Cyclic nucleotide-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclic nucleotide-binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B332_LEIMU

TriTrypDb:

LmxM.31.2530

Length:

958

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9B332

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B332

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	94	98	PF00656	0.601
CLV_NRD_NRD_1	147	149	PF00675	0.312
CLV_NRD_NRD_1	172	174	PF00675	0.296
CLV_NRD_NRD_1	202	204	PF00675	0.653
CLV_NRD_NRD_1	214	216	PF00675	0.710
CLV_NRD_NRD_1	230	232	PF00675	0.556
CLV_NRD_NRD_1	362	364	PF00675	0.456
CLV_NRD_NRD_1	432	434	PF00675	0.466
CLV_NRD_NRD_1	46	48	PF00675	0.425
CLV_NRD_NRD_1	50	52	PF00675	0.443
CLV_NRD_NRD_1	632	634	PF00675	0.627
CLV_NRD_NRD_1	774	776	PF00675	0.361
CLV_NRD_NRD_1	795	797	PF00675	0.395
CLV_NRD_NRD_1	879	881	PF00675	0.615
CLV_NRD_NRD_1	896	898	PF00675	0.611
CLV_NRD_NRD_1	931	933	PF00675	0.554
CLV_PCSK_FUR_1	929	933	PF00082	0.493
CLV_PCSK_KEX2_1	172	174	PF00082	0.296
CLV_PCSK_KEX2_1	202	204	PF00082	0.653
CLV_PCSK_KEX2_1	214	216	PF00082	0.710
CLV_PCSK_KEX2_1	230	232	PF00082	0.647
CLV_PCSK_KEX2_1	362	364	PF00082	0.484
CLV_PCSK_KEX2_1	432	434	PF00082	0.465
CLV_PCSK_KEX2_1	46	48	PF00082	0.365
CLV_PCSK_KEX2_1	632	634	PF00082	0.627
CLV_PCSK_KEX2_1	774	776	PF00082	0.361
CLV_PCSK_KEX2_1	795	797	PF00082	0.451
CLV_PCSK_KEX2_1	879	881	PF00082	0.610
CLV_PCSK_KEX2_1	896	898	PF00082	0.609
CLV_PCSK_KEX2_1	931	933	PF00082	0.626
CLV_PCSK_SKI1_1	149	153	PF00082	0.499
CLV_PCSK_SKI1_1	362	366	PF00082	0.380
CLV_PCSK_SKI1_1	440	444	PF00082	0.584
CLV_PCSK_SKI1_1	482	486	PF00082	0.410
CLV_PCSK_SKI1_1	54	58	PF00082	0.571
CLV_PCSK_SKI1_1	632	636	PF00082	0.562
CLV_PCSK_SKI1_1	719	723	PF00082	0.381
CLV_PCSK_SKI1_1	796	800	PF00082	0.317
CLV_PCSK_SKI1_1	863	867	PF00082	0.428
CLV_PCSK_SKI1_1	896	900	PF00082	0.640
CLV_PCSK_SKI1_1	917	921	PF00082	0.625
CLV_Separin_Metazoa	477	481	PF03568	0.595
DEG_APCC_DBOX_1	46	54	PF00400	0.370
DEG_APCC_DBOX_1	896	904	PF00400	0.634
DEG_SPOP_SBC_1	286	290	PF00917	0.646
DOC_CYCLIN_RxL_1	479	487	PF00134	0.504
DOC_CYCLIN_RxL_1	716	725	PF00134	0.405
DOC_CYCLIN_yClb5_NLxxxL_5	945	954	PF00134	0.477
DOC_MAPK_DCC_7	673	683	PF00069	0.319
DOC_MAPK_gen_1	46	55	PF00069	0.457
DOC_MAPK_gen_1	598	607	PF00069	0.597
DOC_MAPK_gen_1	777	785	PF00069	0.539
DOC_MAPK_gen_1	795	802	PF00069	0.246
DOC_MAPK_MEF2A_6	49	57	PF00069	0.316
