Putative GPI transamidase component Tta1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GPI transamidase component Tta1, putative

Species:

Leishmania mexicana

UniProt:

E9B335_LEIMU

TriTrypDb:

LmxM.31.2560

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0008303	caspase complex	5	1
GO:0032991	protein-containing complex	1	1
GO:0042765	GPI-anchor transamidase complex	3	1
GO:0098796	membrane protein complex	2	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905368	peptidase complex	3	1
GO:1905369	endopeptidase complex	4	1

Expansion

Sequence features

E9B335

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B335

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0003923	GPI-anchor transamidase activity	6	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.524
CLV_NRD_NRD_1	166	168	PF00675	0.607
CLV_NRD_NRD_1	22	24	PF00675	0.477
CLV_PCSK_KEX2_1	162	164	PF00082	0.631
CLV_PCSK_KEX2_1	166	168	PF00082	0.578
CLV_PCSK_KEX2_1	22	24	PF00082	0.464
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.631
CLV_PCSK_SKI1_1	183	187	PF00082	0.674
CLV_PCSK_SKI1_1	271	275	PF00082	0.592
DEG_APCC_DBOX_1	270	278	PF00400	0.392
DEG_SCF_FBW7_1	71	78	PF00400	0.556
DOC_CYCLIN_yCln2_LP_2	366	372	PF00134	0.454
DOC_MAPK_gen_1	348	358	PF00069	0.389
DOC_MAPK_MEF2A_6	50	57	PF00069	0.404
DOC_PP2B_LxvP_1	177	180	PF13499	0.456
DOC_PP2B_LxvP_1	366	369	PF13499	0.397
DOC_PP4_FxxP_1	202	205	PF00568	0.364
DOC_USP7_MATH_1	15	19	PF00917	0.791
DOC_USP7_MATH_1	236	240	PF00917	0.550
DOC_USP7_MATH_1	242	246	PF00917	0.379
DOC_USP7_MATH_1	383	387	PF00917	0.444
DOC_USP7_MATH_1	391	395	PF00917	0.545
DOC_USP7_MATH_1	66	70	PF00917	0.442
DOC_USP7_MATH_1	76	80	PF00917	0.465
DOC_WW_Pin1_4	1	6	PF00397	0.732
DOC_WW_Pin1_4	252	257	PF00397	0.510
DOC_WW_Pin1_4	360	365	PF00397	0.447
DOC_WW_Pin1_4	71	76	PF00397	0.558
DOC_WW_Pin1_4	92	97	PF00397	0.400
LIG_14-3-3_CanoR_1	136	145	PF00244	0.439
LIG_14-3-3_CanoR_1	157	165	PF00244	0.417
LIG_14-3-3_CanoR_1	22	29	PF00244	0.619
LIG_14-3-3_CanoR_1	246	256	PF00244	0.474
LIG_14-3-3_CanoR_1	262	267	PF00244	0.486
LIG_14-3-3_CanoR_1	65	75	PF00244	0.442
LIG_14-3-3_CanoR_1	7	17	PF00244	0.761
LIG_Actin_WH2_2	334	350	PF00022	0.449
LIG_BRCT_BRCA1_1	342	346	PF00533	0.460
LIG_FHA_1	126	132	PF00498	0.409
LIG_FHA_1	361	367	PF00498	0.446
LIG_FHA_1	72	78	PF00498	0.517
LIG_FHA_2	68	74	PF00498	0.469
LIG_LIR_Apic_2	200	205	PF02991	0.359
LIG_LIR_Gen_1	130	137	PF02991	0.421
LIG_LIR_Gen_1	26	37	PF02991	0.561
LIG_LIR_Gen_1	331	341	PF02991	0.442
LIG_LIR_Nem_3	130	135	PF02991	0.414
LIG_LIR_Nem_3	26	32	PF02991	0.561
LIG_LIR_Nem_3	33	38	PF02991	0.444
LIG_LIR_Nem_3	331	337	PF02991	0.451
LIG_MYND_1	360	364	PF01753	0.384
LIG_MYND_1	96	100	PF01753	0.414
LIG_SH2_CRK	132	136	PF00017	0.377
LIG_SH2_CRK	228	232	PF00017	0.343
LIG_SH2_NCK_1	249	253	PF00017	0.313
LIG_SH2_STAT5	132	135	PF00017	0.316
LIG_SH2_STAT5	228	231	PF00017	0.320
LIG_SH2_STAT5	306	309	PF00017	0.338
