SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania mexicana

UniProt:

E9B323_LEIMU

TriTrypDb:

LmxM.31.2430

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0032991	protein-containing complex	1	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B323

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B323

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0032259	methylation	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000154	rRNA modification	6	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0016072	rRNA metabolic process	7	1
GO:0031167	rRNA methylation	5	1
GO:0034470	ncRNA processing	7	1
GO:0034660	ncRNA metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.454
CLV_C14_Caspase3-7	346	350	PF00656	0.727
CLV_C14_Caspase3-7	351	355	PF00656	0.678
CLV_MEL_PAP_1	65	71	PF00089	0.463
CLV_NRD_NRD_1	212	214	PF00675	0.236
CLV_NRD_NRD_1	60	62	PF00675	0.429
CLV_PCSK_FUR_1	210	214	PF00082	0.222
CLV_PCSK_KEX2_1	212	214	PF00082	0.221
CLV_PCSK_SKI1_1	255	259	PF00082	0.248
CLV_PCSK_SKI1_1	284	288	PF00082	0.254
CLV_PCSK_SKI1_1	328	332	PF00082	0.340
CLV_PCSK_SKI1_1	345	349	PF00082	0.444
CLV_PCSK_SKI1_1	377	381	PF00082	0.429
CLV_PCSK_SKI1_1	62	66	PF00082	0.351
DEG_SPOP_SBC_1	404	408	PF00917	0.722
DOC_CKS1_1	363	368	PF01111	0.516
DOC_CYCLIN_RxL_1	374	382	PF00134	0.448
DOC_MAPK_DCC_7	13	22	PF00069	0.432
DOC_MAPK_gen_1	322	329	PF00069	0.417
DOC_MAPK_MEF2A_6	13	22	PF00069	0.432
DOC_PP2B_LxvP_1	378	381	PF13499	0.424
DOC_PP4_FxxP_1	191	194	PF00568	0.478
DOC_USP7_MATH_1	250	254	PF00917	0.478
DOC_USP7_MATH_1	28	32	PF00917	0.595
DOC_USP7_MATH_1	350	354	PF00917	0.772
DOC_USP7_UBL2_3	119	123	PF12436	0.505
DOC_USP7_UBL2_3	23	27	PF12436	0.654
DOC_USP7_UBL2_3	29	33	PF12436	0.623
DOC_WW_Pin1_4	190	195	PF00397	0.478
DOC_WW_Pin1_4	261	266	PF00397	0.447
DOC_WW_Pin1_4	305	310	PF00397	0.422
DOC_WW_Pin1_4	362	367	PF00397	0.581
LIG_14-3-3_CanoR_1	299	309	PF00244	0.449
LIG_14-3-3_CanoR_1	68	74	PF00244	0.509
LIG_BIR_III_4	145	149	PF00653	0.466
LIG_BIR_III_4	354	358	PF00653	0.583
LIG_CtBP_PxDLS_1	265	269	PF00389	0.501
LIG_FHA_1	12	18	PF00498	0.633
LIG_FHA_1	274	280	PF00498	0.473
LIG_FHA_1	291	297	PF00498	0.407
LIG_FHA_1	302	308	PF00498	0.379
LIG_FHA_1	363	369	PF00498	0.683
LIG_FHA_1	76	82	PF00498	0.504
LIG_FHA_2	171	177	PF00498	0.465
LIG_FHA_2	197	203	PF00498	0.454
LIG_FHA_2	227	233	PF00498	0.441
LIG_FHA_2	321	327	PF00498	0.485
LIG_FHA_2	34	40	PF00498	0.437
LIG_FHA_2	344	350	PF00498	0.751
LIG_LIR_Apic_2	235	239	PF02991	0.424
LIG_LIR_Nem_3	36	40	PF02991	0.338
LIG_LIR_Nem_3	373	378	PF02991	0.333
LIG_LIR_Nem_3	47	52	PF02991	0.277
LIG_Pex14_1	387	391	PF04695	0.415
LIG_Rb_LxCxE_1	193	206	PF01857	0.513
LIG_SH2_CRK	375	379	PF00017	0.442
LIG_SH2_SRC	237	240	PF00017	0.492
LIG_SH2_STAT5	153	156	PF00017	0.311
LIG_SH2_STAT5	223	226	PF00017	0.457
LIG_SH3_2	340	345	PF14604	0.454
LIG_SH3_3	244	250	PF00018	0.411
LIG_SH3_3	337	343	PF00018	0.665
LIG_SH3_4	119	126	PF00018	0.440
LIG_SUMO_SIM_par_1	264	270	PF11976	0.501
