LeishMANIAdb
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Aquaporin-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Aquaporin-like protein
Gene product:
aquaporin-like protein
Species:
Leishmania mexicana
UniProt:
E9B316_LEIMU
TriTrypDb:
LmxM.31.2370
Length:
278

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: antonio.jimenez@uah.es
Publication title: A functional BH3 domain in an aquaporin from Leishmania infantum
Publication 1st author(s): Genes
Publication Identifier(s): 27551533
Host organism: taxid:4932
Interaction detection method(s): two hybrid
Interaction type: physical association
Identification method participant A: predetermined participant
Identification method participant B: predetermined participant
ID(s) interactor A: Q07817
ID(s) interactor B: A4I001
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 32
NetGPI no yes: 0, no: 32
Cellular components
Term Name Level Count
GO:0016020 membrane 2 33
GO:0110165 cellular anatomical entity 1 33
GO:0005886 plasma membrane 3 1

Expansion

Sequence features

E9B316
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B316

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0006833 water transport 5 2
GO:0042044 fluid transport 4 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 33
GO:0015267 channel activity 4 33
GO:0022803 passive transmembrane transporter activity 3 33
GO:0022857 transmembrane transporter activity 2 33
GO:0005372 water transmembrane transporter activity 4 2
GO:0015250 water channel activity 5 2
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
DEG_Nend_UBRbox_4 1 3 PF02207 0.553
DEG_ODPH_VHL_1 69 82 PF01847 0.246
DOC_CYCLIN_yClb5_NLxxxL_5 272 278 PF00134 0.442
DOC_MAPK_MEF2A_6 20 27 PF00069 0.551
DOC_PP2B_LxvP_1 140 143 PF13499 0.242
LIG_FHA_1 135 141 PF00498 0.282
LIG_FHA_1 162 168 PF00498 0.284
LIG_FHA_1 217 223 PF00498 0.316
LIG_FHA_1 226 232 PF00498 0.256
LIG_FHA_1 252 258 PF00498 0.572
LIG_FHA_1 45 51 PF00498 0.289
LIG_FHA_1 64 70 PF00498 0.170
LIG_FHA_1 96 102 PF00498 0.364
LIG_FHA_2 8 14 PF00498 0.638
LIG_GBD_Chelix_1 270 278 PF00786 0.239
LIG_LIR_Gen_1 151 162 PF02991 0.279
LIG_LIR_Gen_1 41 50 PF02991 0.260
LIG_LIR_Gen_1 98 107 PF02991 0.293
LIG_LIR_Nem_3 151 157 PF02991 0.264
LIG_LIR_Nem_3 160 166 PF02991 0.287
LIG_LIR_Nem_3 183 187 PF02991 0.340
LIG_LIR_Nem_3 41 45 PF02991 0.266
LIG_LIR_Nem_3 98 102 PF02991 0.336
LIG_NBox_RRM_1 93 103 PF00076 0.240
LIG_PDZ_Class_1 273 278 PF00595 0.488
LIG_SH2_STAT3 176 179 PF00017 0.414
LIG_SH2_STAT3 226 229 PF00017 0.332
LIG_SH2_STAT5 17 20 PF00017 0.570
LIG_SH2_STAT5 226 229 PF00017 0.287
LIG_SH2_STAT5 232 235 PF00017 0.291
LIG_SH2_STAT5 87 90 PF00017 0.457
LIG_SUMO_SIM_par_1 164 169 PF11976 0.240
LIG_TYR_ITIM 230 235 PF00017 0.351
LIG_WRC_WIRS_1 39 44 PF05994 0.291
MOD_CK2_1 46 52 PF00069 0.292
