Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B318_LEIMU

TriTrypDb:

LmxM.31.2390

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B318

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B318

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.702
CLV_C14_Caspase3-7	94	98	PF00656	0.772
CLV_NRD_NRD_1	122	124	PF00675	0.772
CLV_NRD_NRD_1	138	140	PF00675	0.699
CLV_NRD_NRD_1	142	144	PF00675	0.728
CLV_NRD_NRD_1	146	148	PF00675	0.688
CLV_NRD_NRD_1	193	195	PF00675	0.435
CLV_NRD_NRD_1	226	228	PF00675	0.767
CLV_NRD_NRD_1	318	320	PF00675	0.612
CLV_NRD_NRD_1	465	467	PF00675	0.424
CLV_NRD_NRD_1	67	69	PF00675	0.667
CLV_PCSK_FUR_1	139	143	PF00082	0.749
CLV_PCSK_FUR_1	65	69	PF00082	0.626
CLV_PCSK_KEX2_1	122	124	PF00082	0.760
CLV_PCSK_KEX2_1	140	142	PF00082	0.627
CLV_PCSK_KEX2_1	145	147	PF00082	0.730
CLV_PCSK_KEX2_1	226	228	PF00082	0.804
CLV_PCSK_KEX2_1	320	322	PF00082	0.593
CLV_PCSK_KEX2_1	33	35	PF00082	0.770
CLV_PCSK_KEX2_1	384	386	PF00082	0.726
CLV_PCSK_KEX2_1	465	467	PF00082	0.467
CLV_PCSK_KEX2_1	67	69	PF00082	0.640
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.818
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.571
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.770
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.726
CLV_PCSK_PC7_1	141	147	PF00082	0.740
CLV_PCSK_SKI1_1	163	167	PF00082	0.663
CLV_PCSK_SKI1_1	227	231	PF00082	0.714
CLV_PCSK_SKI1_1	332	336	PF00082	0.605
CLV_PCSK_SKI1_1	339	343	PF00082	0.574
CLV_PCSK_SKI1_1	465	469	PF00082	0.437
CLV_PCSK_SKI1_1	67	71	PF00082	0.737
CLV_Separin_Metazoa	148	152	PF03568	0.685
DEG_APCC_DBOX_1	464	472	PF00400	0.367
DEG_Kelch_Keap1_1	104	109	PF01344	0.727
DEG_SCF_FBW7_2	171	178	PF00400	0.708
DEG_SPOP_SBC_1	208	212	PF00917	0.670
DEG_SPOP_SBC_1	28	32	PF00917	0.785
DOC_CKS1_1	157	162	PF01111	0.513
DOC_CKS1_1	172	177	PF01111	0.709
DOC_CKS1_1	405	410	PF01111	0.782
DOC_MAPK_gen_1	140	152	PF00069	0.704
DOC_MAPK_gen_1	226	232	PF00069	0.790
DOC_MAPK_gen_1	271	279	PF00069	0.464
DOC_MAPK_gen_1	384	392	PF00069	0.725
DOC_PP2B_LxvP_1	187	190	PF13499	0.672
DOC_PP4_FxxP_1	354	357	PF00568	0.822
DOC_USP7_MATH_1	131	135	PF00917	0.811
DOC_USP7_MATH_1	20	24	PF00917	0.746
DOC_USP7_MATH_1	241	245	PF00917	0.660
DOC_USP7_MATH_1	26	30	PF00917	0.749
DOC_USP7_MATH_1	260	264	PF00917	0.776
DOC_USP7_MATH_1	330	334	PF00917	0.601
DOC_USP7_MATH_1	348	352	PF00917	0.544
DOC_USP7_MATH_1	391	395	PF00917	0.722
DOC_USP7_MATH_1	417	421	PF00917	0.786
DOC_USP7_MATH_1	423	427	PF00917	0.742
DOC_USP7_MATH_1	432	436	PF00917	0.671
DOC_USP7_MATH_1	475	479	PF00917	0.637
DOC_USP7_MATH_1	511	515	PF00917	0.431
DOC_USP7_UBL2_3	271	275	PF12436	0.625
DOC_USP7_UBL2_3	380	384	PF12436	0.805
DOC_WW_Pin1_4	156	161	PF00397	0.578
DOC_WW_Pin1_4	171	176	PF00397	0.625
DOC_WW_Pin1_4	220	225	PF00397	0.545
DOC_WW_Pin1_4	24	29	PF00397	0.767
DOC_WW_Pin1_4	262	267	PF00397	0.598
DOC_WW_Pin1_4	404	409	PF00397	0.730
DOC_WW_Pin1_4	77	82	PF00397	0.613
LIG_14-3-3_CanoR_1	170	175	PF00244	0.576
LIG_14-3-3_CanoR_1	236	243	PF00244	0.722
LIG_14-3-3_CanoR_1	349	357	PF00244	0.520
LIG_14-3-3_CanoR_1	385	391	PF00244	0.725
LIG_14-3-3_CanoR_1	424	432	PF00244	0.584
LIG_14-3-3_CanoR_1	455	461	PF00244	0.526
LIG_14-3-3_CanoR_1	86	92	PF00244	0.620
LIG_BIR_III_4	130	134	PF00653	0.522
LIG_BRCT_BRCA1_1	350	354	PF00533	0.515
LIG_BRCT_BRCA1_1	88	92	PF00533	0.638
LIG_FHA_1	164	170	PF00498	0.653
LIG_FHA_1	181	187	PF00498	0.619
LIG_FHA_1	274	280	PF00498	0.551
LIG_FHA_1	387	393	PF00498	0.791
LIG_FHA_1	405	411	PF00498	0.566
LIG_FHA_1	455	461	PF00498	0.395
LIG_FHA_2	457	463	PF00498	0.618
LIG_FHA_2	484	490	PF00498	0.521
LIG_FHA_2	517	523	PF00498	0.560
LIG_LIR_Apic_2	351	357	PF02991	0.804
LIG_LIR_Gen_1	177	187	PF02991	0.574
LIG_LIR_Gen_1	473	481	PF02991	0.560
LIG_LIR_Nem_3	153	157	PF02991	0.577
LIG_LIR_Nem_3	177	182	PF02991	0.597
LIG_LIR_Nem_3	517	523	PF02991	0.541
LIG_MLH1_MIPbox_1	88	92	PF16413	0.638
LIG_PCNA_yPIPBox_3	321	335	PF02747	0.524
LIG_SH2_CRK	154	158	PF00017	0.540
LIG_SH2_CRK	5	9	PF00017	0.701
LIG_SH2_STAT5	91	94	PF00017	0.576
LIG_SH3_3	169	175	PF00018	0.690
LIG_SH3_3	402	408	PF00018	0.641
LIG_TRAF2_1	486	489	PF00917	0.573
LIG_TYR_ITIM	152	157	PF00017	0.546
LIG_WRC_WIRS_1	331	336	PF05994	0.598
MOD_CDK_SPxK_1	220	226	PF00069	0.558
MOD_CDK_SPxK_1	262	268	PF00069	0.599
MOD_CDK_SPxxK_3	156	163	PF00069	0.511
MOD_CDK_SPxxK_3	220	227	PF00069	0.561
MOD_CK1_1	117	123	PF00069	0.776
MOD_CK1_1	177	183	PF00069	0.659
MOD_CK1_1	210	216	PF00069	0.698
MOD_CK1_1	250	256	PF00069	0.689
MOD_CK1_1	29	35	PF00069	0.795
MOD_CK1_1	393	399	PF00069	0.728
MOD_CK1_1	404	410	PF00069	0.655
MOD_CK1_1	437	443	PF00069	0.523
MOD_CK1_1	483	489	PF00069	0.556
MOD_CK1_1	514	520	PF00069	0.543
MOD_CK2_1	456	462	PF00069	0.633
MOD_CK2_1	483	489	PF00069	0.530
MOD_GlcNHglycan	106	109	PF01048	0.658
MOD_GlcNHglycan	135	138	PF01048	0.721
MOD_GlcNHglycan	160	163	PF01048	0.664
MOD_GlcNHglycan	22	25	PF01048	0.700
MOD_GlcNHglycan	249	252	PF01048	0.702
MOD_GlcNHglycan	257	260	PF01048	0.698
MOD_GlcNHglycan	314	317	PF01048	0.719
MOD_GlcNHglycan	374	378	PF01048	0.769
MOD_GlcNHglycan	395	399	PF01048	0.737
MOD_GlcNHglycan	419	422	PF01048	0.720
MOD_GlcNHglycan	426	429	PF01048	0.714
MOD_GlcNHglycan	433	437	PF01048	0.485
MOD_GlcNHglycan	483	486	PF01048	0.366
MOD_GSK3_1	100	107	PF00069	0.651
MOD_GSK3_1	131	138	PF00069	0.695
MOD_GSK3_1	170	177	PF00069	0.637
MOD_GSK3_1	20	27	PF00069	0.712
MOD_GSK3_1	204	211	PF00069	0.767
MOD_GSK3_1	249	256	PF00069	0.689
MOD_GSK3_1	28	35	PF00069	0.551
MOD_GSK3_1	386	393	PF00069	0.702
MOD_GSK3_1	396	403	PF00069	0.632
MOD_GSK3_1	437	444	PF00069	0.498
MOD_GSK3_1	449	456	PF00069	0.472
MOD_GSK3_1	72	79	PF00069	0.444
MOD_GSK3_1	92	99	PF00069	0.648
MOD_N-GLC_1	24	29	PF02516	0.719
MOD_N-GLC_1	288	293	PF02516	0.737
MOD_NEK2_1	219	224	PF00069	0.640
MOD_NEK2_1	249	254	PF00069	0.705
MOD_NEK2_1	267	272	PF00069	0.584
MOD_NEK2_1	400	405	PF00069	0.663
MOD_NEK2_1	441	446	PF00069	0.527
MOD_NEK2_1	481	486	PF00069	0.613
MOD_NEK2_1	494	499	PF00069	0.484
MOD_NEK2_1	85	90	PF00069	0.707
MOD_NEK2_1	96	101	PF00069	0.597
MOD_PIKK_1	410	416	PF00454	0.638
MOD_PIKK_1	475	481	PF00454	0.651
MOD_PIKK_1	494	500	PF00454	0.323
MOD_PKA_2	235	241	PF00069	0.691
MOD_PKA_2	267	273	PF00069	0.629
MOD_PKA_2	348	354	PF00069	0.585
MOD_PKA_2	423	429	PF00069	0.534
MOD_PKA_2	454	460	PF00069	0.368
MOD_PKA_2	85	91	PF00069	0.627
MOD_Plk_1	177	183	PF00069	0.731
MOD_Plk_1	310	316	PF00069	0.695
MOD_Plk_1	92	98	PF00069	0.664
MOD_Plk_2-3	273	279	PF00069	0.679
MOD_Plk_4	396	402	PF00069	0.712
MOD_Plk_4	441	447	PF00069	0.535
MOD_Plk_4	456	462	PF00069	0.561
MOD_Plk_4	96	102	PF00069	0.532
MOD_ProDKin_1	156	162	PF00069	0.584
MOD_ProDKin_1	171	177	PF00069	0.632
MOD_ProDKin_1	220	226	PF00069	0.551
MOD_ProDKin_1	24	30	PF00069	0.766
MOD_ProDKin_1	262	268	PF00069	0.599
MOD_ProDKin_1	404	410	PF00069	0.730
MOD_ProDKin_1	77	83	PF00069	0.617
MOD_SUMO_rev_2	270	277	PF00179	0.676
TRG_DiLeu_BaEn_1	153	158	PF01217	0.482
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.704
TRG_ENDOCYTIC_2	154	157	PF00928	0.573
TRG_ENDOCYTIC_2	179	182	PF00928	0.660
TRG_ENDOCYTIC_2	5	8	PF00928	0.699
TRG_ER_diArg_1	139	142	PF00400	0.751
TRG_ER_diArg_1	143	146	PF00400	0.733
TRG_ER_diArg_1	225	227	PF00400	0.788
TRG_ER_diArg_1	465	467	PF00400	0.391
TRG_ER_diArg_1	67	69	PF00400	0.667
TRG_NLS_Bipartite_1	122	144	PF00514	0.742
TRG_NLS_MonoCore_2	138	143	PF00514	0.818
TRG_NLS_MonoExtC_3	138	143	PF00514	0.818
TRG_NLS_MonoExtN_4	139	144	PF00514	0.816
TRG_Pf-PMV_PEXEL_1	227	231	PF00026	0.714
TRG_Pf-PMV_PEXEL_1	466	470	PF00026	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P596	Leptomonas seymouri	42%	96%
A0A3Q8IL99	Leishmania donovani	88%	100%
A4HKN0	Leishmania braziliensis	74%	100%
A4I857	Leishmania infantum	88%	100%
D0AAC7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
Q4Q536	Leishmania major	86%	100%