Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B322_LEIMU

TriTrypDb:

LmxM.31.2420

Length:

886

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B322

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B322

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.615
CLV_NRD_NRD_1	107	109	PF00675	0.548
CLV_NRD_NRD_1	124	126	PF00675	0.549
CLV_NRD_NRD_1	224	226	PF00675	0.664
CLV_NRD_NRD_1	241	243	PF00675	0.675
CLV_NRD_NRD_1	29	31	PF00675	0.551
CLV_NRD_NRD_1	311	313	PF00675	0.521
CLV_NRD_NRD_1	381	383	PF00675	0.451
CLV_NRD_NRD_1	465	467	PF00675	0.608
CLV_NRD_NRD_1	540	542	PF00675	0.465
CLV_NRD_NRD_1	660	662	PF00675	0.688
CLV_NRD_NRD_1	663	665	PF00675	0.714
CLV_NRD_NRD_1	746	748	PF00675	0.563
CLV_PCSK_FUR_1	661	665	PF00082	0.730
CLV_PCSK_KEX2_1	106	108	PF00082	0.533
CLV_PCSK_KEX2_1	124	126	PF00082	0.539
CLV_PCSK_KEX2_1	224	226	PF00082	0.660
CLV_PCSK_KEX2_1	241	243	PF00082	0.675
CLV_PCSK_KEX2_1	29	31	PF00082	0.551
CLV_PCSK_KEX2_1	311	313	PF00082	0.521
CLV_PCSK_KEX2_1	381	383	PF00082	0.451
CLV_PCSK_KEX2_1	400	402	PF00082	0.601
CLV_PCSK_KEX2_1	465	467	PF00082	0.604
CLV_PCSK_KEX2_1	540	542	PF00082	0.465
CLV_PCSK_KEX2_1	660	662	PF00082	0.688
CLV_PCSK_KEX2_1	663	665	PF00082	0.714
CLV_PCSK_KEX2_1	746	748	PF00082	0.563
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.601
CLV_PCSK_PC7_1	120	126	PF00082	0.536
CLV_PCSK_PC7_1	377	383	PF00082	0.549
CLV_PCSK_SKI1_1	433	437	PF00082	0.512
CLV_PCSK_SKI1_1	592	596	PF00082	0.620
CLV_PCSK_SKI1_1	651	655	PF00082	0.617
CLV_PCSK_SKI1_1	809	813	PF00082	0.558
CLV_PCSK_SKI1_1	815	819	PF00082	0.504
CLV_PCSK_SKI1_1	842	846	PF00082	0.568
DEG_APCC_DBOX_1	381	389	PF00400	0.499
DEG_SCF_FBW7_1	580	586	PF00400	0.686
DEG_SPOP_SBC_1	127	131	PF00917	0.550
DEG_SPOP_SBC_1	149	153	PF00917	0.711
DEG_SPOP_SBC_1	232	236	PF00917	0.582
DOC_CDC14_PxL_1	383	391	PF14671	0.486
DOC_CKS1_1	406	411	PF01111	0.618
DOC_CKS1_1	580	585	PF01111	0.706
DOC_CKS1_1	791	796	PF01111	0.395
DOC_CKS1_1	860	865	PF01111	0.504
DOC_CYCLIN_RxL_1	648	658	PF00134	0.526
DOC_CYCLIN_RxL_1	809	822	PF00134	0.571
DOC_CYCLIN_yCln2_LP_2	519	525	PF00134	0.702
DOC_CYCLIN_yCln2_LP_2	595	601	PF00134	0.558
DOC_MAPK_DCC_7	381	391	PF00069	0.494
DOC_MAPK_gen_1	381	388	PF00069	0.503
DOC_MAPK_gen_1	505	515	PF00069	0.566
DOC_MAPK_MEF2A_6	382	391	PF00069	0.489
DOC_MAPK_MEF2A_6	592	601	PF00069	0.614
DOC_MAPK_MEF2A_6	643	652	PF00069	0.537
DOC_PP1_RVXF_1	641	648	PF00149	0.373
