Thioredoxin-like_fold domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B329_LEIMU

TriTrypDb:

LmxM.31.2500

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9B329

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B329

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.645
CLV_NRD_NRD_1	147	149	PF00675	0.413
CLV_NRD_NRD_1	63	65	PF00675	0.571
CLV_PCSK_KEX2_1	147	149	PF00082	0.422
CLV_PCSK_KEX2_1	63	65	PF00082	0.571
CLV_PCSK_SKI1_1	22	26	PF00082	0.636
DOC_MAPK_MEF2A_6	39	48	PF00069	0.412
DOC_PP1_RVXF_1	103	109	PF00149	0.389
LIG_14-3-3_CanoR_1	139	145	PF00244	0.590
LIG_14-3-3_CanoR_1	22	31	PF00244	0.492
LIG_Actin_WH2_2	77	92	PF00022	0.382
LIG_APCC_ABBAyCdc20_2	147	153	PF00400	0.606
LIG_BIR_II_1	1	5	PF00653	0.435
LIG_BIR_III_3	1	5	PF00653	0.435
LIG_deltaCOP1_diTrp_1	107	113	PF00928	0.265
LIG_EVH1_2	5	9	PF00568	0.411
LIG_FHA_1	12	18	PF00498	0.405
LIG_FHA_1	84	90	PF00498	0.372
LIG_FHA_2	23	29	PF00498	0.434
LIG_LIR_Gen_1	40	51	PF02991	0.401
LIG_LIR_Nem_3	107	111	PF02991	0.272
LIG_LIR_Nem_3	40	46	PF02991	0.414
LIG_LIR_Nem_3	79	84	PF02991	0.386
LIG_NRBOX	128	134	PF00104	0.565
LIG_NRP_CendR_1	160	162	PF00754	0.447
LIG_Pex14_1	124	128	PF04695	0.312
LIG_SH2_STAP1	115	119	PF00017	0.308
LIG_SH2_STAP1	151	155	PF00017	0.679
LIG_SH2_STAT3	65	68	PF00017	0.368
LIG_SH2_STAT5	121	124	PF00017	0.291
LIG_SH2_STAT5	128	131	PF00017	0.459
LIG_SH2_STAT5	155	158	PF00017	0.714
LIG_SH2_STAT5	43	46	PF00017	0.402
LIG_SH2_STAT5	65	68	PF00017	0.429
LIG_TRAF2_2	102	107	PF00917	0.393
LIG_WRC_WIRS_1	21	26	PF05994	0.449
MOD_CMANNOS	110	113	PF00535	0.308
MOD_GSK3_1	5	12	PF00069	0.394
MOD_NEK2_1	52	57	PF00069	0.382
MOD_NEK2_1	89	94	PF00069	0.371
MOD_NEK2_1	9	14	PF00069	0.400
MOD_PKA_2	66	72	PF00069	0.462
MOD_PKA_2	89	95	PF00069	0.373
MOD_Plk_4	128	134	PF00069	0.565
MOD_Plk_4	5	11	PF00069	0.473
MOD_Plk_4	89	95	PF00069	0.373
MOD_SUMO_rev_2	79	84	PF00179	0.469
TRG_ENDOCYTIC_2	115	118	PF00928	0.284
TRG_ENDOCYTIC_2	43	46	PF00928	0.391
TRG_ENDOCYTIC_2	59	62	PF00928	0.346
TRG_ER_diArg_1	159	162	PF00400	0.643
TRG_ER_diArg_1	62	64	PF00400	0.365
TRG_Pf-PMV_PEXEL_1	15	20	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5P2	Leptomonas seymouri	88%	100%
A0A1X0NS66	Trypanosomatidae	72%	100%
A0A3Q8ILB8	Leishmania donovani	96%	100%
A0A3R7L0F6	Trypanosoma rangeli	68%	99%
A4HKP0	Leishmania braziliensis	91%	100%
A4I871	Leishmania infantum	97%	100%
D0AAE0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
Q4Q525	Leishmania major	98%	100%