HDc domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HD domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B333_LEIMU

TriTrypDb:

LmxM.31.2540

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9B333

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B333

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006163	purine nucleotide metabolic process	5	2
GO:0006195	purine nucleotide catabolic process	6	2
GO:0006203	dGTP catabolic process	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009117	nucleotide metabolic process	5	2
GO:0009141	nucleoside triphosphate metabolic process	5	2
GO:0009143	nucleoside triphosphate catabolic process	6	2
GO:0009144	purine nucleoside triphosphate metabolic process	6	2
GO:0009146	purine nucleoside triphosphate catabolic process	7	2
GO:0009151	purine deoxyribonucleotide metabolic process	6	2
GO:0009155	purine deoxyribonucleotide catabolic process	6	2
GO:0009166	nucleotide catabolic process	6	2
GO:0009200	deoxyribonucleoside triphosphate metabolic process	6	2
GO:0009204	deoxyribonucleoside triphosphate catabolic process	7	2
GO:0009215	purine deoxyribonucleoside triphosphate metabolic process	7	2
GO:0009217	purine deoxyribonucleoside triphosphate catabolic process	8	2
GO:0009262	deoxyribonucleotide metabolic process	4	2
GO:0009264	deoxyribonucleotide catabolic process	5	2
GO:0009394	2'-deoxyribonucleotide metabolic process	5	2
GO:0009987	cellular process	1	2
GO:0019439	aromatic compound catabolic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0019692	deoxyribose phosphate metabolic process	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046070	dGTP metabolic process	7	2
GO:0046386	deoxyribose phosphate catabolic process	5	2
GO:0046434	organophosphate catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046700	heterocycle catabolic process	4	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072521	purine-containing compound metabolic process	4	2
GO:0072523	purine-containing compound catabolic process	5	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901136	carbohydrate derivative catabolic process	4	2
GO:1901292	nucleoside phosphate catabolic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0008832	dGTPase activity	6	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0016793	triphosphoric monoester hydrolase activity	5	2
GO:0042578	phosphoric ester hydrolase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.456
CLV_C14_Caspase3-7	323	327	PF00656	0.259
CLV_C14_Caspase3-7	92	96	PF00656	0.377
CLV_NRD_NRD_1	13	15	PF00675	0.733
CLV_NRD_NRD_1	157	159	PF00675	0.434
CLV_NRD_NRD_1	170	172	PF00675	0.344
CLV_NRD_NRD_1	376	378	PF00675	0.411
CLV_NRD_NRD_1	384	386	PF00675	0.338
CLV_NRD_NRD_1	620	622	PF00675	0.727
CLV_PCSK_KEX2_1	13	15	PF00082	0.677
CLV_PCSK_KEX2_1	227	229	PF00082	0.445
CLV_PCSK_KEX2_1	24	26	PF00082	0.488
CLV_PCSK_KEX2_1	376	378	PF00082	0.442