DOC_PP2B_LxvP_1	460	463	PF13499	0.596
DOC_PP2B_LxvP_1	595	598	PF13499	0.615
DOC_PP2B_LxvP_1	602	605	PF13499	0.527
DOC_PP4_FxxP_1	339	342	PF00568	0.575
DOC_PP4_FxxP_1	351	354	PF00568	0.500
DOC_PP4_FxxP_1	546	549	PF00568	0.449
DOC_PP4_FxxP_1	791	794	PF00568	0.566
DOC_USP7_MATH_1	127	131	PF00917	0.734
DOC_USP7_MATH_1	147	151	PF00917	0.756
DOC_USP7_MATH_1	213	217	PF00917	0.472
DOC_USP7_MATH_1	232	236	PF00917	0.720
DOC_USP7_MATH_1	354	358	PF00917	0.611
DOC_USP7_MATH_1	527	531	PF00917	0.658
DOC_USP7_MATH_1	666	670	PF00917	0.766
DOC_USP7_MATH_1	689	693	PF00917	0.687
DOC_USP7_MATH_1	7	11	PF00917	0.736
DOC_USP7_MATH_1	742	746	PF00917	0.630
DOC_USP7_MATH_1	85	89	PF00917	0.568
DOC_WW_Pin1_4	128	133	PF00397	0.734
DOC_WW_Pin1_4	151	156	PF00397	0.792
DOC_WW_Pin1_4	159	164	PF00397	0.674
DOC_WW_Pin1_4	280	285	PF00397	0.655
DOC_WW_Pin1_4	400	405	PF00397	0.661
DOC_WW_Pin1_4	415	420	PF00397	0.782
DOC_WW_Pin1_4	48	53	PF00397	0.607
DOC_WW_Pin1_4	579	584	PF00397	0.715
DOC_WW_Pin1_4	603	608	PF00397	0.688
DOC_WW_Pin1_4	627	632	PF00397	0.594
DOC_WW_Pin1_4	697	702	PF00397	0.689
DOC_WW_Pin1_4	790	795	PF00397	0.413
DOC_WW_Pin1_4	859	864	PF00397	0.595
LIG_14-3-3_CanoR_1	124	132	PF00244	0.704
LIG_14-3-3_CanoR_1	257	263	PF00244	0.335
LIG_14-3-3_CanoR_1	632	638	PF00244	0.663
LIG_14-3-3_CanoR_1	675	682	PF00244	0.637
LIG_14-3-3_CanoR_1	852	860	PF00244	0.493
LIG_14-3-3_CanoR_1	875	879	PF00244	0.513
LIG_14-3-3_CterR_2	883	886	PF00244	0.433
LIG_Actin_RPEL_3	305	324	PF02755	0.477
LIG_Actin_WH2_2	310	328	PF00022	0.558
LIG_Actin_WH2_2	827	844	PF00022	0.557
LIG_APCC_ABBA_1	817	822	PF00400	0.591
LIG_BIR_III_4	77	81	PF00653	0.528
LIG_BRCT_BRCA1_1	152	156	PF00533	0.619
LIG_BRCT_BRCA1_1	187	191	PF00533	0.585
LIG_BRCT_BRCA1_1	347	351	PF00533	0.603
LIG_BRCT_BRCA1_1	529	533	PF00533	0.602
LIG_BRCT_BRCA1_1	599	603	PF00533	0.580
LIG_CaM_IQ_9	828	844	PF13499	0.504
LIG_deltaCOP1_diTrp_1	426	436	PF00928	0.489
LIG_deltaCOP1_diTrp_1	43	50	PF00928	0.649
LIG_EH1_1	178	186	PF00400	0.423
LIG_FHA_1	169	175	PF00498	0.422
LIG_FHA_1	180	186	PF00498	0.300
LIG_FHA_1	280	286	PF00498	0.649
LIG_FHA_1	401	407	PF00498	0.626
LIG_FHA_1	473	479	PF00498	0.495
LIG_FHA_1	556	562	PF00498	0.665
LIG_FHA_1	758	764	PF00498	0.592
LIG_FHA_1	783	789	PF00498	0.629
LIG_FHA_2	194	200	PF00498	0.565
LIG_FHA_2	493	499	PF00498	0.522
LIG_FHA_2	825	831	PF00498	0.575
LIG_GBD_Chelix_1	535	543	PF00786	0.542
LIG_GBD_Chelix_1	753	761	PF00786	0.506
LIG_GBD_Chelix_1	799	807	PF00786	0.577