DOC_MAPK_MEF2A_6	947	954	PF00069	0.479
DOC_PP1_RVXF_1	717	724	PF00149	0.393
DOC_PP1_RVXF_1	861	868	PF00149	0.429
DOC_PP2B_LxvP_1	310	313	PF13499	0.362
DOC_PP2B_LxvP_1	40	43	PF13499	0.439
DOC_PP2B_LxvP_1	407	410	PF13499	0.410
DOC_PP2B_LxvP_1	476	479	PF13499	0.601
DOC_PP4_FxxP_1	610	613	PF00568	0.634
DOC_USP7_MATH_1	182	186	PF00917	0.553
DOC_USP7_MATH_1	2	6	PF00917	0.633
DOC_USP7_MATH_1	285	289	PF00917	0.539
DOC_USP7_MATH_1	295	299	PF00917	0.543
DOC_USP7_MATH_1	603	607	PF00917	0.758
DOC_USP7_MATH_1	628	632	PF00917	0.601
DOC_USP7_MATH_1	679	683	PF00917	0.444
DOC_USP7_MATH_1	745	749	PF00917	0.676
DOC_USP7_MATH_1	761	765	PF00917	0.331
DOC_USP7_MATH_1	840	844	PF00917	0.723
DOC_WW_Pin1_4	332	337	PF00397	0.392
DOC_WW_Pin1_4	457	462	PF00397	0.619
DOC_WW_Pin1_4	605	610	PF00397	0.664
DOC_WW_Pin1_4	624	629	PF00397	0.558
DOC_WW_Pin1_4	752	757	PF00397	0.543
LIG_14-3-3_CanoR_1	230	237	PF00244	0.581
LIG_14-3-3_CanoR_1	238	247	PF00244	0.715
LIG_14-3-3_CanoR_1	271	278	PF00244	0.734
LIG_14-3-3_CanoR_1	395	404	PF00244	0.489
LIG_14-3-3_CanoR_1	480	485	PF00244	0.474
LIG_14-3-3_CanoR_1	505	512	PF00244	0.416
LIG_14-3-3_CanoR_1	54	60	PF00244	0.381
LIG_14-3-3_CanoR_1	666	675	PF00244	0.531
LIG_14-3-3_CanoR_1	879	884	PF00244	0.560
LIG_14-3-3_CanoR_1	896	901	PF00244	0.457
LIG_14-3-3_CanoR_1	931	940	PF00244	0.632
LIG_Actin_WH2_2	14	32	PF00022	0.476
LIG_APCC_ABBA_1	634	639	PF00400	0.624
LIG_APCC_ABBA_1	720	725	PF00400	0.397
LIG_APCC_ABBAyCdc20_2	633	639	PF00400	0.624
LIG_APCC_ABBAyCdc20_2	719	725	PF00400	0.396
LIG_BRCT_BRCA1_1	494	498	PF00533	0.429
LIG_Clathr_ClatBox_1	721	725	PF01394	0.406
LIG_deltaCOP1_diTrp_1	153	156	PF00928	0.511
LIG_deltaCOP1_diTrp_1	548	556	PF00928	0.531
LIG_deltaCOP1_diTrp_1	790	799	PF00928	0.327
LIG_FHA_1	187	193	PF00498	0.614
LIG_FHA_1	227	233	PF00498	0.505
LIG_FHA_1	254	260	PF00498	0.608
LIG_FHA_1	305	311	PF00498	0.471
LIG_FHA_1	396	402	PF00498	0.408
LIG_FHA_1	492	498	PF00498	0.421
LIG_FHA_1	550	556	PF00498	0.637
LIG_FHA_1	56	62	PF00498	0.302
LIG_FHA_1	777	783	PF00498	0.356
LIG_FHA_1	814	820	PF00498	0.590
LIG_FHA_1	87	93	PF00498	0.412
LIG_FHA_1	935	941	PF00498	0.722
LIG_FHA_2	441	447	PF00498	0.613
LIG_FHA_2	488	494	PF00498	0.344
LIG_FHA_2	508	514	PF00498	0.339
LIG_FHA_2	633	639	PF00498	0.630
LIG_FHA_2	710	716	PF00498	0.458
LIG_FHA_2	918	924	PF00498	0.562
LIG_FHA_2	92	98	PF00498	0.523
LIG_HP1_1	679	683	PF01393	0.464
LIG_LIR_Apic_2	513	518	PF02991	0.308
LIG_LIR_Apic_2	608	613	PF02991	0.632
LIG_LIR_Gen_1	138	147	PF02991	0.436
LIG_LIR_Gen_1	504	514	PF02991	0.387
LIG_LIR_Gen_1	58	66	PF02991	0.393
LIG_LIR_Gen_1	696	704	PF02991	0.289
LIG_LIR_Nem_3	138	143	PF02991	0.458
LIG_LIR_Nem_3	504	509	PF02991	0.356
LIG_LIR_Nem_3	58	62	PF02991	0.392
LIG_LIR_Nem_3	604	610	PF02991	0.577
LIG_LIR_Nem_3	696	702	PF02991	0.288
LIG_LIR_Nem_3	833	837	PF02991	0.525
LIG_MYND_1	836	840	PF01753	0.494
LIG_PCNA_yPIPBox_3	673	684	PF02747	0.316
LIG_PTAP_UEV_1	296	301	PF05743	0.625
LIG_PTB_Apo_2	134	141	PF02174	0.452
LIG_PTB_Phospho_1	134	140	PF10480	0.458
LIG_REV1ctd_RIR_1	427	437	PF16727	0.344
LIG_REV1ctd_RIR_1	721	731	PF16727	0.443
LIG_RPA_C_Fungi	358	370	PF08784	0.430
LIG_SH2_CRK	506	510	PF00017	0.414
LIG_SH2_CRK	59	63	PF00017	0.308
LIG_SH2_CRK	770	774	PF00017	0.332
LIG_SH2_CRK	834	838	PF00017	0.530
LIG_SH2_NCK_1	506	510	PF00017	0.414
LIG_SH2_NCK_1	93	97	PF00017	0.525
LIG_SH2_PTP2	140	143	PF00017	0.447
LIG_SH2_STAP1	348	352	PF00017	0.248
LIG_SH2_STAT5	140	143	PF00017	0.414
LIG_SH2_STAT5	327	330	PF00017	0.358
LIG_SH2_STAT5	378	381	PF00017	0.429
LIG_SH2_STAT5	506	509	PF00017	0.396
LIG_SH2_STAT5	515	518	PF00017	0.267
LIG_SH2_STAT5	545	548	PF00017	0.335
LIG_SH2_STAT5	770	773	PF00017	0.330
LIG_SH2_STAT5	84	87	PF00017	0.418
LIG_SH2_STAT5	93	96	PF00017	0.543
LIG_SH3_3	294	300	PF00018	0.633
LIG_SH3_3	330	336	PF00018	0.427
LIG_SH3_3	338	344	PF00018	0.420
LIG_SH3_3	5	11	PF00018	0.481
LIG_SH3_3	529	535	PF00018	0.412
LIG_SH3_3	606	612	PF00018	0.555
LIG_SH3_3	816	822	PF00018	0.571
LIG_SH3_3	862	868	PF00018	0.588
LIG_SUMO_SIM_anti_2	160	167	PF11976	0.405
LIG_SUMO_SIM_par_1	781	787	PF11976	0.388
LIG_TRAF2_1	24	27	PF00917	0.460
LIG_TRAF2_1	539	542	PF00917	0.446
LIG_TRAF2_1	67	70	PF00917	0.459
LIG_TRAF2_1	713	716	PF00917	0.438
LIG_TRAF2_1	824	827	PF00917	0.521
LIG_TYR_ITIM	57	62	PF00017	0.301
LIG_TYR_ITIM	768	773	PF00017	0.329
LIG_TYR_ITIM	832	837	PF00017	0.548
LIG_UBA3_1	522	527	PF00899	0.374
LIG_ULM_U2AF65_1	774	779	PF00076	0.424
MOD_CK1_1	217	223	PF00069	0.667
MOD_CK1_1	239	245	PF00069	0.568
MOD_CK1_1	257	263	PF00069	0.532
MOD_CK1_1	288	294	PF00069	0.590
MOD_CK1_1	332	338	PF00069	0.388
MOD_CK1_1	64	70	PF00069	0.457
MOD_CK1_1	902	908	PF00069	0.739
MOD_CK1_1	934	940	PF00069	0.554
MOD_CK2_1	440	446	PF00069	0.406
MOD_CK2_1	487	493	PF00069	0.350
MOD_CK2_1	536	542	PF00069	0.452
MOD_CK2_1	632	638	PF00069	0.664
MOD_CK2_1	64	70	PF00069	0.454
MOD_CK2_1	709	715	PF00069	0.431
MOD_CK2_1	879	885	PF00069	0.629
MOD_CK2_1	917	923	PF00069	0.559
MOD_Cter_Amidation	894	897	PF01082	0.665
MOD_GlcNHglycan	100	103	PF01048	0.684
MOD_GlcNHglycan	11	14	PF01048	0.524
MOD_GlcNHglycan	204	207	PF01048	0.690
MOD_GlcNHglycan	216	219	PF01048	0.618
MOD_GlcNHglycan	248	251	PF01048	0.650
MOD_GlcNHglycan	273	276	PF01048	0.717
MOD_GlcNHglycan	297	300	PF01048	0.640
MOD_GlcNHglycan	538	541	PF01048	0.459
MOD_GlcNHglycan	613	616	PF01048	0.728
MOD_GlcNHglycan	656	659	PF01048	0.640
MOD_GlcNHglycan	668	671	PF01048	0.559
MOD_GlcNHglycan	712	715	PF01048	0.457
MOD_GlcNHglycan	747	750	PF01048	0.603
MOD_GlcNHglycan	752	755	PF01048	0.480
MOD_GlcNHglycan	76	79	PF01048	0.494
MOD_GlcNHglycan	763	766	PF01048	0.411
MOD_GlcNHglycan	891	894	PF01048	0.679
MOD_GlcNHglycan	917	920	PF01048	0.703
MOD_GlcNHglycan	934	937	PF01048	0.584
MOD_GSK3_1	105	112	PF00069	0.703
MOD_GSK3_1	182	189	PF00069	0.590
MOD_GSK3_1	194	201	PF00069	0.738
MOD_GSK3_1	210	217	PF00069	0.572
MOD_GSK3_1	226	233	PF00069	0.721
MOD_GSK3_1	239	246	PF00069	0.659
MOD_GSK3_1	253	260	PF00069	0.480
MOD_GSK3_1	304	311	PF00069	0.526
MOD_GSK3_1	346	353	PF00069	0.406
MOD_GSK3_1	391	398	PF00069	0.452
MOD_GSK3_1	453	460	PF00069	0.567
MOD_GSK3_1	487	494	PF00069	0.393
MOD_GSK3_1	60	67	PF00069	0.297
MOD_GSK3_1	624	631	PF00069	0.601
MOD_GSK3_1	898	905	PF00069	0.753
MOD_GSK3_1	927	934	PF00069	0.664
MOD_GSK3_1	939	946	PF00069	0.737
MOD_N-GLC_1	136	141	PF02516	0.451
MOD_N-GLC_1	180	185	PF02516	0.390
MOD_N-GLC_1	472	477	PF02516	0.553
MOD_N-GLC_1	480	485	PF02516	0.442
MOD_NEK2_1	136	141	PF00069	0.452
MOD_NEK2_1	198	203	PF00069	0.629
MOD_NEK2_1	236	241	PF00069	0.603
MOD_NEK2_1	287	292	PF00069	0.639
MOD_NEK2_1	331	336	PF00069	0.329
MOD_NEK2_1	498	503	PF00069	0.590
MOD_NEK2_1	55	60	PF00069	0.420
MOD_NEK2_1	61	66	PF00069	0.440
MOD_NEK2_1	884	889	PF00069	0.607
MOD_NEK2_1	915	920	PF00069	0.643
MOD_NEK2_1	922	927	PF00069	0.555
MOD_PIKK_1	693	699	PF00454	0.299
MOD_PK_1	879	885	PF00069	0.598
MOD_PKA_1	172	178	PF00069	0.342
MOD_PKA_1	202	208	PF00069	0.630
MOD_PKA_1	214	220	PF00069	0.620
MOD_PKA_1	230	236	PF00069	0.536
MOD_PKA_1	632	638	PF00069	0.562
MOD_PKA_1	879	885	PF00069	0.525
MOD_PKA_1	896	902	PF00069	0.555
MOD_PKA_1	931	937	PF00069	0.526
MOD_PKA_2	172	178	PF00069	0.319
MOD_PKA_2	202	208	PF00069	0.630
MOD_PKA_2	214	220	PF00069	0.588
MOD_PKA_2	230	236	PF00069	0.539
MOD_PKA_2	237	243	PF00069	0.700
MOD_PKA_2	504	510	PF00069	0.419
MOD_PKA_2	632	638	PF00069	0.562
MOD_PKA_2	665	671	PF00069	0.643
MOD_PKA_2	776	782	PF00069	0.415
MOD_PKA_2	879	885	PF00069	0.617
MOD_PKA_2	896	902	PF00069	0.555
MOD_PKA_2	931	937	PF00069	0.770
MOD_PKB_1	929	937	PF00069	0.510
MOD_Plk_1	136	142	PF00069	0.452
MOD_Plk_1	440	446	PF00069	0.560
MOD_Plk_1	472	478	PF00069	0.617
MOD_Plk_1	480	486	PF00069	0.433
MOD_Plk_1	492	498	PF00069	0.239
MOD_Plk_1	541	547	PF00069	0.458
MOD_Plk_1	603	609	PF00069	0.646
MOD_Plk_1	922	928	PF00069	0.487
MOD_Plk_2-3	487	493	PF00069	0.350
MOD_Plk_2-3	91	97	PF00069	0.512
MOD_Plk_4	136	142	PF00069	0.452
MOD_Plk_4	194	200	PF00069	0.558
MOD_Plk_4	2	8	PF00069	0.570
MOD_Plk_4	254	260	PF00069	0.538
MOD_Plk_4	288	294	PF00069	0.763
MOD_Plk_4	541	547	PF00069	0.509
MOD_Plk_4	632	638	PF00069	0.620
MOD_Plk_4	679	685	PF00069	0.428
MOD_Plk_4	80	86	PF00069	0.409
MOD_Plk_4	841	847	PF00069	0.550
MOD_Plk_4	879	885	PF00069	0.510
MOD_ProDKin_1	332	338	PF00069	0.388
MOD_ProDKin_1	457	463	PF00069	0.620
MOD_ProDKin_1	605	611	PF00069	0.664
MOD_ProDKin_1	624	630	PF00069	0.557
MOD_ProDKin_1	752	758	PF00069	0.534
MOD_SUMO_for_1	526	529	PF00179	0.450
TRG_DiLeu_BaEn_1	161	166	PF01217	0.396
TRG_DiLeu_BaEn_1	716	721	PF01217	0.398
TRG_DiLeu_BaLyEn_6	360	365	PF01217	0.395
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.304
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.253
TRG_DiLeu_BaLyEn_6	833	838	PF01217	0.505
TRG_DiLeu_LyEn_5	716	721	PF01217	0.398
TRG_ENDOCYTIC_2	140	143	PF00928	0.566
TRG_ENDOCYTIC_2	348	351	PF00928	0.342
TRG_ENDOCYTIC_2	506	509	PF00928	0.408
TRG_ENDOCYTIC_2	59	62	PF00928	0.303
TRG_ENDOCYTIC_2	770	773	PF00928	0.330
TRG_ENDOCYTIC_2	834	837	PF00928	0.558
TRG_ER_diArg_1	230	232	PF00400	0.576
TRG_ER_diArg_1	362	364	PF00400	0.484
TRG_ER_diArg_1	384	387	PF00400	0.410
TRG_ER_diArg_1	431	433	PF00400	0.457
TRG_ER_diArg_1	45	47	PF00400	0.420
TRG_ER_diArg_1	479	482	PF00400	0.574
TRG_ER_diArg_1	48	51	PF00400	0.436
TRG_ER_diArg_1	632	634	PF00400	0.604
TRG_ER_diArg_1	773	775	PF00400	0.356
TRG_ER_diArg_1	794	796	PF00400	0.412
TRG_ER_diArg_1	928	931	PF00400	0.544
TRG_NLS_MonoExtN_4	49	55	PF00514	0.468
TRG_Pf-PMV_PEXEL_1	362	367	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I352	Leptomonas seymouri	51%	100%
A0A3S7X5T2	Leishmania donovani	89%	100%
A4I874	Leishmania infantum	88%	100%
D0AAE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4Q522	Leishmania major	88%	100%