MOD_CK2_1 7 13 PF00069 0.615
MOD_CMANNOS 234 237 PF00535 0.290
MOD_GlcNHglycan 154 157 PF01048 0.487
MOD_GlcNHglycan 203 206 PF01048 0.453
MOD_GlcNHglycan 88 91 PF01048 0.244
MOD_GSK3_1 7 14 PF00069 0.679
MOD_NEK2_1 166 171 PF00069 0.276
MOD_NEK2_1 193 198 PF00069 0.312
MOD_NEK2_1 216 221 PF00069 0.254
MOD_NEK2_1 251 256 PF00069 0.516
MOD_NEK2_1 44 49 PF00069 0.303
MOD_PIKK_1 134 140 PF00454 0.181
MOD_PIKK_1 174 180 PF00454 0.532
MOD_PIKK_1 193 199 PF00454 0.390
MOD_PIKK_1 225 231 PF00454 0.319
MOD_PKA_2 25 31 PF00069 0.580
MOD_Plk_4 127 133 PF00069 0.385
MOD_Plk_4 166 172 PF00069 0.288
MOD_Plk_4 38 44 PF00069 0.297
MOD_SUMO_for_1 258 261 PF00179 0.522
MOD_SUMO_rev_2 7 16 PF00179 0.530
TRG_DiLeu_BaLyEn_6 20 25 PF01217 0.539
TRG_ENDOCYTIC_2 232 235 PF00928 0.351
TRG_ENDOCYTIC_2 275 278 PF00928 0.634

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1D2 Leptomonas seymouri 38% 98%
A0A0N1ILB4 Leptomonas seymouri 40% 100%
A0A0N1PB10 Leptomonas seymouri 76% 100%
A0A0S4IS36 Bodo saltans 39% 79%
A0A0S4IS78 Bodo saltans 58% 100%
A0A0S4JRP5 Bodo saltans 28% 83%
A0A0S4KLV5 Bodo saltans 41% 100%
A0A1X0ND19 Trypanosomatidae 39% 100%
A0A1X0NT73 Trypanosomatidae 66% 100%
A0A1X0NTY8 Trypanosomatidae 34% 100%
A0A3R7RFH0 Trypanosoma rangeli 67% 100%
A0A3S5H7B2 Leishmania donovani 37% 95%
A0A3S5H7S4 Leishmania donovani 95% 100%
A0A3S7X8F2 Leishmania donovani 41% 100%
A0A422N493 Trypanosoma rangeli 37% 100%
A0A422N886 Trypanosoma rangeli 43% 66%
A0A422NSX8 Trypanosoma rangeli 40% 100%
A0A6M3QG69 Musa acuminata 27% 99%
A0A804KTT0 Musa acuminata subsp. malaccensis 29% 97%
A2IBY8 Canis lupus familiaris 27% 100%
A4HBA6 Leishmania braziliensis 40% 100%
A4HCI0 Leishmania braziliensis 35% 100%
A4HIW6 Leishmania braziliensis 26% 100%
A4HKM8 Leishmania braziliensis 82% 100%
A4HKM9 Leishmania braziliensis 36% 100%
A4I001 Leishmania infantum 37% 95%
A4I859 Leishmania infantum 95% 100%
A4IAF4 Leishmania infantum 41% 100%
A4L9J0 Oryctolagus cuniculus 29% 100%
A6ZX66 Saccharomyces cerevisiae (strain YJM789) 26% 91%
A8W649 Sus scrofa 28% 100%
A9Y006 Sus scrofa 26% 96%
C8ZJM1 Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) 28% 85%
E9AVX4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9B1F0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 89%
E9B5H8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
F9UUB3 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) 26% 100%
F9UUD2 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) 33% 100%
G5CTG1 Milnesium tardigradum 23% 80%
G5CTG2 Milnesium tardigradum 24% 100%
G5CTG3 Milnesium tardigradum 26% 98%
G5CTG4 Milnesium tardigradum 28% 88%
G5CTG6 Milnesium tardigradum 23% 99%
O22588 Arabidopsis thaliana 29% 100%
O26206 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 29% 100%
