_PCSK_PC7_1	603	609	PF00082	0.591
CLV_PCSK_PC7_1	716	722	PF00082	0.543
CLV_PCSK_SKI1_1	160	164	PF00082	0.423
CLV_PCSK_SKI1_1	23	27	PF00082	0.713
CLV_PCSK_SKI1_1	294	298	PF00082	0.602
CLV_PCSK_SKI1_1	49	53	PF00082	0.494
CLV_PCSK_SKI1_1	64	68	PF00082	0.442
CLV_PCSK_SKI1_1	736	740	PF00082	0.452
CLV_PCSK_SKI1_1	782	786	PF00082	0.492
DEG_APCC_DBOX_1	179	187	PF00400	0.473
DEG_APCC_DBOX_1	678	686	PF00400	0.494
DEG_Nend_Nbox_1	1	3	PF02207	0.647
DEG_SPOP_SBC_1	231	235	PF00917	0.525
DEG_SPOP_SBC_1	261	265	PF00917	0.492
DOC_CKS1_1	767	772	PF01111	0.358
DOC_CYCLIN_RxL_1	298	310	PF00134	0.615
DOC_MAPK_gen_1	113	122	PF00069	0.550
DOC_MAPK_MEF2A_6	113	122	PF00069	0.550
DOC_MAPK_MEF2A_6	303	311	PF00069	0.602
DOC_MAPK_NFAT4_5	113	121	PF00069	0.545
DOC_MAPK_RevD_3	157	171	PF00069	0.505
DOC_PP1_RVXF_1	734	741	PF00149	0.451
DOC_PP2B_LxvP_1	683	686	PF13499	0.498
DOC_PP2B_LxvP_1	768	771	PF13499	0.517
DOC_PP4_FxxP_1	465	468	PF00568	0.498
DOC_USP7_MATH_1	125	129	PF00917	0.634
DOC_USP7_MATH_1	248	252	PF00917	0.807
DOC_USP7_MATH_1	261	265	PF00917	0.749
DOC_USP7_MATH_1	535	539	PF00917	0.512
DOC_USP7_MATH_1	548	552	PF00917	0.594
DOC_USP7_MATH_1	630	634	PF00917	0.682
DOC_USP7_MATH_2	400	406	PF00917	0.286
DOC_USP7_UBL2_3	29	33	PF12436	0.661
DOC_USP7_UBL2_3	610	614	PF12436	0.589
DOC_WW_Pin1_4	12	17	PF00397	0.710
DOC_WW_Pin1_4	237	242	PF00397	0.783
DOC_WW_Pin1_4	246	251	PF00397	0.804
DOC_WW_Pin1_4	279	284	PF00397	0.739
DOC_WW_Pin1_4	557	562	PF00397	0.469
DOC_WW_Pin1_4	766	771	PF00397	0.473
LIG_14-3-3_CanoR_1	196	204	PF00244	0.589
LIG_14-3-3_CanoR_1	219	227	PF00244	0.661
LIG_14-3-3_CanoR_1	334	338	PF00244	0.404
LIG_14-3-3_CanoR_1	358	364	PF00244	0.490
LIG_14-3-3_CanoR_1	47	52	PF00244	0.514
LIG_14-3-3_CanoR_1	472	477	PF00244	0.532
LIG_14-3-3_CanoR_1	592	598	PF00244	0.539
LIG_Actin_WH2_2	469	484	PF00022	0.566
LIG_Actin_WH2_2	614	630	PF00022	0.360
LIG_ActinCP_TwfCPI_2	465	474	PF01115	0.558
LIG_AP2alpha_2	713	715	PF02296	0.595
LIG_BRCT_BRCA1_1	198	202	PF00533	0.623
LIG_BRCT_BRCA1_1	337	341	PF00533	0.579
LIG_deltaCOP1_diTrp_1	387	392	PF00928	0.384
LIG_deltaCOP1_diTrp_1	776	781	PF00928	0.480
LIG_FHA_1	162	168	PF00498	0.538
LIG_FHA_1	352	358	PF00498	0.512
LIG_FHA_1	368	374	PF00498	0.325
LIG_FHA_1	416	422	PF00498	0.558
LIG_FHA_1	592	598	PF00498	0.444
LIG_FHA_1	743	749	PF00498	0.553
LIG_FHA_1	91	97	PF00498	0.463
LIG_FHA_2	104	110	PF00498	0.564
LIG_FHA_2	315	321	PF00498	0.536
LIG_FHA_2	50	56	PF00498	0.468
LIG_FHA_2	557	563	PF00498	0.738
LIG_FHA_2	92	98	PF00498	0.509
LIG_GBD_Chelix_1	311	319	PF00786	0.565
LIG_LIR_Apic_2	462	468	PF02991	0.504
LIG_LIR_Apic_2	769	775	PF02991	0.337
LIG_LIR_Gen_1	109	119	PF02991	0.548
LIG_LIR_Gen_1	323	333	PF02991	0.380
LIG_LIR_Gen_1	53	62	PF02991	0.486
LIG_LIR_Gen_1	616	626	PF02991	0.552
LIG_LIR_Nem_3	109	114	PF02991	0.548
LIG_LIR_Nem_3	323	328	PF02991	0.389
LIG_LIR_Nem_3	330	335	PF02991	0.372
LIG_LIR_Nem_3	404	410	PF02991	0.445
LIG_LIR_Nem_3	53	59	PF02991	0.487
LIG_LIR_Nem_3	616	621	PF02991	0.539
LIG_MYND_1	680	684	PF01753	0.497
LIG_NRBOX	640	646	PF00104	0.608
LIG_Pex14_2	328	332	PF04695	0.389
LIG_Pex14_2	727	731	PF04695	0.547
LIG_PTAP_UEV_1	244	249	PF05743	0.638
LIG_SH2_STAP1	353	357	PF00017	0.466
LIG_SH2_STAP1	361	365	PF00017	0.494
LIG_SH2_STAP1	393	397	PF00017	0.397
LIG_SH2_STAP1	519	523	PF00017	0.539
LIG_SH2_STAT3	166	169	PF00017	0.543
LIG_SH2_STAT5	166	169	PF00017	0.432
LIG_SH2_STAT5	353	356	PF00017	0.420
LIG_SH2_STAT5	376	379	PF00017	0.580
LIG_SH2_STAT5	483	486	PF00017	0.424
LIG_SH2_STAT5	691	694	PF00017	0.430
LIG_SH2_STAT5	90	93	PF00017	0.530
LIG_SH3_1	764	770	PF00018	0.516
LIG_SH3_1	772	778	PF00018	0.461
LIG_SH3_3	242	248	PF00018	0.765
LIG_SH3_3	394	400	PF00018	0.512
LIG_SH3_3	465	471	PF00018	0.603
LIG_SH3_3	678	684	PF00018	0.493
LIG_SH3_3	731	737	PF00018	0.438
LIG_SH3_3	764	770	PF00018	0.509
LIG_SH3_3	772	778	PF00018	0.472
LIG_SUMO_SIM_anti_2	308	314	PF11976	0.589
LIG_SUMO_SIM_anti_2	369	375	PF11976	0.445
LIG_TRAF2_1	213	216	PF00917	0.624
LIG_TRAF2_1	379	382	PF00917	0.566
LIG_TRAF2_1	508	511	PF00917	0.315
LIG_TRAF2_2	119	124	PF00917	0.672
LIG_UBA3_1	315	324	PF00899	0.563
LIG_UBA3_1	656	665	PF00899	0.503
MOD_CK1_1	175	181	PF00069	0.621
MOD_CK1_1	19	25	PF00069	0.763
MOD_CK1_1	232	238	PF00069	0.665
MOD_CK1_1	251	257	PF00069	0.691
MOD_CK1_1	263	269	PF00069	0.504
MOD_CK1_1	314	320	PF00069	0.582
MOD_CK1_1	591	597	PF00069	0.510
MOD_CK1_1	690	696	PF00069	0.442
MOD_CK2_1	252	258	PF00069	0.811
MOD_CK2_1	307	313	PF00069	0.606
MOD_CK2_1	314	320	PF00069	0.533
MOD_CK2_1	472	478	PF00069	0.455
MOD_CK2_1	49	55	PF00069	0.474
MOD_CK2_1	663	669	PF00069	0.465
MOD_GlcNHglycan	267	270	PF01048	0.706
MOD_GlcNHglycan	435	438	PF01048	0.689
MOD_GlcNHglycan	537	540	PF01048	0.703
MOD_GlcNHglycan	553	557	PF01048	0.565
MOD_GlcNHglycan	692	695	PF01048	0.430
MOD_GlcNHglycan	710	713	PF01048	0.466
MOD_GSK3_1	125	132	PF00069	0.647
MOD_GSK3_1	17	24	PF00069	0.674
MOD_GSK3_1	239	246	PF00069	0.795
MOD_GSK3_1	248	255	PF00069	0.817
MOD_GSK3_1	261	268	PF00069	0.777
MOD_GSK3_1	277	284	PF00069	0.732
MOD_GSK3_1	307	314	PF00069	0.547
MOD_GSK3_1	548	555	PF00069	0.755
MOD_GSK3_1	593	600	PF00069	0.522
MOD_GSK3_1	8	15	PF00069	0.729
MOD_NEK2_1	129	134	PF00069	0.595
MOD_NEK2_1	18	23	PF00069	0.796
MOD_NEK2_1	230	235	PF00069	0.685
MOD_NEK2_1	288	293	PF00069	0.668
MOD_NEK2_1	297	302	PF00069	0.580
MOD_NEK2_1	307	312	PF00069	0.520
MOD_NEK2_1	335	340	PF00069	0.483
MOD_NEK2_1	552	557	PF00069	0.492
MOD_NEK2_1	740	745	PF00069	0.493
MOD_NEK2_1	91	96	PF00069	0.507
MOD_NEK2_2	103	108	PF00069	0.576
MOD_NEK2_2	139	144	PF00069	0.518
MOD_NEK2_2	353	358	PF00069	0.535
MOD_OFUCOSY	262	267	PF10250	0.703
MOD_PIKK_1	129	135	PF00454	0.592
MOD_PIKK_1	191	197	PF00454	0.463
MOD_PIKK_1	335	341	PF00454	0.449
MOD_PIKK_1	451	457	PF00454	0.627
MOD_PIKK_1	591	597	PF00454	0.536
MOD_PK_1	359	365	PF00069	0.615
MOD_PKA_1	606	612	PF00069	0.616
MOD_PKA_2	333	339	PF00069	0.408
MOD_PKA_2	588	594	PF00069	0.581
MOD_PKA_2	606	612	PF00069	0.517
MOD_PKB_1	217	225	PF00069	0.669
MOD_Plk_1	139	145	PF00069	0.509
MOD_Plk_1	307	313	PF00069	0.548
MOD_Plk_1	91	97	PF00069	0.509
MOD_Plk_2-3	57	63	PF00069	0.435
MOD_Plk_2-3	663	669	PF00069	0.465
MOD_Plk_4	139	145	PF00069	0.509
MOD_Plk_4	307	313	PF00069	0.496
MOD_Plk_4	593	599	PF00069	0.540
MOD_Plk_4	687	693	PF00069	0.458
MOD_Plk_4	91	97	PF00069	0.455
MOD_ProDKin_1	12	18	PF00069	0.711
MOD_ProDKin_1	237	243	PF00069	0.784
MOD_ProDKin_1	246	252	PF00069	0.806
MOD_ProDKin_1	279	285	PF00069	0.735
MOD_ProDKin_1	557	563	PF00069	0.466
MOD_ProDKin_1	766	772	PF00069	0.472
MOD_SUMO_for_1	379	382	PF00179	0.603
MOD_SUMO_for_1	613	616	PF00179	0.580
MOD_SUMO_rev_2	402	410	PF00179	0.548
MOD_SUMO_rev_2	661	666	PF00179	0.459
TRG_DiLeu_BaEn_1	640	645	PF01217	0.644
TRG_DiLeu_BaLyEn_6	734	739	PF01217	0.462
TRG_DiLeu_LyEn_5	640	645	PF01217	0.644
TRG_DiLeu_LyEn_5	678	683	PF01217	0.511
TRG_ENDOCYTIC_2	393	396	PF00928	0.467
TRG_ENDOCYTIC_2	407	410	PF00928	0.365
TRG_ENDOCYTIC_2	486	489	PF00928	0.492
TRG_ENDOCYTIC_2	519	522	PF00928	0.430
TRG_ER_diArg_1	167	170	PF00400	0.561
TRG_ER_diArg_1	357	359	PF00400	0.563
TRG_ER_diArg_1	479	482	PF00400	0.455
TRG_ER_diArg_1	516	518	PF00400	0.487
TRG_ER_diArg_1	605	608	PF00400	0.580
TRG_ER_diArg_1	761	764	PF00400	0.519
TRG_ER_diArg_1	87	89	PF00400	0.489
TRG_NLS_MonoExtC_3	27	32	PF00514	0.692
TRG_NLS_MonoExtC_3	715	720	PF00514	0.594
TRG_NLS_MonoExtN_4	26	32	PF00514	0.698
TRG_NLS_MonoExtN_4	290	296	PF00514	0.675
TRG_NLS_MonoExtN_4	714	720	PF00514	0.509
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	516	521	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I355	Leptomonas seymouri	71%	93%
A0A0S4JPP8	Bodo saltans	42%	100%
A0A1X0NS88	Trypanosomatidae	50%	99%
A0A3R7LBC9	Trypanosoma rangeli	51%	100%
A0A3S7X5U8	Leishmania donovani	94%	100%
A4HKQ8	Leishmania braziliensis	84%	99%
A4I888	Leishmania infantum	94%	100%
Q4Q508	Leishmania major	93%	100%
V5AUT0	Trypanosoma cruzi	52%	96%