Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B330_LEIMU

TriTrypDb:

LmxM.31.2510

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B330

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B330

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	1
GO:0006518	peptide metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	1
GO:0043043	peptide biosynthetic process	5	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043603	amide metabolic process	3	1
GO:0043604	amide biosynthetic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	1
GO:0005198	structural molecule activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.555
CLV_C14_Caspase3-7	272	276	PF00656	0.657
CLV_C14_Caspase3-7	387	391	PF00656	0.454
CLV_C14_Caspase3-7	79	83	PF00656	0.596
CLV_C14_Caspase3-7	97	101	PF00656	0.469
CLV_NRD_NRD_1	116	118	PF00675	0.386
CLV_NRD_NRD_1	138	140	PF00675	0.578
CLV_NRD_NRD_1	16	18	PF00675	0.597
CLV_NRD_NRD_1	184	186	PF00675	0.588
CLV_NRD_NRD_1	255	257	PF00675	0.556
CLV_NRD_NRD_1	301	303	PF00675	0.432
CLV_NRD_NRD_1	304	306	PF00675	0.451
CLV_NRD_NRD_1	427	429	PF00675	0.431
CLV_NRD_NRD_1	618	620	PF00675	0.450
CLV_NRD_NRD_1	641	643	PF00675	0.473
CLV_PCSK_FUR_1	302	306	PF00082	0.453
CLV_PCSK_KEX2_1	115	117	PF00082	0.381
CLV_PCSK_KEX2_1	137	139	PF00082	0.730
CLV_PCSK_KEX2_1	16	18	PF00082	0.597
CLV_PCSK_KEX2_1	184	186	PF00082	0.588
CLV_PCSK_KEX2_1	254	256	PF00082	0.551
CLV_PCSK_KEX2_1	267	269	PF00082	0.602
CLV_PCSK_KEX2_1	303	305	PF00082	0.468
CLV_PCSK_KEX2_1	348	350	PF00082	0.477
CLV_PCSK_KEX2_1	426	428	PF00082	0.460
CLV_PCSK_KEX2_1	618	620	PF00082	0.455
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.664
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.367
CLV_PCSK_PC1ET2_1	348	350	PF00082	0.433
CLV_PCSK_PC7_1	134	140	PF00082	0.570
CLV_PCSK_PC7_1	344	350	PF00082	0.480
CLV_PCSK_SKI1_1	125	129	PF00082	0.576
CLV_PCSK_SKI1_1	26	30	PF00082	0.510
CLV_PCSK_SKI1_1	296	300	PF00082	0.400
CLV_PCSK_SKI1_1	305	309	PF00082	0.436
CLV_PCSK_SKI1_1	312	316	PF00082	0.496
CLV_PCSK_SKI1_1	34	38	PF00082	0.459
CLV_PCSK_SKI1_1	344	348	PF00082	0.490
CLV_PCSK_SKI1_1	374	378	PF00082	0.487
CLV_PCSK_SKI1_1	511	515	PF00082	0.455
CLV_PCSK_SKI1_1	519	523	PF00082	0.363
CLV_PCSK_SKI1_1	618	622	PF00082	0.519
CLV_PCSK_SKI1_1	94	98	PF00082	0.735
DEG_APCC_DBOX_1	114	122	PF00400	0.554
DEG_SIAH_1	501	509	PF03145	0.339
DOC_CKS1_1	460	465	PF01111	0.759
DOC_CYCLIN_RxL_1	120	132	PF00134	0.503
DOC_MAPK_gen_1	120	129	PF00069	0.423
DOC_MAPK_gen_1	426	435	PF00069	0.399
DOC_MAPK_gen_1	618	624	PF00069	0.620
DOC_MAPK_gen_1	642	648	PF00069	0.505
DOC_MAPK_HePTP_8	569	581	PF00069	0.327
DOC_MAPK_MEF2A_6	123	131	PF00069	0.496
DOC_MAPK_MEF2A_6	174	183	PF00069	0.490
DOC_MAPK_MEF2A_6	572	581	PF00069	0.402
DOC_PP1_RVXF_1	517	523	PF00149	0.404
DOC_PP2B_LxvP_1	455	458	PF13499	0.600
DOC_PP2B_LxvP_1	492	495	PF13499	0.583
DOC_USP7_MATH_1	217	221	PF00917	0.781
DOC_USP7_MATH_1	273	277	PF00917	0.706
DOC_USP7_MATH_1	278	282	PF00917	0.623
DOC_USP7_MATH_1	380	384	PF00917	0.498