CLV_PCSK_KEX2_1	384	386	PF00082	0.338
CLV_PCSK_KEX2_1	426	428	PF00082	0.460
CLV_PCSK_KEX2_1	608	610	PF00082	0.596
CLV_PCSK_KEX2_1	620	622	PF00082	0.563
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.445
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.529
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.460
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.639
CLV_PCSK_SKI1_1	361	365	PF00082	0.604
CLV_PCSK_SKI1_1	384	388	PF00082	0.374
CLV_PCSK_SKI1_1	44	48	PF00082	0.411
CLV_PCSK_SKI1_1	56	60	PF00082	0.281
CLV_PCSK_SKI1_1	608	612	PF00082	0.676
DEG_APCC_DBOX_1	290	298	PF00400	0.436
DEG_APCC_DBOX_1	383	391	PF00400	0.415
DEG_COP1_1	99	109	PF00400	0.314
DOC_ANK_TNKS_1	90	97	PF00023	0.314
DOC_CKS1_1	247	252	PF01111	0.469
DOC_CKS1_1	528	533	PF01111	0.483
DOC_CKS1_1	645	650	PF01111	0.534
DOC_CYCLIN_RxL_1	605	616	PF00134	0.607
DOC_CYCLIN_yCln2_LP_2	645	651	PF00134	0.539
DOC_MAPK_gen_1	227	233	PF00069	0.400
DOC_MAPK_gen_1	302	312	PF00069	0.419
DOC_MAPK_gen_1	608	614	PF00069	0.609
DOC_MAPK_MEF2A_6	534	541	PF00069	0.563
DOC_PP1_RVXF_1	536	542	PF00149	0.430
DOC_PP2B_PxIxI_1	40	46	PF00149	0.361
DOC_PP4_FxxP_1	104	107	PF00568	0.377
DOC_PP4_FxxP_1	488	491	PF00568	0.467
DOC_PP4_MxPP_1	1	4	PF00568	0.627
DOC_USP7_MATH_1	23	27	PF00917	0.491
DOC_USP7_MATH_1	333	337	PF00917	0.466
DOC_USP7_MATH_1	366	370	PF00917	0.447
DOC_USP7_MATH_1	4	8	PF00917	0.669
DOC_USP7_MATH_1	491	495	PF00917	0.514
DOC_USP7_MATH_1	517	521	PF00917	0.494
DOC_USP7_MATH_1	567	571	PF00917	0.796
DOC_USP7_MATH_1	638	642	PF00917	0.784
DOC_USP7_MATH_1	71	75	PF00917	0.420
DOC_USP7_MATH_2	531	537	PF00917	0.437
DOC_WW_Pin1_4	246	251	PF00397	0.467
DOC_WW_Pin1_4	46	51	PF00397	0.400
DOC_WW_Pin1_4	527	532	PF00397	0.447
DOC_WW_Pin1_4	556	561	PF00397	0.562
DOC_WW_Pin1_4	582	587	PF00397	0.763
DOC_WW_Pin1_4	644	649	PF00397	0.533
LIG_14-3-3_CanoR_1	147	155	PF00244	0.366
LIG_14-3-3_CanoR_1	158	167	PF00244	0.396
LIG_14-3-3_CanoR_1	218	224	PF00244	0.411
LIG_14-3-3_CanoR_1	25	30	PF00244	0.465
LIG_14-3-3_CanoR_1	393	402	PF00244	0.483
LIG_14-3-3_CanoR_1	403	410	PF00244	0.489
LIG_14-3-3_CanoR_1	414	419	PF00244	0.525
LIG_14-3-3_CanoR_1	44	52	PF00244	0.376
LIG_14-3-3_CanoR_1	492	501	PF00244	0.513
LIG_14-3-3_CanoR_1	538	548	PF00244	0.506
LIG_14-3-3_CanoR_1	595	605	PF00244	0.683
LIG_Actin_WH2_2	177	194	PF00022	0.413
LIG_Actin_WH2_2	300	318	PF00022	0.399
LIG_BRCT_BRCA1_1	138	142	PF00533	0.344
LIG_BRCT_BRCA1_1	255	259	PF00533	0.340
LIG_Clathr_ClatBox_1	309	313	PF01394	0.404
LIG_FHA_1	218	224	PF00498	0.411
LIG_FHA_1	302	308	PF00498	0.475
LIG_FHA_1	362	368	PF00498	0.389
LIG_FHA_1	506	512	PF00498	0.577
LIG_FHA_1	665	671	PF00498	0.642
LIG_FHA_2	185	191	PF00498	0.472
LIG_FHA_2	360	366	PF00498	0.487
LIG_FHA_2	439	445	PF00498	0.411
LIG_FHA_2	470	476	PF00498	0.508
LIG_FHA_2	528	534	PF00498	0.461
LIG_LIR_Apic_2	103	107	PF02991	0.314
LIG_LIR_Apic_2	486	491	PF02991	0.450
LIG_LIR_Apic_2	64	69	PF02991	0.417
LIG_LIR_Gen_1	139	150	PF02991	0.344
LIG_LIR_Gen_1	190	201	PF02991	0.310
LIG_LIR_Gen_1	249	259	PF02991	0.464
LIG_LIR_Gen_1	348	356	PF02991	0.395
LIG_LIR_Gen_1	509	518	PF02991	0.678
LIG_LIR_Gen_1	540	548	PF02991	0.502
LIG_LIR_LC3C_4	519	523	PF02991	0.403
LIG_LIR_Nem_3	139	145	PF02991	0.344
LIG_LIR_Nem_3	190	196	PF02991	0.303
LIG_LIR_Nem_3	31	37	PF02991	0.456
LIG_LIR_Nem_3	348	353	PF02991	0.385
LIG_LIR_Nem_3	38	42	PF02991	0.399
LIG_LIR_Nem_3	540	544	PF02991	0.490
LIG_LIR_Nem_3	64	68	PF02991	0.388
LIG_LIR_Nem_3	88	93	PF02991	0.369
LIG_PCNA_yPIPBox_3	296	307	PF02747	0.448
LIG_PTB_Apo_2	60	67	PF02174	0.429
LIG_PTB_Phospho_1	60	66	PF10480	0.426
LIG_SH2_CRK	396	400	PF00017	0.396
LIG_SH2_CRK	651	655	PF00017	0.609
LIG_SH2_CRK	90	94	PF00017	0.377
LIG_SH2_NCK_1	396	400	PF00017	0.396
LIG_SH2_PTP2	193	196	PF00017	0.400
LIG_SH2_PTP2	66	69	PF00017	0.457
LIG_SH2_SRC	344	347	PF00017	0.342
LIG_SH2_SRC	66	69	PF00017	0.398
LIG_SH2_STAT5	193	196	PF00017	0.400
LIG_SH2_STAT5	238	241	PF00017	0.376
LIG_SH2_STAT5	344	347	PF00017	0.346
LIG_SH2_STAT5	396	399	PF00017	0.451
LIG_SH2_STAT5	487	490	PF00017	0.458
LIG_SH2_STAT5	66	69	PF00017	0.364
LIG_SH2_STAT5	84	87	PF00017	0.284
LIG_SH3_3	208	214	PF00018	0.401
LIG_SH3_3	335	341	PF00018	0.435
LIG_SH3_3	525	531	PF00018	0.396
LIG_SUMO_SIM_anti_2	166	171	PF11976	0.377
LIG_SUMO_SIM_anti_2	519	525	PF11976	0.376
LIG_SUMO_SIM_par_1	304	311	PF11976	0.413
LIG_SUMO_SIM_par_1	320	326	PF11976	0.249
LIG_TRAF2_1	421	424	PF00917	0.612
LIG_TRAF2_1	530	533	PF00917	0.439
LIG_TYR_ITIM	191	196	PF00017	0.405
LIG_UBA3_1	167	172	PF00899	0.425
LIG_UBA3_1	197	205	PF00899	0.390
LIG_WRC_WIRS_1	142	147	PF05994	0.377
MOD_CDK_SPxxK_3	527	534	PF00069	0.495
MOD_CK1_1	359	365	PF00069	0.670
MOD_CK1_1	405	411	PF00069	0.479
MOD_CK1_1	540	546	PF00069	0.487
MOD_CK1_1	554	560	PF00069	0.658
MOD_CK1_1	582	588	PF00069	0.698
MOD_CK2_1	359	365	PF00069	0.574
MOD_CK2_1	4	10	PF00069	0.673
MOD_CK2_1	418	424	PF00069	0.633
MOD_CK2_1	433	439	PF00069	0.272
MOD_CK2_1	527	533	PF00069	0.451
MOD_CK2_1	638	644	PF00069	0.581
MOD_CK2_1	71	77	PF00069	0.386
MOD_GlcNHglycan	148	151	PF01048	0.312
MOD_GlcNHglycan	228	231	PF01048	0.421
MOD_GlcNHglycan	368	371	PF01048	0.520
MOD_GlcNHglycan	483	486	PF01048	0.511
MOD_GlcNHglycan	580	584	PF01048	0.663
MOD_GSK3_1	141	148	PF00069	0.353
MOD_GSK3_1	25	32	PF00069	0.553
MOD_GSK3_1	394	401	PF00069	0.400
MOD_GSK3_1	4	11	PF00069	0.609
MOD_GSK3_1	414	421	PF00069	0.382
MOD_GSK3_1	439	446	PF00069	0.318
MOD_GSK3_1	501	508	PF00069	0.482
MOD_GSK3_1	533	540	PF00069	0.431
MOD_GSK3_1	548	555	PF00069	0.486
MOD_GSK3_1	582	589	PF00069	0.674
MOD_GSK3_1	639	646	PF00069	0.477
MOD_GSK3_1	664	671	PF00069	0.641
MOD_N-GLC_1	110	115	PF02516	0.394
MOD_N-GLC_1	176	181	PF02516	0.388
MOD_N-GLC_1	359	364	PF02516	0.466
MOD_N-GLC_1	505	510	PF02516	0.569
MOD_N-GLC_1	586	591	PF02516	0.563
MOD_NEK2_1	141	146	PF00069	0.321
MOD_NEK2_1	289	294	PF00069	0.413
MOD_NEK2_1	356	361	PF00069	0.447
MOD_NEK2_1	395	400	PF00069	0.461
MOD_NEK2_1	443	448	PF00069	0.401
MOD_NEK2_1	537	542	PF00069	0.516
MOD_NEK2_1	596	601	PF00069	0.684
MOD_NEK2_1	61	66	PF00069	0.373
MOD_NEK2_1	643	648	PF00069	0.506
MOD_NEK2_1	76	81	PF00069	0.338
MOD_NEK2_1	89	94	PF00069	0.344
MOD_PIKK_1	419	425	PF00454	0.569
MOD_PIKK_1	467	473	PF00454	0.659
MOD_PIKK_1	559	565	PF00454	0.667
MOD_PIKK_1	568	574	PF00454	0.641
MOD_PIKK_1	613	619	PF00454	0.669
MOD_PIKK_1	655	661	PF00454	0.643
MOD_PK_1	25	31	PF00069	0.485
MOD_PK_1	414	420	PF00069	0.522
MOD_PK_1	8	14	PF00069	0.610
MOD_PKA_1	158	164	PF00069	0.314
MOD_PKA_2	146	152	PF00069	0.302
MOD_PKA_2	217	223	PF00069	0.434
MOD_PKA_2	240	246	PF00069	0.382
MOD_PKA_2	29	35	PF00069	0.562
MOD_PKA_2	301	307	PF00069	0.430
MOD_PKA_2	402	408	PF00069	0.529
MOD_PKA_2	491	497	PF00069	0.523
MOD_PKA_2	537	543	PF00069	0.511
MOD_PKA_2	594	600	PF00069	0.710
MOD_Plk_1	269	275	PF00069	0.458
MOD_Plk_1	359	365	PF00069	0.574
MOD_Plk_1	405	411	PF00069	0.589
MOD_Plk_1	438	444	PF00069	0.458
MOD_Plk_1	551	557	PF00069	0.738
MOD_Plk_1	586	592	PF00069	0.552
MOD_Plk_1	76	82	PF00069	0.344
MOD_Plk_2-3	308	314	PF00069	0.343
MOD_Plk_2-3	433	439	PF00069	0.396
MOD_Plk_2-3	627	633	PF00069	0.515
MOD_Plk_4	141	147	PF00069	0.325
MOD_Plk_4	163	169	PF00069	0.373
MOD_Plk_4	248	254	PF00069	0.483
MOD_Plk_4	29	35	PF00069	0.551
MOD_Plk_4	405	411	PF00069	0.493
MOD_Plk_4	483	489	PF00069	0.423
MOD_Plk_4	507	513	PF00069	0.548
MOD_Plk_4	517	523	PF00069	0.369
MOD_Plk_4	61	67	PF00069	0.396
MOD_ProDKin_1	246	252	PF00069	0.462
MOD_ProDKin_1	46	52	PF00069	0.396
MOD_ProDKin_1	527	533	PF00069	0.441
MOD_ProDKin_1	556	562	PF00069	0.560
MOD_ProDKin_1	582	588	PF00069	0.763
MOD_ProDKin_1	644	650	PF00069	0.534
MOD_SUMO_for_1	425	428	PF00179	0.456
MOD_SUMO_rev_2	16	26	PF00179	0.611
TRG_DiLeu_BaEn_3	15	21	PF01217	0.544
TRG_DiLeu_BaEn_4	665	671	PF01217	0.642
TRG_ENDOCYTIC_2	193	196	PF00928	0.400
TRG_ENDOCYTIC_2	34	37	PF00928	0.423
TRG_ENDOCYTIC_2	396	399	PF00928	0.358
TRG_ENDOCYTIC_2	651	654	PF00928	0.607
TRG_ENDOCYTIC_2	84	87	PF00928	0.377
TRG_ENDOCYTIC_2	90	93	PF00928	0.377
TRG_ER_diArg_1	12	14	PF00400	0.760
TRG_ER_diArg_1	384	386	PF00400	0.442
TRG_NLS_MonoExtC_3	607	613	PF00514	0.673
TRG_NLS_MonoExtN_4	605	612	PF00514	0.635
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	56	60	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD02	Leptomonas seymouri	66%	100%
A0A0S4J714	Bodo saltans	33%	95%
A0A3Q8IGB9	Leishmania donovani	96%	100%
A0A3R7LQB8	Trypanosoma rangeli	33%	89%
A0A3S7WPC5	Leishmania donovani	34%	100%
A4H4I2	Leishmania braziliensis	35%	100%
A4HKP4	Leishmania braziliensis	89%	100%
A4HSQ7	Leishmania infantum	34%	100%
A4I875	Leishmania infantum	96%	100%
C9ZTA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AKP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q09374	Caenorhabditis elegans	28%	100%
Q4Q521	Leishmania major	96%	100%
Q4QJ63	Leishmania major	34%	100%
Q6INN8	Xenopus laevis	31%	100%