LIG_SH2_STAT5	367	370	PF00017	0.369
LIG_SH3_2	2	7	PF14604	0.659
LIG_SH3_3	121	127	PF00018	0.509
LIG_SH3_3	230	236	PF00018	0.398
LIG_SH3_3	377	383	PF00018	0.388
LIG_SH3_3	50	56	PF00018	0.482
LIG_SH3_3	90	96	PF00018	0.376
LIG_SUMO_SIM_anti_2	193	198	PF11976	0.224
LIG_SUMO_SIM_anti_2	376	382	PF11976	0.429
LIG_SUMO_SIM_par_1	273	279	PF11976	0.385
LIG_TRAF2_1	232	235	PF00917	0.422
LIG_TYR_ITSM	128	135	PF00017	0.383
LIG_WRC_WIRS_1	131	136	PF05994	0.368
LIG_WRC_WIRS_1	284	289	PF05994	0.360
MOD_CDC14_SPxK_1	4	7	PF00782	0.712
MOD_CDK_SPxK_1	1	7	PF00069	0.760
MOD_CK1_1	155	161	PF00069	0.357
MOD_CK1_1	200	206	PF00069	0.395
MOD_CK1_1	25	31	PF00069	0.486
MOD_CK1_1	250	256	PF00069	0.305
MOD_CK1_1	276	282	PF00069	0.395
MOD_CK1_1	310	316	PF00069	0.397
MOD_CK1_1	373	379	PF00069	0.429
MOD_CK1_1	67	73	PF00069	0.424
MOD_CK2_1	391	397	PF00069	0.419
MOD_CK2_1	66	72	PF00069	0.409
MOD_GlcNHglycan	154	157	PF01048	0.690
MOD_GlcNHglycan	159	162	PF01048	0.650
MOD_GlcNHglycan	206	209	PF01048	0.557
MOD_GlcNHglycan	249	252	PF01048	0.686
MOD_GlcNHglycan	309	312	PF01048	0.434
MOD_GlcNHglycan	32	35	PF01048	0.470
MOD_GlcNHglycan	342	345	PF01048	0.610
MOD_GlcNHglycan	78	81	PF01048	0.701
MOD_GSK3_1	1	8	PF00069	0.683
MOD_GSK3_1	148	155	PF00069	0.445
MOD_GSK3_1	200	207	PF00069	0.379
MOD_GSK3_1	279	286	PF00069	0.289
MOD_GSK3_1	306	313	PF00069	0.413
MOD_GSK3_1	67	74	PF00069	0.465
MOD_LATS_1	340	346	PF00433	0.306
MOD_N-GLC_1	23	28	PF02516	0.505
MOD_NEK2_1	197	202	PF00069	0.412
MOD_NEK2_1	64	69	PF00069	0.411
MOD_NEK2_2	127	132	PF00069	0.427
MOD_NEK2_2	283	288	PF00069	0.399
MOD_NEK2_2	311	316	PF00069	0.243
MOD_PIKK_1	136	142	PF00454	0.426
MOD_PIKK_1	276	282	PF00454	0.435
MOD_PIKK_1	373	379	PF00454	0.429
MOD_PKA_1	22	28	PF00069	0.653
MOD_PKA_2	22	28	PF00069	0.634
MOD_PKA_2	247	253	PF00069	0.469
MOD_PKA_2	64	70	PF00069	0.427
MOD_PKB_1	260	268	PF00069	0.496
MOD_Plk_1	370	376	PF00069	0.351
MOD_Plk_4	127	133	PF00069	0.413
MOD_Plk_4	197	203	PF00069	0.384
MOD_Plk_4	273	279	PF00069	0.303
MOD_Plk_4	342	348	PF00069	0.385
MOD_Plk_4	370	376	PF00069	0.300
MOD_Plk_4	385	391	PF00069	0.251
MOD_ProDKin_1	1	7	PF00069	0.732
MOD_ProDKin_1	252	258	PF00069	0.504
MOD_ProDKin_1	360	366	PF00069	0.451
MOD_ProDKin_1	71	77	PF00069	0.558
MOD_ProDKin_1	92	98	PF00069	0.398
TRG_ENDOCYTIC_2	132	135	PF00928	0.451
TRG_ENDOCYTIC_2	228	231	PF00928	0.308
TRG_ER_diArg_1	165	167	PF00400	0.362
TRG_ER_diArg_1	21	23	PF00400	0.657
TRG_ER_diArg_1	246	249	PF00400	0.351
TRG_ER_diArg_1	259	262	PF00400	0.493
TRG_ER_diLys_1	416	419	PF00400	0.706
TRG_Pf-PMV_PEXEL_1	393	397	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I345	Leptomonas seymouri	58%	97%
A0A3S5IR84	Trypanosoma rangeli	31%	100%
A0A3S7X5V4	Leishmania donovani	89%	100%
A4HKP6	Leishmania braziliensis	78%	100%
A4I877	Leishmania infantum	89%	100%
D0AAE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4Q519	Leishmania major	88%	100%
V5AUS2	Trypanosoma cruzi	30%	96%