LIG_TRAF2_1	73	76	PF00917	0.448
MOD_CK1_1	261	267	PF00069	0.537
MOD_CK1_1	272	278	PF00069	0.481
MOD_CK1_1	303	309	PF00069	0.418
MOD_CK1_1	333	339	PF00069	0.573
MOD_CK1_1	353	359	PF00069	0.597
MOD_CK1_1	405	411	PF00069	0.617
MOD_CK2_1	196	202	PF00069	0.462
MOD_CK2_1	264	270	PF00069	0.480
MOD_CK2_1	305	311	PF00069	0.461
MOD_CK2_1	320	326	PF00069	0.391
MOD_CK2_1	33	39	PF00069	0.502
MOD_CK2_1	353	359	PF00069	0.730
MOD_CK2_1	79	85	PF00069	0.514
MOD_GlcNHglycan	158	161	PF01048	0.369
MOD_GlcNHglycan	260	263	PF01048	0.281
MOD_GlcNHglycan	30	33	PF01048	0.611
MOD_GlcNHglycan	333	336	PF01048	0.451
MOD_GlcNHglycan	354	358	PF01048	0.583
MOD_GlcNHglycan	407	410	PF01048	0.533
MOD_GSK3_1	196	203	PF00069	0.507
MOD_GSK3_1	269	276	PF00069	0.458
MOD_GSK3_1	301	308	PF00069	0.447
MOD_GSK3_1	329	336	PF00069	0.455
MOD_GSK3_1	75	82	PF00069	0.521
MOD_N-GLC_1	11	16	PF02516	0.647
MOD_N-GLC_1	200	205	PF02516	0.214
MOD_N-GLC_1	99	104	PF02516	0.572
MOD_NEK2_1	258	263	PF00069	0.478
MOD_NEK2_1	320	325	PF00069	0.408
MOD_NEK2_1	4	9	PF00069	0.551
MOD_NEK2_2	290	295	PF00069	0.462
MOD_PIKK_1	226	232	PF00454	0.422
MOD_PIKK_1	67	73	PF00454	0.473
MOD_PKA_2	226	232	PF00069	0.552
MOD_PKA_2	4	10	PF00069	0.587
MOD_PKA_2	67	73	PF00069	0.416
MOD_PKB_1	9	17	PF00069	0.648
MOD_Plk_1	370	376	PF00069	0.369
MOD_Plk_2-3	232	238	PF00069	0.515
MOD_Plk_4	170	176	PF00069	0.392
MOD_Plk_4	232	238	PF00069	0.440
MOD_Plk_4	364	370	PF00069	0.513
MOD_Plk_4	85	91	PF00069	0.421
MOD_ProDKin_1	190	196	PF00069	0.478
MOD_ProDKin_1	261	267	PF00069	0.447
MOD_ProDKin_1	305	311	PF00069	0.422
MOD_ProDKin_1	362	368	PF00069	0.565
MOD_SUMO_rev_2	113	120	PF00179	0.499
MOD_SUMO_rev_2	396	404	PF00179	0.445
TRG_DiLeu_BaEn_1	85	90	PF01217	0.544
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.455
TRG_ENDOCYTIC_2	152	155	PF00928	0.319
TRG_ENDOCYTIC_2	375	378	PF00928	0.340
TRG_ENDOCYTIC_2	41	44	PF00928	0.367
TRG_ER_diArg_1	210	213	PF00400	0.437
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.214
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.211
TRG_Pf-PMV_PEXEL_1	255	259	PF00026	0.211
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.265
TRG_Pf-PMV_PEXEL_1	377	382	PF00026	0.407

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK00	Leptomonas seymouri	68%	100%
A0A0S4J448	Bodo saltans	42%	100%
A0A1X0NRJ9	Trypanosomatidae	41%	100%
A0A3Q8ID92	Leishmania donovani	92%	100%
A0A3R7K4S3	Trypanosoma rangeli	47%	100%
A4HKN4	Leishmania braziliensis	80%	100%
A4I865	Leishmania infantum	92%	100%
D0AAD3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q0P5D8	Bos taurus	30%	100%
Q0V8R7	Bos taurus	28%	100%
Q4KMK0	Danio rerio	31%	100%
Q4Q532	Leishmania major	90%	100%
Q5M7E3	Xenopus laevis	29%	100%
Q5SII2	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	27%	91%
Q66KI9	Xenopus tropicalis	29%	100%
Q8CCT7	Mus musculus	29%	100%
Q96CB9	Homo sapiens	26%	100%
Q9CZ57	Mus musculus	27%	100%
Q9H649	Homo sapiens	30%	100%
V5B8C1	Trypanosoma cruzi	45%	100%