O28846 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 28% 100%
O43315 Homo sapiens 27% 94%
O64964 Zea mays 29% 100%
O68874 Shigella flexneri 30% 100%
O82598 Arabidopsis thaliana 28% 100%
O94778 Homo sapiens 31% 100%
P08995 Glycine max 29% 100%
P09011 Rattus norvegicus 28% 100%
P0C112 Brucella abortus biovar 1 (strain 9-941) 28% 100%
P0CD89 Saccharomyces cerevisiae 29% 96%
P0CD91 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 91%
P0CD92 Saccharomyces cerevisiae 27% 85%
P0DO53 Musa acuminata 30% 100%
P0DO54 Musa acuminata 31% 100%
P25794 Pisum sativum 30% 96%
P25818 Arabidopsis thaliana 31% 100%
P26587 Arabidopsis thaliana 27% 100%
P29972 Homo sapiens 28% 100%
P29975 Rattus norvegicus 28% 100%
P30302 Arabidopsis thaliana 27% 98%
P33560 Antirrhinum majus 31% 100%
P42067 Medicago sativa 29% 100%
P43286 Arabidopsis thaliana 27% 97%
P43287 Arabidopsis thaliana 27% 98%
P47865 Bos taurus 30% 100%
P49173 Nicotiana alata 27% 100%
P50156 Oryza sativa subsp. japonica 29% 100%
P50501 Pelophylax lessonae 27% 100%
P51180 Mus musculus 28% 100%
P55064 Homo sapiens 25% 100%
P55088 Mus musculus 30% 86%
P56401 Ovis aries 28% 100%
P56404 Mus musculus 28% 100%
P56405 Rattus norvegicus 32% 100%
P56627 Rattus norvegicus 26% 94%
P60844 Escherichia coli (strain K12) 30% 100%
P60845 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 30% 100%
P60925 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 25% 100%
P61837 Arabidopsis thaliana 29% 97%
P61838 Vicia faba 29% 97%
P73809 Synechocystis sp. (strain PCC 6803 / Kazusa) 26% 100%
P93004 Arabidopsis thaliana 29% 99%
Q02013 Mus musculus 28% 100%
Q06611 Arabidopsis thaliana 29% 97%
Q08451 Solanum lycopersicum 27% 97%
Q08733 Arabidopsis thaliana 29% 97%
Q08DE6 Bos taurus 26% 95%
Q0DK16 Oryza sativa subsp. japonica 28% 97%
Q0IWF3 Oryza sativa subsp. japonica 31% 89%
Q0JPT5 Oryza sativa subsp. japonica 31% 92%
Q19KC1 Zea mays 27% 94%
Q23808 Cicadella viridis 26% 100%
Q25074 Haematobia irritans exigua 29% 100%
Q2YR68 Brucella abortus (strain 2308) 28% 100%
Q39196 Arabidopsis thaliana 29% 97%
Q40746 Oryza sativa subsp. japonica 27% 98%
Q41870 Zea mays 28% 97%
Q41951 Arabidopsis thaliana 30% 100%
Q41963 Arabidopsis thaliana 30% 100%
Q4Q2F7 Leishmania major 40% 100%
Q4Q538 Leishmania major 94% 100%
Q4QBK5 Leishmania major 37% 100%
Q54V53 Dictyostelium discoideum 27% 100%
Q54WT8 Dictyostelium discoideum 31% 95%
Q5I4F8 Notomys alexis 30% 100%
Q5R819 Pongo abelii 29% 100%
Q5Z6F0 Oryza sativa subsp. japonica 30% 100%
Q651D5 Oryza sativa subsp. japonica 29% 96%
Q67WJ8 Oryza sativa subsp. japonica 28% 93%
Q6EU94 Oryza sativa subsp. japonica 30% 96%
Q6K215 Oryza sativa subsp. japonica 28% 97%
Q6PQZ1 Sus scrofa 28% 100%
Q6Z2T3 Oryza sativa subsp. japonica 27% 93%
Q7EYH7 Oryza sativa subsp. japonica 26% 91%
Q7MIV9 Vibrio vulnificus (strain YJ016) 30% 100%