LIG_LIR_Apic_2	11	17	PF02991	0.622
LIG_LIR_Apic_2	336	342	PF02991	0.585
LIG_LIR_Apic_2	348	354	PF02991	0.497
LIG_LIR_Apic_2	544	549	PF02991	0.423
LIG_LIR_Gen_1	261	271	PF02991	0.490
LIG_LIR_Gen_1	452	462	PF02991	0.508
LIG_LIR_Nem_3	101	105	PF02991	0.424
LIG_LIR_Nem_3	261	267	PF02991	0.532
LIG_LIR_Nem_3	452	457	PF02991	0.507
LIG_LIR_Nem_3	529	535	PF02991	0.510
LIG_LIR_Nem_3	693	699	PF02991	0.521
LIG_LIR_Nem_3	88	93	PF02991	0.509
LIG_MLH1_MIPbox_1	529	533	PF16413	0.529
LIG_NRBOX	498	504	PF00104	0.580
LIG_NRBOX	644	650	PF00104	0.564
LIG_PCNA_yPIPBox_3	241	250	PF02747	0.515
LIG_PCNA_yPIPBox_3	643	653	PF02747	0.578
LIG_PDZ_Class_1	881	886	PF00595	0.621
LIG_Pex14_1	542	546	PF04695	0.355
LIG_Pex14_2	538	542	PF04695	0.540
LIG_PTAP_UEV_1	549	554	PF05743	0.512
LIG_SH2_CRK	14	18	PF00017	0.565
LIG_SH2_CRK	347	351	PF00017	0.603
LIG_SH2_CRK	591	595	PF00017	0.614
LIG_SH2_PTP2	24	27	PF00017	0.560
LIG_SH2_SRC	136	139	PF00017	0.560
LIG_SH2_STAP1	295	299	PF00017	0.534
LIG_SH2_STAP1	347	351	PF00017	0.603
LIG_SH2_STAT3	31	34	PF00017	0.577
LIG_SH2_STAT3	848	851	PF00017	0.604
LIG_SH2_STAT5	24	27	PF00017	0.560
LIG_SH2_STAT5	532	535	PF00017	0.498
LIG_SH2_STAT5	699	702	PF00017	0.535
LIG_SH3_1	416	422	PF00018	0.539
LIG_SH3_3	152	158	PF00018	0.622
LIG_SH3_3	403	409	PF00018	0.628
LIG_SH3_3	416	422	PF00018	0.685
LIG_SH3_3	46	52	PF00018	0.652
LIG_SH3_3	514	520	PF00018	0.653
LIG_SH3_3	547	553	PF00018	0.690
LIG_SH3_3	729	735	PF00018	0.684
LIG_SH3_3	857	863	PF00018	0.507
LIG_SUMO_SIM_anti_2	180	185	PF11976	0.422
LIG_SUMO_SIM_anti_2	321	326	PF11976	0.544
LIG_SUMO_SIM_par_1	843	850	PF11976	0.607
LIG_TYR_ITIM	22	27	PF00017	0.567
LIG_UBA3_1	439	445	PF00899	0.546
LIG_WRC_WIRS_1	535	540	PF05994	0.538
LIG_WRC_WIRS_1	87	92	PF05994	0.482
LIG_WW_3	374	378	PF00397	0.608
MOD_CDK_SPK_2	627	632	PF00069	0.623
MOD_CDK_SPxxK_3	128	135	PF00069	0.737
MOD_CDK_SPxxK_3	627	634	PF00069	0.634
MOD_CK1_1	123	129	PF00069	0.550
MOD_CK1_1	148	154	PF00069	0.814
MOD_CK1_1	159	165	PF00069	0.571
MOD_CK1_1	177	183	PF00069	0.352
MOD_CK1_1	231	237	PF00069	0.732
MOD_CK1_1	355	361	PF00069	0.769
MOD_CK1_1	551	557	PF00069	0.731
MOD_CK1_1	606	612	PF00069	0.494
MOD_CK1_1	636	642	PF00069	0.467
MOD_CK1_1	692	698	PF00069	0.687
MOD_CK1_1	705	711	PF00069	0.584
MOD_CK1_1	8	14	PF00069	0.694
MOD_CK2_1	193	199	PF00069	0.546
MOD_CK2_1	492	498	PF00069	0.582
MOD_CK2_1	738	744	PF00069	0.678
MOD_CK2_1	824	830	PF00069	0.576
MOD_CK2_1	853	859	PF00069	0.622
