Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B319_LEIMU

TriTrypDb:

LmxM.31.2400

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B319

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B319

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.435
CLV_C14_Caspase3-7	247	251	PF00656	0.339
CLV_C14_Caspase3-7	277	281	PF00656	0.365
CLV_NRD_NRD_1	133	135	PF00675	0.523
CLV_NRD_NRD_1	163	165	PF00675	0.376
CLV_PCSK_KEX2_1	133	135	PF00082	0.435
CLV_PCSK_SKI1_1	222	226	PF00082	0.431
CLV_PCSK_SKI1_1	244	248	PF00082	0.248
DOC_MAPK_gen_1	133	141	PF00069	0.444
DOC_MAPK_gen_1	220	228	PF00069	0.383
DOC_MAPK_MEF2A_6	3	10	PF00069	0.354
DOC_PP2B_LxvP_1	207	210	PF13499	0.454
DOC_USP7_MATH_1	177	181	PF00917	0.477
DOC_USP7_MATH_1	233	237	PF00917	0.534
DOC_USP7_MATH_1	275	279	PF00917	0.563
DOC_WW_Pin1_4	183	188	PF00397	0.463
DOC_WW_Pin1_4	199	204	PF00397	0.564
DOC_WW_Pin1_4	236	241	PF00397	0.306
DOC_WW_Pin1_4	254	259	PF00397	0.375
LIG_14-3-3_CanoR_1	101	110	PF00244	0.537
LIG_14-3-3_CanoR_1	244	253	PF00244	0.432
LIG_14-3-3_CanoR_1	28	36	PF00244	0.472
LIG_14-3-3_CanoR_1	3	9	PF00244	0.452
LIG_14-3-3_CanoR_1	70	79	PF00244	0.476
LIG_BIR_III_2	192	196	PF00653	0.437
LIG_CaM_IQ_9	157	172	PF13499	0.370
LIG_FHA_1	18	24	PF00498	0.472
LIG_FHA_1	30	36	PF00498	0.357
LIG_FHA_1	320	326	PF00498	0.482
LIG_FHA_2	106	112	PF00498	0.384
LIG_FHA_2	245	251	PF00498	0.268
LIG_FHA_2	272	278	PF00498	0.303
LIG_FHA_2	51	57	PF00498	0.339
LIG_FHA_2	86	92	PF00498	0.543
LIG_LIR_Apic_2	250	256	PF02991	0.580
LIG_LIR_Gen_1	136	144	PF02991	0.429
LIG_LIR_Gen_1	29	36	PF02991	0.447
LIG_LIR_Gen_1	7	17	PF02991	0.351
LIG_LIR_Gen_1	94	104	PF02991	0.394
LIG_LIR_Nem_3	136	141	PF02991	0.427
LIG_LIR_Nem_3	29	34	PF02991	0.446
LIG_LIR_Nem_3	322	326	PF02991	0.376
LIG_LIR_Nem_3	7	13	PF02991	0.345
LIG_LIR_Nem_3	94	99	PF02991	0.362
LIG_PDZ_Class_2	341	346	PF00595	0.416
LIG_SH2_CRK	253	257	PF00017	0.435
LIG_SH2_NCK_1	253	257	PF00017	0.435
LIG_SH2_STAP1	31	35	PF00017	0.396
LIG_SH2_STAT5	138	141	PF00017	0.462
LIG_SH2_STAT5	31	34	PF00017	0.250
LIG_SH2_STAT5	312	315	PF00017	0.384
LIG_SUMO_SIM_anti_2	332	337	PF11976	0.257
LIG_SUMO_SIM_par_1	4	9	PF11976	0.349
LIG_TRAF2_1	53	56	PF00917	0.444
LIG_TRAF2_1	88	91	PF00917	0.497
LIG_WRC_WIRS_1	31	36	PF05994	0.413
LIG_WRC_WIRS_1	92	97	PF05994	0.478
MOD_CK1_1	236	242	PF00069	0.406
MOD_CK1_1	271	277	PF00069	0.363
MOD_CK1_1	278	284	PF00069	0.460
MOD_CK1_1	30	36	PF00069	0.530
MOD_CK2_1	169	175	PF00069	0.558
MOD_CK2_1	271	277	PF00069	0.293
MOD_CK2_1	50	56	PF00069	0.345
MOD_CK2_1	85	91	PF00069	0.509
MOD_GlcNHglycan	174	178	PF01048	0.665
MOD_GlcNHglycan	179	182	PF01048	0.731
MOD_GlcNHglycan	235	238	PF01048	0.584
MOD_GlcNHglycan	277	280	PF01048	0.635
MOD_GlcNHglycan	338	341	PF01048	0.594
MOD_GlcNHglycan	75	78	PF01048	0.621
MOD_GSK3_1	144	151	PF00069	0.537
MOD_GSK3_1	169	176	PF00069	0.597
MOD_GSK3_1	195	202	PF00069	0.706
MOD_GSK3_1	236	243	PF00069	0.415
MOD_GSK3_1	26	33	PF00069	0.436
MOD_GSK3_1	271	278	PF00069	0.580
MOD_N-GLC_1	47	52	PF02516	0.496
MOD_NEK2_1	100	105	PF00069	0.442
MOD_NEK2_1	144	149	PF00069	0.474
MOD_NEK2_1	212	217	PF00069	0.468
MOD_NEK2_1	336	341	PF00069	0.532
MOD_NEK2_1	42	47	PF00069	0.467
MOD_OFUCOSY	46	51	PF10250	0.481
MOD_PKA_2	100	106	PF00069	0.373
MOD_PKA_2	169	175	PF00069	0.408
MOD_PKA_2	27	33	PF00069	0.454
MOD_Plk_1	173	179	PF00069	0.482
MOD_Plk_4	105	111	PF00069	0.448
MOD_Plk_4	12	18	PF00069	0.332
MOD_Plk_4	148	154	PF00069	0.444
MOD_Plk_4	30	36	PF00069	0.359
MOD_ProDKin_1	183	189	PF00069	0.463
MOD_ProDKin_1	199	205	PF00069	0.547
MOD_ProDKin_1	236	242	PF00069	0.295
MOD_ProDKin_1	254	260	PF00069	0.369
MOD_SUMO_rev_2	76	82	PF00179	0.457
TRG_DiLeu_BaLyEn_6	237	242	PF01217	0.450
TRG_ENDOCYTIC_2	138	141	PF00928	0.469
TRG_ENDOCYTIC_2	31	34	PF00928	0.366
TRG_ER_diArg_1	132	134	PF00400	0.525
TRG_ER_diArg_1	219	222	PF00400	0.461
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N9	Leptomonas seymouri	52%	100%
A0A1X0NS57	Trypanosomatidae	28%	100%
A0A3Q8IG17	Leishmania donovani	84%	97%
A0A422N888	Trypanosoma rangeli	29%	100%
A4HKN1	Leishmania braziliensis	74%	100%
D0AAC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4Q535	Leishmania major	84%	100%
V5BCW8	Trypanosoma cruzi	26%	100%