DOC_USP7_MATH_1	444	448	PF00917	0.524
DOC_USP7_MATH_1	480	484	PF00917	0.618
DOC_USP7_MATH_1	513	517	PF00917	0.391
DOC_WW_Pin1_4	276	281	PF00397	0.513
DOC_WW_Pin1_4	284	289	PF00397	0.487
DOC_WW_Pin1_4	326	331	PF00397	0.450
DOC_WW_Pin1_4	459	464	PF00397	0.771
DOC_WW_Pin1_4	496	501	PF00397	0.439
LIG_14-3-3_CanoR_1	167	173	PF00244	0.561
LIG_14-3-3_CanoR_1	26	36	PF00244	0.456
LIG_14-3-3_CanoR_1	427	433	PF00244	0.370
LIG_14-3-3_CanoR_1	618	623	PF00244	0.455
LIG_14-3-3_CanoR_1	642	647	PF00244	0.555
LIG_Actin_WH2_2	363	380	PF00022	0.385
LIG_APCC_ABBAyCdc20_2	137	143	PF00400	0.534
LIG_BIR_II_1	1	5	PF00653	0.750
LIG_BIR_III_4	51	55	PF00653	0.504
LIG_BIR_III_4	98	102	PF00653	0.484
LIG_BRCT_BRCA1_1	583	587	PF00533	0.333
LIG_Clathr_ClatBox_1	566	570	PF01394	0.424
LIG_Clathr_ClatBox_1	69	73	PF01394	0.541
LIG_FHA_1	140	146	PF00498	0.603
LIG_FHA_1	27	33	PF00498	0.595
LIG_FHA_1	420	426	PF00498	0.453
LIG_FHA_1	470	476	PF00498	0.656
LIG_FHA_1	615	621	PF00498	0.476
LIG_FHA_1	624	630	PF00498	0.479
LIG_FHA_2	105	111	PF00498	0.552
LIG_FHA_2	95	101	PF00498	0.748
LIG_LIR_Gen_1	395	404	PF02991	0.461
LIG_LIR_Gen_1	501	508	PF02991	0.554
LIG_LIR_Gen_1	516	523	PF02991	0.487
LIG_LIR_Gen_1	604	615	PF02991	0.281
LIG_LIR_Nem_3	395	401	PF02991	0.392
LIG_LIR_Nem_3	501	506	PF02991	0.566
LIG_LIR_Nem_3	516	520	PF02991	0.502
LIG_LIR_Nem_3	604	610	PF02991	0.362
LIG_PCNA_PIPBox_1	429	438	PF02747	0.225
LIG_PCNA_yPIPBox_3	426	436	PF02747	0.246
LIG_Pex14_2	58	62	PF04695	0.554
LIG_PTAP_UEV_1	462	467	PF05743	0.508
LIG_SH2_GRB2like	436	439	PF00017	0.228
LIG_SH2_PTP2	327	330	PF00017	0.537
LIG_SH2_STAP1	309	313	PF00017	0.641
LIG_SH2_STAP1	39	43	PF00017	0.407
LIG_SH2_STAP1	398	402	PF00017	0.448
LIG_SH2_STAT3	39	42	PF00017	0.432
LIG_SH2_STAT5	309	312	PF00017	0.450
LIG_SH2_STAT5	327	330	PF00017	0.537
LIG_SH3_3	319	325	PF00018	0.492
LIG_SH3_3	457	463	PF00018	0.588
LIG_SH3_3	464	470	PF00018	0.565
LIG_SH3_3	492	498	PF00018	0.617
LIG_SH3_3	617	623	PF00018	0.468
LIG_SUMO_SIM_par_1	565	570	PF11976	0.315
LIG_TRAF2_1	331	334	PF00917	0.482
LIG_WRC_WIRS_1	381	386	PF05994	0.389
LIG_WRC_WIRS_1	514	519	PF05994	0.250
MOD_CDK_SPxxK_3	498	505	PF00069	0.392
MOD_CK1_1	148	154	PF00069	0.572
MOD_CK1_1	243	249	PF00069	0.576
MOD_CK1_1	276	282	PF00069	0.696
MOD_CK1_1	447	453	PF00069	0.651
MOD_CK1_1	556	562	PF00069	0.571
MOD_CK1_1	57	63	PF00069	0.493
MOD_CK2_1	215	221	PF00069	0.608
MOD_CK2_1	337	343	PF00069	0.622
MOD_CK2_1	380	386	PF00069	0.432
MOD_CK2_1	57	63	PF00069	0.589
MOD_Cter_Amidation	265	268	PF01082	0.667
MOD_GlcNHglycan	131	134	PF01048	0.576
MOD_GlcNHglycan	151	154	PF01048	0.433
MOD_GlcNHglycan	217	220	PF01048	0.616
MOD_GlcNHglycan	242	245	PF01048	0.566
MOD_GlcNHglycan	262	265	PF01048	0.510
MOD_GlcNHglycan	275	278	PF01048	0.601
MOD_GlcNHglycan	280	283	PF01048	0.774
MOD_GlcNHglycan	452	455	PF01048	0.603
MOD_GlcNHglycan	463	466	PF01048	0.591
MOD_GlcNHglycan	482	485	PF01048	0.571
MOD_GlcNHglycan	51	55	PF01048	0.471
MOD_GlcNHglycan	527	530	PF01048	0.340
MOD_GlcNHglycan	583	586	PF01048	0.445
MOD_GlcNHglycan	589	592	PF01048	0.497
MOD_GlcNHglycan	59	62	PF01048	0.492
MOD_GlcNHglycan	631	634	PF01048	0.699
MOD_GlcNHglycan	661	664	PF01048	0.538
MOD_GlcNHglycan	73	79	PF01048	0.571
MOD_GSK3_1	144	151	PF00069	0.616
MOD_GSK3_1	255	262	PF00069	0.525
MOD_GSK3_1	276	283	PF00069	0.607
MOD_GSK3_1	380	387	PF00069	0.597
MOD_GSK3_1	444	451	PF00069	0.539
MOD_GSK3_1	46	53	PF00069	0.551
MOD_GSK3_1	480	487	PF00069	0.602
MOD_GSK3_1	545	552	PF00069	0.411
MOD_GSK3_1	575	582	PF00069	0.391
MOD_GSK3_1	610	617	PF00069	0.458
MOD_GSK3_1	625	632	PF00069	0.432
MOD_GSK3_1	638	645	PF00069	0.563
MOD_GSK3_1	90	97	PF00069	0.689
MOD_NEK2_1	149	154	PF00069	0.652
MOD_NEK2_1	193	198	PF00069	0.634
MOD_NEK2_1	384	389	PF00069	0.544
MOD_NEK2_1	448	453	PF00069	0.593
MOD_NEK2_1	553	558	PF00069	0.467
MOD_NEK2_1	581	586	PF00069	0.478
MOD_NEK2_1	587	592	PF00069	0.473
MOD_NEK2_1	598	603	PF00069	0.542
MOD_NEK2_1	624	629	PF00069	0.591
MOD_NEK2_2	54	59	PF00069	0.567
MOD_PIKK_1	296	302	PF00454	0.520
MOD_PIKK_1	384	390	PF00454	0.517
MOD_PIKK_1	448	454	PF00454	0.523
MOD_PIKK_1	545	551	PF00454	0.348
MOD_PIKK_1	572	578	PF00454	0.328
MOD_PKA_1	16	22	PF00069	0.568
MOD_PKA_1	223	229	PF00069	0.439
MOD_PKA_1	255	261	PF00069	0.582
MOD_PKA_1	618	624	PF00069	0.432
MOD_PKA_1	642	648	PF00069	0.404
MOD_PKA_2	16	22	PF00069	0.611
MOD_PKA_2	166	172	PF00069	0.587
MOD_PKA_2	255	261	PF00069	0.665
MOD_PKA_2	610	616	PF00069	0.453
MOD_PKA_2	618	624	PF00069	0.472
MOD_PKA_2	641	647	PF00069	0.564
MOD_PKB_1	137	145	PF00069	0.511
MOD_PKB_1	426	434	PF00069	0.403
MOD_Plk_1	419	425	PF00069	0.319
MOD_Plk_4	145	151	PF00069	0.658
MOD_Plk_4	444	450	PF00069	0.581
MOD_Plk_4	487	493	PF00069	0.457
MOD_Plk_4	513	519	PF00069	0.303
MOD_Plk_4	553	559	PF00069	0.456
MOD_Plk_4	601	607	PF00069	0.382
MOD_Plk_4	625	631	PF00069	0.622
MOD_ProDKin_1	276	282	PF00069	0.512
MOD_ProDKin_1	284	290	PF00069	0.485
MOD_ProDKin_1	326	332	PF00069	0.449
MOD_ProDKin_1	459	465	PF00069	0.771
MOD_ProDKin_1	496	502	PF00069	0.431
MOD_SUMO_for_1	70	73	PF00179	0.640
MOD_SUMO_rev_2	218	225	PF00179	0.453
TRG_DiLeu_BaEn_1	341	346	PF01217	0.366
TRG_DiLeu_BaEn_1	65	70	PF01217	0.514
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.508
TRG_DiLeu_BaLyEn_6	474	479	PF01217	0.571
TRG_ENDOCYTIC_2	398	401	PF00928	0.461
TRG_ENDOCYTIC_2	436	439	PF00928	0.228
TRG_ER_diArg_1	115	117	PF00400	0.574
TRG_ER_diArg_1	137	139	PF00400	0.581
TRG_ER_diArg_1	183	185	PF00400	0.593
TRG_ER_diArg_1	253	256	PF00400	0.550
TRG_ER_diArg_1	302	305	PF00400	0.448
TRG_ER_diArg_1	425	428	PF00400	0.562
TRG_ER_diArg_1	618	620	PF00400	0.493
TRG_NLS_MonoCore_2	301	306	PF00514	0.371
TRG_NLS_MonoExtN_4	302	307	PF00514	0.378
TRG_Pf-PMV_PEXEL_1	34	38	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A1	Leptomonas seymouri	46%	100%
A0A1X0NRK2	Trypanosomatidae	32%	100%
A0A3Q8IG27	Leishmania donovani	86%	100%
A4HKP1	Leishmania braziliensis	72%	100%
A4I872	Leishmania infantum	86%	100%
D0AAE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4Q524	Leishmania major	86%	100%
V5AUP9	Trypanosoma cruzi	31%	100%