MOD_Cter_Amidation	27	30	PF01082	0.520
MOD_GlcNHglycan	125	128	PF01048	0.545
MOD_GlcNHglycan	146	150	PF01048	0.734
MOD_GlcNHglycan	187	190	PF01048	0.580
MOD_GlcNHglycan	206	209	PF01048	0.393
MOD_GlcNHglycan	215	218	PF01048	0.428
MOD_GlcNHglycan	230	233	PF01048	0.745
MOD_GlcNHglycan	357	360	PF01048	0.603
MOD_GlcNHglycan	430	433	PF01048	0.549
MOD_GlcNHglycan	470	473	PF01048	0.560
MOD_GlcNHglycan	485	488	PF01048	0.656
MOD_GlcNHglycan	52	55	PF01048	0.779
MOD_GlcNHglycan	523	526	PF01048	0.721
MOD_GlcNHglycan	528	532	PF01048	0.623
MOD_GlcNHglycan	550	553	PF01048	0.583
MOD_GlcNHglycan	574	577	PF01048	0.692
MOD_GlcNHglycan	616	619	PF01048	0.589
MOD_GlcNHglycan	668	671	PF01048	0.712
MOD_GlcNHglycan	682	685	PF01048	0.817
MOD_GlcNHglycan	696	699	PF01048	0.600
MOD_GlcNHglycan	7	10	PF01048	0.674
MOD_GlcNHglycan	707	710	PF01048	0.618
MOD_GlcNHglycan	740	743	PF01048	0.708
MOD_GSK3_1	123	130	PF00069	0.581
MOD_GSK3_1	141	148	PF00069	0.783
MOD_GSK3_1	168	175	PF00069	0.369
MOD_GSK3_1	228	235	PF00069	0.688
MOD_GSK3_1	32	39	PF00069	0.620
MOD_GSK3_1	362	369	PF00069	0.634
MOD_GSK3_1	389	396	PF00069	0.552
MOD_GSK3_1	468	475	PF00069	0.597
MOD_GSK3_1	477	484	PF00069	0.737
MOD_GSK3_1	548	555	PF00069	0.701
MOD_GSK3_1	561	568	PF00069	0.629
MOD_GSK3_1	572	579	PF00069	0.687
MOD_GSK3_1	603	610	PF00069	0.686
MOD_GSK3_1	623	630	PF00069	0.660
MOD_GSK3_1	666	673	PF00069	0.766
MOD_GSK3_1	69	76	PF00069	0.625
MOD_GSK3_1	738	745	PF00069	0.688
MOD_GSK3_1	773	780	PF00069	0.720
MOD_N-GLC_1	228	233	PF02516	0.711
MOD_N-GLC_1	355	360	PF02516	0.639
MOD_N-GLC_1	362	367	PF02516	0.587
MOD_N-GLC_1	492	497	PF02516	0.608
MOD_N-GLC_1	5	10	PF02516	0.526
MOD_N-GLC_1	757	762	PF02516	0.449
MOD_NEK2_1	174	179	PF00069	0.499
MOD_NEK2_1	185	190	PF00069	0.365
MOD_NEK2_1	206	211	PF00069	0.495
MOD_NEK2_1	230	235	PF00069	0.591
MOD_NEK2_1	279	284	PF00069	0.659
MOD_NEK2_1	389	394	PF00069	0.529
MOD_NEK2_1	449	454	PF00069	0.556
MOD_NEK2_1	563	568	PF00069	0.747
MOD_NEK2_1	616	621	PF00069	0.484
MOD_NEK2_1	738	743	PF00069	0.609
MOD_NEK2_1	757	762	PF00069	0.595
MOD_NEK2_1	807	812	PF00069	0.567
MOD_NEK2_1	837	842	PF00069	0.542
MOD_NEK2_1	846	851	PF00069	0.534
MOD_NEK2_1	881	886	PF00069	0.621
MOD_PIKK_1	172	178	PF00454	0.548
MOD_PIKK_1	234	240	PF00454	0.520
MOD_PIKK_1	288	294	PF00454	0.603
MOD_PIKK_1	393	399	PF00454	0.508
MOD_PIKK_1	477	483	PF00454	0.627
MOD_PIKK_1	847	853	PF00454	0.444
MOD_PKA_2	123	129	PF00069	0.644
