WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B337_LEIMU

TriTrypDb:

LmxM.31.2580

Length:

364

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B337

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B337

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	255	259	PF00656	0.537
CLV_PCSK_SKI1_1	292	296	PF00082	0.382
DEG_Nend_UBRbox_3	1	3	PF02207	0.381
DOC_CKS1_1	315	320	PF01111	0.415
DOC_CKS1_1	63	68	PF01111	0.472
DOC_MAPK_gen_1	226	236	PF00069	0.411
DOC_MAPK_gen_1	277	287	PF00069	0.470
DOC_MAPK_HePTP_8	191	203	PF00069	0.462
DOC_MAPK_MEF2A_6	111	119	PF00069	0.217
DOC_MAPK_MEF2A_6	194	203	PF00069	0.465
DOC_MAPK_MEF2A_6	280	289	PF00069	0.424
DOC_PP1_RVXF_1	147	153	PF00149	0.325
DOC_PP1_RVXF_1	88	95	PF00149	0.449
DOC_USP7_MATH_1	103	107	PF00917	0.414
DOC_USP7_MATH_1	67	71	PF00917	0.417
DOC_WW_Pin1_4	314	319	PF00397	0.394
DOC_WW_Pin1_4	62	67	PF00397	0.459
LIG_14-3-3_CanoR_1	131	137	PF00244	0.384
LIG_BIR_III_2	258	262	PF00653	0.524
LIG_FHA_1	13	19	PF00498	0.350
LIG_FHA_1	202	208	PF00498	0.395
LIG_FHA_1	270	276	PF00498	0.446
LIG_FHA_1	33	39	PF00498	0.479
LIG_FHA_1	54	60	PF00498	0.380
LIG_FHA_2	293	299	PF00498	0.332
LIG_FHA_2	7	13	PF00498	0.440
LIG_LIR_Apic_2	211	217	PF02991	0.350
LIG_LIR_Gen_1	130	139	PF02991	0.494
LIG_LIR_Gen_1	238	246	PF02991	0.462
LIG_LIR_Nem_3	130	136	PF02991	0.519
LIG_LIR_Nem_3	196	201	PF02991	0.428
LIG_LIR_Nem_3	231	235	PF02991	0.492
LIG_LIR_Nem_3	238	242	PF02991	0.439
LIG_PTAP_UEV_1	111	116	PF05743	0.448
LIG_SH2_PTP2	214	217	PF00017	0.397
LIG_SH2_SRC	11	14	PF00017	0.559
LIG_SH2_STAP1	41	45	PF00017	0.449
LIG_SH2_STAT3	41	44	PF00017	0.428
LIG_SH2_STAT3	73	76	PF00017	0.342
LIG_SH2_STAT5	16	19	PF00017	0.354
LIG_SH2_STAT5	214	217	PF00017	0.341
LIG_SH2_STAT5	235	238	PF00017	0.344
LIG_SH3_3	109	115	PF00018	0.439
LIG_SH3_3	60	66	PF00018	0.409
LIG_TRAF2_1	171	174	PF00917	0.472
MOD_CK1_1	32	38	PF00069	0.374
MOD_CK1_1	334	340	PF00069	0.709
MOD_CK2_1	157	163	PF00069	0.322
MOD_CK2_1	168	174	PF00069	0.351
MOD_CK2_1	292	298	PF00069	0.329
MOD_CK2_1	6	12	PF00069	0.407
MOD_GlcNHglycan	100	103	PF01048	0.473
MOD_GlcNHglycan	112	115	PF01048	0.445
MOD_GlcNHglycan	159	162	PF01048	0.316
MOD_GlcNHglycan	242	245	PF01048	0.492
MOD_GlcNHglycan	249	252	PF01048	0.486
MOD_GlcNHglycan	321	324	PF01048	0.703
MOD_GlcNHglycan	342	345	PF01048	0.769
MOD_GlcNHglycan	351	354	PF01048	0.771
MOD_GSK3_1	25	32	PF00069	0.343
MOD_GSK3_1	310	317	PF00069	0.530
MOD_GSK3_1	319	326	PF00069	0.592
MOD_GSK3_1	40	47	PF00069	0.388
MOD_GSK3_1	67	74	PF00069	0.377
MOD_N-GLC_1	23	28	PF02516	0.463
MOD_NEK2_1	127	132	PF00069	0.383
MOD_NEK2_1	201	206	PF00069	0.340
MOD_NEK2_1	29	34	PF00069	0.347
MOD_NEK2_1	332	337	PF00069	0.751
MOD_NEK2_1	40	45	PF00069	0.450
MOD_NEK2_1	71	76	PF00069	0.404
MOD_NEK2_1	98	103	PF00069	0.427
MOD_PIKK_1	269	275	PF00454	0.508
MOD_PIKK_1	32	38	PF00454	0.470
MOD_PIKK_1	40	46	PF00454	0.477
MOD_PIKK_1	53	59	PF00454	0.441
MOD_PKA_2	228	234	PF00069	0.396
MOD_PKA_2	349	355	PF00069	0.695
MOD_Plk_1	145	151	PF00069	0.323
MOD_Plk_4	12	18	PF00069	0.412
MOD_Plk_4	44	50	PF00069	0.468
MOD_Plk_4	67	73	PF00069	0.358
MOD_ProDKin_1	314	320	PF00069	0.403
MOD_ProDKin_1	62	68	PF00069	0.458
MOD_SUMO_rev_2	148	158	PF00179	0.370
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.444
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.453
TRG_ER_diArg_1	149	152	PF00400	0.318
TRG_ER_diArg_1	360	363	PF00400	0.761
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8A3	Leptomonas seymouri	78%	99%
A0A0S4J2R9	Bodo saltans	44%	96%
A0A1X0NRV1	Trypanosomatidae	44%	100%
A0A3Q8IDA1	Leishmania donovani	95%	82%
A0A3R7L0G4	Trypanosoma rangeli	53%	100%
A4HKP8	Leishmania braziliensis	86%	100%
A4I879	Leishmania infantum	95%	82%
D0AAE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
Q4Q517	Leishmania major	95%	100%
V5BET5	Trypanosoma cruzi	51%	88%