LeishMANIAdb
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CHCH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
CHCH domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B338_LEIMU
TriTrypDb:
LmxM.31.2590
Length:
132

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B338
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B338

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 69 71 PF00675 0.582
CLV_PCSK_KEX2_1 69 71 PF00082 0.502
CLV_PCSK_SKI1_1 62 66 PF00082 0.545
DOC_CKS1_1 72 77 PF01111 0.504
DOC_MAPK_gen_1 22 30 PF00069 0.453
DOC_USP7_UBL2_3 62 66 PF12436 0.545
DOC_WW_Pin1_4 7 12 PF00397 0.736
DOC_WW_Pin1_4 71 76 PF00397 0.527
LIG_14-3-3_CanoR_1 48 56 PF00244 0.629
LIG_14-3-3_CanoR_1 69 73 PF00244 0.587
LIG_BIR_II_1 1 5 PF00653 0.666
LIG_BRCT_BRCA1_1 109 113 PF00533 0.292
LIG_LIR_Apic_2 71 75 PF02991 0.499
LIG_LIR_Nem_3 29 33 PF02991 0.640
LIG_LIR_Nem_3 63 68 PF02991 0.545
LIG_PDZ_Class_2 127 132 PF00595 0.470
LIG_Pex14_1 72 76 PF04695 0.502
LIG_SH3_3 21 27 PF00018 0.759
LIG_SH3_4 22 29 PF00018 0.451
LIG_TRAF2_1 18 21 PF00917 0.560
LIG_WW_3 22 26 PF00397 0.449
MOD_CK1_1 71 77 PF00069 0.535
MOD_GlcNHglycan 59 62 PF01048 0.637
MOD_N-GLC_1 2 7 PF02516 0.638
MOD_NEK2_1 115 120 PF00069 0.358
MOD_PKA_2 68 74 PF00069 0.584
MOD_ProDKin_1 7 13 PF00069 0.736
MOD_ProDKin_1 71 77 PF00069 0.530
TRG_ER_diArg_1 68 70 PF00400 0.580
TRG_Pf-PMV_PEXEL_1 104 108 PF00026 0.392

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PF38 Leptomonas seymouri 52% 100%
A0A1X0NRK0 Trypanosomatidae 53% 100%
A0A3Q8IH69 Leishmania donovani 87% 100%
A0A422NHY0 Trypanosoma rangeli 51% 100%
A4HKP9 Leishmania braziliensis 77% 100%
A4I880 Leishmania infantum 88% 100%
Q4Q516 Leishmania major 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS