Aquaporin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aquaporin-like protein

Species:

Leishmania mexicana

UniProt:

E9B317_LEIMU

TriTrypDb:

LmxM.31.2380

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9B317

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B317

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0015267	channel activity	4	7
GO:0022803	passive transmembrane transporter activity	3	7
GO:0022857	transmembrane transporter activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	546	550	PF00656	0.736
CLV_C14_Caspase3-7	556	560	PF00656	0.721
CLV_C14_Caspase3-7	562	566	PF00656	0.678
CLV_C14_Caspase3-7	62	66	PF00656	0.617
CLV_NRD_NRD_1	155	157	PF00675	0.475
CLV_NRD_NRD_1	164	166	PF00675	0.485
CLV_NRD_NRD_1	214	216	PF00675	0.436
CLV_NRD_NRD_1	463	465	PF00675	0.446
CLV_NRD_NRD_1	542	544	PF00675	0.456
CLV_PCSK_FUR_1	540	544	PF00082	0.447
CLV_PCSK_KEX2_1	155	157	PF00082	0.475
CLV_PCSK_KEX2_1	164	166	PF00082	0.485
CLV_PCSK_KEX2_1	542	544	PF00082	0.456
CLV_PCSK_SKI1_1	155	159	PF00082	0.471
CLV_PCSK_SKI1_1	165	169	PF00082	0.410
CLV_PCSK_SKI1_1	340	344	PF00082	0.543
CLV_PCSK_SKI1_1	464	468	PF00082	0.461
CLV_PCSK_SKI1_1	531	535	PF00082	0.570
DEG_Nend_UBRbox_2	1	3	PF02207	0.696
DEG_ODPH_VHL_1	436	449	PF01847	0.310
DEG_SCF_FBW7_1	88	93	PF00400	0.658
DEG_SPOP_SBC_1	143	147	PF00917	0.731
DEG_SPOP_SBC_1	504	508	PF00917	0.704
DEG_SPOP_SBC_1	583	587	PF00917	0.716
DOC_CKS1_1	43	48	PF01111	0.609
DOC_MAPK_MEF2A_6	180	187	PF00069	0.614
DOC_PP2B_LxvP_1	224	227	PF13499	0.583
DOC_PP4_FxxP_1	32	35	PF00568	0.700
DOC_USP7_MATH_1	109	113	PF00917	0.615
DOC_USP7_MATH_1	115	119	PF00917	0.670
DOC_USP7_MATH_1	136	140	PF00917	0.740
DOC_USP7_MATH_1	254	258	PF00917	0.310
DOC_USP7_MATH_1	298	302	PF00917	0.474
DOC_USP7_MATH_1	345	349	PF00917	0.262
DOC_USP7_MATH_1	35	39	PF00917	0.705
DOC_USP7_MATH_1	410	414	PF00917	0.326
DOC_USP7_MATH_1	48	52	PF00917	0.708
DOC_USP7_MATH_1	493	497	PF00917	0.670
DOC_USP7_MATH_1	64	68	PF00917	0.628
DOC_USP7_MATH_1	90	94	PF00917	0.713
DOC_WW_Pin1_4	113	118	PF00397	0.665
DOC_WW_Pin1_4	12	17	PF00397	0.653
DOC_WW_Pin1_4	25	30	PF00397	0.663
DOC_WW_Pin1_4	270	275	PF00397	0.233
DOC_WW_Pin1_4	42	47	PF00397	0.676
DOC_WW_Pin1_4	49	54	PF00397	0.680
DOC_WW_Pin1_4	86	91	PF00397	0.711
LIG_14-3-3_CanoR_1	101	109	PF00244	0.719
LIG_14-3-3_CanoR_1	486	494	PF00244	0.549
LIG_Actin_WH2_2	414	431	PF00022	0.274
LIG_AP2alpha_2	199	201	PF02296	0.644
LIG_BRCT_BRCA1_1	282	286	PF00533	0.334
LIG_BRCT_BRCA1_1	353	357	PF00533	0.310
LIG_BRCT_BRCA1_1	378	382	PF00533	0.474
LIG_FHA_1	180	186	PF00498	0.600
LIG_FHA_1	250	256	PF00498	0.340
LIG_FHA_1	280	286	PF00498	0.297
LIG_FHA_1	456	462	PF00498	0.609
LIG_FHA_1	489	495	PF00498	0.585
LIG_FHA_1	585	591	PF00498	0.633
LIG_FHA_2	509	515	PF00498	0.735
LIG_FHA_2	521	527	PF00498	0.674
LIG_FHA_2	584	590	PF00498	0.698
LIG_FHA_2	60	66	PF00498	0.680
LIG_GBD_Chelix_1	302	310	PF00786	0.262
LIG_GBD_Chelix_1	444	452	PF00786	0.373
LIG_LIR_Apic_2	31	35	PF02991	0.700
LIG_LIR_Gen_1	138	148	PF02991	0.632
LIG_LIR_Gen_1	219	227	PF02991	0.621
LIG_LIR_Gen_1	228	236	PF02991	0.605
LIG_LIR_Gen_1	238	247	PF02991	0.368
LIG_LIR_Gen_1	354	365	PF02991	0.340
LIG_LIR_Nem_3	138	143	PF02991	0.636
LIG_LIR_Nem_3	219	224	PF02991	0.630
LIG_LIR_Nem_3	228	232	PF02991	0.612
LIG_LIR_Nem_3	238	243	PF02991	0.368
LIG_LIR_Nem_3	246	250	PF02991	0.367
LIG_LIR_Nem_3	287	291	PF02991	0.351
LIG_LIR_Nem_3	354	360	PF02991	0.342
LIG_MAD2	192	200	PF02301	0.564
LIG_NBox_RRM_1	296	306	PF00076	0.499
LIG_Pex14_2	382	386	PF04695	0.344
LIG_PTB_Apo_2	369	376	PF02174	0.310
LIG_PTB_Phospho_1	369	375	PF10480	0.310
LIG_SH2_CRK	221	225	PF00017	0.604
LIG_SH2_NCK_1	4	8	PF00017	0.604
LIG_SH2_STAP1	181	185	PF00017	0.617
LIG_SH2_STAP1	221	225	PF00017	0.604
LIG_SH2_STAT3	375	378	PF00017	0.474
LIG_SH2_STAT5	181	184	PF00017	0.623
LIG_SH2_STAT5	239	242	PF00017	0.310
LIG_SH2_STAT5	290	293	PF00017	0.351
LIG_SH2_STAT5	318	321	PF00017	0.351
LIG_SH2_STAT5	351	354	PF00017	0.275
LIG_SH3_1	570	576	PF00018	0.690
LIG_SH3_3	167	173	PF00018	0.678
LIG_SH3_3	37	43	PF00018	0.719
LIG_SH3_3	47	53	PF00018	0.651
LIG_SH3_3	570	576	PF00018	0.716
LIG_SUMO_SIM_anti_2	252	257	PF11976	0.328
LIG_SUMO_SIM_par_1	181	186	PF11976	0.694
LIG_SUMO_SIM_par_1	251	257	PF11976	0.342
LIG_TRFH_1	434	438	PF08558	0.310
LIG_WRC_WIRS_1	244	249	PF05994	0.351
LIG_WRC_WIRS_1	285	290	PF05994	0.351
LIG_WRC_WIRS_1	361	366	PF05994	0.351
LIG_WRC_WIRS_1	590	595	PF05994	0.617
MOD_CK1_1	141	147	PF00069	0.732
MOD_CK1_1	267	273	PF00069	0.287
MOD_CK1_1	350	356	PF00069	0.269
MOD_CK1_1	376	382	PF00069	0.479
MOD_CK1_1	393	399	PF00069	0.294
MOD_CK1_1	506	512	PF00069	0.723
MOD_CK1_1	51	57	PF00069	0.754
MOD_CK1_1	518	524	PF00069	0.802
MOD_CK2_1	508	514	PF00069	0.707
MOD_CK2_1	574	580	PF00069	0.735
MOD_CK2_1	583	589	PF00069	0.665
MOD_CK2_1	72	78	PF00069	0.714
MOD_CMANNOS	432	435	PF00535	0.351
MOD_Cter_Amidation	153	156	PF01082	0.474
MOD_Cter_Amidation	162	165	PF01082	0.478
MOD_GlcNHglycan	146	149	PF01048	0.492
MOD_GlcNHglycan	16	19	PF01048	0.507
MOD_GlcNHglycan	23	26	PF01048	0.620
MOD_GlcNHglycan	291	294	PF01048	0.337
MOD_GlcNHglycan	353	356	PF01048	0.310
MOD_GlcNHglycan	37	40	PF01048	0.494
MOD_GlcNHglycan	378	381	PF01048	0.270
MOD_GlcNHglycan	392	395	PF01048	0.363
MOD_GlcNHglycan	397	400	PF01048	0.482
MOD_GlcNHglycan	402	405	PF01048	0.523
MOD_GlcNHglycan	412	415	PF01048	0.427
MOD_GlcNHglycan	565	568	PF01048	0.537
MOD_GlcNHglycan	74	77	PF01048	0.587
MOD_GlcNHglycan	80	83	PF01048	0.479
MOD_GlcNHglycan	94	97	PF01048	0.413
MOD_GSK3_1	109	116	PF00069	0.707
MOD_GSK3_1	138	145	PF00069	0.764
MOD_GSK3_1	179	186	PF00069	0.621
MOD_GSK3_1	21	28	PF00069	0.692
MOD_GSK3_1	280	287	PF00069	0.329
MOD_GSK3_1	343	350	PF00069	0.276
MOD_GSK3_1	351	358	PF00069	0.271
MOD_GSK3_1	48	55	PF00069	0.823
MOD_GSK3_1	484	491	PF00069	0.661
MOD_GSK3_1	503	510	PF00069	0.663
MOD_GSK3_1	514	521	PF00069	0.758
MOD_GSK3_1	584	591	PF00069	0.746
MOD_GSK3_1	86	93	PF00069	0.684
MOD_N-GLC_1	130	135	PF02516	0.496
MOD_N-GLC_1	136	141	PF02516	0.520
MOD_N-GLC_1	259	264	PF02516	0.474
MOD_N-GLC_1	270	275	PF02516	0.474
MOD_N-GLC_1	55	60	PF02516	0.431
MOD_N-GLC_1	78	83	PF02516	0.516
MOD_NEK2_1	119	124	PF00069	0.706
MOD_NEK2_1	179	184	PF00069	0.609
MOD_NEK2_1	235	240	PF00069	0.493
MOD_NEK2_1	243	248	PF00069	0.371
MOD_NEK2_1	279	284	PF00069	0.349
MOD_NEK2_1	310	315	PF00069	0.449
MOD_NEK2_1	360	365	PF00069	0.322
MOD_NEK2_1	390	395	PF00069	0.310
MOD_NEK2_1	59	64	PF00069	0.616
MOD_NEK2_1	84	89	PF00069	0.614
MOD_NEK2_1	91	96	PF00069	0.618
MOD_NEK2_2	254	259	PF00069	0.310
MOD_PIKK_1	101	107	PF00454	0.720
MOD_PIKK_1	310	316	PF00454	0.399
MOD_PIKK_1	447	453	PF00454	0.404
MOD_PIKK_1	455	461	PF00454	0.608
MOD_PIKK_1	554	560	PF00454	0.739
MOD_PK_1	259	265	PF00069	0.274
MOD_PKA_2	100	106	PF00069	0.700
MOD_PKA_2	376	382	PF00069	0.474
MOD_PKA_2	400	406	PF00069	0.262
MOD_PKA_2	485	491	PF00069	0.660
MOD_PKA_2	504	510	PF00069	0.624
MOD_PKA_2	514	520	PF00069	0.682
MOD_Plk_1	136	142	PF00069	0.727
MOD_Plk_1	259	265	PF00069	0.274
MOD_Plk_1	55	61	PF00069	0.630
MOD_Plk_1	588	594	PF00069	0.617
MOD_Plk_1	64	70	PF00069	0.609
MOD_Plk_4	109	115	PF00069	0.611
MOD_Plk_4	235	241	PF00069	0.477
MOD_Plk_4	259	265	PF00069	0.281
MOD_Plk_4	280	286	PF00069	0.351
MOD_Plk_4	347	353	PF00069	0.368
MOD_Plk_4	427	433	PF00069	0.303
MOD_ProDKin_1	113	119	PF00069	0.665
MOD_ProDKin_1	12	18	PF00069	0.655
MOD_ProDKin_1	25	31	PF00069	0.663
MOD_ProDKin_1	270	276	PF00069	0.233
MOD_ProDKin_1	42	48	PF00069	0.679
MOD_ProDKin_1	49	55	PF00069	0.678
MOD_ProDKin_1	86	92	PF00069	0.710
MOD_SUMO_rev_2	186	194	PF00179	0.592
MOD_SUMO_rev_2	426	431	PF00179	0.299
MOD_SUMO_rev_2	457	467	PF00179	0.613
TRG_DiLeu_BaLyEn_6	231	236	PF01217	0.570
TRG_ENDOCYTIC_2	221	224	PF00928	0.606
TRG_ER_diArg_1	155	157	PF00400	0.651
TRG_ER_diArg_1	475	478	PF00400	0.650
TRG_ER_diArg_1	540	543	PF00400	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I348	Leptomonas seymouri	57%	98%
A0A3Q8IFK5	Leishmania donovani	86%	100%
A4HKM9	Leishmania braziliensis	77%	100%
A4I858	Leishmania infantum	86%	100%
Q4Q537	Leishmania major	84%	100%