MOD_PKA_2	141	147	PF00069	0.634
MOD_PKA_2	467	473	PF00069	0.580
MOD_PKA_2	555	561	PF00069	0.711
MOD_PKA_2	633	639	PF00069	0.646
MOD_PKA_2	782	788	PF00069	0.707
MOD_PKA_2	853	859	PF00069	0.578
MOD_PKA_2	874	880	PF00069	0.509
MOD_PKB_1	466	474	PF00069	0.485
MOD_Plk_1	425	431	PF00069	0.602
MOD_Plk_1	449	455	PF00069	0.521
MOD_Plk_1	492	498	PF00069	0.611
MOD_Plk_1	527	533	PF00069	0.541
MOD_Plk_1	692	698	PF00069	0.648
MOD_Plk_1	757	763	PF00069	0.445
MOD_Plk_1	837	843	PF00069	0.548
MOD_Plk_1	85	91	PF00069	0.552
MOD_Plk_4	174	180	PF00069	0.497
MOD_Plk_4	206	212	PF00069	0.436
MOD_Plk_4	345	351	PF00069	0.605
MOD_Plk_4	389	395	PF00069	0.531
MOD_Plk_4	534	540	PF00069	0.588
MOD_Plk_4	597	603	PF00069	0.461
MOD_ProDKin_1	128	134	PF00069	0.736
MOD_ProDKin_1	151	157	PF00069	0.789
MOD_ProDKin_1	159	165	PF00069	0.660
MOD_ProDKin_1	280	286	PF00069	0.649
MOD_ProDKin_1	400	406	PF00069	0.675
MOD_ProDKin_1	415	421	PF00069	0.781
MOD_ProDKin_1	48	54	PF00069	0.609
MOD_ProDKin_1	579	585	PF00069	0.713
MOD_ProDKin_1	603	609	PF00069	0.695
MOD_ProDKin_1	627	633	PF00069	0.594
MOD_ProDKin_1	697	703	PF00069	0.692
MOD_ProDKin_1	790	796	PF00069	0.404
MOD_ProDKin_1	859	865	PF00069	0.590
TRG_DiLeu_BaEn_1	113	118	PF01217	0.487
TRG_DiLeu_BaEn_1	498	503	PF01217	0.576
TRG_DiLeu_BaEn_1	640	645	PF01217	0.603
TRG_DiLeu_BaLyEn_6	197	202	PF01217	0.526
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.541
TRG_DiLeu_BaLyEn_6	384	389	PF01217	0.487
TRG_DiLeu_BaLyEn_6	812	817	PF01217	0.568
TRG_DiLeu_LyEn_5	640	645	PF01217	0.545
TRG_ENDOCYTIC_2	24	27	PF00928	0.560
TRG_ENDOCYTIC_2	295	298	PF00928	0.539
TRG_ENDOCYTIC_2	347	350	PF00928	0.601
TRG_ENDOCYTIC_2	532	535	PF00928	0.498
TRG_ENDOCYTIC_2	591	594	PF00928	0.608
TRG_ER_diArg_1	105	108	PF00400	0.562
TRG_ER_diArg_1	224	227	PF00400	0.664
TRG_ER_diArg_1	240	242	PF00400	0.670
TRG_ER_diArg_1	254	257	PF00400	0.405
TRG_ER_diArg_1	29	31	PF00400	0.551
TRG_ER_diArg_1	381	383	PF00400	0.451
TRG_ER_diArg_1	465	468	PF00400	0.540
TRG_ER_diArg_1	539	541	PF00400	0.466
TRG_ER_diArg_1	631	634	PF00400	0.697
TRG_ER_diArg_1	660	663	PF00400	0.765
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.624
TRG_Pf-PMV_PEXEL_1	651	655	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	801	805	PF00026	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X5R7	Leishmania donovani	85%	87%
A4HKN3	Leishmania braziliensis	70%	100%
A4I864	Leishmania infantum	85%	87%
Q4Q533	Leishmania major	86%	100%