Q7N5C1 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) 25% 100%
Q7NNP3 Gloeobacter violaceus (strain ATCC 29082 / PCC 7421) 26% 100%
Q7NU39 Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757) 32% 100%
Q7PWV1 Anopheles gambiae 29% 100%
Q7W917 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) 31% 100%
Q7WKG2 Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 31% 100%
Q7XLR1 Oryza sativa subsp. japonica 29% 99%
Q7XSQ9 Oryza sativa subsp. japonica 29% 97%
Q7XU31 Oryza sativa subsp. japonica 27% 100%
Q7XUA6 Oryza sativa subsp. japonica 27% 96%
Q84RL6 Zea mays 31% 100%
Q84RL7 Zea mays 31% 96%
Q84S07 Oryza sativa subsp. japonica 25% 100%
Q866S3 Ovis aries 25% 100%
Q87MQ5 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) 28% 100%
Q89EG9 Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) 27% 100%
Q8DB17 Vibrio vulnificus (strain CMCP6) 30% 100%
Q8EHC1 Shewanella oneidensis (strain MR-1) 30% 100%
Q8FY85 Brucella suis biovar 1 (strain 1330) 28% 100%
Q8GRI8 Oryza sativa subsp. japonica 29% 98%
Q8GRT8 Oryza sativa subsp. japonica 26% 97%
Q8H5N9 Oryza sativa subsp. japonica 31% 96%
Q8LAA6 Arabidopsis thaliana 28% 97%
Q8LFP7 Arabidopsis thaliana 28% 95%
Q8R2N1 Mus musculus 25% 95%
Q8VZW1 Arabidopsis thaliana 25% 94%
Q8W036 Arabidopsis thaliana 28% 98%
Q8W037 Arabidopsis thaliana 26% 97%
Q8X6K6 Escherichia coli O157:H7 30% 100%
Q92482 Homo sapiens 25% 95%
Q9AQU5 Zea mays 29% 95%
Q9AR14 Zea mays 29% 97%
Q9AT74 Zea mays 27% 92%
Q9AT75 Zea mays 26% 100%
Q9ATL2 Zea mays 29% 100%
Q9ATL3 Zea mays 26% 100%
Q9ATL4 Zea mays 29% 100%
Q9ATL8 Zea mays 30% 100%
Q9ATM4 Zea mays 30% 97%
Q9ATM6 Zea mays 27% 97%
Q9ATM7 Zea mays 27% 96%
Q9ATM8 Zea mays 31% 95%
Q9ATN0 Zea mays 28% 94%
Q9ATN1 Zea mays 30% 92%
Q9ATN2 Zea mays 25% 95%
Q9ATN4 Zea mays 30% 99%
Q9C4Z5 Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) 31% 100%
Q9C6T0 Arabidopsis thaliana 26% 86%
Q9FF53 Arabidopsis thaliana 26% 96%
Q9FGL2 Arabidopsis thaliana 27% 100%
Q9FIZ9 Arabidopsis thaliana 27% 98%
Q9FY14 Medicago truncatula 30% 100%
Q9HWZ3 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 25% 100%
Q9L772 Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) 28% 100%
Q9N2J4 Canis lupus familiaris 29% 100%
Q9NHW7 Aedes aegypti 29% 100%
Q9SAI4 Arabidopsis thaliana 24% 91%
Q9STX9 Arabidopsis thaliana 30% 100%
Q9SV84 Arabidopsis thaliana 29% 91%
Q9SXF8 Oryza sativa subsp. japonica 29% 97%
Q9U8P7 Dictyostelium discoideum 29% 100%
Q9V5Z7 Drosophila melanogaster 30% 100%
Q9WTY4 Mus musculus 29% 100%
Q9XF58 Zea mays 27% 98%
Q9XF59 Zea mays 29% 96%
Q9ZV07 Arabidopsis thaliana 28% 96%
Q9ZVX8 Arabidopsis thaliana 28% 100%
S5ZH89 Musa acuminata 28% 97%
V5ANF5 Trypanosoma cruzi 66% 100%
V5B469 Trypanosoma cruzi 37% 100%
V5BW46 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS